Project name: a99905a95aceec5

Chain sequence(s)	A: MLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS; C: LPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS; B: PLFQQRPYPSPGAVLRANAEASR; E: MLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS; D: PLFQQRPYPSPGAVLRANAEASRTKQ; G: MLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS; F: PLFQQRPYPSPGAVLRANAEASRTK; H: PLFQQRPYPSPGAVLRANAEASRTKQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1943
• Maximal score value: 1.977
• Average score: -0.8823
• Total score value: -560.2761

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	M	A	1.0370
5	L	A	0.0000
6	P	A	-0.1204
7	H	A	-0.6320
8	L	A	0.0000
9	H	A	-1.5633
10	N	A	-1.6024
11	G	A	0.0000
12	W	A	0.3288
13	Q	A	-0.5135
14	V	A	0.0000
15	D	A	-0.0511
16	Q	A	-0.0775
17	A	A	0.0000
18	I	A	0.0000
19	L	A	0.1358
20	S	A	-0.6653
21	E	A	-1.7248
22	E	A	-3.0041
23	D	A	-2.9963
24	R	A	-2.4040
25	V	A	0.0000
26	V	A	0.0000
27	V	A	0.0000
28	I	A	0.0000
29	R	A	0.0000
30	F	A	0.0000
31	G	A	0.0000
32	H	A	-0.5383
33	D	A	-0.6859
34	W	A	-0.6076
35	D	A	-0.7226
36	P	A	-0.7481
37	T	A	-0.8084
38	C	A	0.0000
39	M	A	-1.1602
40	K	A	-2.4772
41	M	A	0.0000
42	D	A	0.0000
43	E	A	-1.8016
44	V	A	0.0000
45	L	A	0.0000
46	Y	A	0.3434
47	S	A	-0.6952
48	I	A	0.0000
49	A	A	-1.6221
50	E	A	-2.9903
51	K	A	-3.0493
52	V	A	0.0000
53	K	A	-3.3277
54	N	A	-3.0339
55	F	A	0.0000
56	A	A	0.0000
57	V	A	-0.7726
58	I	A	0.0000
59	Y	A	0.0338
60	L	A	0.0000
61	V	A	0.0000
62	D	A	0.0000
63	I	A	-0.3611
64	T	A	-0.4675
65	E	A	-1.0756
66	V	A	0.0000
67	P	A	-1.1601
68	D	A	-1.4653
69	F	A	0.0000
70	N	A	-1.4029
71	K	A	-2.1903
72	M	A	-1.2023
73	Y	A	0.0000
74	E	A	-1.4710
75	L	A	0.0000
76	Y	A	0.3251
77	D	A	-0.2532
78	P	A	-0.3238
79	C	A	0.0000
80	T	A	0.0000
81	V	A	0.0000
82	M	A	0.0000
83	F	A	0.0000
84	F	A	0.0000
85	F	A	0.0000
86	R	A	-2.7335
87	N	A	-1.8977
88	K	A	-1.9542
89	H	A	0.0000
90	I	A	0.0000
91	M	A	0.0000
92	I	A	0.0000
93	D	A	-0.6873
94	L	A	0.0000
95	G	A	-1.2268
96	T	A	-0.9780
97	G	A	-1.0209
98	N	A	-1.0394
99	N	A	-0.9197
100	N	A	0.0000
101	K	A	0.0000
102	I	A	0.0000
103	N	A	-0.3535
104	W	A	-0.5031
105	A	A	-1.2039
106	M	A	0.0000
107	E	A	-2.7916
108	D	A	-2.4158
