Project name: 2H8H

Chain sequence(s)	A: TFVALYDYESRTETDLSFKKGERLQIVNNTEEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQQP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7833
• Maximal score value: 1.1283
• Average score: -0.9685
• Total score value: -429.0661

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
85	T	A	-0.5745
86	F	A	-0.5545
87	V	A	-1.3402
88	A	A	0.0000
89	L	A	-1.4956
90	Y	A	-2.0673
91	D	A	-3.2868
92	Y	A	0.0000
93	E	A	-2.5799
94	S	A	-1.4942
95	R	A	-1.6501
96	T	A	-1.6365
97	E	A	-2.0283
98	T	A	-1.1003
99	D	A	-1.1251
100	L	A	0.0000
101	S	A	-1.6327
102	F	A	0.0000
103	K	A	-3.3866
104	K	A	-2.8000
105	G	A	-2.0006
106	E	A	-1.8450
107	R	A	-2.0121
108	L	A	0.0000
109	Q	A	-0.5258
110	I	A	0.0000
111	V	A	0.2846
112	N	A	-1.1942
113	N	A	-2.1286
114	T	A	-1.7644
115	E	A	-2.7796
116	G	A	-2.2849
117	D	A	-2.6091
118	W	A	0.0000
119	W	A	-1.0760
120	L	A	-0.2577
121	A	A	0.0000
122	H	A	-0.7496
123	S	A	0.0000
124	L	A	0.2572
125	S	A	-0.3328
126	T	A	-0.6518
127	G	A	-0.8052
128	Q	A	-1.4332
129	T	A	-0.6495
130	G	A	0.0000
131	Y	A	-0.3193
132	I	A	0.0000
133	P	A	0.0000
134	S	A	-1.1113
135	N	A	-1.2752
136	Y	A	0.0000
137	V	A	0.0000
138	A	A	0.0000
139	P	A	-0.8872
140	S	A	-1.3192
141	D	A	-1.9601
142	S	A	-1.1576
143	I	A	-1.0252
144	Q	A	-1.5010
145	A	A	-1.4235
146	E	A	-1.8417
147	E	A	-2.1039
148	W	A	0.0000
149	Y	A	-0.8811
150	F	A	-0.6007
151	G	A	-0.8163
152	K	A	-1.8855
153	I	A	-1.1052
154	T	A	-1.2951
155	R	A	-1.6311
156	R	A	-1.1689
157	E	A	-0.7289
158	S	A	0.0000
159	E	A	-0.5636
160	R	A	0.0000
161	L	A	-0.1763
162	L	A	0.0000
163	L	A	0.3517
164	N	A	-0.8636
165	A	A	-0.8586
166	E	A	-2.0898
167	N	A	-1.2877
168	P	A	-1.0853
169	R	A	-1.6327
170	G	A	0.0000
171	T	A	0.0000
172	F	A	0.0000
173	L	A	0.0000
174	V	A	0.0000
175	R	A	0.0000
176	E	A	-1.6466
177	S	A	-2.1801
178	E	A	-2.6821
179	T	A	-1.5371
180	T	A	-1.8511
181	K	A	-2.5550
182	G	A	-2.0353
183	A	A	0.0000
184	Y	A	-1.4570
185	C	A	0.0000
186	L	A	0.0000
187	S	A	0.0000
188	V	A	0.0000
189	S	A	0.0000
190	D	A	-0.3103
191	F	A	0.0569
192	D	A	-1.4376
193	N	A	-1.7391
194	A	A	-1.4121
195	K	A	-2.0062
196	G	A	-0.8936
197	L	A	0.1377
198	N	A	-0.1583
199	V	A	0.0863
200	K	A	-0.7413
201	H	A	0.0000
202	Y	A	0.0000
203	K	A	-1.5609
204	I	A	0.0000
205	R	A	-2.8314
206	K	A	-3.1492
208	D	A	-2.5755
209	S	A	-1.4219
210	G	A	-2.0203
211	G	A	-2.0470
212	F	A	-1.8748
213	Y	A	-1.5556
214	I	A	-1.1338
215	T	A	-1.2832
216	S	A	-1.4237
217	R	A	-2.1692
218	T	A	-1.5546
219	Q	A	-2.2364
