Project name: 3AY5
Status: done
submitted: 2018-01-12 16:20:54, status changed: 2018-01-12 16:31:05
Settings
Chain sequence(s)
|
A: LASPLEQLRHLAEELRLLLPRVRVGEATEEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEESDPQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMSHLTVRINSAKLVSVLKKALEITKASHVTPSWIPLLINAIDHCMNRIKELTQSELEL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.291
-
Maximal score value
-
1.8314
-
Average score
-
-0.9235
-
Total score value
-
-275.211
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
14 |
L |
A |
0.9891 |
|
15 |
A |
A |
0.1026 |
|
16 |
S |
A |
-0.5003 |
|
17 |
P |
A |
-0.8398 |
|
18 |
L |
A |
-0.4048 |
|
19 |
E |
A |
-1.6396 |
|
20 |
Q |
A |
-1.6410 |
|
21 |
L |
A |
0.0000 |
|
22 |
R |
A |
-3.3565 |
|
23 |
H |
A |
-3.4516 |
|
24 |
L |
A |
0.0000 |
|
25 |
A |
A |
0.0000 |
|
26 |
E |
A |
-4.0199 |
|
27 |
E |
A |
-3.0418 |
|
28 |
L |
A |
0.0000 |
|
29 |
R |
A |
-2.5087 |
|
30 |
L |
A |
-1.0389 |
|
31 |
L |
A |
-1.5306 |
|
32 |
L |
A |
-1.3528 |
|
33 |
P |
A |
-1.2803 |
|
34 |
R |
A |
-2.0831 |
|
35 |
V |
A |
0.0000 |
|
36 |
R |
A |
-1.8472 |
|
37 |
V |
A |
-0.2112 |
|
38 |
G |
A |
-1.0801 |
|
39 |
E |
A |
-1.7012 |
|
40 |
A |
A |
-0.8636 |
|
44 |
T |
A |
-2.0909 |
|
45 |
E |
A |
-3.0103 |
|
46 |
E |
A |
-3.0514 |
|
47 |
F |
A |
-2.3080 |
|
48 |
N |
A |
-2.9118 |
|
49 |
R |
A |
-3.5038 |
|
50 |
E |
A |
-3.0305 |
|
51 |
M |
A |
-2.0182 |
|
52 |
F |
A |
0.0000 |
|
53 |
W |
A |
0.0000 |
|
54 |
R |
A |
-3.7915 |
|
55 |
R |
A |
-3.2495 |
|
56 |
L |
A |
0.0000 |
|
57 |
N |
A |
-2.3063 |
|
58 |
E |
A |
-2.5022 |
|
59 |
A |
A |
0.0000 |
|
60 |
A |
A |
0.0000 |
|
61 |
V |
A |
0.1422 |
|
62 |
T |
A |
-0.4520 |
|
63 |
V |
A |
0.0000 |
|
64 |
S |
A |
-0.3016 |
|
65 |
R |
A |
-1.4848 |
|
66 |
E |
A |
-0.7224 |
|
67 |
A |
A |
0.0000 |
|
68 |
T |
A |
-0.1440 |
|
69 |
T |
A |
0.1388 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
0.8645 |
|
72 |
I |
A |
1.8314 |
|
73 |
V |
A |
1.2574 |
|
74 |
F |
A |
0.0000 |
|
75 |
S |
A |
0.3789 |
|
76 |
Q |
A |
-0.0117 |
|
77 |
L |
A |
0.9699 |
|
78 |
P |
A |
0.6258 |
|
79 |
L |
A |
0.4196 |
|
80 |
P |
A |
-0.5466 |
|
81 |
S |
A |
-1.0800 |
|
82 |
P |
A |
-1.3695 |
|
83 |
Q |
A |
-2.5514 |
|
84 |
E |
A |
-3.2103 |
|
85 |
T |
A |
0.0000 |
|
86 |
Q |
A |
-2.9372 |
|
87 |
K |
A |
-3.6128 |
|
88 |
F |
A |
-2.1598 |
|
89 |
C |
A |
0.0000 |
|
90 |
E |
A |
-2.7354 |
|
91 |
Q |
A |
-1.8545 |
|
92 |
V |
A |
0.0000 |
|
93 |
H |
A |
-1.7157 |
|
94 |
A |
A |
-1.1849 |
|
95 |
A |
A |
0.0000 |
|
96 |
I |
A |
0.0000 |
|
97 |
K |
A |
-1.4694 |
|
98 |
A |
A |
-1.0427 |
|
99 |
F |
A |
0.0000 |
|
100 |
I |
A |
0.0000 |
|
101 |
A |
A |
-0.0468 |
|
102 |
V |
A |
0.0000 |
|
103 |
Y |
A |
0.0000 |
|
