Project name: 2ZB4
Status: done
submitted: 2018-02-20 14:26:26, status changed: 2018-02-20 14:41:51
Settings
Chain sequence(s)
|
A: AMIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEIS
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.1624
-
Maximal score value
-
2.2654
-
Average score
-
-0.9093
-
Total score value
-
-319.1512
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
-1 |
A |
A |
0.4809 |
|
1 |
M |
A |
1.5823 |
|
2 |
I |
A |
2.2654 |
|
3 |
V |
A |
0.0000 |
|
4 |
Q |
A |
-1.0164 |
|
5 |
R |
A |
-1.4147 |
|
6 |
V |
A |
0.0000 |
|
7 |
V |
A |
0.0000 |
|
8 |
L |
A |
0.0000 |
|
9 |
N |
A |
-1.7153 |
|
10 |
S |
A |
-1.1207 |
|
11 |
R |
A |
-1.5121 |
|
12 |
P |
A |
-1.5835 |
|
13 |
G |
A |
-2.6126 |
|
14 |
K |
A |
-4.1624 |
|
15 |
N |
A |
-3.7066 |
|
16 |
G |
A |
-2.5818 |
|
17 |
N |
A |
-2.1497 |
|
18 |
P |
A |
0.0000 |
|
19 |
V |
A |
-0.6498 |
|
20 |
A |
A |
-1.3982 |
|
21 |
E |
A |
-2.2856 |
|
22 |
N |
A |
0.0000 |
|
23 |
F |
A |
0.0000 |
|
24 |
R |
A |
-2.7716 |
|
25 |
M |
A |
-2.1079 |
|
26 |
E |
A |
-2.0169 |
|
27 |
E |
A |
-1.2818 |
|
28 |
V |
A |
0.5453 |
|
29 |
Y |
A |
1.7681 |
|
30 |
L |
A |
0.0000 |
|
31 |
P |
A |
-0.9075 |
|
32 |
D |
A |
-2.3100 |
|
33 |
N |
A |
-2.7224 |
|
34 |
I |
A |
0.0000 |
|
35 |
N |
A |
-3.2530 |
|
36 |
E |
A |
-3.3734 |
|
37 |
G |
A |
-2.6905 |
|
38 |
Q |
A |
-2.7272 |
|
39 |
V |
A |
0.0000 |
|
40 |
Q |
A |
-1.7766 |
|
41 |
V |
A |
0.0000 |
|
42 |
R |
A |
-0.9700 |
|
43 |
T |
A |
0.0000 |
|
44 |
L |
A |
0.0000 |
|
45 |
Y |
A |
-0.0523 |
|
46 |
L |
A |
0.0000 |
|
47 |
S |
A |
0.0000 |
|
48 |
V |
A |
0.0000 |
|
49 |
D |
A |
-0.1305 |
|
50 |
P |
A |
0.1453 |
|
51 |
Y |
A |
0.4447 |
|
52 |
M |
A |
0.0000 |
|
53 |
R |
A |
0.0000 |
|
54 |
C |
A |
-1.0460 |
|
55 |
R |
A |
0.0000 |
|
56 |
M |
A |
0.0000 |
|
57 |
N |
A |
0.0000 |
|
58 |
E |
A |
-3.2406 |
|
59 |
D |
A |
-3.2149 |
|
60 |
T |
A |
-1.7568 |
|
61 |
G |
A |
-1.4651 |
|
62 |
T |
A |
-0.9491 |
|
63 |
D |
A |
-1.3897 |
|
64 |
Y |
A |
0.5455 |
|
65 |
I |
A |
0.1258 |
|
66 |
T |
A |
-0.7926 |
|
67 |
P |
A |
-1.3100 |
|
68 |
W |
A |
0.0000 |
|
69 |
Q |
A |
-1.6321 |
|
70 |
L |
A |
-0.7496 |
|
71 |
S |
A |
-1.0418 |
|
72 |
Q |
A |
-1.2507 |
|
73 |
V |
A |
-0.6124 |
|
74 |
V |
A |
0.0000 |
|
75 |
D |
A |
0.1761 |
|
76 |
G |
A |
0.0000 |
|
77 |
G |
A |
0.6309 |
|
78 |
G |
A |