220	F	A	0.0000
221	N	A	-1.9218
222	S	A	-1.3002
223	L	A	0.0000
224	Q	A	-0.9029
225	Q	A	-1.1351
226	L	A	0.0000
227	V	A	0.0000
228	A	A	-0.6298
229	Y	A	-0.8912
230	Y	A	0.0000
231	S	A	-1.4304
232	K	A	-2.4983
233	H	A	-2.5934
234	A	A	-2.1209
235	D	A	-2.2271
236	G	A	-1.3644
237	L	A	0.0000
238	C	A	-0.5605
239	H	A	-1.3647
240	R	A	-2.3947
241	L	A	0.0000
242	T	A	-0.9797
243	T	A	-0.2646
244	V	A	-0.0972
245	C	A	0.0000
246	P	A	-0.8425
247	T	A	-0.6033
248	S	A	-1.4555
249	K	A	-2.2533
250	P	A	-1.5732
251	Q	A	-1.7285
252	T	A	0.0000
253	Q	A	-1.7326
254	G	A	-1.1047
255	L	A	0.0000
256	A	A	-1.1050
257	K	A	-2.0463
258	D	A	-2.5288
259	A	A	-1.4865
260	W	A	-1.4478
261	E	A	-2.0361
262	I	A	0.0000
263	P	A	-1.6665
264	R	A	-2.1137
265	E	A	-2.5971
266	S	A	-1.9098
267	L	A	0.0000
268	R	A	-2.4542
269	L	A	-0.5515
270	E	A	-0.6984
271	V	A	0.5778
272	K	A	-0.3692
273	L	A	0.4232
274	G	A	-0.5556
275	Q	A	-1.5085
276	G	A	-1.0229
277	C	A	-0.5009
278	F	A	-0.7890
279	G	A	-1.1101
280	E	A	-1.1928
281	V	A	0.0356
282	W	A	0.0945
283	M	A	-0.0613
284	G	A	0.0000
285	T	A	-1.6939
286	W	A	0.0000
287	N	A	-2.0949
288	G	A	-1.5085
289	T	A	-1.3128
290	T	A	-1.5430
291	R	A	-2.1637
292	V	A	0.0000
293	A	A	-0.0097
294	I	A	0.0000
295	K	A	-0.3892
296	T	A	-0.7893
297	L	A	0.0000
298	K	A	-2.0748
299	P	A	-1.8546
300	G	A	-1.5418
301	T	A	0.0000
302	M	A	0.0000
303	S	A	-1.3979
304	P	A	-1.8598
305	E	A	-2.2835
306	A	A	-1.1551
307	F	A	0.0000
308	L	A	-1.3935
309	Q	A	-1.6385
310	E	A	0.0000
311	A	A	0.0000
312	Q	A	-1.6970
313	V	A	-1.0400
314	M	A	0.0000
315	K	A	-2.4438
316	K	A	-2.7601
317	L	A	0.0000
318	R	A	-3.0735
319	H	A	-2.1269
320	E	A	-2.3391
321	K	A	0.0000
322	L	A	0.0000
323	V	A	0.0000
324	Q	A	-1.4160
325	L	A	0.0000
326	Y	A	-0.4426
327	A	A	0.0000
328	V	A	0.0000
329	V	A	0.0000
330	S	A	-1.7769
331	E	A	-2.7910
332	E	A	-2.3276
333	P	A	-1.8230
334	I	A	0.0000
335	Y	A	-0.8344
336	I	A	0.0000
337	V	A	0.0000
338	T	A	-0.3137
339	E	A	-0.4599
340	Y	A	-0.3366
341	M	A	0.0000
342	S	A	-1.2630
343	K	A	-2.0602
344	G	A	-0.9445
345	S	A	-0.7501
346	L	A	0.0000
347	L	A	-0.9178
348	D	A	-2.6222
349	F	A	0.0000
350	L	A	0.0000
351	K	A	-3.0883
352	G	A	-2.7243
353	E	A	-2.8900
354	T	A	-2.0054
355	G	A	0.0000
356	K	A	-2.4010
357	Y	A	-0.2964
358	L	A	-1.1441
359	R	A	-1.6802
360	L	A	-0.8399
361	P	A	-0.6361
362	Q	A	-0.8893
363	L	A	0.0000
364	V	A	0.0000
365	D	A	-0.7510
366	M	A	0.0000
367	A	A	0.0000
368	A	A	0.0000
369	Q	A	0.0000
370	I	A	0.0000
371	A	A	0.0000
372	S	A	-0.6878
373	G	A	0.0000
