Project name: neu2
Status: done
submitted: 2017-12-06 17:11:55, status changed: 2017-12-06 17:25:07
Settings
Chain sequence(s)
|
A: MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLNDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEY
|
Distance of aggregation |
5 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-2.0663
-
Maximal score value
-
1.8023
-
Average score
-
-0.292
-
Total score value
-
-108.0239
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
1.0642 |
|
2 |
A |
A |
0.2443 |
|
3 |
S |
A |
-0.0069 |
|
4 |
L |
A |
0.1060 |
|
5 |
P |
A |
-0.1707 |
|
6 |
V |
A |
0.3154 |
|
7 |
L |
A |
0.4073 |
|
8 |
Q |
A |
0.0000 |
|
9 |
K |
A |
-1.7262 |
|
10 |
E |
A |
-1.3336 |
|
11 |
S |
A |
-0.3995 |
|
12 |
V |
A |
0.0000 |
|
13 |
F |
A |
0.0000 |
|
14 |
Q |
A |
-1.2752 |
|
15 |
S |
A |
-0.3856 |
|
16 |
G |
A |
-0.4697 |
|
17 |
A |
A |
-0.0858 |
|
18 |
H |
A |
-0.3040 |
|
19 |
A |
A |
0.0000 |
|
20 |
Y |
A |
0.0000 |
|
21 |
R |
A |
0.0000 |
|
22 |
I |
A |
0.0000 |
|
23 |
P |
A |
0.0000 |
|
24 |
A |
A |
0.0000 |
|
25 |
L |
A |
0.0000 |
|
26 |
L |
A |
0.0000 |
|
27 |
Y |
A |
0.1301 |
|
28 |
L |
A |
0.0000 |
|
29 |
P |
A |
-0.4588 |
|
30 |
G |
A |
-0.6042 |
|
31 |
Q |
A |
-0.7943 |
|
32 |
Q |
A |
-1.2679 |
|
33 |
S |
A |
0.0000 |
|
34 |
L |
A |
0.0000 |
|
35 |
L |
A |
0.0000 |
|
36 |
A |
A |
0.0000 |
|
37 |
F |
A |
0.0000 |
|
38 |
A |
A |
0.0000 |
|
39 |
E |
A |
0.0000 |
|
40 |
Q |
A |
-0.1217 |
|
41 |
R |
A |
0.0000 |
|
42 |
A |
A |
0.0479 |
|
43 |
S |
A |
-0.1621 |
|
44 |
K |
A |
-0.9508 |
|
45 |
K |
A |
-2.0663 |
|
46 |
D |
A |
-1.7145 |
|
47 |
E |
A |
-0.5416 |
|
48 |
H |
A |
-0.3505 |
|
49 |
A |
A |
0.0000 |
|
50 |
E |
A |
-0.6076 |
|
51 |
L |
A |
0.1167 |
|
52 |
I |
A |
0.0000 |
|
53 |
V |
A |
0.0000 |
|
54 |
L |
A |
0.0998 |
|
55 |
R |
A |
-0.3586 |
|
56 |
R |
A |
-0.4396 |
|
57 |
G |
A |
0.0000 |
|
58 |
D |
A |
-0.8548 |
|
59 |
Y |
A |
-0.1056 |
|
60 |
D |
A |
-0.6962 |
|
61 |
A |
A |
-0.1665 |
|
62 |
P |
A |
-0.2574 |
|
63 |
T |
A |
-0.1870 |
|
64 |
H |
A |
-0.4649 |
|
65 |
Q |
A |
-0.4775 |
|
66 |
V |
A |
0.0000 |
|
67 |
Q |
A |
-1.1730 |
|
68 |
W |
A |
-0.3128 |
|
69 |
Q |
A |
-1.1620 |
|
70 |
A |
A |
-0.2442 |
|
71 |
Q |
A |
-0.7937 |
|
72 |
E |
A |
-1.8078 |
|
73 |
V |
A |
0.1699 |
|
74 |
V |
A |
0.0000 |
|
75 |
A |
A |
-0.0535 |
|
76 |
Q |
A |
-0.5208 |
|
77 |
A |
A |
0.0000 |
|
78 |
R |
A |
-1.4080 |
|
79 |
L |
A |
-0.4015 |
|
80 |
D |
A |
-1.8399 |
|
81 |
G |
A |
-0.8390 |
|