0.0000 |
|
79 |
I |
A |
0.0000 |
|
80 |
G |
A |
0.0000 |
|
81 |
I |
A |
0.0000 |
|
82 |
I |
A |
0.0000 |
|
83 |
E |
A |
-1.8303 |
|
84 |
E |
A |
-2.2849 |
|
85 |
S |
A |
-2.4712 |
|
86 |
K |
A |
-3.0610 |
|
87 |
H |
A |
-2.4927 |
|
88 |
T |
A |
-1.3640 |
|
89 |
N |
A |
-1.8192 |
|
90 |
L |
A |
-1.9821 |
|
91 |
T |
A |
-1.9332 |
|
92 |
K |
A |
-2.6341 |
|
93 |
G |
A |
-1.4654 |
|
94 |
D |
A |
-1.5109 |
|
95 |
F |
A |
-1.0508 |
|
96 |
V |
A |
0.0000 |
|
97 |
T |
A |
-0.5278 |
|
98 |
S |
A |
0.0621 |
|
99 |
F |
A |
1.1061 |
|
100 |
Y |
A |
1.5259 |
|
101 |
W |
A |
0.0000 |
|
102 |
P |
A |
0.1976 |
|
103 |
W |
A |
0.0000 |
|
104 |
Q |
A |
0.0000 |
|
105 |
T |
A |
-0.3880 |
|
106 |
K |
A |
-0.3324 |
|
107 |
V |
A |
0.0000 |
|
108 |
I |
A |
-0.9644 |
|
109 |
L |
A |
-0.9619 |
|
110 |
D |
A |
-2.4872 |
|
111 |
G |
A |
0.0000 |
|
112 |
N |
A |
-2.3083 |
|
113 |
S |
A |
-1.2737 |
|
114 |
L |
A |
-1.5286 |
|
115 |
E |
A |
-2.7742 |
|
116 |
K |
A |
-2.8284 |
|
117 |
V |
A |
-1.7275 |
|
118 |
D |
A |
-2.1985 |
|
119 |
P |
A |
-1.9757 |
|
120 |
Q |
A |
-2.4700 |
|
121 |
L |
A |
-1.4587 |
|
122 |
V |
A |
0.0000 |
|
123 |
D |
A |
-2.8677 |
|
124 |
G |
A |
-2.0467 |
|
125 |
H |
A |
-1.3261 |
|
126 |
L |
A |
0.0000 |
|
127 |
S |
A |
0.0000 |
|
128 |
Y |
A |
-0.2173 |
|
129 |
F |
A |
0.2225 |
|
130 |
L |
A |
0.0000 |
|
131 |
G |
A |
0.0000 |
|
132 |
A |
A |
0.0000 |
|
133 |
I |
A |
0.0000 |
|
134 |
G |
A |
0.0000 |
|
135 |
M |
A |
0.5086 |
|
136 |
P |
A |
0.1491 |
|
137 |
G |
A |
0.0000 |
|
138 |
L |
A |
0.0000 |
|
139 |
T |
A |
0.1867 |
|
140 |
S |
A |
0.0000 |
|
141 |
L |
A |
0.0000 |
|
142 |
I |
A |
0.0000 |
|
143 |
G |
A |
0.0000 |
|
144 |
I |
A |
0.0000 |
|
145 |
Q |
A |
-1.9639 |
|
146 |
E |
A |
-2.0504 |
|
147 |
K |
A |
-1.9205 |
|
148 |
G |
A |
0.0000 |
|
149 |
H |
A |
-1.5117 |
|
150 |
I |
A |
-0.9478 |
|
151 |
T |
A |
-0.5967 |
|
152 |
A |
A |
-0.3336 |
|
153 |
G |
A |
-0.9101 |
|
154 |
S |
A |
-1.1321 |
|
155 |
N |
A |
-1.8749 |
|
156 |
K |
A |
-1.4819 |
|
157 |
T |
A |
0.0000 |
|
158 |
M |
A |
0.0000 |
|
159 |
V |
A |
0.0000 |
|
160 |
V |
A |
0.0000 |
|
161 |
S |
A |
0.0000 |
|
162 |
G |
A |
-0.1399 |
|
163 |
A |
A |
0.0000 |
|
164 |
A |
A |
0.0000 |
|
165 |
G |
A |
-0.2181 |
|
166 |
A |
A |
-0.0964 |
|
167 |
C |
A |
0.0703 |
|
168 |
G |
A |
0.0000 |
|
169 |
S |
A |
0.0000 |
|
170 |
