Project name: 2WCV [mutate: EA112L, EB112L, EC112L, ED112L, EE112L, EF112L, EG112L, EH112L, EI112L, EJ112L]

Status: done

submitted: 2017-09-13 11:09:50, status changed: 2017-09-13 11:59:40
Settings
Chain sequence(s) A: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
C: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
B: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
E: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
D: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
G: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
F: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
I: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
H: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
J: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues EA112L, EB112L, EC112L, ED112L, EE112L, EF112L, EG112L, EH112L, EI112L, EJ112L
Energy difference between WT (input) and mutated protein (by FoldX) -6.05692 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-3.6894
Maximal score value
1.6992
Average score
-0.524
Total score value
-731.0029

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 1.4699
2 L A 1.2603
3 K A -0.6434
4 T A -0.2068
5 I A 0.6701
6 S A 0.3480
7 P A 0.5483
8 L A 0.5338
9 I A 0.0000
10 S A -0.7339
11 P A -1.1126
12 E A -2.4394
13 L A 0.0000
14 L A -1.1468
15 K A -2.4379
16 V A 0.0000
17 L A 0.0000
18 A A -0.8463
19 E A -1.1283
20 M A 0.0000
21 G A 0.0000
22 H A 0.0000
23 G A -0.1131
24 D A 0.0000
25 E A -0.5849
26 I A 0.0000
27 I A 0.0000
28 F A 0.0000
29 S A 0.0000
30 D A 0.0000
31 A A -1.1177
32 H A -0.5871
33 F A 0.0000
34 P A 0.0000
35 A A 0.0000
36 H A -0.5806
37 S A -0.6334
38 M A -0.7186
39 G A -1.2687
40 P A -1.2134
41 Q A -0.9209
42 V A -0.3518
43 I A -0.8162
44 R A -1.2640
45 A A -1.0882
46 D A -2.1028
47 G A -1.4398
48 L A -0.6711
49 L A -0.4332
50 V A 0.0000
51 S A 0.0000
52 D A -0.7999
53 L A 0.0000
54 L A 0.0000
55 Q A -1.5532
56 A A 0.0000
57 I A 0.0000
58 I A -0.0982
59 P A -0.0745
60 L A 0.5163
61 F A 0.0000
62 E A -0.6157
63 L A -0.1660
64 D A 0.0000
65 S A -0.2721
66 Y A 0.1362
67 A A 0.1258
68 P A -0.0665
69 P A 0.0000
70 L A 0.0000
71 V A 0.0000
72 M A 0.0000
73 M A 0.0000
74 A A -0.0093
75 A A -0.6349
76 V A 0.0000
77 E A -1.4305
78 G A -0.9365
79 D A -0.6986
80 T A -0.7684
81 L A -1.0077
82 D A -2.4804
83 P A -2.3162
84 E A -3.2265
85 V A 0.0000
86 E A -2.4906
87 R A -3.3642
88 R A -2.5913
89 Y A 0.0000
90 R A -2.6777
91 N A -2.4181
92 A A -1.7940
93 L A 0.0000
94 S A -0.9158
95 L A -0.5748
98 P A -0.0542
99 C A 0.0896
100 P A -0.3780
101 D A -1.4535
102 I A 0.0000
103 I A 0.5040
104 R A 0.0107
105 I A 0.3709
106 N A 0.1065
107 R A 0.0000
108 F A 1.5302
109 A A 0.9999
110 F A 0.0000
111 Y A 0.7957
112 L A 1.1110 mutated: EA112L