82 |
H |
A |
-0.3210 |
|
83 |
R |
A |
0.0000 |
|
84 |
S |
A |
0.0000 |
|
85 |
M |
A |
0.1064 |
|
86 |
N |
A |
0.0000 |
|
87 |
P |
A |
0.0000 |
|
88 |
C |
A |
0.0000 |
|
89 |
P |
A |
0.0000 |
|
90 |
L |
A |
0.0000 |
|
91 |
Y |
A |
0.2357 |
|
92 |
D |
A |
0.0000 |
|
93 |
A |
A |
-0.1597 |
|
94 |
Q |
A |
-1.1981 |
|
95 |
T |
A |
-0.3064 |
|
96 |
G |
A |
-0.1675 |
|
97 |
T |
A |
-0.0378 |
|
98 |
L |
A |
0.0000 |
|
99 |
F |
A |
0.0000 |
|
100 |
L |
A |
0.0000 |
|
101 |
F |
A |
0.0000 |
|
102 |
F |
A |
0.0000 |
|
103 |
I |
A |
0.0000 |
|
104 |
A |
A |
0.0000 |
|
105 |
I |
A |
0.0000 |
|
106 |
P |
A |
-0.1564 |
|
107 |
G |
A |
-0.5774 |
|
108 |
Q |
A |
-1.1542 |
|
109 |
V |
A |
0.3650 |
|
110 |
T |
A |
-0.1226 |
|
111 |
E |
A |
-1.4135 |
|
112 |
Q |
A |
-1.5943 |
|
113 |
Q |
A |
-1.1565 |
|
114 |
Q |
A |
0.0000 |
|
115 |
L |
A |
-0.1214 |
|
116 |
Q |
A |
-1.1836 |
|
117 |
T |
A |
-0.3862 |
|
118 |
R |
A |
-0.5013 |
|
119 |
A |
A |
-0.0910 |
|
120 |
N |
A |
-0.0207 |
|
121 |
V |
A |
0.5628 |
|
122 |
T |
A |
0.0000 |
|
123 |
R |
A |
-0.9766 |
|
124 |
L |
A |
0.0000 |
|
125 |
C |
A |
0.0000 |
|
126 |
Q |
A |
0.0000 |
|
127 |
V |
A |
0.0000 |
|
128 |
T |
A |
-0.0121 |
|
129 |
S |
A |
0.0000 |
|
130 |
T |
A |
-0.1278 |
|
131 |
D |
A |
-0.3635 |
|
132 |
H |
A |
-0.2990 |
|
133 |
G |
A |
-0.4421 |
|
134 |
R |
A |
-1.8678 |
|
135 |
T |
A |
-0.3839 |
|
136 |
W |
A |
0.1244 |
|
137 |
S |
A |
-0.0915 |
|
138 |
S |
A |
-0.2394 |
|
139 |
P |
A |
-0.2739 |
|
140 |
R |
A |
-1.0373 |
|
141 |
D |
A |
-0.7320 |
|
142 |
L |
A |
0.0000 |
|
143 |
T |
A |
0.0000 |
|
144 |
D |
A |
-1.7861 |
|
145 |
A |
A |
-0.2706 |
|
146 |
A |
A |
0.0000 |
|
147 |
I |
A |
0.0000 |
|
148 |
G |
A |
-0.3397 |
|
149 |
P |
A |
-0.2649 |
|
150 |
A |
A |
0.0000 |
|
151 |
Y |
A |
-0.1398 |
|
152 |
R |
A |
-1.9624 |
|
153 |
E |
A |
-1.1815 |
|
154 |
W |
A |
0.0000 |
|
155 |
S |
A |
0.0000 |
|
156 |
T |
A |
0.0000 |
|
157 |
F |
A |
0.0000 |
|
158 |
A |
A |
0.0000 |
|
159 |
V |
A |
0.0000 |
|
160 |
G |
A |
0.0000 |
|
161 |
P |
A |
0.0000 |
|
162 |
G |
A |
0.0000 |
|
163 |
H |
A |
0.0000 |
|
164 |
C |
A |
0.0000 |
|
165 |
L |
A |
0.1987 |
|
166 |
Q |
A |
0.0000 |
|
167 |
L |
A |
0.0000 |
|
168 |
N |
A |
-1.0869 |
|
169 |
D |
A |
-0.8723 |
|
170 |
R |
A |
-1.9052 |
|
171 |
A |
A |
-0.4313 |
|
172 |
R |
A |
-0.5101 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
V |
A |
0.0000 |
|
176 |
V |
A |
0.0000 |
|
177 |
P |
A |
0.0000 |
|
178 |