V |
A |
0.0000 |
|
171 |
A |
A |
0.0000 |
|
172 |
G |
A |
0.0000 |
|
173 |
Q |
A |
0.0000 |
|
174 |
I |
A |
0.0000 |
|
175 |
G |
A |
0.0000 |
|
176 |
H |
A |
-0.4205 |
|
177 |
F |
A |
0.4402 |
|
178 |
L |
A |
0.2843 |
|
179 |
G |
A |
-0.4564 |
|
180 |
C |
A |
0.0000 |
|
181 |
S |
A |
-1.3433 |
|
182 |
R |
A |
-1.6756 |
|
183 |
V |
A |
0.0000 |
|
184 |
V |
A |
0.0000 |
|
185 |
G |
A |
0.0000 |
|
186 |
I |
A |
0.0000 |
|
187 |
C |
A |
0.0000 |
|
188 |
G |
A |
0.0000 |
|
189 |
T |
A |
-1.4229 |
|
190 |
H |
A |
-1.9137 |
|
191 |
E |
A |
-1.6357 |
|
192 |
K |
A |
0.0000 |
|
193 |
C |
A |
-0.0952 |
|
194 |
I |
A |
0.4278 |
|
195 |
L |
A |
-0.2708 |
|
196 |
L |
A |
0.0000 |
|
197 |
T |
A |
-0.6797 |
|
198 |
S |
A |
-0.8656 |
|
199 |
E |
A |
-1.8533 |
|
200 |
L |
A |
0.0000 |
|
201 |
G |
A |
-1.7592 |
|
202 |
F |
A |
0.0000 |
|
203 |
D |
A |
-1.9032 |
|
204 |
A |
A |
-0.9921 |
|
205 |
A |
A |
-0.1020 |
|
206 |
I |
A |
0.0000 |
|
207 |
N |
A |
0.0000 |
|
208 |
Y |
A |
-1.3808 |
|
209 |
K |
A |
-2.7354 |
|
210 |
K |
A |
-3.1053 |
|
211 |
D |
A |
-2.8468 |
|
212 |
N |
A |
-2.6984 |
|
213 |
V |
A |
-2.0895 |
|
214 |
A |
A |
-2.1312 |
|
215 |
E |
A |
-3.4691 |
|
216 |
Q |
A |
-2.8758 |
|
217 |
L |
A |
0.0000 |
|
218 |
R |
A |
-3.5843 |
|
219 |
E |
A |
-3.3530 |
|
220 |
S |
A |
-2.2077 |
|
221 |
C |
A |
0.0000 |
|
222 |
P |
A |
-1.5218 |
|
223 |
A |
A |
-0.8556 |
|
224 |
G |
A |
-1.2147 |
|
225 |
V |
A |
0.0000 |
|
226 |
D |
A |
-1.4078 |
|
227 |
V |
A |
0.0000 |
|
228 |
Y |
A |
0.0000 |
|
229 |
F |
A |
0.0000 |
|
230 |
D |
A |
0.0000 |
|
231 |
N |
A |
-0.0503 |
|
232 |
V |
A |
0.0000 |
|
233 |
G |
A |
0.0000 |
|
234 |
G |
A |
-0.9104 |
|
235 |
N |
A |
-1.5595 |
|
236 |
I |
A |
0.0000 |
|
237 |
S |
A |
0.0000 |
|
238 |
D |
A |
-1.2084 |
|
239 |
T |
A |
-0.8387 |
|
240 |
V |
A |
0.0000 |
|
241 |
I |
A |
0.0000 |
|
242 |
S |
A |
-0.5719 |
|
243 |
Q |
A |
-1.1389 |
|
244 |
M |
A |
0.0000 |
|
245 |
N |
A |
-2.0387 |
|
246 |
E |
A |
-3.7125 |
|
247 |
N |
A |
-3.3062 |
|
248 |
S |
A |
0.0000 |
|
249 |
H |
A |
-1.4957 |
|
250 |
I |
A |
0.0000 |
|
251 |
I |
A |
0.0000 |
|
252 |
L |
A |
0.0000 |
|
253 |
C |
A |
-0.2567 |
|
254 |
G |
A |
0.0000 |
|
255 |
Q |
A |
0.0000 |
|
256 |
I |
A |
0.3505 |
|
257 |
S |
A |
-0.4447 |
|
258 |
Q |
A |
-0.8418 |
|
259 |
Y |
A |
-1.1343 |
|
260 |
N |
A |
-2.5839 |