109	K	A	-2.2030
110	Q	A	-1.9219
111	E	A	-1.9013
112	M	A	0.0000
113	V	A	0.0000
114	D	A	-1.2872
115	I	A	0.0000
116	I	A	0.0000
117	E	A	-0.7326
118	T	A	-0.4014
119	V	A	0.0000
120	Y	A	-1.0706
121	R	A	-1.6722
122	G	A	-1.4891
123	A	A	0.0000
124	R	A	-3.0155
125	K	A	-3.0439
126	G	A	-2.8241
127	R	A	-2.8072
128	G	A	-1.7853
129	L	A	-0.4425
130	V	A	0.0000
131	V	A	0.9998
132	S	A	-0.5310
133	P	A	-1.2979
134	K	A	-2.5554
135	D	A	-2.5289
136	Y	A	-1.3655
137	S	A	-0.9810
238	P	B	0.5973
239	L	B	1.9770
240	F	B	1.7607
241	Q	B	-0.4150
242	Q	B	-1.3039
243	R	B	-2.0281
244	P	B	-1.2990
245	Y	B	-0.7057
246	P	B	-0.5316
247	S	B	-0.7652
248	P	B	0.0000
249	G	B	0.0000
250	A	B	-0.7196
251	V	B	0.0000
252	L	B	-1.0099
253	R	B	-2.2961
254	A	B	-1.6128
255	N	B	-2.0417
256	A	B	-2.0535
257	E	B	-2.9716
258	A	B	-1.8873
259	S	B	-1.7556
260	R	B	-2.5104
5	L	C	0.6299
6	P	C	-0.1548
7	H	C	-0.7205
8	L	C	0.0000
9	H	C	-1.3269
10	N	C	-1.1902
11	G	C	0.0000
12	W	C	0.0000
13	Q	C	-0.7004
14	V	C	0.0000
15	D	C	-0.2876
16	Q	C	-0.3612
17	A	C	0.0000
18	I	C	0.0000
19	L	C	-0.1581
20	S	C	-0.7164
21	E	C	-1.6527
22	E	C	-3.2026
23	D	C	-3.2769
24	R	C	-2.3889
25	V	C	0.0000
26	V	C	0.0000
27	V	C	0.0000
28	I	C	0.0000
29	R	C	0.0000
30	F	C	0.0000
31	G	C	0.0000
32	H	C	-0.8678
33	D	C	-1.2380
34	W	C	0.3919
35	D	C	-0.3513
36	P	C	-0.5481
37	T	C	-0.9080
38	C	C	0.0000
39	M	C	-1.0606
40	K	C	-2.6203
41	M	C	0.0000
42	D	C	-1.2835
43	E	C	-2.2464
44	V	C	0.0000
45	L	C	0.0000
46	Y	C	0.2568
47	S	C	-0.8048
48	I	C	0.0000
49	A	C	-1.4460
50	E	C	-3.1888
51	K	C	-3.2433
52	V	C	0.0000
53	K	C	-3.4017
54	N	C	-2.8126
55	F	C	-1.9748
56	A	C	0.0000
57	V	C	-0.6074
58	I	C	0.0000
59	Y	C	0.3176
60	L	C	0.0000
61	V	C	0.0000
62	D	C	-1.3952
63	I	C	-0.8569
64	T	C	-1.0590
65	E	C	-2.0282
66	V	C	0.0000
67	P	C	-1.2630
68	D	C	-1.0985
69	F	C	0.0000
70	N	C	-1.2492
71	K	C	-2.0685
72	M	C	-1.1145
73	Y	C	0.0000
74	E	C	-1.4841
75	L	C	0.0000
76	Y	C	0.2912
77	D	C	-0.2771
78	P	C	-0.3182
79	C	C	0.0000
80	T	C	0.0000
81	V	C	0.0000
82	M	C	0.0000
83	F	C	0.0000
84	F	C	0.0000
85	F	C	0.0000
86	R	C	-2.1156
87	N	C	-1.0227
88	K	C	-1.1698
89	H	C	0.0000
90	I	C	0.0000
91	M	C	0.0000
92	I	C	0.0000
93	D	C	-0.7654
94	L	C	0.0000
95	G	C	-1.2629
