Project name: 2WCV [mutate: EA77Y, EB77Y, EC77Y, ED77Y, EE77Y, EF77Y, EG77Y, EH77Y, EI77Y, EJ77Y]

Status: done

submitted: 2017-09-13 11:07:23, status changed: 2017-09-13 11:56:17
Settings
Chain sequence(s) A: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
C: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
B: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
E: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
D: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
G: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
F: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
I: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
H: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
J: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues EA77Y, EB77Y, EC77Y, ED77Y, EE77Y, EF77Y, EG77Y, EH77Y, EI77Y, EJ77Y
Energy difference between WT (input) and mutated protein (by FoldX) -2.80423 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-3.7155
Maximal score value
1.5522
Average score
-0.4965
Total score value
-692.5936

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 1.4699
2 L A 1.2603
3 K A -0.6434
4 T A -0.2068
5 I A 0.6701
6 S A 0.3480
7 P A 0.5483
8 L A 0.5338
9 I A 0.0000
10 S A -0.7339
11 P A -1.1126
12 E A -2.4394
13 L A 0.0000
14 L A -1.1468
15 K A -2.4379
16 V A 0.0000
17 L A 0.0000
18 A A -0.8463
19 E A -1.1282
20 M A 0.0000
21 G A 0.0000
22 H A 0.0000
23 G A -0.1127
24 D A 0.0000
25 E A -0.5856
26 I A 0.0000
27 I A 0.0000
28 F A 0.0000
29 S A 0.0000
30 D A 0.0000
31 A A -1.1218
32 H A -0.5910
33 F A 0.0000
34 P A 0.0000
35 A A 0.0000
36 H A -0.5908
37 S A -0.6831
38 M A -1.3013
39 G A -1.3265
40 P A -1.2596
41 Q A -0.9210
42 V A -0.3521
43 I A -0.8164
44 R A -1.2682
45 A A -1.0882
46 D A -2.1028
47 G A -1.4398
48 L A -0.6711
49 L A -0.4332
50 V A 0.0000
51 S A 0.0000
52 D A -0.7999
53 L A 0.0000
54 L A 0.0000
55 Q A -1.5741
56 A A 0.0000
57 I A 0.0000
58 I A -0.0982
59 P A -0.0745
60 L A 0.5163
61 F A 0.0000
62 E A -0.6156
63 L A -0.1599
64 D A 0.0000
65 S A -0.2697
66 Y A 0.0853
67 A A -0.2809
68 P A -0.4045
69 P A 0.0000
70 L A 0.0000
71 V A 0.0000
72 M A 0.0000
73 M A 0.0000
74 A A 0.0893
75 A A -0.3358
76 V A 0.0000
77 Y A -0.2158 mutated: EA77Y
78 G A -0.3130
79 D A -0.2785
80 T A -0.5424
81 L A -0.9936
82 D A -2.4725
83 P A -2.3103
84 E A -3.2420
85 V A 0.0000
86 E A -2.5409
87 R A -3.4238
88 R A -2.6470
89 Y A 0.0000
90 R A -2.8702
91 N A -2.5118
92 A A -1.8539
93 L A 0.0000
94 S A -0.9711
95 L A -0.6458
98 P A -0.0547
99 C A 0.0938
100 P A -0.3758
101 D A -1.4846
102 I A 0.0000
103 I A 0.4423
104 R A -0.0803
105 I A 0.2338
106 N A -0.2957
107 R A -0.0361
108 F A 0.3714
109 A A -0.3537
110 F A 0.0000
111 Y A -1.0121
112 E A -2.3907