113 R A -0.2358
114 A A 0.0000
115 Q A -1.3752
116 K A -2.0003
117 A A 0.0000
118 F A -0.7557
119 A A 0.0000
120 I A 0.0000
121 V A 0.0000
122 I A 0.0000
123 T A 0.0000
124 G A -1.3940
125 E A 0.0000
126 R A -2.0233
127 A A -1.6667
128 K A -1.4036
129 Y A 0.0000
130 G A 0.0000
131 N A 0.0000
132 I A 0.0000
133 L A 0.0000
134 L A 0.0000
135 K A -0.4033
136 K A 0.0000
137 G A 0.0000
138 V A -0.3362
139 T A -0.3938
140 P A -0.6023
1 M B 1.1962
2 L B 0.7121
3 K B -0.9363
4 T B -0.3911
5 I B 0.3749
6 S B 0.1490
7 P B 0.4139
8 L B 0.4679
9 I B 0.0000
10 S B -0.7025
11 P B -1.1022
12 E B -2.3082
13 L B 0.0000
14 L B -1.1334
15 K B -2.3595
16 V B 0.0000
17 L B 0.0000
18 A B -0.6343
19 E B -1.1229
20 M B 0.0000
21 G B 0.0000
22 H B -0.2478
23 G B -0.4658
24 D B 0.0000
25 E B -0.6337
26 I B 0.0000
27 I B 0.0000
28 F B 0.0000
29 S B 0.0000
30 D B 0.0000
31 A B -1.1369
32 H B 0.0000
33 F B 0.0000
34 P B 0.0000
35 A B 0.0000
36 H B -0.6544
37 S B -0.7874
38 M B -0.9255
39 G B -1.3126
40 P B -1.2761
41 Q B -1.0129
42 V B -0.4002
43 I B -0.8385
44 R B -1.2937
45 A B -1.0696
46 D B -2.0651
47 G B -1.3639
48 L B -0.3429
49 L B -0.2622
50 V B 0.0000
51 S B -1.1783
52 D B -0.7518
53 L B 0.0000
54 L B 0.0000
55 Q B -1.6631
56 A B 0.0000
57 I B 0.0000
58 I B 0.0000
59 P B -0.3401
60 L B 0.2890
61 F B 0.0000
62 E B -0.7648
63 L B -0.2366
64 D B 0.0000
65 S B -0.0852
66 Y B 0.2814
67 A B 0.1583
68 P B -0.3489
69 P B 0.0000
70 L B 0.0000
71 V B 0.0000
72 M B 0.0000
73 M B 0.0000
74 A B 0.0000
75 A B -0.6466
76 V B -0.3706
77 E B -1.4511
78 G B -1.3595
79 D B -1.4874
80 T B -1.3775
81 L B -1.1313
82 D B -2.4449
83 P B -2.0307
84 E B -2.7283
85 V B 0.0000
86 E B -2.5307
87 R B -3.6572
88 R B -2.7930
89 Y B 0.0000
90 R B -3.1742
91 N B -2.7115
92 A B 0.0000
93 L B 0.0000
94 S B -1.1181
95 L B -0.5062
96 Q B -1.1063
97 A B -0.5519
98 P B -0.9230
99 C B -0.9919
100 P B -1.1338
101 D B -1.9930
102 I B 0.0000
103 I B -0.6711
104 R B -0.5036
105 I B 0.0000
106 N B 0.0016
107 R B 0.5077
108 F B 1.6992
109 A B 0.0000
110 F B 0.0000
111 Y B 0.2042
112 L B 0.0000 mutated: EB112L
113 R B -0.6437
114 A B 0.0000
115 Q B -1.8393
116 K B -2.4660
117 A B 0.0000
118 F B 0.0000
119 A B 0.0000
120 I B 0.0000
121 V B 0.0000
122 I B 0.0000
123 T B 0.0000
124 G B -1.2823
125 E B 0.0000
126 R B -2.0708
127 A B -1.5257
128 K B -1.5868
129 Y B 0.0000
130 G B 0.0000
131 N B 0.0000
132 I B 0.0000
133 L B 0.0000
134 L B 0.0000
135 K B -0.4467
136 K B 0.0000
137 G B 0.0000
138 V B -0.3027
139 T B -0.4352
140 P B -0.5413
1 M C 1.4930
2 L C 1.2700
3 K C -0.6383
4 T C -0.2041
5 I C 0.6572
6 S C 0.4281
7 P C 0.6455
8 L C 0.6550
9 I C 0.0000
10 S C -0.6862
11 P C -1.0904
12 E C -2.3816
13 L C 0.0000
14 L C -1.1561
15 K C -2.4117
16 V C 0.0000
