Project name: 2OSL

Chain sequence(s)	A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5144
• Maximal score value: 1.8392
• Average score: -0.6603
• Total score value: -287.2349

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-0.8417
2	I	A	0.1204
3	V	A	1.2330
4	L	A	0.0000
5	S	A	-0.5797
6	Q	A	-0.8491
7	S	A	-0.2573
8	P	A	0.3498
9	A	A	0.6664
10	I	A	1.7980
11	L	A	0.8476
12	S	A	-0.0787
13	A	A	0.0000
14	S	A	-1.9905
15	P	A	-2.4657
16	G	A	-2.1981
17	E	A	-2.9272
18	K	A	-3.0728
19	V	A	0.0000
20	T	A	-0.6215
21	M	A	0.0000
22	T	A	-0.5622
23	C	A	0.0000
24	R	A	-1.7050
25	A	A	-0.5808
26	S	A	-0.2898
27	S	A	-0.3838
28	S	A	-0.5790
29	V	A	0.0000
30	S	A	-0.1228
31	Y	A	0.4308
32	I	A	0.0000
33	H	A	0.0000
34	W	A	0.0000
35	F	A	0.0000
36	Q	A	0.0000
37	Q	A	-0.4474
38	K	A	0.0000
39	P	A	-0.7032
40	G	A	-0.7425
41	S	A	-0.5557
42	S	A	-0.3727
43	P	A	0.0000
44	K	A	-0.6283
45	P	A	0.0000
46	W	A	-0.0101
47	I	A	0.0000
48	Y	A	0.2035
49	A	A	0.1401
50	T	A	-0.0651
51	S	A	-0.3692
52	N	A	-0.4608
53	L	A	0.3140
54	A	A	0.0000
55	S	A	-0.6936
56	G	A	-0.5046
57	V	A	0.0000
58	P	A	0.5452
59	V	A	1.5116
60	R	A	-0.3472
61	F	A	0.0000
62	S	A	-0.0621
63	G	A	-0.3362
64	S	A	-0.4192
65	G	A	-0.6937
66	S	A	-0.6328
67	G	A	-0.6779
68	T	A	-0.9388
69	S	A	-1.1195
70	Y	A	0.0000
71	S	A	-0.5498
72	L	A	0.0000
73	T	A	-0.8282
74	I	A	0.0000
75	S	A	-1.8982
76	R	A	-3.5144
77	V	A	0.0000
78	E	A	-3.0301
79	A	A	0.0000
80	E	A	-3.0528
81	D	A	0.0000
82	A	A	0.0000
83	A	A	0.0000
84	T	A	-0.0765
85	Y	A	0.0000
86	Y	A	-0.0459
87	C	A	0.0000
88	Q	A	0.0000
89	Q	A	0.0000
90	W	A	0.0000
91	T	A	-0.5298
92	S	A	-1.1455
93	N	A	-1.7427
94	P	A	-1.4099
95	P	A	0.0000
96	T	A	0.0952
97	F	A	0.3479
98	G	A	-0.1672
99	G	A	-0.8965
100	G	A	-0.2064
101	T	A	0.0000
102	K	A	0.1200
103	L	A	0.0000
104	E	A	0.0000
105	I	A	0.0000
106	K	A	-1.9868
107	R	A	-1.3601
108	T	A	-0.3622
109	V	A	-0.0328
110	A	A	-0.2108
111	A	A	-0.2467
112	P	A	-0.3149
113	S	A	-0.3927
114	V	A	0.0000
115	F	A	0.1824
116	I	A	0.2124
117	F	A	0.0000
118	P	A	-0.6516
119	P	A	-0.6079
120	S	A	-1.1865
121	D	A	-2.3753
122	E	A	-1.9982
123	Q	A	0.0000
124	L	A	-1.5656
125	K	A	-1.9257
126	S	A	-1.4362
127	G	A	-1.1510
128	T	A	-1.3124
129	A	A	0.0000
130	S	A	0.0000
131	V	A	0.0000
132	V	A	0.0000
133	C	A	0.0000
134	L	A	0.0000
135	L	A	0.0000
136	N	A	-0.5691
137	N	A	-1.2303
138	F	A	0.0000
