Project name: 15%_pro_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1946
• Maximal score value: 2.5642
• Average score: -0.7425
• Total score value: -320.027

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6008
3	E	A	-2.5122
4	L	A	0.0000
5	T	A	-1.5695
6	Q	A	-1.5088
7	D	A	-2.3879
8	P	A	-1.7683
9	A	A	-1.3811
10	V	A	-0.9751
11	S	A	-0.2826
12	V	A	-0.2484
13	A	A	0.1092
14	L	A	-0.0437
15	G	A	-0.9012
16	Q	A	-1.2479
17	T	A	-1.1955
18	V	A	0.0000
19	R	A	-1.8401
20	V	A	0.0000
21	T	A	-1.1752
22	C	A	0.0000
23	Q	A	-2.2063
24	G	A	-2.4671
25	D	A	-3.1946
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.7297
29	S	A	-1.3411
30	Y	A	-0.8215
31	Y	A	-0.6206
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	K	A	-1.9160
39	P	A	-1.4520
40	G	A	-1.3378
41	Q	A	-1.9124
42	A	A	-1.1357
43	P	A	0.0000
44	V	A	0.2321
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.2134
49	G	A	0.0000
50	K	A	-2.5993
51	N	A	-2.3998
52	N	A	-2.2839
53	R	A	-2.0888
54	P	A	-0.8709
55	S	A	-0.6991
56	G	A	-0.8414
57	I	A	-0.7360
58	P	A	-1.3199
59	D	A	-2.1851
60	R	A	-1.3242
61	F	A	0.0000
62	S	A	-1.5293
63	G	A	0.0000
64	S	A	-0.8937
65	S	A	-1.1339
66	S	A	-1.0127
67	G	A	-1.8052
68	N	A	-2.0713
69	T	A	-1.4089
70	A	A	0.0000
71	S	A	-0.7898
72	L	A	0.0000
73	T	A	-0.9443
74	I	A	0.0000
75	T	A	-1.2430
76	G	A	-0.9475
77	A	A	0.0000
78	Q	A	-1.6194
79	A	A	0.0000
80	E	A	-2.8146
81	D	A	0.0000
82	E	A	-2.3904
83	A	A	0.0000
84	D	A	-1.8454
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.3098
89	S	A	0.0000
90	R	A	-0.8583
91	D	A	-1.4648
92	S	A	-1.6118
93	S	A	-0.8141
94	G	A	-0.8182
95	N	A	-1.4678
96	H	A	-1.1187
97	W	A	0.0000
98	V	A	-0.6706
99	F	A	-0.5133
100	G	A	0.0000
101	G	A	-1.5634
102	G	A	-1.5189
103	T	A	0.0000
104	E	A	-2.6704
105	L	A	0.0000
106	T	A	-0.5564
107	V	A	0.0000
108	L	A	0.6628
109	G	A	-0.0589
110	Q	A	0.0000
111	P	A	-0.9838
112	K	A	-2.1894
113	A	A	-1.3266
114	A	A	-0.8507
115	P	A	-0.3522
116	S	A	-0.4004
117	V	A	0.0000
118	T	A	-0.4048
119	L	A	-0.3299
120	F	A	0.0000
121	P	A	-0.0597
122	P	A	0.0000
123	S	A	-1.0162
124	S	A	-1.3162
125	E	A	-2.1223
126	E	A	0.0000
127	L	A	-1.9775
128	Q	A	-2.2951
129	A	A	-1.9036
130	N	A	-2.6908
131	K	A	-2.7873
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.6763
140	D	A	-1.2640
141	F	A	0.0000
142	Y	A	-1.1439
143	P	A	-0.9834
144	G	A	-0.8529
145	A	A	-0.2802
146	V	A	-0.1268
147	T	A	-0.1328
148	V	A	0.0326
149	A	A	-0.2700
150	W	A	0.0000
151	K	A	-0.8859
152	A	A	0.0000
153	D	A	-1.1657
154	S	A	-0.7951
155	S	A	-0.6809
156	P	A	-0.8183
157	V	A	-0.6132
158	K	A	-1.4856
159	A	A	-0.6164
160	G	A	-0.2430
161	V	A	0.2400
162	E	A	0.0555
163	T	A	0.1576
164	T	A	0.0156
165	T	A	-0.1207
166	P	A	-0.2596
167	S	A	-0.5314
168	K	A	-1.3860
169	Q	A	-1.0971
170	S	A	-1.2166
171	N	A	-1.7452
172	N	A	-1.9332
173	K	A	-1.7352
174	Y	A	-0.7408
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	0.8702
181	S	A	-0.1174
182	L	A	0.0000
183	T	A	-2.0147
184	P	A	-2.4933
185	E	A	-3.1821
186	Q	A	-2.5383
187	W	A	0.0000
188	K	A	-3.0914
189	S	A	0.0000
190	H	A	-2.3218
191	R	A	-2.5019
192	S	A	-1.5291
193	Y	A	0.0000
194	S	A	-0.9693
195	C	A	0.0000
196	Q	A	-1.1257
197	V	A	0.0000
198	T	A	-0.7481
199	H	A	0.0000
200	E	A	-2.3474
201	G	A	-1.4126
202	S	A	-0.9462
203	T	A	-0.8052
204	V	A	-0.8850
205	E	A	-2.1749
206	K	A	-1.8016
207	T	A	-1.0160
208	V	A	0.0000
209	A	A	-0.9565
