Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP B: RKQLATKAARSAPATG |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.8611 | |
887 | V | A | 2.1608 | |
888 | S | A | 1.6040 | |
889 | I | A | 2.3425 | |
890 | Y | A | 1.1004 | |
891 | P | A | 0.0748 | |
892 | S | A | -0.9858 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.3485 | |
895 | E | A | -1.8188 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.4468 | |
898 | K | A | -2.0673 | |
899 | A | A | -1.2926 | |
900 | C | A | -1.4819 | |
901 | R | A | -2.7795 | |
902 | N | A | -2.0189 | |
903 | L | A | -0.3473 | |
904 | G | A | -1.3664 | |
905 | K | A | -2.5362 | |
906 | N | A | -2.2977 | |
907 | G | A | -1.2068 | |
908 | L | A | -0.2277 | |
909 | S | A | -1.2238 | |
910 | N | A | -1.6377 | |
911 | S | A | -0.3827 | |
912 | S | A | 0.1412 | |
913 | I | A | 0.9193 | |
914 | L | A | 0.6008 | |
915 | L | A | 0.5370 | |
916 | D | A | -1.8067 | |
917 | K | A | -1.9162 | |
918 | C | A | -0.7506 | |
919 | P | A | -0.7716 | |
920 | P | A | -0.9748 | |
921 | P | A | -1.4227 | |
922 | R | A | -2.1338 | |
923 | P | A | -1.3813 | |
924 | P | A | -0.8681 | |
925 | S | A | -0.6353 | |
926 | S | A | -0.1640 | |
927 | P | A | 0.2730 | |
928 | Y | A | 1.0007 | |
929 | P | A | 0.4512 | |
930 | P | A | -0.2021 | |
931 | L | A | -0.8515 | |
932 | P | A | -1.9047 | |
933 | K | A | -3.3920 | |
934 | D | A | -3.6212 | |
935 | K | A | -3.4867 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.5533 | |
938 | P | A | -1.6234 | |
939 | P | A | -0.9217 | |
940 | T | A | -0.3956 | |
941 | P | A | -0.1582 | |
942 | S | A | 0.3583 | |
943 | I | A | 0.6622 | |
944 | Y | A | 0.8032 | |
945 | L | A | -1.0067 | |
946 | E | A | -2.4995 | |
947 | N | A | -2.7387 | |
948 | K | A | -2.5869 | |
949 | R | A | -2.1670 | |
950 | D | A | -1.2449 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.2014 | |
953 | F | A | 1.4767 | |
954 | P | A | 0.6530 | |
955 | P | A | 0.0904 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.5563 | |
958 | Q | A | -1.2558 | |
959 | F | A | -0.6365 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.8095 | |
962 | N | A | -1.3230 | |
963 | P | A | -1.2790 | |
964 | N | A | -1.6498 | |
965 | N | A | -0.9418 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.2770 | |
972 | G | A | -0.8793 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -1.9070 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.6619 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.2141 | |
981 | L | A | -1.0502 | |
982 | G | A | -0.9782 | |
983 | L | A | -0.3830 | |
984 | F | A | 0.0000 | |
985 | S | A | -0.8300 | |
986 | T | A | -1.2189 | |
987 | K | A | -2.3542 | |
988 | T | A | -1.5510 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.3294 | |
991 | E | A | -2.6654 | |
992 | A | A | -1.7926 | |
993 | N | A | -1.8143 | |
994 | N | A | -2.7235 | |
995 | E | A | -2.6570 | |
996 | H | A | -1.3310 | |
997 | M | A | -0.2866 | |
998 | V | A | 0.0000 | |
999 | E | A | 0.0000 | |
1000 | V | A | 0.0000 | |
1001 | R | A | 0.0000 | |
1002 | T | A | -1.1529 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.4661 | |
1005 | L | A | -0.0877 | |
1006 | Q | A | -0.2622 | |
1007 | P | A | -0.3559 | |
1008 | A | A | -0.1389 | |
1009 | D | A | -0.6265 | |
1010 | E | A | -0.9092 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.7909 | |
1013 | D | A | -0.9950 | |
1014 | P | A | -0.8155 | |
1015 | T | A | -0.5196 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -1.0064 | |
1018 | K | A | -1.8117 | |
1019 | K | A | -1.3263 | |
1020 | I | A | -0.5810 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -1.0872 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.5453 | |
1025 | S | A | 0.0000 | |
1026 | N | A | -1.9349 | |
1027 | R | A | -2.5274 | |
1028 | S | A | -1.7886 | |
1029 | H | A | -1.3494 | |
1030 | T | A | -1.0589 | |
1031 | T | A | -1.4022 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.2700 | |
1034 | K | A | -2.4221 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | 0.0000 | |
1037 | Q | A | -1.6758 | |
1038 | Y | A | -0.6834 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.6826 | |
1041 | S | A | -0.7133 | |
1042 | S | A | -0.3851 | |
1043 | F | A | 0.2176 | |
1044 | Q | A | -1.4193 | |