17 L C 0.0000
18 A C -0.8139
19 E C -1.0594
20 M C 0.0000
21 G C 0.0000
22 H C 0.0000
23 G C -0.1574
24 D C 0.0000
25 E C -0.7002
26 I C 0.0000
27 I C 0.0000
28 F C 0.0000
29 S C 0.0000
30 D C 0.0000
31 A C -1.0835
32 H C -0.6072
33 F C 0.0000
34 P C 0.0000
35 A C 0.0000
36 H C -0.5749
37 S C -0.8995
38 M C 0.0000
39 G C -1.4379
40 P C -1.2601
41 Q C -0.7911
42 V C -0.2579
43 I C -0.7384
44 R C -1.2116
45 A C -1.0378
46 D C -2.0576
47 G C -1.2120
48 L C -0.6650
49 L C -0.4725
50 V C 0.0000
51 S C -0.9143
52 D C -0.8877
53 L C 0.0000
54 L C 0.0000
55 Q C -1.4637
56 A C -0.3937
57 I C 0.0000
58 I C -0.1507
59 P C -0.1193
60 L C 0.4381
61 F C 0.0000
62 E C -0.8019
63 L C -0.3146
64 D C 0.0000
65 S C -0.1594
66 Y C 0.0601
67 A C 0.0054
68 P C -0.3898
69 P C 0.0000
70 L C 0.0000
71 V C 0.0000
72 M C 0.0000
73 M C 0.0000
74 A C -0.6560
75 A C -0.9947
76 V C -1.3054
77 E C -2.4828
78 G C -1.6929
79 D C -1.1041
80 T C -0.7997
81 L C -0.6881
82 D C -2.0489
83 P C -2.1219
84 E C -3.0075
85 V C 0.0000
86 E C -2.3343
87 R C -3.4040
88 R C -2.4817
89 Y C 0.0000
90 R C -2.3417
91 N C -2.3734
92 A C 0.0000
93 L C 0.0000
94 S C -0.9140
97 A C -0.0999
98 P C -0.6828
99 C C -0.8388
100 P C -1.0092
101 D C -1.7402
102 I C 0.0000
103 I C 0.2032
104 R C -0.2836
105 I C -0.4817
106 N C -1.5858
107 R C -1.2392
108 F C 0.0000
109 A C -0.6511
110 F C 0.0000
111 Y C -1.0292
112 L C -1.0427 mutated: EC112L
113 R C -1.5558
114 A C 0.0000
115 Q C -2.2472
116 K C -2.5452
117 A C 0.0000
118 F C -0.8645
119 A C 0.0000
120 I C 0.0000
121 V C 0.0000
122 I C 0.0000
123 T C 0.0000
124 G C 0.0000
125 E C 0.0000
126 R C -1.9036
127 A C -1.5364
128 K C -1.2167
129 Y C -0.6314
130 G C 0.0000
131 N C 0.0000
132 I C 0.0000
133 L C 0.0000
134 L C 0.0000
135 K C -0.4912
136 K C 0.0000
137 G C 0.0000
138 V C -0.4045
139 T C -0.5724
140 P C -0.7530
1 M D 1.3532
2 L D 1.0625
3 K D -0.7431
4 T D -0.2503
5 I D 0.5801
6 S D 0.1682
7 P D 0.3942
8 L D 0.2700
9 I D 0.0000
10 S D -0.7260
11 P D -1.1266
12 E D -2.4135
13 L D 0.0000
14 L D -1.1967
15 K D -2.4139
16 V D 0.0000
17 L D 0.0000
18 A D -0.8239
19 E D -1.1397
20 M D 0.0000
21 G D 0.0000
22 H D 0.0000
23 G D -0.3646
24 D D 0.0000
25 E D -0.6237
26 I D 0.0000
27 I D 0.0000
28 F D 0.0000
29 S D 0.0000
30 D D 0.0000
31 A D -1.0573
32 H D 0.0000
33 F D 0.0000
34 P D 0.0000
35 A D 0.0000
36 H D -0.5938
37 S D -0.7920
38 M D -0.9391
39 G D -1.3251
40 P D -1.2603
41 Q D -0.8999
42 V D -0.4702
43 I D -0.7421
44 R D -1.2965
45 A D -0.9499
46 D D -1.9606
47 G D -1.2856
48 L D -0.5116
49 L D -0.1631
50 V D 0.0000
51 S D 0.0000
52 D D -1.2365
53 L D 0.0000
54 L D 0.0000
55 Q D -1.5436
56 A D -0.4563
57 I D 0.0000
58 I D -0.1057
59 P D -0.1172
60 L D 0.4990
61 F D 0.0000
62 E D -0.4949
63 L D -0.0769