96	T	C	-1.0020
97	G	C	-1.0400
98	N	C	-0.9632
99	N	C	-0.9690
100	N	C	0.0000
101	K	C	0.0000
102	I	C	0.0000
103	N	C	-0.3706
104	W	C	-0.4533
105	A	C	-1.2596
106	M	C	0.0000
107	E	C	-3.3912
108	D	C	-3.1547
109	K	C	-3.1453
110	Q	C	-2.5409
111	E	C	-2.5134
112	M	C	0.0000
113	V	C	0.0000
114	D	C	-1.7044
115	I	C	0.0000
116	I	C	0.0000
117	E	C	-1.5308
118	T	C	0.0000
119	V	C	0.0000
120	Y	C	-2.3100
121	R	C	-3.2638
122	G	C	0.0000
123	A	C	0.0000
124	R	C	-4.0884
125	K	C	-3.8292
126	G	C	-3.0708
127	R	C	-2.8728
128	G	C	-1.5552
129	L	C	-0.1413
130	V	C	0.0000
131	V	C	1.0623
132	S	C	0.0000
133	P	C	-1.1329
134	K	C	-2.3254
135	D	C	-2.3970
136	Y	C	-1.2873
137	S	C	-0.8431
238	P	D	0.5429
239	L	D	1.9253
240	F	D	1.6615
241	Q	D	-0.5989
242	Q	D	-1.4630
243	R	D	-2.0759
244	P	D	-1.2777
245	Y	D	-0.6751
246	P	D	-0.4243
247	S	D	-0.4985
248	P	D	0.0000
249	G	D	-0.4202
250	A	D	-0.5130
251	V	D	0.0000
252	L	D	0.0000
253	R	D	-1.8101
254	A	D	-1.4546
255	N	D	-1.6143
256	A	D	-1.9652
257	E	D	-3.0933
258	A	D	-2.2708
259	S	D	-2.5884
260	R	D	-3.4918
261	T	D	-2.6136
262	K	D	-3.1310
263	Q	D	-2.4318
4	M	E	1.0486
5	L	E	0.0000
6	P	E	-0.4138
7	H	E	-0.7708
8	L	E	0.0000
9	H	E	-1.0801
10	N	E	-0.9717
11	G	E	-0.6915
12	W	E	0.0000
13	Q	E	0.0000
14	V	E	0.0000
15	D	E	0.0000
16	Q	E	-0.0824
17	A	E	0.0000
18	I	E	0.0000
19	L	E	0.0873
20	S	E	-0.7618
21	E	E	-1.9973
22	E	E	-3.3067
23	D	E	-3.5003
24	R	E	-2.6055
25	V	E	0.0000
26	V	E	0.0000
27	V	E	0.0000
28	I	E	0.0000
29	R	E	0.0000
30	F	E	0.0000
31	G	E	0.0000
32	H	E	-0.7752
33	D	E	-1.0135
34	W	E	0.4120
35	D	E	-0.2526
36	P	E	-0.4331
37	T	E	-0.7264
38	C	E	0.0000
39	M	E	-0.8691
40	K	E	-2.1162
41	M	E	0.0000
42	D	E	-1.2624
43	E	E	-2.1445
44	V	E	0.0000
45	L	E	0.0000
46	Y	E	0.0806
47	S	E	-1.0142
48	I	E	0.0000
49	A	E	-1.7058
50	E	E	-3.2263
51	K	E	-3.3396
52	V	E	0.0000
53	K	E	-3.4684
54	N	E	-2.9542
55	F	E	0.0000
56	A	E	0.0000
57	V	E	-0.7309
58	I	E	0.0000
59	Y	E	0.1037
60	L	E	0.0000
61	V	E	0.0000
62	D	E	-1.1733
63	I	E	-0.7370
64	T	E	-1.1760
65	E	E	-2.1457
66	V	E	0.0000
67	P	E	-1.3331
68	D	E	-1.2397
69	F	E	0.0000
70	N	E	-1.3415
71	K	E	-2.1593
72	M	E	-1.1570
73	Y	E	0.0000
74	E	E	-1.7103
75	L	E	0.0000
76	Y	E	0.2319
77	D	E	-0.3035