1045 | E | A | -2.6220 | |
1046 | S | A | -1.8371 | |
1047 | L | A | -2.1596 | |
1048 | R | A | -4.3740 | |
1049 | E | A | -4.7241 | |
1050 | E | A | -4.4196 | |
1051 | N | A | -4.7222 | |
1052 | E | A | -4.9736 | |
1053 | K | A | -5.2558 | |
1054 | R | A | -4.4308 | |
1055 | S | A | -3.1105 | |
1056 | H | A | -2.9558 | |
1057 | H | A | -3.1908 | |
1058 | K | A | -3.8557 | |
1059 | D | A | -3.5590 | |
1060 | H | A | -2.6469 | |
1061 | S | A | -2.0045 | |
1062 | D | A | -2.5204 | |
1063 | S | A | -2.2967 | |
1064 | E | A | -2.8524 | |
1065 | S | A | -2.8912 | |
1066 | T | A | -2.4880 | |
1067 | S | A | -2.5685 | |
1068 | S | A | -4.0237 | |
1069 | D | A | -4.7639 | |
1070 | N | A | -4.2243 | |
1071 | S | A | -2.8458 | |
1072 | G | A | -2.2926 | |
1073 | R | A | -4.1335 | |
1074 | R | A | -4.7664 | |
1075 | R | A | -4.2488 | |
1076 | K | A | -3.2833 | |
1077 | G | A | 0.0000 | |
1078 | P | A | -1.2803 | |
1079 | F | A | -1.0229 | |
1080 | K | A | -1.3962 | |
1081 | T | A | -0.7311 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -0.9701 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | 0.0000 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.2617 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.4049 | |
1092 | D | A | -2.6270 | |
1093 | D | A | -3.6902 | |
1094 | K | A | -3.5347 | |
1095 | K | A | -2.7722 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -2.7519 | |
1098 | L | A | -0.3312 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.1235 | |
1101 | H | A | -1.1672 | |
1102 | E | A | 0.0000 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.6375 | |
1105 | K | A | -1.5153 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.2144 | |
1109 | F | A | 0.1540 | |
1110 | V | A | 0.0000 | |
1111 | R | A | -0.0384 | |
1112 | V | A | 0.7831 | |
1113 | V | A | 1.5732 | |
1114 | S | A | 0.6304 | |
1115 | A | A | 0.0742 | |
1116 | G | A | -0.0044 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.1667 | |
1121 | H | A | -0.5079 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -1.4490 | |
1124 | H | A | 0.0000 | |
1125 | T | A | -0.5126 | |
1126 | I | A | 0.0000 | |
1127 | L | A | -0.1011 | |
1128 | G | A | -0.1784 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.1195 | |
1131 | T | A | -0.0799 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | 0.0000 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | 0.1521 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4334 | |
1140 | G | A | 0.2318 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.0481 | |
1144 | P | A | 0.0000 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.1779 | |
1147 | Q | A | -0.4971 | |
1148 | E | A | -0.5855 | |
1149 | N | A | -0.9698 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | -0.1434 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5976 | |
1162 | G | A | -0.4840 | |
1163 | D | A | -0.6178 | |
1164 | C | A | 0.0000 | |
1165 | E | A | 0.0000 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.6046 | |
1171 | E | A | -0.8826 | |
1172 | G | A | -0.4139 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | 0.0000 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.6395 | |
1177 | L | A | 0.0000 | |
1178 | N | A | -1.6915 | |
1179 | D | A | -3.0809 | |
1180 | F | A | -2.2484 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -3.9580 | |
1183 | K | A | -3.6650 | |
1184 | N | A | -2.7475 | |
1185 | N | A | -2.9732 | |
1186 | L | A | -1.9568 | |
1187 | N | A | -1.4247 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.4090 | |
1190 | M | A | 0.9373 | |
1191 | G | A | 0.0181 | |
1192 | S | A | 0.0000 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | -1.0649 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -2.6210 | |
1199 | D | A | -2.0101 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -1.9424 | |
1202 | E | A | -2.6217 | |
1203 | A | A | -1.4356 | |
1204 | N | A | -1.8185 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.7696 | |
1209 | R | A | -0.9869 | |
1210 | F | A | 0.0000 | |
1211 | I | A | 0.4084 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.3350 | |
1214 | P | A | -0.9476 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0116 | |
1232 | G | A | 0.3634 | |