64 D D 0.0000
65 S D -0.0836
66 Y D 0.2032
67 A D -0.0341
68 P D -0.3184
69 P D 0.0000
70 L D 0.0000
71 V D 0.0000
72 M D 0.0000
73 M D 0.0000
74 A D -0.6029
75 A D -1.0718
76 V D -1.0852
77 E D -2.0443
78 G D -1.5005
79 D D -1.4539
80 T D -0.9960
81 L D -1.1392
82 D D -2.5495
83 P D -2.4082
84 E D -3.2314
85 V D 0.0000
86 E D -2.4577
87 R D -3.5912
88 R D -2.8097
89 Y D 0.0000
90 R D -2.3399
91 N D -2.2294
92 A D 0.0000
93 L D 0.0000
94 S D -0.8962
95 L D -0.3370
96 Q D -0.9161
97 A D -0.5379
98 P D -0.8349
99 C D -0.8433
100 P D -1.0363
101 D D -1.8035
102 I D 0.0000
103 I D -0.0105
104 R D -0.4100
105 I D -0.4441
106 N D -1.1076
107 R D -0.5319
108 F D 0.0397
109 A D -0.2105
110 F D 0.0000
111 Y D -0.3170
112 L D -0.4478 mutated: ED112L
113 R D -0.9631
114 A D 0.0000
115 Q D -1.9042
116 K D -2.3259
117 A D 0.0000
118 F D 0.0000
119 A D 0.0000
120 I D 0.0000
121 V D 0.0000
122 I D 0.0000
123 T D 0.0000
124 G D 0.0000
125 E D 0.0000
126 R D -1.9738
127 A D -1.6518
128 K D -1.5788
129 Y D 0.0000
130 G D 0.0000
131 N D 0.0000
132 I D 0.0000
133 L D 0.0000
134 L D 0.0000
135 K D -0.3331
136 K D 0.0000
137 G D 0.0000
138 V D -0.2715
139 T D -0.3994
140 P D -0.5762
1 M E 1.4138
2 L E 1.1184
3 K E -0.7195
4 T E -0.2579
5 I E 0.6014
6 S E 0.1985
7 P E 0.5558
8 L E 0.5708
9 I E 0.0000
10 S E -0.6869
11 P E -1.1079
12 E E -2.4376
13 L E 0.0000
14 L E -1.2205
15 K E -2.4287
16 V E 0.0000
17 L E 0.0000
18 A E -0.8204
19 E E -1.1300
20 M E 0.0000
21 G E 0.0000
22 H E 0.0000
23 G E -0.0555
24 D E 0.0000
25 E E 0.0000
26 I E 0.0000
27 I E 0.0000
28 F E 0.0000
29 S E 0.0000
30 D E 0.0000
31 A E -1.0482
32 H E -0.6262
33 F E 0.0000
34 P E 0.0000
35 A E 0.0000
36 H E -0.5924
37 S E -0.8175
38 M E 0.0000
39 G E -1.1757
40 P E -1.1273
41 Q E -0.9960
42 V E -0.3552
43 I E -0.8131
44 R E -1.2568
45 A E -1.0882
46 D E -2.0526
47 G E -1.1664
48 L E -0.5249
49 L E -0.0807
50 V E 0.0000
51 S E -0.9078
52 D E -0.5819
53 L E 0.0000
54 L E 0.0000
55 Q E -1.1293
56 A E 0.0000
57 I E 0.0000
58 I E 0.0000
59 P E 0.1361
60 L E 0.4487
61 F E 0.0000
62 E E -0.6794
63 L E -0.1946
64 D E 0.0000
65 S E -0.2292
66 Y E 0.0180
67 A E -0.1172
68 P E 0.0000
69 P E 0.0000
70 L E 0.0000
71 V E 0.0000
72 M E 0.0000
73 M E 0.0000
74 A E -0.2727
75 A E -0.6099
76 V E -0.6643
77 E E -1.9861
78 G E -1.4053
79 D E -1.0100
80 T E -0.6726
81 L E -0.5503
82 D E -1.7480
83 P E -2.0530
84 E E -3.1330
85 V E 0.0000
86 E E -2.5318
87 R E -3.6064
88 R E -2.8157
89 Y E 0.0000
90 R E -2.4043
91 N E -2.2025
92 A E 0.0000
93 L E 0.0000
94 S E -0.2330
95 L E 1.0272
97 A E 0.4316
98 P E -0.3454
99 C E 0.0000
100 P E -0.8982
101 D E -1.7853
102 I E 0.0000
103 I E 0.0000
104 R E -0.7032
105 I E 0.0000
106 N E -0.1091
107 R E 0.0000
108 F E -0.2800
