Project name: a6dc41effe23a98

Chain sequence(s)	A: TPVAKNGQLSIKGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGYIDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTPNVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQLKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSREWLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6999
• Maximal score value: 0.6156
• Average score: -0.8631
• Total score value: -257.2132

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
34	T	A	-0.5877
35	P	A	-0.7547
36	V	A	-1.0385
37	A	A	-0.8607
38	K	A	-2.2085
39	N	A	0.0000
40	G	A	-1.8067
41	Q	A	-2.2380
42	L	A	0.0000
43	S	A	-1.8166
44	I	A	-1.1821
45	K	A	-2.3217
46	G	A	-1.5219
47	T	A	-1.4558
48	Q	A	-1.9302
49	L	A	0.0000
50	V	A	0.0000
51	N	A	0.0000
52	R	A	-3.6423
53	D	A	-3.6427
54	G	A	-2.9227
55	K	A	-3.0177
56	A	A	-1.6726
57	V	A	-0.5727
58	Q	A	-0.9606
59	L	A	0.0000
60	K	A	-0.1892
61	G	A	0.0000
62	I	A	0.0000
63	S	A	0.0000
64	S	A	0.0000
65	H	A	0.0000
66	G	A	0.0000
67	L	A	0.0000
68	Q	A	-0.6022
69	W	A	0.4711
70	Y	A	-0.2692
71	G	A	0.0000
72	E	A	-1.9921
73	Y	A	0.0000
74	V	A	0.0000
75	N	A	-2.4425
76	K	A	-2.9985
77	D	A	-2.8577
78	S	A	0.0000
79	L	A	0.0000
80	K	A	-2.7110
81	W	A	-1.7101
82	L	A	0.0000
83	R	A	-1.7742
84	D	A	-2.0595
85	D	A	-1.1229
86	W	A	0.0000
87	G	A	-0.9113
88	I	A	0.0000
89	T	A	-0.2538
90	V	A	0.0000
91	F	A	0.0000
92	R	A	0.0000
93	A	A	0.0000
94	A	A	0.0000
95	M	A	0.0000
96	Y	A	0.0000
97	T	A	0.0000
98	A	A	-1.6351
99	D	A	-2.5949
100	G	A	-1.9347
101	G	A	0.0000
102	Y	A	-1.3508
103	I	A	-1.2433
104	D	A	-2.5484
105	N	A	-2.4145
106	P	A	-1.4576
107	S	A	-1.3189
108	V	A	-1.3194
109	K	A	-1.6420
110	N	A	-2.0370
111	K	A	-2.0084
112	V	A	0.0000
113	K	A	-1.9511
114	E	A	-2.5821
115	A	A	0.0000
116	V	A	0.0000
117	E	A	-3.3284
118	A	A	0.0000
119	A	A	0.0000
120	K	A	-2.4214
121	E	A	-3.0483
122	L	A	0.0000
123	G	A	-1.2129
124	I	A	0.0000
125	Y	A	0.0000
126	V	A	0.0000
127	I	A	0.0000
128	I	A	0.0000
129	D	A	0.0000
130	W	A	0.0000
131	H	A	0.0000
132	I	A	0.0000
133	L	A	-0.6561
134	N	A	-1.7298
135	D	A	-1.5139
136	G	A	-1.2811
137	N	A	-1.7552
138	P	A	0.0000
139	N	A	-1.7705
140	Q	A	-2.0954
141	N	A	0.0000
142	K	A	-2.5846
143	E	A	-3.4617
144	K	A	-3.1822
145	A	A	0.0000
146	K	A	-2.9776
147	E	A	-3.6999
148	F	A	0.0000
149	F	A	0.0000
150	K	A	-3.1618
151	E	A	-2.1508
152	M	A	0.0000
153	S	A	0.0000
154	S	A	-1.1086
155	L	A	0.2387
156	Y	A	0.0000
157	G	A	-1.4413
158	N	A	-1.4898
159	T	A	0.0000
160	P	A	-1.0811
161	N	A	0.0000
162	V	A	0.0000
163	I	A	0.0000
164	Y	A	0.0000
165	E	A	0.0000
166	I	A	0.0000
167	A	A	0.0000
168	N	A	0.0000