139	Y	A	0.0000
140	P	A	-1.7011
141	R	A	-2.4813
142	E	A	-3.0190
143	A	A	0.0000
144	K	A	-2.8127
145	V	A	-1.7185
146	Q	A	-1.6330
147	W	A	0.0000
148	K	A	-0.9162
149	V	A	0.0000
150	D	A	-1.8457
151	N	A	-1.6207
152	A	A	-0.4564
153	L	A	0.0747
154	Q	A	-0.6831
155	S	A	-0.8894
156	G	A	-1.1587
157	N	A	-1.3767
158	S	A	-1.2681
159	Q	A	-1.3728
160	E	A	-1.6891
161	S	A	-0.4642
162	V	A	0.1810
163	T	A	-0.3650
164	E	A	-1.0997
165	Q	A	0.0000
166	D	A	-2.3675
167	S	A	-2.7060
168	K	A	-3.1247
169	D	A	-2.1812
170	S	A	0.0000
171	T	A	0.0000
172	Y	A	0.0000
173	S	A	0.0000
174	L	A	0.0000
175	S	A	0.0000
176	S	A	0.0000
177	T	A	-0.2995
178	L	A	0.0531
179	T	A	-0.1140
180	L	A	-0.5524
181	S	A	-1.2055
182	K	A	-2.0523
183	A	A	-1.7526
184	D	A	-2.4172
185	Y	A	0.0000
186	E	A	-2.8624
187	K	A	-3.1501
188	H	A	-2.8948
189	K	A	-3.4555
190	V	A	0.0000
191	Y	A	0.0000
192	A	A	0.0000
193	C	A	0.0000
194	E	A	-1.1901
195	V	A	0.0000
196	T	A	-1.3916
197	H	A	0.0000
198	Q	A	-1.7462
199	G	A	-0.5046
200	L	A	-0.2960
201	S	A	-0.4576
202	S	A	-0.4437
203	P	A	-0.6231
204	V	A	-0.1495
205	T	A	-0.6170
206	K	A	-0.6874
207	S	A	-0.6980
208	F	A	-1.3302
209	N	A	-2.7301
210	R	A	-2.7309
211	G	A	-2.4818
212	E	A	-2.9701
1	Q	A	-0.9394
2	V	A	0.1490
3	Q	A	-1.1452
4	L	A	0.0000
5	Q	A	-1.5352
6	Q	A	-1.0662
7	P	A	-0.9732
8	G	A	-1.1650
9	A	A	-0.8590
10	E	A	-0.8628
11	L	A	-0.4319
12	V	A	0.0000
13	K	A	-1.9387
14	P	A	-1.3823
15	G	A	-1.1856
16	A	A	-0.9707
17	S	A	-1.2793
18	V	A	0.0000
19	K	A	-2.0756
20	M	A	0.0000
21	S	A	-0.7695
22	C	A	0.0000
23	K	A	-1.4248
24	A	A	0.0000
25	S	A	-0.6036
26	G	A	-0.3082
27	Y	A	0.0619
28	T	A	-0.2160
29	F	A	0.0000
30	T	A	-0.6614
31	S	A	0.2767
32	Y	A	0.8350
33	N	A	0.6942
34	M	A	0.0000
35	H	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	K	A	0.0000
39	Q	A	-0.5905
40	T	A	-1.2368
41	P	A	-1.3341
42	G	A	-1.5517
43	R	A	-2.3574
44	G	A	-1.3510
45	L	A	-0.5280
46	E	A	-0.7071
47	W	A	0.0000
48	I	A	0.0000
49	G	A	0.0000
50	A	A	0.0000
51	I	A	0.0000
52	Y	A	-0.3270
53	P	A	0.0000
54	G	A	-1.3284
55	N	A	-1.9710
56	G	A	-2.1468
57	D	A	-2.3236
58	T	A	-1.1080
59	S	A	-0.7935
60	Y	A	-1.1782
61	N	A	0.0000
62	Q	A	-2.7034
63	K	A	-2.8618
64	F	A	-2.1812
65	K	A	-2.9575
66	G	A	-2.1822
67	K	A	-2.0055
68	A	A	0.0000
69	T	A	-0.9501
70	L	A	0.0000
71	T	A	-0.5220
72	A	A	-1.2335
73	D	A	-1.9317
74	K	A	-2.3552
75	S	A	-1.3829