113 R A -1.9767
114 A A 0.0000
115 Q A -2.6314
116 K A -2.7481
117 A A 0.0000
118 F A -0.7801
119 A A 0.0000
120 I A 0.0000
121 V A 0.0000
122 I A 0.0000
123 T A 0.0000
124 G A -1.3940
125 E A 0.0000
126 R A -2.0233
127 A A -1.6650
128 K A -1.4008
129 Y A 0.0000
130 G A 0.0000
131 N A 0.0000
132 I A 0.0000
133 L A 0.0000
134 L A 0.0000
135 K A -0.3940
136 K A 0.0000
137 G A 0.0000
138 V A -0.3368
139 T A -0.3938
140 P A -0.6023
1 M B 1.1348
2 L B 0.6132
3 K B -0.9852
4 T B -0.4162
5 I B 0.3374
6 S B 0.1015
7 P B 0.3459
8 L B 0.3711
9 I B 0.0000
10 S B -0.7259
11 P B -1.1244
12 E B -2.3087
13 L B 0.0000
14 L B -1.1400
15 K B -2.3601
16 V B 0.0000
17 L B 0.0000
18 A B -0.6292
19 E B -1.1127
20 M B 0.0000
21 G B 0.0000
22 H B -0.1528
23 G B 0.0437
24 D B 0.0000
25 E B -0.6055
26 I B 0.0000
27 I B 0.0000
28 F B 0.0000
29 S B 0.0000
30 D B 0.0000
31 A B -1.1413
32 H B 0.0000
33 F B 0.0000
34 P B 0.0000
35 A B 0.0000
36 H B -0.6496
37 S B -0.7770
38 M B -0.9071
39 G B -1.2981
40 P B -1.2666
41 Q B -1.0127
42 V B -0.4000
43 I B -0.8385
44 R B -1.2983
45 A B -1.0929
46 D B -2.0780
47 G B -1.3841
48 L B -0.4015
49 L B -0.2879
50 V B 0.0000
51 S B -1.1919
52 D B -0.7924
53 L B 0.0000
54 L B 0.0000
55 Q B -1.6738
56 A B 0.0000
57 I B 0.0000
58 I B 0.0000
59 P B -0.3163
60 L B 0.3338
61 F B 0.0000
62 E B -0.7257
63 L B -0.2177
64 D B 0.0000
65 S B -0.0679
66 Y B 0.3031
67 A B 0.1772
68 P B -0.3458
69 P B 0.0000
70 L B 0.0000
71 V B 0.0000
72 M B 0.0000
73 M B 0.0000
74 A B 0.0000
75 A B 0.0476
76 V B 0.7803
77 Y B 1.5522 mutated: EB77Y
78 G B 0.6534
79 D B 0.3103
80 T B 0.1253
81 L B -0.4989
82 D B -1.6785
83 P B -1.8125
84 E B -2.5843
85 V B 0.0000
86 E B -2.4460
87 R B -3.6020
88 R B -2.7948
89 Y B 0.0000
90 R B -3.1742
91 N B -2.7115
92 A B 0.0000
93 L B 0.0000
94 S B -1.1181
95 L B -0.5062
96 Q B -1.1063
97 A B -0.5519
98 P B -0.9230
99 C B -0.9962
100 P B -1.1384
101 D B -1.9933
102 I B 0.0000
103 I B -0.6720
104 R B -0.5195
105 I B 0.0000
106 N B -0.4237
107 R B -0.1279
108 F B 0.4033
109 A B 0.0000
110 F B 0.0000
111 Y B -0.2217
112 E B 0.0000
113 R B -0.8471
114 A B 0.0000
115 Q B -1.8040
116 K B -2.1561
117 A B 0.0000
118 F B 0.0000
119 A B 0.0000
120 I B 0.0000
121 V B 0.0000
122 I B 0.0000
123 T B 0.0000
124 G B -1.2970
125 E B 0.0000
126 R B -2.0708
127 A B -1.4515
128 K B -1.5110
129 Y B 0.0000
130 G B 0.0000
131 N B 0.0000
132 I B 0.0000
133 L B 0.0000
134 L B 0.0000
135 K B -0.3761
136 K B 0.0000
137 G B 0.0000
138 V B -0.2371
139 T B -0.3823
140 P B -0.5114
1 M C 1.5059
2 L C 1.2916
3 K C -0.6147
4 T C -0.1684
5 I C 0.7261
6 S C 0.4725
7 P C 0.6654
8 L C 0.6669
9 I C 0.0000
10 S C -0.6853
11 P C -1.0894
12 E C -2.3808
13 L C 0.0000
14 L C -1.1490
15 K C -2.4104
16 V C 0.0000
17 L C 0.0000