210	P	A	-1.0609
2	V	A	1.1067
3	Q	A	-0.9327
4	L	A	0.0000
5	Q	A	-1.9821
6	Q	A	-1.3545
7	S	A	-1.3239
8	G	A	-1.1959
9	A	A	-1.0157
10	E	A	-1.2797
11	V	A	-0.8832
12	K	A	-1.7385
13	K	A	-2.5207
14	P	A	-2.0942
15	G	A	-1.5019
16	S	A	-1.1802
17	S	A	-1.3364
18	V	A	0.0000
19	R	A	-2.4921
20	V	A	0.0000
21	S	A	-1.1418
22	C	A	0.0000
23	K	A	-1.5081
24	A	A	0.0000
25	S	A	-0.7704
26	G	A	-0.6601
27	G	A	-1.1058
28	T	A	-1.5065
29	F	A	0.0000
30	N	A	-1.8472
31	N	A	-0.9432
32	N	A	-0.5789
33	A	A	-0.0147
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.6303
39	Q	A	-0.8268
40	A	A	-1.0947
41	P	A	-0.8772
42	G	A	-1.2382
43	Q	A	-1.8137
44	G	A	-1.3305
45	L	A	0.0000
46	E	A	-1.0511
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.2903
52	I	A	0.1907
53	P	A	-0.5448
54	M	A	0.0603
55	F	A	1.1404
56	G	A	0.2079
57	T	A	-0.1045
58	A	A	-0.3190
59	K	A	-1.2941
60	Y	A	-0.6103
61	S	A	-1.3034
62	Q	A	-2.1639
63	N	A	-2.2197
64	F	A	0.0000
65	Q	A	-2.0898
66	G	A	-1.4702
67	R	A	-1.1709
68	V	A	-0.8699
69	A	A	-0.7225
70	I	A	0.0000
71	T	A	-0.6556
72	A	A	-1.2304
73	D	A	-2.5048
74	E	A	-2.5547
75	S	A	-1.5703
76	T	A	-1.4036
77	G	A	0.0000
78	T	A	-1.4515
79	A	A	0.0000
80	S	A	-1.1086
81	M	A	0.0000
82	E	A	-2.0229
83	L	A	0.0000
84	S	A	-1.2201
85	S	A	-1.1348
86	L	A	0.0000
87	R	A	-2.7255
88	S	A	-2.1880
89	E	A	-2.5109
90	D	A	0.0000
91	T	A	-0.9888
92	A	A	0.0000
93	V	A	-0.0081
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	0.0000
99	S	A	0.0000
100	R	A	-0.3477
101	D	A	0.6445
102	L	A	1.5369
103	L	A	2.5642
104	L	A	2.4606
105	F	A	1.4680
106	P	A	0.6728
107	H	A	-0.8004
108	H	A	-0.6727
109	A	A	0.0000
110	L	A	0.0000
111	S	A	0.0065
112	P	A	-0.0175
113	W	A	-0.3920
114	G	A	0.0000
115	R	A	-2.3381
116	G	A	0.0000
117	T	A	0.0000
118	M	A	-0.2710
119	V	A	0.0000
120	T	A	0.0000
121	V	A	0.0000
122	S	A	-1.1379
123	S	A	-0.9942
124	A	A	-0.6706
125	S	A	-0.7388
126	T	A	-0.6224
127	K	A	-0.8636
128	G	A	-1.2980
129	P	A	-0.5783
130	S	A	-0.2614
131	V	A	0.0000
132	F	A	-0.4996
133	P	A	-1.0201
134	L	A	0.0000
135	A	A	-0.9030
136	P	A	0.0000
137	S	A	-0.9420
138	S	A	-1.2600
139	K	A	-2.0178
140	S	A	-1.4664
141	T	A	-0.8957
142	S	A	-0.8946
143	G	A	-0.8386
144	G	A	-1.1547
145	T	A	-0.8897
146	A	A	0.0000
147	A	A	0.0000
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.2849
154	D	A	-0.4485
155	Y	A	0.0000
156	F	A	-0.2289
157	P	A	0.0000
158	E	A	-0.6054
159	P	A	-0.7805
160	V	A	0.0000
161	T	A	-0.6214
162	V	A	-0.3376
163	S	A	-0.4047
164	W	A	0.0000
165	N	A	-0.7419
166	S	A	-0.6454
167	G	A	-0.5557
168	A	A	-0.2126
169	L	A	0.0228
170	T	A	-0.1887
171	S	A	-0.2509
172	G	A	-0.2978
173	V	A	-0.0561
174	H	A	-0.4620
175	T	A	-0.2143
176	F	A	0.0000
177	P	A	-0.1520
178	A	A	0.1511
179	V	A	0.0000
180	L	A	0.8045
181	Q	A	-0.0292
182	S	A	-0.3068
183	S	A	-0.3504
184	G	A	-0.2133
185	L	A	0.0319
186	Y	A	0.2342
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.2773
194	V	A	0.0000
195	P	A	-0.5403
196	S	A	-0.9820
197	S	A	-0.8361
198	S	A	-0.6255
199	L	A	-0.9987
200	G	A	-1.0680
201	T	A	-0.8351
202	Q	A	-1.5007
203	T	A	-1.2662
204	Y	A	0.0000
205	I	A	-1.2825
206	C	A	0.0000
207	N	A	-1.4585
208	V	A	0.0000
209	N	A	-1.8618
210	H	A	0.0000
211	K	A	-2.8851
212	P	A	-1.6900
213	S	A	-1.8297
214	N	A	-2.4984
215	T	A	-2.0756
216	K	A	-2.6346
217	V	A	-1.4970
218	D	A	-2.3010
219	K	A	-2.0478
220	K	A	-2.5493
221	V	A	0.0000
222	E	A	-2.4749
223	P	A	-1.2267