109 A E 0.0000
110 F E 0.0000
111 Y E 0.0000
112 L E 0.0000 mutated: EE112L
113 R E -1.0429
114 A E 0.0000
115 Q E -1.5775
116 K E -2.0261
117 A E 0.0000
118 F E -0.6434
119 A E 0.0000
120 I E 0.0000
121 V E 0.0000
122 I E 0.0000
123 T E 0.0000
124 G E 0.0000
125 E E 0.0000
126 R E -1.8814
127 A E -1.4313
128 K E -1.1630
129 Y E 0.0000
130 G E 0.0000
131 N E 0.0000
132 I E 0.0000
133 L E 0.0000
134 L E 0.0000
135 K E -0.3015
136 K E 0.0000
137 G E 0.0000
138 V E -0.2028
139 T E -0.3805
140 P E -0.6337
1 M F 1.4334
2 L F 1.2025
3 K F -0.7069
4 T F -0.3096
5 I F 0.4512
6 S F 0.2532
7 P F 0.4698
8 L F 0.4189
9 I F 0.0000
10 S F -0.7354
11 P F -1.0912
12 E F -2.5033
13 L F 0.0000
14 L F -1.2001
15 K F -2.4066
16 V F 0.0000
17 L F 0.0000
18 A F -0.8340
19 E F -1.1726
20 M F 0.0000
21 G F 0.0000
22 H F 0.0000
23 G F -0.0796
24 D F 0.0000
25 E F 0.0000
26 I F 0.0000
27 I F 0.0000
28 F F 0.0000
29 S F 0.0000
30 D F 0.0000
31 A F -1.0864
32 H F 0.0000
33 F F 0.0000
34 P F 0.0000
35 A F 0.0000
36 H F -0.6691
37 S F -0.9273
38 M F 0.0000
39 G F -1.4557
40 P F -1.3495
41 Q F -0.9408
42 V F -0.3251
43 I F -0.8000
44 R F -1.4409
45 A F -1.0333
46 D F -2.0326
47 G F -1.3339
48 L F -0.5350
49 L F -0.2733
50 V F 0.0000
51 S F -1.1241
52 D F -0.9189
53 L F 0.0000
54 L F 0.0000
55 Q F -1.5739
56 A F 0.0000
57 I F 0.0000
58 I F -0.1006
59 P F -0.0876
60 L F 0.5101
61 F F 0.0000
62 E F -0.6190
63 L F -0.1313
64 D F 0.0000
65 S F -0.0079
66 Y F 0.3753
67 A F 0.0485
68 P F -0.2065
69 P F 0.0000
70 L F 0.0000
71 V F 0.0000
72 M F 0.0000
73 M F 0.0000
74 A F -0.5885
75 A F -1.2556
76 V F 0.0000
77 E F -2.7105
78 G F -1.8761
79 D F -1.6937
80 T F -1.1550
81 L F -1.1832
82 D F -2.6474
83 P F -2.4277
84 E F -3.2712
85 V F 0.0000
86 E F -2.4377
87 R F -3.5346
88 R F -2.6128
89 Y F 0.0000
90 R F -2.7348
91 N F -2.6030
92 A F 0.0000
93 L F 0.0000
94 S F -1.3690
95 L F 0.0000
96 Q F -1.6897
97 A F -0.7084
98 P F -0.4701
99 C F -0.2967
100 P F -0.6388
101 D F -1.4978
102 I F -0.3986
103 I F 0.2963
104 R F -0.1647
105 I F -0.2072
106 N F -1.1698
107 R F 0.0000
108 F F -0.0562
109 A F 0.0550
110 F F 0.0000
111 Y F -0.1958
112 L F 0.1476 mutated: EF112L
113 R F -0.7395
114 A F 0.0000
115 Q F -1.9162
116 K F -2.2602
117 A F 0.0000
118 F F 0.0000
119 A F 0.0000
120 I F 0.0000
121 V F 0.0000
122 I F 0.0000
123 T F 0.0000
124 G F 0.0000
125 E F 0.0000
126 R F -2.0252
127 A F -1.7782
128 K F -1.7344
129 Y F 0.0000
130 G F 0.0000
131 N F 0.0000
132 I F 0.0000
133 L F 0.0000
134 L F 0.0000
135 K F -0.3213
136 K F 0.0000
137 G F 0.0000
138 V F -0.2937
139 T F -0.4147
140 P F -0.6261
1 M G 1.3690
2 L G 1.0294
3 K G -0.7903
4 T G -0.3160
5 I G 0.4897
6 S G 0.1777
7 P G 0.5237
8 L G 0.5240
9 I G 0.0000
10 S G -0.5750
11 P G -0.8842