A |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
A |
A |
0.0000 |
|
181 |
Y |
A |
0.0000 |
|
182 |
R |
A |
-0.6930 |
|
183 |
K |
A |
-0.3309 |
|
184 |
L |
A |
0.9573 |
|
185 |
H |
A |
-0.3277 |
|
186 |
P |
A |
0.0281 |
|
187 |
I |
A |
1.8023 |
|
188 |
Q |
A |
-0.7648 |
|
189 |
R |
A |
-1.4792 |
|
190 |
P |
A |
0.0000 |
|
191 |
I |
A |
0.3149 |
|
192 |
P |
A |
0.0000 |
|
193 |
S |
A |
0.0000 |
|
194 |
A |
A |
0.0000 |
|
195 |
F |
A |
0.0000 |
|
196 |
C |
A |
0.0000 |
|
197 |
F |
A |
0.0000 |
|
198 |
L |
A |
0.0000 |
|
199 |
S |
A |
0.0000 |
|
200 |
H |
A |
-0.7914 |
|
201 |
D |
A |
-0.5633 |
|
202 |
H |
A |
-0.3260 |
|
203 |
G |
A |
0.0000 |
|
204 |
R |
A |
-1.8570 |
|
205 |
T |
A |
-0.4072 |
|
206 |
W |
A |
0.0000 |
|
207 |
A |
A |
-0.0878 |
|
208 |
R |
A |
-0.6187 |
|
209 |
G |
A |
0.0000 |
|
210 |
H |
A |
-0.9170 |
|
211 |
F |
A |
0.2550 |
|
212 |
V |
A |
0.2564 |
|
213 |
A |
A |
-0.1503 |
|
214 |
Q |
A |
-1.2600 |
|
215 |
D |
A |
-0.5944 |
|
216 |
T |
A |
0.0000 |
|
217 |
L |
A |
0.0000 |
|
218 |
E |
A |
0.0000 |
|
219 |
C |
A |
0.0000 |
|
220 |
Q |
A |
0.0000 |
|
221 |
V |
A |
0.0000 |
|
222 |
A |
A |
0.0000 |
|
223 |
E |
A |
-0.2336 |
|
224 |
V |
A |
0.0000 |
|
225 |
E |
A |
-1.6362 |
|
229 |
Q |
A |
-1.4647 |
|
230 |
R |
A |
-1.8463 |
|
231 |
V |
A |
0.0000 |
|
232 |
V |
A |
0.0000 |
|
233 |
T |
A |
0.0000 |
|
234 |
L |
A |
0.0000 |
|
235 |
N |
A |
0.0000 |
|
236 |
A |
A |
0.0000 |
|
237 |
R |
A |
-0.2111 |
|
238 |
S |
A |
0.0000 |
|
239 |
H |
A |
-1.0789 |
|
240 |
L |
A |
-0.1643 |
|
241 |
R |
A |
-1.7776 |
|
242 |
A |
A |
0.0000 |
|
243 |
R |
A |
0.0000 |
|
244 |
V |
A |
0.0000 |
|
245 |
Q |
A |
0.0000 |
|
246 |
A |
A |
0.0000 |
|
247 |
Q |
A |
-0.2772 |
|
248 |
S |
A |
0.0000 |
|
249 |
T |
A |
-0.2024 |
|
250 |
N |
A |
-0.8719 |
|
251 |
D |
A |
-0.9611 |
|
252 |
G |
A |
0.0000 |
|
253 |
L |
A |
0.2129 |
|
254 |
D |
A |
-0.6841 |
|
255 |
F |
A |
-0.1778 |
|
256 |
Q |
A |
-1.4999 |
|
257 |
E |
A |
-2.0580 |
|
258 |
S |
A |
-0.6460 |
|
259 |
Q |
A |
-1.0989 |
|
260 |
L |
A |
0.4074 |
|
261 |
V |
A |
0.0000 |
|
262 |
K |
A |
-1.9276 |
|
263 |
K |
A |
-1.5646 |
|
264 |
L |
A |
0.0000 |
|
265 |
V |
A |
0.4037 |
|
266 |
E |
A |
0.0000 |
|
267 |
P |
A |
0.0000 |
|
268 |
P |
A |
-0.1663 |
|
269 |
P |
A |
-0.4517 |
|
270 |
Q |
A |
-1.1611 |
|
271 |
G |
A |
0.0000 |
|
272 |
C |
A |
0.0000 |
|
273 |
Q |
A |
0.0000 |
|
274 |
G |
A |
0.0000 |
|
275 |
S |
A |
0.0000 |
|
276 |
V |
A |
0.0000 |
|
277 |
I |
A |
0.0000 |
|