1233 | W | A | 0.4727 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.4742 | |
1245 | T | A | -0.2090 | |
1246 | A | A | -0.7518 | |
1247 | C | A | -0.2927 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.4190 | |
1251 | L | A | -0.8796 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -0.9207 | |
1254 | E | A | -1.9997 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -1.4545 | |
1258 | W | A | 0.0000 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -1.2354 | |
1261 | L | A | 0.1684 | |
1262 | Q | A | -0.4930 | |
1263 | S | A | -0.7081 | |
1264 | V | A | -0.8853 | |
1265 | K | A | -2.1644 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.0000 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.1830 | |
1272 | H | A | -0.1022 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -0.8724 | |
1277 | M | A | 0.0000 | |
1278 | A | A | 0.0000 | |
1279 | R | A | -2.0045 | |
1280 | N | A | -1.9994 | |
1281 | I | A | -1.5158 | |
1282 | K | A | -2.0833 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.2796 | |
1285 | D | A | -1.9432 | |
1286 | P | A | -1.6820 | |
1287 | K | A | -2.3827 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -1.1477 | |
1290 | E | A | -0.9407 | |
1291 | M | A | -0.6613 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.5227 | |
1295 | C | A | 0.1061 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.0788 | |
1299 | T | A | -0.6546 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.1228 | |
1302 | Q | A | -1.8237 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -1.2215 | |
1306 | L | A | -0.5887 | |
1307 | R | A | -0.8606 | |
1308 | E | A | -1.0226 | |
1309 | A | A | -0.2538 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 0.8385 | |
1312 | A | A | 0.2881 | |
1313 | A | A | -0.1829 | |
1314 | G | A | -0.3804 | |
1315 | K | A | -0.9138 | |
1316 | E | A | -1.0543 | |
1317 | I | A | 0.4281 | |
1318 | I | A | 1.4310 | |
1319 | W | A | 0.7508 | |
1320 | H | A | 0.0000 | |
1321 | G | A | 0.0000 | |
1322 | R | A | -1.7331 | |
1323 | T | A | -1.9766 | |
1324 | K | A | -3.0107 | |
1325 | E | A | -3.1064 | |
1326 | E | A | -2.0536 | |
1327 | P | A | -1.3260 | |
1328 | A | A | -0.4224 | |
1329 | H | A | 0.0000 | |
1330 | Y | A | -0.2013 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.3306 | |
1333 | I | A | 1.4439 | |
1334 | C | A | -0.1383 | |
1335 | E | A | -0.9162 | |
1336 | V | A | -0.4620 | |
1337 | E | A | -0.4672 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.1663 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -1.0352 | |
1346 | N | A | -2.2840 | |
1347 | E | A | -2.1196 | |
1348 | S | A | -1.6602 | |
1349 | N | A | -2.3298 | |
1350 | S | A | -2.6135 | |
1351 | R | A | -3.3574 | |
1352 | K | A | -3.5370 | |
1353 | T | A | -2.2719 | |
1354 | Y | A | -1.3236 | |
1355 | I | A | -0.0508 | |
1356 | V | A | 0.0000 | |
1357 | H | A | 0.0000 | |
1358 | C | A | 0.0000 | |
1359 | Q | A | -1.8459 | |
1360 | D | A | -2.9542 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -3.8318 | |
1364 | K | A | -3.2888 | |
1365 | T | A | -2.3037 | |
1366 | S | A | -2.5471 | |
1367 | G | A | -2.7222 | |
1368 | N | A | -2.8805 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.0987 | |
1371 | N | A | -2.3482 | |
1372 | F | A | 0.0000 | |
1373 | V | A | -0.2690 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.0000 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | 0.0000 | |
1379 | K | A | -2.0793 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.8041 | |
1382 | D | A | -2.4473 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.8827 | |
1385 | Q | A | -2.7346 | |
1386 | V | A | -1.9689 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -2.2014 | |
1389 | Q | A | -2.1330 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.8116 | |
1392 | L | A | -0.3701 | |
1393 | A | A | -0.6203 | |
1394 | P | A | -0.6257 | |
17 | R | B | -2.4622 | |
18 | K | B | -2.5122 | |
19 | Q | B | -2.1971 | |
20 | L | B | -1.0172 | |
21 | A | B | -0.8525 | |
22 | T | B | -0.9114 | |
23 | K | B | -1.7551 | |
24 | A | B | -0.8770 | |
25 | A | B | -0.7970 | |
26 | R | B | -0.6839 | |
28 | S | B | -0.3568 | |
29 | A | B | -0.2258 | |
30 | P | B | -0.3008 | |
31 | A | B | -0.8800 | |
32 | T | B | -1.0225 |