104 |
Y |
A |
0.1109 |
|
105 |
L |
A |
0.5092 |
|
106 |
L |
A |
0.0000 |
|
107 |
P |
A |
0.0000 |
|
108 |
K |
A |
-2.6222 |
|
109 |
D |
A |
-2.7671 |
|
110 |
Q |
A |
-2.3138 |
|
111 |
G |
A |
0.0000 |
|
112 |
I |
A |
-0.6385 |
|
113 |
T |
A |
0.0000 |
|
114 |
L |
A |
0.0000 |
|
115 |
R |
A |
-1.3356 |
|
116 |
K |
A |
-1.3667 |
|
117 |
L |
A |
-0.5333 |
|
118 |
V |
A |
0.0000 |
|
119 |
R |
A |
-1.3808 |
|
120 |
G |
A |
-1.3895 |
|
121 |
A |
A |
-1.0997 |
|
122 |
T |
A |
0.0000 |
|
123 |
L |
A |
-1.6362 |
|
124 |
D |
A |
-1.7760 |
|
125 |
I |
A |
0.0000 |
|
126 |
V |
A |
0.0000 |
|
127 |
D |
A |
-1.3583 |
|
128 |
G |
A |
0.0000 |
|
129 |
M |
A |
0.0000 |
|
130 |
A |
A |
0.0000 |
|
131 |
Q |
A |
-1.6236 |
|
132 |
L |
A |
0.0000 |
|
133 |
M |
A |
0.0000 |
|
134 |
E |
A |
-1.7930 |
|
135 |
V |
A |
1.0706 |
|
136 |
L |
A |
0.6911 |
|
137 |
S |
A |
0.1383 |
|
138 |
V |
A |
1.6489 |
|
153 |
N |
A |
-0.8513 |
|
154 |
S |
A |
-0.6841 |
|
155 |
V |
A |
0.0000 |
|
156 |
W |
A |
0.2589 |
|
157 |
V |
A |
0.7237 |
|
158 |
A |
A |
0.0000 |
|
159 |
C |
A |
0.0000 |
|
160 |
Q |
A |
-0.7894 |
|
161 |
Q |
A |
-1.3488 |
|
162 |
M |
A |
0.0000 |
|
163 |
P |
A |
-1.4103 |
|
164 |
Q |
A |
-1.8389 |
|
165 |
I |
A |
0.0000 |
|
166 |
P |
A |
-1.0075 |
|
167 |
R |
A |
-2.2106 |
|
168 |
D |
A |
-1.9805 |
|
169 |
N |
A |
0.0000 |
|
170 |
K |
A |
-1.5168 |
|
171 |
A |
A |
-0.6381 |
|
172 |
A |
A |
0.0000 |
|
173 |
A |
A |
0.0000 |
|
174 |
L |
A |
0.2260 |
|
175 |
L |
A |
0.1647 |
|
176 |
M |
A |
-0.4467 |
|
177 |
L |
A |
0.0000 |
|
178 |
T |
A |
-0.8462 |
|
179 |
K |
A |
-1.4950 |
|
180 |
N |
A |
0.0000 |
|
181 |
V |
A |
0.0000 |
|
182 |
D |
A |
-1.8940 |
|
183 |
F |
A |
-0.7942 |
|
184 |
V |
A |
0.0000 |
|
185 |
K |
A |
-2.9637 |
|
186 |
D |
A |
-3.3195 |
|
187 |
A |
A |
-2.5403 |
|
188 |
H |
A |
-3.2589 |
|
189 |
E |
A |
-4.2910 |
|
190 |
E |
A |
-4.1409 |
|
191 |
M |
A |
0.0000 |
|
192 |
E |
A |
-3.4246 |
|
193 |
Q |
A |
-3.8158 |
|
194 |
A |
A |
-2.6875 |
|
195 |
V |
A |
-2.5047 |
|
196 |
E |
A |
-3.8496 |
|
197 |
E |
A |
-3.6514 |
|
198 |
S |
A |
-2.4970 |
|
199 |
D |
A |
-2.5234 |
|
200 |
P |
A |
-1.8037 |
|
229 |
Q |
A |
-1.3341 |
|
230 |
D |
A |
-1.2306 |
|
231 |
L |
A |
1.0053 |
|
232 |
Y |
A |
0.6395 |
|
233 |
W |
A |
-0.6638 |
|
234 |
S |
A |
-1.8766 |
|
235 |
E |
A |
-3.1567 |
|
236 |
D |
A |
-3.3505 |
|
237 |
D |
A |
-1.8768 |
|
238 |
Q |
A |
-1.8551 |
|
239 |
E |
A |
-2.0334 |
|
240 |
L |
A |
0.0000 |
|
241 |
I |
A |
0.0000 |
|
242 |
I |
A |
1.3545 |
|
243 |
P |
A |
0.0000 |
|
244 |
C |
A |
0.0000 |
|
245 |
L |
A |
-0.0163 |
|
246 |
A |
A |
-0.2415 |
|
247 |
L |
A |
0.0000 |
|
248 |
V |
A |
0.0000 |
|
249 |
R |
A |
-2.2191 |
|
250 |
A |
A |
0.0000 |
|
251 |
S |
A |