12 E G -1.9570
13 L G 0.0000
14 L G -0.9968
15 K G -2.2313
16 V G 0.0000
17 L G 0.0000
18 A G -0.6261
19 E G -1.0993
20 M G 0.0000
21 G G 0.0000
22 H G -0.2079
23 G G -0.2313
24 D G 0.0000
25 E G -0.6613
26 I G 0.0000
27 I G 0.0000
28 F G 0.0000
29 S G 0.0000
30 D G 0.0000
31 A G -1.1289
32 H G -0.6350
33 F G 0.0000
34 P G 0.0000
35 A G 0.0000
36 H G -0.6998
37 S G -0.9012
38 M G 0.0000
39 G G -1.3724
40 P G -1.3093
41 Q G -0.9056
42 V G -0.5335
43 I G 0.0000
44 R G -1.3273
45 A G -1.0594
46 D G -2.0511
47 G G -1.3526
48 L G -0.5110
49 L G -0.3240
50 V G 0.0000
51 S G -1.1244
52 D G -0.6775
53 L G 0.0000
54 L G 0.0000
55 Q G -1.6106
56 A G 0.0000
57 I G 0.0000
58 I G 0.0000
59 P G -0.3568
60 L G 0.3148
61 F G 0.0000
62 E G -0.6175
63 L G -0.1157
64 D G 0.0000
65 S G -0.0814
66 Y G 0.3136
67 A G 0.0503
68 P G -0.3674
69 P G 0.0000
70 L G 0.0000
71 V G 0.0000
72 M G 0.0000
73 M G 0.0000
74 A G -0.3426
75 A G -0.8516
76 V G -0.9792
77 E G -2.0438
78 G G -1.4828
79 D G -1.2069
80 T G -0.7572
81 L G -0.5946
82 D G -1.9501
83 P G -2.1055
84 E G -3.1500
85 V G 0.0000
86 E G -2.5062
87 R G -3.6603
88 R G -2.7952
89 Y G 0.0000
90 R G -2.9223
91 N G -2.5588
92 A G 0.0000
93 L G 0.0000
94 S G -1.0524
95 L G -0.3976
96 Q G -1.0832
97 A G -0.5501
98 P G -0.8240
99 C G -0.8931
100 P G -1.0699
101 D G -1.9106
102 I G 0.0000
103 I G -0.0640
104 R G -0.4962
105 I G -0.0634
106 N G -0.4703
107 R G -0.0980
108 F G 0.8110
109 A G 0.1788
110 F G 0.0000
111 Y G -0.0140
112 L G -0.0520 mutated: EG112L
113 R G -0.9633
114 A G 0.0000
115 Q G -1.9812
116 K G -2.4591
117 A G 0.0000
118 F G 0.0000
119 A G 0.0000
120 I G 0.0000
121 V G 0.0000
122 I G 0.0000
123 T G 0.0000
124 G G 0.0000
125 E G 0.0000
126 R G -2.0106
127 A G -1.6381
128 K G -1.3804
129 Y G 0.0000
130 G G 0.0000
131 N G 0.0000
132 I G 0.0000
133 L G 0.0000
134 L G 0.0000
135 K G -0.3932
136 K G 0.0000
137 G G 0.0000
138 V G -0.2817
139 T G -0.4266
140 P G -0.6057
1 M H 1.2764
2 L H 0.7349
3 K H -0.9103
4 T H -0.3692
5 I H 0.5067
6 S H 0.2533
7 P H 0.6697
8 L H 1.0174
9 I H 0.0000
10 S H -0.6156
11 P H -1.1238
12 E H -2.4300
13 L H 0.0000
14 L H -1.1901
15 K H -2.4105
16 V H 0.0000
17 L H 0.0000
18 A H -0.8062
19 E H -1.0893
20 M H 0.0000
21 G H 0.0000
22 H H 0.0000
23 G H -0.1126
24 D H 0.0000
25 E H 0.0000
26 I H 0.0000
27 I H 0.0000
28 F H 0.0000
29 S H 0.0000
30 D H 0.0000
31 A H -0.9885
32 H H -0.6118
33 F H 0.0000
34 P H 0.0000
35 A H 0.0000
36 H H -0.6507
37 S H -0.7636
38 M H 0.0000
39 G H -1.1914
40 P H -1.1889
41 Q H -1.0731
42 V H -0.3914
43 I H -0.7909
44 R H -1.2093
45 A H -0.8947
46 D H -1.7972
47 G H -1.0409
48 L H -0.3192
49 L H -0.2662
50 V H 0.0000
51 S H -1.0870
52 D H -0.7560
53 L H 0.0000
54 L H 0.0000
55 Q H -1.5063
56 A H 0.0000