18 A C -0.8181
19 E C -1.0591
20 M C 0.0000
21 G C 0.0000
22 H C 0.0000
23 G C -0.1906
24 D C 0.0000
25 E C -0.7013
26 I C 0.0000
27 I C 0.0000
28 F C 0.0000
29 S C 0.0000
30 D C 0.0000
31 A C -1.0331
32 H C 0.0000
33 F C 0.0000
34 P C 0.0000
35 A C 0.0000
36 H C -0.5803
37 S C -0.9112
38 M C 0.0000
39 G C -1.4411
40 P C -1.2617
41 Q C -0.7922
42 V C -0.2591
43 I C -0.7384
44 R C -1.2117
45 A C -1.0376
46 D C -2.0574
47 G C -1.2112
48 L C -0.6629
49 L C -0.4690
50 V C 0.0000
51 S C -0.8887
52 D C -0.8556
53 L C 0.0000
54 L C 0.0000
55 Q C -1.3777
56 A C -0.3432
57 I C 0.0000
58 I C -0.1344
59 P C -0.1114
60 L C 0.4218
61 F C 0.0000
62 E C -0.8107
63 L C -0.3434
64 D C 0.0000
65 S C -0.2566
66 Y C 0.2271
67 A C -0.0920
68 P C -0.4309
69 P C 0.0000
70 L C 0.0000
71 V C 0.0000
72 M C 0.0000
73 M C 0.0000
74 A C -0.2524
75 A C -0.2125
76 V C 0.2165
77 Y C 0.6456 mutated: EC77Y
78 G C -0.1619
79 D C -0.0660
80 T C -0.2660
81 L C -0.6900
82 D C -2.0499
83 P C -2.1221
84 E C -3.0080
85 V C 0.0000
86 E C -2.3349
87 R C -3.4049
88 R C -2.4836
89 Y C 0.0000
90 R C -2.3325
91 N C -2.3609
92 A C 0.0000
93 L C 0.0000
94 S C -0.8986
97 A C -0.0999
98 P C -0.6828
99 C C -0.8388
100 P C -1.0092
101 D C -1.7402
102 I C 0.0000
103 I C 0.2032
104 R C -0.2837
105 I C -0.4964
106 N C -1.3818
107 R C -1.0662
108 F C 0.0000
109 A C -1.1115
110 F C 0.0000
111 Y C 0.0000
112 E C -1.9107
113 R C -2.1629
114 A C 0.0000
115 Q C -2.6731
116 K C -2.8191
117 A C 0.0000
118 F C -0.8652
119 A C 0.0000
120 I C 0.0000
121 V C 0.0000
122 I C 0.0000
123 T C 0.0000
124 G C 0.0000
125 E C 0.0000
126 R C -1.8822
127 A C -1.5233
128 K C -1.2019
129 Y C -0.6213
130 G C 0.0000
131 N C 0.0000
132 I C 0.0000
133 L C 0.0000
134 L C 0.0000
135 K C -0.5140
136 K C 0.0000
137 G C 0.0000
138 V C -0.4292
139 T C -0.5775
140 P C -0.7530
1 M D 1.3770
2 L D 1.1057
3 K D -0.7081
4 T D -0.2075
5 I D 0.6558
6 S D 0.2063
7 P D 0.4179
8 L D 0.2806
9 I D 0.0000
10 S D -0.7290
11 P D -1.1279
12 E D -2.4169
13 L D 0.0000
14 L D -1.2027
15 K D -2.4215
16 V D 0.0000
17 L D 0.0000
18 A D -0.8353
19 E D -1.1456
20 M D 0.0000
21 G D 0.0000
22 H D 0.0000
23 G D -0.1705
24 D D 0.0000
25 E D -0.6232
26 I D 0.0000
27 I D 0.0000
28 F D 0.0000
29 S D 0.0000
30 D D 0.0000
31 A D -1.0573
32 H D 0.0000
33 F D 0.0000
34 P D 0.0000
35 A D 0.0000
36 H D -0.5933
37 S D -0.7886
38 M D -1.0448
39 G D -1.3194
40 P D -1.2512
41 Q D -0.8997
42 V D -0.4700
43 I D -0.7421
44 R D -1.2965
45 A D -0.9499
46 D D -1.9606
47 G D -1.2856
48 L D -0.5116
49 L D -0.1631
50 V D 0.0000
51 S D 0.0000
52 D D -1.2373
53 L D 0.0000
54 L D 0.0000
55 Q D -1.5511
56 A D -0.4519
57 I D 0.0000
58 I D -0.1275
59 P D -0.1441
60 L D 0.4640
61 F D 0.0000
62 E D -0.5226
63 L D -0.0778