0.0000 |
|
252 |
K |
A |
-1.4114 |
|
253 |
A |
A |
-1.1706 |
|
254 |
C |
A |
0.0000 |
|
255 |
L |
A |
0.0000 |
|
256 |
K |
A |
-1.4436 |
|
257 |
K |
A |
-0.7103 |
|
258 |
I |
A |
0.0000 |
|
259 |
R |
A |
-0.9080 |
|
260 |
M |
A |
-0.7568 |
|
261 |
L |
A |
0.0000 |
|
262 |
V |
A |
0.0000 |
|
263 |
A |
A |
-1.1407 |
|
264 |
E |
A |
-2.1526 |
|
265 |
N |
A |
-1.8153 |
|
266 |
G |
A |
0.0000 |
|
267 |
K |
A |
-3.3044 |
|
268 |
K |
A |
-3.5402 |
|
269 |
D |
A |
-3.2845 |
|
270 |
Q |
A |
-2.4215 |
|
271 |
V |
A |
-1.8701 |
|
272 |
A |
A |
-1.1534 |
|
273 |
Q |
A |
-1.8777 |
|
274 |
L |
A |
0.0000 |
|
275 |
D |
A |
0.0000 |
|
276 |
D |
A |
-2.3980 |
|
277 |
I |
A |
0.0000 |
|
278 |
V |
A |
0.0000 |
|
279 |
D |
A |
-2.7154 |
|
280 |
I |
A |
0.0000 |
|
281 |
S |
A |
0.0000 |
|
282 |
D |
A |
-1.7166 |
|
283 |
E |
A |
-1.7069 |
|
284 |
I |
A |
0.0000 |
|
285 |
S |
A |
0.0000 |
|
286 |
P |
A |
-1.2628 |
|
287 |
S |
A |
0.0000 |
|
288 |
V |
A |
0.0000 |
|
289 |
D |
A |
-1.2244 |
|
290 |
D |
A |
-1.8894 |
|
291 |
L |
A |
0.0000 |
|
292 |
A |
A |
0.0000 |
|
293 |
L |
A |
0.8095 |
|
294 |
S |
A |
0.1616 |
|
295 |
I |
A |
0.0000 |
|
296 |
Y |
A |
1.1548 |
|
297 |
P |
A |
0.7049 |
|
298 |
P |
A |
-0.1015 |
|
299 |
M |
A |
0.0000 |
|
300 |
S |
A |
-0.3207 |
|
301 |
H |
A |
-0.6582 |
|
302 |
L |
A |
0.0555 |
|
303 |
T |
A |
-0.0208 |
|
304 |
V |
A |
0.0000 |
|
305 |
R |
A |
-0.7571 |
|
306 |
I |
A |
0.4077 |
|
307 |
N |
A |
0.0000 |
|
308 |
S |
A |
0.0000 |
|
309 |
A |
A |
-0.7151 |
|
310 |
K |
A |
-1.4272 |
|
311 |
L |
A |
0.0000 |
|
312 |
V |
A |
0.0000 |
|
313 |
S |
A |
-1.1838 |
|
314 |
V |
A |
-1.4695 |
|
315 |
L |
A |
0.0000 |
|
316 |
K |
A |
-1.7039 |
|
317 |
K |
A |
-2.6300 |
|
318 |
A |
A |
0.0000 |
|
319 |
L |
A |
0.0000 |
|
320 |
E |
A |
-2.6867 |
|
321 |
I |
A |
-1.7391 |
|
322 |
T |
A |
0.0000 |
|
323 |
K |
A |
-1.8393 |
|
324 |
A |
A |
-0.8976 |
|
325 |
S |
A |
0.0000 |
|
326 |
H |
A |
-0.8196 |
|
327 |
V |
A |
0.0000 |
|
328 |
T |
A |
-0.8372 |
|
329 |
P |
A |
-0.6675 |
|
334 |
S |
A |
0.3081 |
|
335 |
W |
A |
1.0717 |
|
336 |
I |
A |
0.0000 |
|
337 |
P |
A |
0.3451 |
|
338 |
L |
A |
0.7540 |
|
339 |
L |
A |
0.0000 |
|
340 |
I |
A |
-0.1742 |
|
341 |
N |
A |
-1.2217 |
|
342 |
A |
A |
-0.8262 |
|
343 |
I |
A |
0.0000 |
|
344 |
D |
A |
-1.8143 |
|
345 |
H |
A |
-2.1523 |
|
346 |
C |
A |
-1.3059 |
|
347 |
M |
A |
0.0000 |
|
348 |
N |
A |
-2.1664 |
|
349 |
R |
A |
-2.1382 |
|
350 |
I |
A |
0.0000 |
|
351 |
K |
A |
-2.3296 |
|
352 |
E |
A |
-2.8677 |
|
353 |
L |
A |
-2.0913 |
|
354 |
T |
A |
0.0000 |
|
355 |
Q |
A |
-2.4396 |
|
356 |
S |
A |
-1.6161 |
|
357 |
E |
A |
-1.4660 |
|
358 |
L |
A |
-0.4355 |
|
359 |
E |
A |
-1.2520 |
|
360 |
L |
A |
0.7148 |
|