278 |
S |
A |
-0.0374 |
|
279 |
F |
A |
0.0000 |
|
280 |
P |
A |
-0.3033 |
|
281 |
S |
A |
-0.1358 |
|
282 |
P |
A |
-0.4533 |
|
283 |
R |
A |
-1.8641 |
|
288 |
S |
A |
-0.2193 |
|
289 |
P |
A |
-0.0691 |
|
290 |
A |
A |
-0.0337 |
|
291 |
Q |
A |
-0.3364 |
|
292 |
W |
A |
0.0000 |
|
293 |
L |
A |
0.0000 |
|
294 |
L |
A |
0.0000 |
|
295 |
Y |
A |
0.0000 |
|
296 |
T |
A |
0.0000 |
|
297 |
H |
A |
0.0000 |
|
298 |
P |
A |
0.0000 |
|
299 |
T |
A |
-0.1079 |
|
300 |
H |
A |
-0.5454 |
|
301 |
S |
A |
-0.0866 |
|
302 |
W |
A |
0.9249 |
|
303 |
Q |
A |
-1.0496 |
|
304 |
R |
A |
-0.6093 |
|
305 |
A |
A |
-0.1453 |
|
306 |
D |
A |
-0.4539 |
|
307 |
L |
A |
0.0000 |
|
308 |
G |
A |
0.0000 |
|
309 |
A |
A |
0.0000 |
|
310 |
Y |
A |
0.0000 |
|
311 |
L |
A |
0.0000 |
|
312 |
N |
A |
0.0000 |
|
313 |
P |
A |
-0.3798 |
|
314 |
R |
A |
-1.8518 |
|
315 |
P |
A |
0.0000 |
|
316 |
P |
A |
-0.0355 |
|
317 |
A |
A |
0.0021 |
|
318 |
P |
A |
-0.3689 |
|
319 |
E |
A |
-1.8247 |
|
320 |
A |
A |
-0.3213 |
|
321 |
W |
A |
0.0000 |
|
322 |
S |
A |
-0.3866 |
|
323 |
E |
A |
-1.8432 |
|
324 |
P |
A |
-0.3606 |
|
325 |
V |
A |
0.3342 |
|
326 |
L |
A |
0.4596 |
|
327 |
L |
A |
0.0000 |
|
328 |
A |
A |
0.0000 |
|
329 |
K |
A |
-1.7606 |
|
330 |
G |
A |
-0.4963 |
|
331 |
S |
A |
-0.2706 |
|
332 |
C |
A |
0.0000 |
|
333 |
A |
A |
0.0000 |
|
334 |
Y |
A |
0.0000 |
|
335 |
S |
A |
0.0000 |
|
336 |
D |
A |
0.0000 |
|
337 |
L |
A |
0.0000 |
|
338 |
Q |
A |
-0.1284 |
|
339 |
S |
A |
-0.0914 |
|
340 |
M |
A |
0.0000 |
|
341 |
G |
A |
-0.4794 |
|
342 |
T |
A |
-0.1603 |
|
343 |
G |
A |
0.0000 |
|
344 |
P |
A |
-0.3456 |
|
345 |
D |
A |
-1.3766 |
|
346 |
G |
A |
-0.7038 |
|
347 |
S |
A |
0.0000 |
|
348 |
P |
A |
-0.0380 |
|
349 |
L |
A |
0.0000 |
|
350 |
F |
A |
0.0000 |
|
351 |
G |
A |
0.0000 |
|
352 |
C |
A |
0.0000 |
|
353 |
L |
A |
0.0000 |
|
354 |
Y |
A |
0.0000 |
|
355 |
E |
A |
0.0000 |
|
356 |
A |
A |
0.0000 |
|
357 |
N |
A |
-1.6189 |
|
358 |
D |
A |
-1.9862 |
|
359 |
Y |
A |
-0.3713 |
|
360 |
E |
A |
-1.5037 |
|
361 |
E |
A |
-0.8629 |
|
362 |
I |
A |
0.0000 |
|
363 |
V |
A |
0.0000 |
|
364 |
F |
A |
0.0000 |
|
365 |
L |
A |
0.0000 |
|
366 |
M |
A |
0.0000 |
|
367 |
F |
A |
0.0000 |
|
368 |
T |
A |
0.0000 |
|
369 |
L |
A |
0.0000 |
|
370 |
K |
A |
-0.9089 |
|
371 |
Q |
A |
-0.4081 |
|
372 |
A |
A |
0.0000 |
|
373 |
F |
A |
0.1451 |
|
374 |
P |
A |
-0.2763 |
|
375 |
A |
A |
-0.0968 |
|
376 |
E |
A |
-0.3583 |
|
377 |
Y |
A |
1.2019 |
|