76	S	A	-1.1149
77	S	A	-1.2901
78	T	A	0.0000
79	A	A	0.0000
80	Y	A	-0.4919
81	M	A	0.0000
82	Q	A	-1.4875
83	L	A	0.0000
84	S	A	-1.0513
85	S	A	-0.8825
86	L	A	0.0000
87	T	A	-1.2027
88	S	A	-1.3291
89	E	A	-1.7130
90	D	A	-1.0366
91	S	A	-0.7500
92	A	A	0.0000
93	V	A	0.1182
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	0.0000
99	S	A	0.0000
100	T	A	0.8782
101	Y	A	1.8305
102	Y	A	1.8392
103	G	A	0.2936
104	G	A	-0.3735
105	D	A	0.0059
106	W	A	0.0000
107	Y	A	0.4515
108	F	A	0.0000
109	N	A	-0.1739
110	V	A	0.0000
111	W	A	0.0000
112	G	A	0.0000
113	A	A	-0.6337
114	G	A	-0.3585
115	T	A	0.0000
116	T	A	-0.2858
117	V	A	0.0000
118	T	A	-0.6484
119	V	A	0.0000
120	S	A	-0.7696
121	A	A	-0.7164
122	A	A	-0.4350
123	S	A	-0.5476
124	T	A	-0.6611
125	K	A	-1.1992
126	G	A	-1.6272
127	P	A	0.0000
128	S	A	-0.6011
129	V	A	0.0000
130	F	A	-0.4536
131	P	A	-0.9881
132	L	A	0.0000
133	A	A	-0.7990
134	P	A	-1.0725
135	S	A	-1.9226
136	S	A	-1.6519
137	K	A	-2.3633
138	S	A	-1.5064
139	T	A	-1.1911
140	S	A	-1.0093
141	G	A	-0.8950
142	G	A	-0.8966
143	T	A	-0.6587
144	A	A	0.0000
145	A	A	0.0000
146	L	A	0.0000
147	G	A	0.0000
148	C	A	0.0000
149	L	A	0.0000
150	V	A	0.0000
151	K	A	-0.2899
152	D	A	-0.8297
153	Y	A	0.0000
154	F	A	-0.3104
155	P	A	0.0000
156	E	A	-0.3858
157	P	A	-0.6791
158	V	A	-0.6054
159	T	A	-0.5734
160	V	A	-0.2647
161	S	A	-0.3388
162	W	A	0.0000
163	N	A	-0.7335
164	S	A	-0.6276
165	G	A	-0.4773
166	A	A	-0.1775
167	L	A	0.0357
168	T	A	-0.1998
169	S	A	-0.2452
170	G	A	-0.3246
171	V	A	-0.0224
172	H	A	-0.2624
173	T	A	-0.0576
174	F	A	0.0000
175	P	A	-0.2243
176	A	A	0.0163
177	V	A	0.2131
178	L	A	0.6919
179	Q	A	-0.1017
180	S	A	-0.4045
181	S	A	-0.4026
182	G	A	-0.2067
183	L	A	-0.0900
184	Y	A	0.2235
185	S	A	0.0000
186	L	A	0.0000
187	S	A	-0.0823
188	S	A	0.0000
189	V	A	0.0000
190	V	A	0.0000
191	T	A	-0.1673
192	V	A	0.0000
193	P	A	-0.6858
194	S	A	-0.6835
195	S	A	-0.7356
196	S	A	-0.7455
197	L	A	0.0000
198	G	A	-1.3641
199	T	A	-0.8208
200	Q	A	-1.4293
201	T	A	-1.1105
202	Y	A	0.0000
203	I	A	-1.2277
204	C	A	0.0000
205	N	A	-1.3410
206	V	A	0.0000
207	N	A	-1.9451
208	H	A	0.0000
209	K	A	-2.8308
210	P	A	-1.8395
211	S	A	-1.9187
212	N	A	-2.6452
213	T	A	-2.1615
214	K	A	-2.5744
215	V	A	-1.3169
216	D	A	-2.0802
217	K	A	-1.8246
218	K	A	-2.4105
219	V	A	0.0000
220	E	A	-2.7048
221	P	A	-1.9905
222	K	A	-2.2543
223	S	A	-1.2167