64 D D 0.0000
65 S D -0.0521
66 Y D 0.2603
67 A D -0.0171
68 P D -0.3018
69 P D 0.0000
70 L D 0.0000
71 V D 0.0000
72 M D 0.0000
73 M D 0.0000
74 A D -0.2356
75 A D -0.3623
76 V D 0.3746
77 Y D 1.0449 mutated: ED77Y
78 G D 0.0047
79 D D -0.5459
80 T D -0.5824
81 L D -1.1548
82 D D -2.5724
83 P D -2.4209
84 E D -3.2418
85 V D 0.0000
86 E D -2.4669
87 R D -3.5994
88 R D -2.8188
89 Y D 0.0000
90 R D -2.3433
91 N D -2.2329
92 A D 0.0000
93 L D 0.0000
94 S D -0.8990
95 L D -0.3402
96 Q D -0.9195
97 A D -0.5397
98 P D -0.8349
99 C D -0.8429
100 P D -1.0356
101 D D -1.8033
102 I D 0.0000
103 I D -0.0076
104 R D -0.4039
105 I D -0.4337
106 N D -1.1740
107 R D -0.6235
108 F D -0.1362
109 A D -0.4752
110 F D 0.0000
111 Y D -0.6546
112 E D -1.1737
113 R D -1.3261
114 A D 0.0000
115 Q D -2.1373
116 K D -2.4701
117 A D 0.0000
118 F D 0.0000
119 A D 0.0000
120 I D 0.0000
121 V D 0.0000
122 I D 0.0000
123 T D 0.0000
124 G D 0.0000
125 E D 0.0000
126 R D -1.9738
127 A D -1.6556
128 K D -1.5824
129 Y D 0.0000
130 G D 0.0000
131 N D 0.0000
132 I D 0.0000
133 L D 0.0000
134 L D 0.0000
135 K D -0.3280
136 K D 0.0000
137 G D 0.0000
138 V D -0.2587
139 T D -0.4134
140 P D -0.5818
1 M E 1.4346
2 L E 1.1616
3 K E -0.6994
4 T E -0.2496
5 I E 0.6095
6 S E 0.2000
7 P E 0.5644
8 L E 0.5648
9 I E 0.0000
10 S E -0.6880
11 P E -1.1027
12 E E -2.4376
13 L E 0.0000
14 L E -1.2261
15 K E -2.4387
16 V E 0.0000
17 L E 0.0000
18 A E -0.8383
19 E E -1.1673
20 M E 0.0000
21 G E 0.0000
22 H E 0.0000
23 G E -0.0987
24 D E 0.0000
25 E E -0.5441
26 I E 0.0000
27 I E 0.0000
28 F E 0.0000
29 S E 0.0000
30 D E 0.0000
31 A E -1.0665
32 H E -0.6142
33 F E 0.0000
34 P E 0.0000
35 A E 0.0000
36 H E -0.5744
37 S E -0.7745
38 M E 0.0000
39 G E -1.1665
40 P E -1.1244
41 Q E -0.9920
42 V E -0.3528
43 I E -0.8176
44 R E -1.2718
45 A E -1.1227
46 D E -2.0897
47 G E -1.2071
48 L E -0.6027
49 L E -0.2228
50 V E 0.0000
51 S E -0.9597
52 D E -0.6536
53 L E 0.0000
54 L E 0.0000
55 Q E -1.1387
56 A E 0.0000
57 I E 0.0000
58 I E 0.0000
59 P E 0.1355
60 L E 0.4480
61 F E 0.0000
62 E E -0.6793
63 L E -0.1944
64 D E 0.0000
65 S E -0.2310
66 Y E 0.0157
67 A E -0.1176
68 P E 0.0000
69 P E 0.0000
70 L E 0.0000
71 V E 0.0000
72 M E 0.0000
73 M E 0.0000
74 A E 0.1014
75 A E 0.1971
76 V E 0.9036
77 Y E 1.1696 mutated: EE77Y
78 G E 0.1454
79 D E -0.0046
80 T E -0.1631
81 L E -0.4584
82 D E -1.6947
83 P E -2.0378
84 E E -3.1227
85 V E 0.0000
86 E E -2.5209
87 R E -3.6003
88 R E -2.8066
89 Y E 0.0000
90 R E -2.4340
91 N E -2.1995
92 A E 0.0000
93 L E 0.0000
94 S E -0.2330
95 L E 1.0266
97 A E 0.4316
98 P E -0.3707
99 C E 0.0000
100 P E -0.9963
101 D E -1.9839
102 I E 0.0000
103 I E 0.0000
104 R E -0.7188
105 I E 0.0000
106 N E -0.1743
107 R E -0.1627
108 F E 0.1436