57 I H 0.0000
58 I H 0.0000
59 P H -0.2557
60 L H 0.5275
61 F H 0.0000
62 E H -0.5875
63 L H -0.1888
64 D H 0.0000
65 S H -0.2659
66 Y H 0.0009
67 A H -0.1331
68 P H 0.0000
69 P H 0.0000
70 L H 0.0000
71 V H 0.0000
72 M H 0.0000
73 M H 0.0000
74 A H -0.3489
75 A H -0.7440
76 V H -0.7987
77 E H -2.1079
78 G H -1.5800
79 D H -1.2607
80 T H -0.7726
81 L H -0.5560
82 D H -1.9044
83 P H -2.0308
84 E H -2.9659
85 V H 0.0000
86 E H -2.5159
87 R H -3.5013
88 R H -2.6070
89 Y H 0.0000
90 R H -2.4773
91 N H -2.3136
92 A H 0.0000
93 L H 0.0000
94 S H -0.9068
95 L H -0.4276
96 Q H -0.8990
97 A H -0.4824
98 P H -0.8331
99 C H 0.0000
100 P H -1.1668
101 D H -2.2286
102 I H 0.0000
103 I H 0.0000
104 R H -0.6177
105 I H 0.0000
106 N H -0.3807
107 R H -0.3716
108 F H -0.2589
109 A H 0.0000
110 F H 0.0000
111 Y H 0.0000
112 L H 0.0000 mutated: EH112L
113 R H -0.9347
114 A H 0.0000
115 Q H -1.6784
116 K H -2.0132
117 A H 0.0000
118 F H -0.6331
119 A H 0.0000
120 I H 0.0000
121 V H 0.0000
122 I H 0.0000
123 T H 0.0000
124 G H 0.0000
125 E H 0.0000
126 R H -1.9287
127 A H -1.5215
128 K H -1.1640
129 Y H 0.0000
130 G H 0.0000
131 N H 0.0000
132 I H 0.0000
133 L H 0.0000
134 L H 0.0000
135 K H -0.2883
136 K H 0.0000
137 G H 0.0000
138 V H -0.3757
139 T H -0.4010
140 P H -0.6175
1 M I 1.3135
2 L I 0.9720
3 K I -0.8073
4 T I -0.3113
5 I I 0.4783
6 S I 0.1781
7 P I 0.3871
8 L I 0.4335
9 I I 0.0000
10 S I -0.6895
11 P I -1.0664
12 E I -2.3406
13 L I 0.0000
14 L I -1.0581
15 K I -2.3448
16 V I 0.0000
17 L I 0.0000
18 A I -0.8226
19 E I -1.1243
20 M I 0.0000
21 G I 0.0000
22 H I -0.2417
23 G I -0.1940
24 D I 0.0000
25 E I -0.6386
26 I I 0.0000
27 I I 0.0000
28 F I 0.0000
29 S I 0.0000
30 D I 0.0000
31 A I -1.1131
32 H I -0.6723
33 F I 0.0000
34 P I 0.0000
35 A I 0.0000
36 H I -0.5959
37 S I -0.7980
38 M I -0.8138
39 G I -1.3800
40 P I -1.2597
41 Q I -0.7937
42 V I -0.4531
43 I I -0.7661
44 R I -1.3766
45 A I -1.0025
46 D I -1.9961
47 G I -1.2990
48 L I -0.2867
49 L I -0.1120
50 V I 0.0000
51 S I 0.0000
52 D I -0.6892
53 L I 0.0000
54 L I 0.0000
55 Q I -1.0858
56 A I 0.0000
57 I I 0.0000
58 I I -0.0772
59 P I -0.1519
60 L I 0.4358
61 F I 0.0000
62 E I -0.6658
63 L I -0.2140
64 D I 0.0000
65 S I -0.2489
66 Y I 0.1034
67 A I -0.0486
68 P I -0.2568
69 P I -0.3409
70 L I 0.0000
71 V I 0.0000
72 M I 0.0000
73 M I 0.0000
74 A I -0.2881
75 A I -0.8597
76 V I 0.0000
77 E I -1.5973
78 G I -0.8635
79 D I -0.7566
80 T I -0.7958
81 L I -1.2877
82 D I -2.7791
83 P I -2.5330
84 E I -3.1333
85 V I 0.0000
86 E I -2.6915
87 R I -3.6894
88 R I -2.6290
89 Y I 0.0000
90 R I -2.4326
91 N I -2.4542
92 A I 0.0000
93 L I 0.0000
94 S I -0.9267
95 L I -0.3462
96 Q I -1.0657
97 A I -0.6093
98 P I -0.8279
99 C I 0.0000
100 P I -0.6556
101 D I -0.8357