374	M	A	0.0000
375	A	A	0.0000
376	Y	A	-1.4269
377	V	A	0.0000
378	E	A	-1.6369
379	R	A	-2.3669
380	M	A	-1.2975
381	N	A	-1.5802
382	Y	A	-0.5357
383	V	A	-0.1428
384	H	A	0.0000
385	R	A	-1.1034
386	D	A	-0.8027
387	L	A	0.0000
388	R	A	-0.4402
389	A	A	0.0000
390	A	A	-0.3759
391	N	A	0.0000
392	I	A	0.0000
393	L	A	-0.1511
394	V	A	0.0000
395	G	A	-1.2682
396	E	A	-2.2082
397	N	A	-0.9461
398	L	A	-0.4448
399	V	A	-0.5459
400	C	A	0.0000
401	K	A	0.0000
402	V	A	0.0000
403	A	A	0.0000
404	D	A	-0.7379
405	F	A	0.0000
406	G	A	0.0000
407	L	A	0.0000
408	A	A	-1.3711
409	R	A	-2.1059
410	L	A	-1.2836
411	I	A	0.0000
412	E	A	-2.8518
413	D	A	-2.3846
414	N	A	-2.8267
415	E	A	-2.9901
416	Y	A	0.0000
417	T	A	-2.1111
418	A	A	-1.3726
419	R	A	-1.3689
420	Q	A	-2.6446
421	G	A	-2.1676
422	A	A	-1.3059
423	K	A	-1.3511
424	F	A	0.0000
425	P	A	0.0000
426	I	A	0.0000
427	K	A	0.0000
428	W	A	-0.0433
429	T	A	-0.0375
430	A	A	0.0000
431	P	A	0.0000
432	E	A	-0.6653
433	A	A	0.0000
434	A	A	0.0000
435	L	A	0.5379
436	Y	A	0.8597
437	G	A	-0.3062
438	R	A	-1.3621
439	F	A	-0.7833
440	T	A	-0.4748
441	I	A	-0.5266
442	K	A	-1.1390
443	S	A	0.0000
444	D	A	0.0000
445	V	A	0.0000
446	W	A	0.0000
447	S	A	0.0000
448	F	A	0.0000
449	G	A	0.0000
450	I	A	0.0000
451	L	A	0.0000
452	L	A	0.0000
453	T	A	0.0000
454	E	A	0.0000
455	L	A	0.0000
456	T	A	-0.8072
457	T	A	-0.8576
458	K	A	-1.7254
459	G	A	-0.9338
460	R	A	-0.2451
461	V	A	1.1283
462	P	A	0.0000
463	Y	A	0.0000
464	P	A	0.0821
465	G	A	-0.2269
466	M	A	-0.4279
467	V	A	-0.4440
468	N	A	-2.1793
469	R	A	-3.0672
470	E	A	-2.5643
471	V	A	0.0000
472	L	A	-2.0626
473	D	A	-3.5145
474	Q	A	-2.9283
475	V	A	0.0000
476	E	A	-2.9305
477	R	A	-3.2676
478	G	A	-2.3149
479	Y	A	-1.1002
480	R	A	-0.7716
481	M	A	0.0000
482	P	A	-0.5810
483	C	A	-1.0548
484	P	A	0.0000
485	P	A	-1.3161
486	E	A	-2.1166
487	C	A	0.0000
488	P	A	-1.6887
489	E	A	-2.7163
490	S	A	-1.7040
491	L	A	0.0000
492	H	A	-1.7817
493	D	A	-2.4836
494	L	A	0.0000
495	M	A	0.0000
496	C	A	-1.2756
497	Q	A	-1.6353
498	C	A	0.0000
499	W	A	0.0000
500	R	A	-3.1516
501	K	A	-3.7833
502	E	A	-3.4654
503	P	A	-2.8663
504	E	A	-3.4605
505	E	A	-3.6604
506	R	A	0.0000
507	P	A	-1.1613
508	T	A	-0.9706
509	F	A	0.0000
510	E	A	-1.8042
511	Y	A	-0.2112
512	L	A	0.0000
513	Q	A	-0.8646
514	A	A	-0.6836
515	F	A	-0.1349
516	L	A	0.0000
517	E	A	-1.0992
518	D	A	-1.4680
519	Y	A	-0.1547
520	F	A	0.6243
521	T	A	-0.3861
522	S	A	-1.0454
523	T	A	-1.1505
524	E	A	-2.4973
525	P	A	-2.1501
526	Q	A	-2.2801
528	Q	A	-2.0135
529	P	A	-0.9842