109 A E 0.0000
110 F E 0.0000
111 Y E 0.0000
112 E E 0.0000
113 R E -0.9078
114 A E 0.0000
115 Q E -1.3746
116 K E -2.0609
117 A E 0.0000
118 F E -0.7058
119 A E 0.0000
120 I E 0.0000
121 V E 0.0000
122 I E 0.0000
123 T E 0.0000
124 G E -1.2506
125 E E 0.0000
126 R E -1.8832
127 A E -1.3802
128 K E -1.0266
129 Y E 0.0000
130 G E 0.0000
131 N E 0.0000
132 I E 0.0000
133 L E 0.0000
134 L E 0.0000
135 K E -0.3720
136 K E 0.0000
137 G E 0.0000
138 V E -0.2029
139 T E -0.3805
140 P E -0.6337
1 M F 1.4339
2 L F 1.2034
3 K F -0.7059
4 T F -0.3081
5 I F 0.4546
6 S F 0.2550
7 P F 0.4706
8 L F 0.4193
9 I F 0.0000
10 S F -0.7346
11 P F -1.0901
12 E F -2.5023
13 L F 0.0000
14 L F -1.1967
15 K F -2.4051
16 V F 0.0000
17 L F 0.0000
18 A F -0.8332
19 E F -1.1726
20 M F 0.0000
21 G F 0.0000
22 H F 0.0000
23 G F -0.0777
24 D F 0.0000
25 E F 0.0000
26 I F 0.0000
27 I F 0.0000
28 F F 0.0000
29 S F 0.0000
30 D F 0.0000
31 A F -1.0864
32 H F 0.0000
33 F F 0.0000
34 P F 0.0000
35 A F 0.0000
36 H F -0.6691
37 S F -0.9321
38 M F 0.0000
39 G F -1.4557
40 P F -1.3495
41 Q F -0.9408
42 V F -0.3251
43 I F -0.8000
44 R F -1.4409
45 A F -1.0333
46 D F -2.0326
47 G F -1.3339
48 L F -0.5350
49 L F -0.2733
50 V F 0.0000
51 S F -1.1223
52 D F -0.9189
53 L F 0.0000
54 L F 0.0000
55 Q F -1.5718
56 A F 0.0000
57 I F 0.0000
58 I F -0.1086
59 P F -0.0923
60 L F 0.5025
61 F F 0.0000
62 E F -0.6537
63 L F -0.1567
64 D F 0.0000
65 S F -0.0051
66 Y F 0.3919
67 A F 0.0562
68 P F -0.2026
69 P F 0.0000
70 L F 0.0000
71 V F 0.0000
72 M F 0.0000
73 M F 0.0000
74 A F -0.1296
75 A F -0.4249
76 V F 0.0000
77 Y F 0.7421 mutated: EF77Y
78 G F -0.2848
79 D F -0.7500
80 T F -0.6411
81 L F -1.1461
82 D F -2.7017
83 P F -2.4519
84 E F -3.2894
85 V F 0.0000
86 E F -2.4467
87 R F -3.5434
88 R F -2.6089
89 Y F 0.0000
90 R F -2.7163
91 N F -2.5947
92 A F 0.0000
93 L F 0.0000
94 S F -1.3631
95 L F 0.0000
96 Q F -1.6845
97 A F -0.7068
98 P F -0.4685
99 C F -0.2932
100 P F -0.6359
101 D F -1.4855
102 I F -0.3769
103 I F 0.3307
104 R F -0.1055
105 I F -0.1941
106 N F -0.8249
107 R F 0.0000
108 F F -0.2785
109 A F -0.9373
110 F F 0.0000
111 Y F -1.3062
112 E F -2.6457
113 R F -2.1109
114 A F 0.0000
115 Q F -2.9181
116 K F -2.9088
117 A F 0.0000
118 F F 0.0000
119 A F 0.0000
120 I F 0.0000
121 V F 0.0000
122 I F 0.0000
123 T F 0.0000
124 G F 0.0000
125 E F 0.0000
126 R F -2.0252
127 A F -1.7845
128 K F -1.7360
129 Y F 0.0000
130 G F 0.0000
131 N F 0.0000
132 I F 0.0000
133 L F 0.0000
134 L F 0.0000
135 K F -0.3273
136 K F 0.0000
137 G F 0.0000
138 V F -0.2968
139 T F -0.4231
140 P F -0.6296
1 M G 1.4718
2 L G 1.2374
3 K G -0.6818
4 T G -0.2486
5 I G 0.5931
6 S G 0.2389
7 P G 0.5827
8 L G 0.5308
9 I G 0.0000
10 S G -0.5726
11 P G -0.8586