169	E	A	0.0000
170	P	A	0.0000
171	N	A	-0.9710
172	G	A	-1.6526
173	D	A	-2.3130
174	V	A	0.0000
175	N	A	-2.4704
176	W	A	0.0000
177	K	A	-3.3628
178	R	A	-3.0385
179	D	A	-2.3011
180	I	A	0.0000
181	K	A	-1.7455
182	P	A	-1.4839
183	Y	A	0.0000
184	A	A	0.0000
185	E	A	-1.4719
186	E	A	-1.3889
187	V	A	0.0000
188	I	A	0.0000
189	S	A	-1.2864
190	V	A	-1.7584
191	I	A	0.0000
192	R	A	-1.9543
193	K	A	-2.4126
194	N	A	-2.3408
195	D	A	0.0000
196	P	A	-1.9957
197	D	A	-2.3512
198	N	A	0.0000
199	I	A	0.0000
200	I	A	0.0000
201	I	A	0.0000
202	V	A	0.0000
203	G	A	0.0000
204	T	A	0.0000
205	G	A	0.0000
206	T	A	-0.2541
207	W	A	0.6156
208	S	A	0.0000
209	Q	A	-0.2490
210	D	A	-0.6648
211	V	A	0.0000
212	N	A	-1.8348
213	D	A	-2.1149
214	A	A	0.0000
215	A	A	0.0000
216	D	A	-2.8228
217	D	A	-2.1761
218	Q	A	-2.0155
219	L	A	-1.4342
220	K	A	-2.0002
221	D	A	-1.5196
222	A	A	-1.0914
223	N	A	0.0000
224	V	A	0.0000
225	M	A	0.0000
226	Y	A	0.0000
227	A	A	0.0000
228	L	A	0.0000
229	H	A	0.0000
230	F	A	0.0000
231	Y	A	0.0000
232	A	A	0.0000
233	G	A	-0.5935
234	T	A	-0.3855
235	H	A	-0.2321
236	G	A	-0.6110
237	Q	A	-0.9653
238	F	A	0.5645
239	L	A	0.0000
240	R	A	0.0000
241	D	A	-1.7232
242	K	A	-1.2577
243	A	A	0.0000
244	N	A	-1.6588
245	Y	A	-1.2247
246	A	A	0.0000
247	L	A	-1.1584
248	S	A	-0.9875
249	K	A	-1.9760
250	G	A	-1.4043
251	A	A	0.0000
252	P	A	0.0000
253	I	A	0.0000
254	F	A	0.0000
255	V	A	0.0000
256	T	A	0.0000
257	E	A	0.0000
258	W	A	0.0000
259	G	A	0.0000
260	T	A	0.0000
261	S	A	0.0000
262	D	A	-0.7122
263	A	A	-0.3866
264	S	A	-0.6235
265	G	A	0.0000
266	N	A	-1.2534
267	G	A	-0.9207
268	G	A	-0.3372
269	V	A	0.2341
270	F	A	-0.0757
271	L	A	-0.4884
272	D	A	-2.3471
273	Q	A	-2.3157
274	S	A	0.0000
275	R	A	-3.3047
276	E	A	-3.2690
277	W	A	0.0000
278	L	A	0.0000
279	K	A	-3.3956
280	Y	A	-2.1570
281	L	A	0.0000
282	D	A	-2.9155
283	S	A	-2.1445
284	K	A	-2.5250
285	T	A	-1.8268
286	I	A	0.0000
287	S	A	0.0000
288	W	A	0.0000
289	V	A	0.0000
290	N	A	0.0000
291	W	A	0.0000
292	N	A	0.0000
293	L	A	0.0000
294	S	A	0.0000
295	D	A	-1.6529
296	K	A	-1.4658
297	Q	A	-1.9616
298	E	A	-1.5131
299	S	A	-0.9976
300	S	A	0.0000
301	S	A	0.0000
302	A	A	0.0000
303	L	A	0.0000
304	K	A	-2.0694
305	P	A	-1.6794
306	G	A	-1.2619
307	A	A	0.0000
308	S	A	-1.5012
309	K	A	-2.0541
310	T	A	-1.8855
311	G	A	0.0000
312	G	A	-1.2359
313	W	A	0.0000
314	R	A	-1.3555
315	L	A	0.4210
316	S	A	-0.3821
317	D	A	-1.0981
318	L	A	0.0000
319	S	A	-0.3657
320	A	A	0.0373
321	S	A	0.0000
322	G	A	0.0000
323	T	A	-0.4059
324	F	A	0.0000
325	V	A	0.0000
326	R	A	-0.9850
327	E	A	-1.7113
328	N	A	-1.2024
329	I	A	-0.2399
330	L	A	0.4047
331	G	A	-0.2837