102 I I 0.0000
103 I I 0.2963
104 R I -0.0273
105 I I 0.1180
106 N I -0.2456
107 R I 0.0000
108 F I 1.1141
109 A I 0.6544
110 F I 0.0000
111 Y I 0.4986
112 L I 0.8190 mutated: EI112L
113 R I -0.5046
114 A I 0.0000
115 Q I -1.7035
116 K I -2.1906
117 A I 0.0000
118 F I 0.0000
119 A I 0.0000
120 I I 0.0000
121 V I 0.0000
122 I I 0.0000
123 T I 0.0000
124 G I 0.0000
125 E I 0.0000
126 R I -2.0679
127 A I -1.7355
128 K I -1.6240
129 Y I 0.0000
130 G I 0.0000
131 N I 0.0000
132 I I 0.0000
133 L I 0.0000
134 L I 0.0000
135 K I -0.4368
136 K I 0.0000
137 G I 0.0000
138 V I -0.4494
139 T I -0.4639
140 P I -0.5866
1 M J 1.3116
2 L J 0.8562
3 K J -0.8513
4 T J -0.3226
5 I J 0.5681
6 S J 0.1742
7 P J 0.5419
8 L J 0.7487
9 I J 0.0000
10 S J -0.6595
11 P J -1.1148
12 E J -2.4240
13 L J 0.0000
14 L J -1.1766
15 K J -2.4256
16 V J 0.0000
17 L J 0.0000
18 A J -0.8245
19 E J -1.1554
20 M J 0.0000
21 G J 0.0000
22 H J 0.0000
23 G J -0.4614
24 D J 0.0000
25 E J -0.5965
26 I J 0.0000
27 I J 0.0000
28 F J 0.0000
29 S J 0.0000
30 D J 0.0000
31 A J -1.1040
32 H J -0.6903
33 F J 0.0000
34 P J 0.0000
35 A J 0.0000
36 H J -0.5540
37 S J -0.7909
38 M J 0.0000
39 G J -1.3699
40 P J -1.2052
41 Q J -0.8729
42 V J -0.2937
43 I J -0.8181
44 R J -1.3958
45 A J -1.1293
46 D J -2.1183
47 G J -1.2297
48 L J -0.4604
49 L J -0.2862
50 V J 0.0000
51 S J 0.0000
52 D J -0.7100
53 L J 0.0000
54 L J 0.0000
55 Q J -1.2820
56 A J 0.0000
57 I J 0.0000
58 I J 0.0000
59 P J -0.0441
60 L J 0.7519
61 F J 0.0000
62 E J -0.5667
63 L J 0.0000
64 D J 0.0000
65 S J -0.1712
66 Y J -0.0567
67 A J -0.3031
68 P J -0.4848
69 P J -0.5532
70 L J 0.0000
71 V J 0.0000
72 M J 0.0000
73 M J 0.0000
74 A J -0.1705
75 A J -0.6750
76 V J -0.4485
77 E J -1.9591
78 G J 0.0000
79 D J -1.0060
80 T J -1.1902
81 L J -0.9609
82 D J -2.4987
83 P J -2.3807
84 E J -3.0629
85 V J 0.0000
86 E J 0.0000
87 R J -3.4290
88 R J -2.5647
89 Y J 0.0000
90 R J -2.4163
91 N J -2.0128
92 A J 0.0000
93 L J 0.0000
94 S J -0.5662
95 L J 0.2830
96 Q J -0.6824
97 A J -0.3864
98 P J -0.2847
99 C J -0.6531
100 P J -1.0515
101 D J -1.8453
102 I J 0.0000
103 I J 0.0000
104 R J -0.3557
105 I J 0.0000
106 N J -0.0900
107 R J 0.2954
108 F J 1.5456
109 A J 0.0000
110 F J 0.0000
111 Y J 0.1832
112 L J 0.1217 mutated: EJ112L
113 R J -0.4881
114 A J 0.0000
115 Q J -2.0608
116 K J -2.2964
117 A J 0.0000
118 F J -0.7437
119 A J 0.0000
120 I J 0.0000
121 V J 0.0000
122 I J 0.0000
123 T J 0.0000
124 G J 0.0000
125 E J 0.0000
126 R J -2.0019
127 A J -1.7081
128 K J -1.5723
129 Y J -0.7934
130 G J 0.0000
131 N J 0.0000
132 I J 0.0000
133 L J 0.0000
134 L J 0.0000
135 K J -0.4828
136 K J -0.5022
137 G J 0.0000
138 V J -0.3684
139 T J -0.3950
140 P J -0.6995

 

Laboratory of Theory of Biopolymers 2015