12 E G -1.9541
13 L G 0.0000
14 L G -0.9796
15 K G -2.2269
16 V G 0.0000
17 L G 0.0000
18 A G -0.6202
19 E G -1.0898
20 M G 0.0000
21 G G 0.0000
22 H G -0.2148
23 G G -0.2399
24 D G 0.0000
25 E G -0.6543
26 I G 0.0000
27 I G 0.0000
28 F G 0.0000
29 S G 0.0000
30 D G 0.0000
31 A G -1.1289
32 H G -0.6343
33 F G 0.0000
34 P G 0.0000
35 A G 0.0000
36 H G -0.6703
37 S G -0.8729
38 M G -1.2890
39 G G -1.3624
40 P G -1.3071
41 Q G -0.8916
42 V G -0.5210
43 I G 0.0000
44 R G -1.3273
45 A G -1.0594
46 D G -2.0511
47 G G -1.3526
48 L G -0.5110
49 L G -0.3240
50 V G 0.0000
51 S G -1.1244
52 D G -0.6775
53 L G 0.0000
54 L G 0.0000
55 Q G -1.6078
56 A G 0.0000
57 I G 0.0000
58 I G 0.0000
59 P G -0.3371
60 L G 0.3488
61 F G 0.0000
62 E G -0.6133
63 L G -0.1265
64 D G 0.0000
65 S G -0.0864
66 Y G 0.3115
67 A G 0.0473
68 P G -0.3708
69 P G 0.0000
70 L G 0.0000
71 V G 0.0000
72 M G 0.0000
73 M G 0.0000
74 A G 0.2061
75 A G -0.0401
76 V G 0.5965
77 Y G 1.0831 mutated: EG77Y
78 G G 0.0467
79 D G -0.2855
80 T G -0.2776
81 L G -0.5987
82 D G -1.9518
83 P G -2.1055
84 E G -3.1500
85 V G 0.0000
86 E G -2.5062
87 R G -3.6603
88 R G -2.7952
89 Y G 0.0000
90 R G -2.9223
91 N G -2.5588
92 A G 0.0000
93 L G 0.0000
94 S G -1.0524
95 L G -0.3976
96 Q G -1.0832
97 A G -0.5501
98 P G -0.8240
99 C G -0.8953
100 P G -1.0720
101 D G -1.9102
102 I G 0.0000
103 I G -0.0607
104 R G -0.4450
105 I G 0.1841
106 N G 0.0199
107 R G 0.3304
108 F G 1.3707
109 A G 0.0530
110 F G 0.0000
111 Y G -0.5255
112 E G -1.6374
113 R G -1.7355
114 A G 0.0000
115 Q G -2.6913
116 K G -2.7390
117 A G 0.0000
118 F G 0.0000
119 A G 0.0000
120 I G 0.0000
121 V G 0.0000
122 I G 0.0000
123 T G 0.0000
124 G G 0.0000
125 E G 0.0000
126 R G -2.0111
127 A G -1.6397
128 K G -1.3850
129 Y G 0.0000
130 G G 0.0000
131 N G 0.0000
132 I G 0.0000
133 L G 0.0000
134 L G 0.0000
135 K G -0.3950
136 K G 0.0000
137 G G 0.0000
138 V G -0.2980
139 T G -0.4298
140 P G -0.6081
1 M H 1.3804
2 L H 0.9596
3 K H -0.7956
4 T H -0.3032
5 I H 0.5921
6 S H 0.2936
7 P H 0.7071
8 L H 0.9835
9 I H 0.0000
10 S H -0.6235
11 P H -1.1019
12 E H -2.4278
13 L H 0.0000
14 L H -1.1828
15 K H -2.4078
16 V H 0.0000
17 L H 0.0000
18 A H -0.8038
19 E H -1.0860
20 M H 0.0000
21 G H 0.0000
22 H H 0.0000
23 G H -0.1365
24 D H 0.0000
25 E H 0.0000
26 I H 0.0000
27 I H 0.0000
28 F H 0.0000
29 S H 0.0000
30 D H 0.0000
31 A H -0.9927
32 H H -0.6189
33 F H 0.0000
34 P H 0.0000
35 A H 0.0000
36 H H -0.6634
37 S H -0.6303
38 M H 0.0000
39 G H -1.3116
40 P H -1.2907
41 Q H -1.1164
42 V H -0.3830
43 I H -0.7871
44 R H -1.2073
45 A H -0.8989
46 D H -1.7964
47 G H -1.0432
48 L H -0.3206
49 L H -0.2607
50 V H 0.0000
51 S H -1.0852
52 D H -0.7481
53 L H 0.0000
54 L H 0.0000
55 Q H -1.5052
56 A H 0.0000
57 I H 0.0000