|
261 |
K |
A |
-3.6089 |
|
262 |
D |
A |
-3.2965 |
|
263 |
V |
A |
-1.2487 |
|
264 |
P |
A |
-0.4858 |
|
265 |
Y |
A |
0.0508 |
|
266 |
P |
A |
-0.2082 |
|
267 |
P |
A |
-0.0832 |
|
268 |
P |
A |
-0.3643 |
|
269 |
L |
A |
-0.6702 |
|
270 |
S |
A |
-0.6516 |
|
271 |
P |
A |
-0.7383 |
|
272 |
A |
A |
-0.6359 |
|
273 |
I |
A |
-1.1163 |
|
274 |
E |
A |
-2.3561 |
|
275 |
A |
A |
-1.8997 |
|
276 |
I |
A |
-2.0797 |
|
277 |
Q |
A |
-2.9939 |
|
278 |
K |
A |
-3.8900 |
|
279 |
E |
A |
-3.8624 |
|
280 |
R |
A |
-3.8451 |
|
281 |
N |
A |
-3.7428 |
|
282 |
I |
A |
0.0000 |
|
283 |
T |
A |
-2.0053 |
|
284 |
R |
A |
-1.7639 |
|
285 |
E |
A |
-2.7025 |
|
286 |
R |
A |
-2.2790 |
|
287 |
F |
A |
0.0000 |
|
288 |
L |
A |
-0.1220 |
|
289 |
V |
A |
0.0000 |
|
290 |
L |
A |
-0.4873 |
|
291 |
N |
A |
-1.5850 |
|
292 |
Y |
A |
-1.8790 |
|
293 |
K |
A |
-3.1353 |
|
294 |
D |
A |
-3.3565 |
|
295 |
K |
A |
-2.5873 |
|
296 |
F |
A |
-1.9178 |
|
297 |
E |
A |
-2.4586 |
|
298 |
P |
A |
-1.2995 |
|
299 |
G |
A |
0.0000 |
|
300 |
I |
A |
-0.2266 |
|
301 |
L |
A |
0.0136 |
|
302 |
Q |
A |
-0.6708 |
|
303 |
L |
A |
0.0000 |
|
304 |
S |
A |
0.0000 |
|
305 |
Q |
A |
-1.8847 |
|
306 |
W |
A |
-1.8636 |
|
307 |
F |
A |
-2.0965 |
|
308 |
K |
A |
-3.3339 |
|
309 |
E |
A |
-3.3274 |
|
310 |
G |
A |
-2.7374 |
|
311 |
K |
A |
-2.8111 |
|
312 |
L |
A |
0.0000 |
|
313 |
K |
A |
-1.6103 |
|
314 |
I |
A |
-0.5453 |
|
315 |
K |
A |
-0.8507 |
|
316 |
E |
A |
-0.4038 |
|
317 |
T |
A |
0.2583 |
|
318 |
V |
A |
0.8908 |
|
319 |
I |
A |
0.2437 |
|
320 |
N |
A |
-1.1741 |
|
321 |
G |
A |
-1.1787 |
|
322 |
L |
A |
0.0000 |
|
323 |
E |
A |
-2.6154 |
|
324 |
N |
A |
-1.7421 |
|
325 |
M |
A |
0.0000 |
|
326 |
G |
A |
0.0000 |
|
327 |
A |
A |
-0.7012 |
|
328 |
A |
A |
0.0000 |
|
329 |
F |
A |
0.0000 |
|
330 |
Q |
A |
-0.7611 |
|
331 |
S |
A |
-0.3298 |
|
332 |
M |
A |
0.0000 |
|
333 |
M |
A |
-0.3134 |
|
334 |
T |
A |
-0.4897 |
|
335 |
G |
A |
-0.4444 |
|
336 |
G |
A |
-0.5514 |
|
337 |
N |
A |
0.0000 |
|
338 |
I |
A |
-0.0887 |
|
339 |
G |
A |
0.0000 |
|
340 |
K |
A |
0.0000 |
|
341 |
Q |
A |
0.0000 |
|
342 |
I |
A |
0.0000 |
|
343 |
V |
A |
0.0000 |
|
344 |
C |
A |
0.0000 |
|
345 |
I |
A |
-0.9993 |
|
346 |
S |
A |
-1.4562 |
|
347 |
E |
A |
-2.4554 |
|
348 |
E |
A |
-2.3333 |
|
349 |
I |
A |
-0.7219 |
|
350 |
S |
A |
-0.6233 |
|