58 I H 0.0000
59 P H -0.2527
60 L H 0.5313
61 F H 0.0000
62 E H -0.5884
63 L H -0.1940
64 D H 0.0000
65 S H -0.2934
66 Y H -0.0313
67 A H -0.1416
68 P H 0.0000
69 P H 0.0000
70 L H 0.0000
71 V H 0.0000
72 M H 0.0000
73 M H 0.0000
74 A H 0.0600
75 A H 0.0668
76 V H 0.7386
77 Y H 1.0344 mutated: EH77Y
78 G H -0.0398
79 D H -0.2648
80 T H -0.2964
81 L H -0.6169
82 D H -1.9427
83 P H -2.0509
84 E H -2.9778
85 V H 0.0000
86 E H -2.5417
87 R H -3.5173
88 R H -2.6181
89 Y H 0.0000
90 R H -2.5090
91 N H -2.3293
92 A H 0.0000
93 L H 0.0000
94 S H -0.9144
95 L H -0.4312
96 Q H -0.8990
97 A H -0.4820
98 P H -0.8365
99 C H 0.0000
100 P H -1.1668
101 D H -2.2651
102 I H 0.0000
103 I H 0.0000
104 R H -0.6506
105 I H 0.0000
106 N H -0.0493
107 R H -0.1968
108 F H 0.1406
109 A H 0.0000
110 F H 0.0000
111 Y H 0.0000
112 E H 0.0000
113 R H -0.9149
114 A H 0.0000
115 Q H -1.9028
116 K H -2.2176
117 A H 0.0000
118 F H -0.6897
119 A H 0.0000
120 I H 0.0000
121 V H 0.0000
122 I H 0.0000
123 T H 0.0000
124 G H 0.0000
125 E H 0.0000
126 R H -1.9352
127 A H -1.5388
128 K H -1.1977
129 Y H 0.0000
130 G H 0.0000
131 N H 0.0000
132 I H 0.0000
133 L H 0.0000
134 L H 0.0000
135 K H -0.3012
136 K H 0.0000
137 G H 0.0000
138 V H -0.3801
139 T H -0.4010
140 P H -0.6175
1 M I 1.3575
2 L I 1.0463
3 K I -0.7679
4 T I -0.2854
5 I I 0.5255
6 S I 0.2173
7 P I 0.4302
8 L I 0.4864
9 I I 0.0000
10 S I -0.6722
11 P I -1.0470
12 E I -2.3352
13 L I 0.0000
14 L I -1.0340
15 K I -2.3365
16 V I 0.0000
17 L I 0.0000
18 A I -0.8181
19 E I -1.1222
20 M I 0.0000
21 G I 0.0000
22 H I -0.2361
23 G I -0.1881
24 D I 0.0000
25 E I -0.6365
26 I I 0.0000
27 I I 0.0000
28 F I 0.0000
29 S I 0.0000
30 D I 0.0000
31 A I -1.1106
32 H I -0.6743
33 F I 0.0000
34 P I 0.0000
35 A I 0.0000
36 H I -0.5972
37 S I -0.8101
38 M I -1.3446
39 G I -1.3992
40 P I -1.2735
41 Q I -0.7945
42 V I -0.4539
43 I I -0.7661
44 R I -1.3738
45 A I -0.9902
46 D I -1.9893
47 G I -1.2885
48 L I -0.2610
49 L I -0.1081
50 V I 0.0000
51 S I 0.0000
52 D I -0.6918
53 L I 0.0000
54 L I 0.0000
55 Q I -1.0850
56 A I 0.0000
57 I I 0.0000
58 I I -0.0772
59 P I -0.1496
60 L I 0.4405
61 F I 0.0000
62 E I -0.6630
63 L I -0.2103
64 D I 0.0000
65 S I -0.2446
66 Y I -0.0421
67 A I -0.1793
68 P I -0.2764
69 P I -0.3550
70 L I 0.0000
71 V I 0.0000
72 M I 0.0000
73 M I 0.0000
74 A I -0.0277
75 A I -0.4500
76 V I 0.0000
77 Y I -0.0243 mutated: EI77Y
78 G I -0.2022
79 D I -0.3252
80 T I -0.5727
81 L I -1.3076
82 D I -2.7880
83 P I -2.5504
84 E I -3.1669
85 V I 0.0000
86 E I -2.7133
87 R I -3.7155
88 R I -2.6677
89 Y I 0.0000
90 R I -2.4567
91 N I -2.4664
92 A I 0.0000
93 L I 0.0000
94 S I -0.9277
95 L I -0.3467
96 Q I -1.0657
97 A I -0.6093
98 P I -0.8362
99 C I 0.0000
100 P I -0.6933
101 D I -0.9093
102 I I 0.0000
103 I I 0.1005
104 R I -0.2033
105 I I 0.0611
106 N I -0.4163
107 R I 0.0000
108 F I 0.3629
109 A I -0.5023
110 F I 0.0000
111 Y I -1.1299
112 E I -2.5448
113 R I -2.1626
114 A I 0.0000
115 Q I -2.9028
116 K I -2.9409
117 A I 0.0000
118 F I 0.0000
119 A I 0.0000
120 I I 0.0000
121 V I 0.0000
122 I I 0.0000
123 T I 0.0000
124 G I 0.0000
125 E I 0.0000
126 R I -2.0683
127 A I -1.7384
128 K I -1.6240
129 Y I 0.0000
130 G I 0.0000
131 N I 0.0000
132 I I 0.0000
133 L I 0.0000
134 L I 0.0000
135 K I -0.4310
136 K I 0.0000
137 G I 0.0000
138 V I -0.4197
139 T I -0.4586
140 P I -0.5838
1 M J 1.3116
2 L J 0.8562
3 K J -0.8513
4 T J -0.3226
5 I J 0.5681
6 S J 0.1749
7 P J 0.5419
8 L J 0.7487
9 I J 0.0000
10 S J -0.6595
11 P J -1.1148
12 E J -2.4240
13 L J 0.0000
14 L J -1.1766
15 K J -2.4256
16 V J 0.0000
17 L J 0.0000
18 A J -0.8245
19 E J -1.1554
20 M J 0.0000
21 G J 0.0000
22 H J 0.0000
23 G J -0.0415
24 D J 0.0000
25 E J -0.5748
26 I J 0.0000
27 I J 0.0000
28 F J 0.0000
29 S J 0.0000
30 D J 0.0000
31 A J -1.0839
32 H J -0.6618
33 F J 0.0000
34 P J 0.0000
35 A J 0.0000
36 H J -0.5218
37 S J -0.7056
38 M J -0.9060
39 G J -1.2340
40 P J -1.1150
41 Q J -0.8331
42 V J -0.2802
43 I J -0.8181
44 R J -1.3958
45 A J -1.1293
46 D J -2.1183
47 G J -1.2297
48 L J -0.4604
49 L J -0.2862
50 V J 0.0000
51 S J 0.0000
52 D J -0.7084
53 L J 0.0000
54 L J 0.0000
55 Q J -1.2770
56 A J 0.0000
57 I J 0.0000
58 I J 0.0000
59 P J -0.0452
60 L J 0.7670
61 F J 0.0000
62 E J -0.5029
63 L J -0.2200
64 D J 0.0000
65 S J -0.1293
66 Y J 0.5057
67 A J 0.1591
68 P J -0.4731
69 P J -0.5149
70 L J 0.0000
71 V J 0.0000
72 M J 0.0000
73 M J 0.0000
74 A J 0.2416
75 A J 0.1134
76 V J 0.9091
77 Y J 0.7072 mutated: EJ77Y
78 G J 0.0000
79 D J -0.1040
80 T J -0.0711
81 L J -0.4274
82 D J -1.9249
83 P J -1.9940
84 E J -3.0826
85 V J 0.0000
86 E J 0.0000
87 R J -3.4381
88 R J -2.5688
89 Y J 0.0000
90 R J -2.4159
91 N J -2.0122
92 A J 0.0000
93 L J 0.0000
94 S J -0.5657
95 L J 0.2838
96 Q J -0.6818
97 A J -0.3872
98 P J -0.2690
99 C J -0.6332
100 P J -1.0258
101 D J -1.8454
102 I J 0.0000
103 I J 0.0000
104 R J -0.3689
105 I J 0.0000
106 N J 0.1677
107 R J 0.5089
108 F J 1.3628
109 A J 0.0000
110 F J 0.0000
111 Y J 0.0151
112 E J -0.4567
113 R J 0.0000
114 A J 0.0000
115 Q J -1.9222
116 K J -2.2338
117 A J 0.0000
118 F J -0.7114
119 A J 0.0000
120 I J 0.0000
121 V J 0.0000
122 I J 0.0000
123 T J 0.0000
124 G J 0.0000
125 E J 0.0000
126 R J -1.9678
127 A J -1.6449
128 K J -1.4378
129 Y J -0.7284
130 G J 0.0000
131 N J 0.0000
132 I J 0.0000
133 L J 0.0000
134 L J 0.0000
135 K J -0.4674
136 K J -0.4661
137 G J 0.0000
138 V J -0.3455
139 T J -0.3739
140 P J -0.7013

 

Laboratory of Theory of Biopolymers 2015