78	P	E	-0.2760
79	C	E	0.0000
80	T	E	0.0000
81	V	E	0.0000
82	M	E	0.0000
83	F	E	0.0000
84	F	E	0.0000
85	F	E	0.0000
86	R	E	-3.2261
87	N	E	-2.2097
88	K	E	-2.2109
89	H	E	0.0000
90	I	E	0.0000
91	M	E	0.0000
92	I	E	0.0000
93	D	E	-0.6189
94	L	E	0.0000
95	G	E	-1.1492
96	T	E	-0.9845
97	G	E	-0.9051
98	N	E	-1.0503
99	N	E	-0.9241
100	N	E	0.0000
101	K	E	0.0000
102	I	E	0.0000
103	N	E	-0.3902
104	W	E	-0.3938
105	A	E	-1.1902
106	M	E	0.0000
107	E	E	-3.6382
108	D	E	-3.5436
109	K	E	-3.3150
110	Q	E	-2.9437
111	E	E	-2.5645
112	M	E	0.0000
113	V	E	0.0000
114	D	E	-1.7210
115	I	E	0.0000
116	I	E	0.0000
117	E	E	-1.2730
118	T	E	-0.6721
119	V	E	0.0000
120	Y	E	-1.7913
121	R	E	-2.5026
122	G	E	0.0000
123	A	E	0.0000
124	R	E	-2.8919
125	K	E	-3.1801
126	G	E	-2.4724
127	R	E	-2.7744
128	G	E	-1.6946
129	L	E	-0.3585
130	V	E	0.0000
131	V	E	1.0558
132	S	E	0.0000
133	P	E	-1.1094
134	K	E	-2.2319
135	D	E	-2.3547
136	Y	E	-1.2916
137	S	E	-0.9413
238	P	F	0.5703
239	L	F	1.9431
240	F	F	1.7022
241	Q	F	-0.5495
242	Q	F	-1.4019
243	R	F	-2.1088
244	P	F	-1.4349
245	Y	F	0.0000
246	P	F	-0.6412
247	S	F	-0.8600
248	P	F	0.0000
249	G	F	-0.3560
250	A	F	-0.5180
251	V	F	0.0000
252	L	F	0.0000
253	R	F	-1.7650
254	A	F	-1.3179
255	N	F	-1.9149
256	A	F	-2.1390
257	E	F	-3.1568
258	A	F	-2.2429
259	S	F	-2.3659
260	R	F	-3.2342
261	T	F	-2.2526
262	K	F	-2.5753
4	M	G	1.1595
5	L	G	0.0000
6	P	G	0.0122
7	H	G	-0.6793
8	L	G	0.0000
9	H	G	-1.6963
10	N	G	-1.7696
11	G	G	-0.7733
12	W	G	0.3009
13	Q	G	-0.5585
14	V	G	0.0000
15	D	G	-0.1250
16	Q	G	-0.1725
17	A	G	0.0000
18	I	G	0.0000
19	L	G	-0.0414
20	S	G	-0.7514
21	E	G	-1.8800
22	E	G	-3.1786
23	D	G	-3.5107
24	R	G	-2.7443
25	V	G	0.0000
26	V	G	0.0000
27	V	G	0.0000
28	I	G	0.0000
29	R	G	0.0000
30	F	G	0.0000
31	G	G	0.0000
32	H	G	-0.8216
33	D	G	-0.9928
34	W	G	-0.5479
35	D	G	-0.8340
36	P	G	-0.8463
37	T	G	-0.8713
38	C	G	0.0000
39	M	G	-1.2352
40	K	G	-2.1562
41	M	G	0.0000
42	D	G	0.0000
43	E	G	-1.5645
44	V	G	0.0000
45	L	G	0.0000
46	Y	G	0.1022
47	S	G	-0.8036
48	I	G	0.0000
49	A	G	-1.6669
50	E	G	-3.2679
51	K	G	-3.2399
52	V	G	0.0000
53	K	G	-3.4859
54	N	G	-2.9426
55	F	G	0.0000
56	A	G	0.0000
57	V	G	-0.8994
58	I	G	0.0000
59	Y	G	0.0224
60	L	G	0.0000
61	V	G	0.0000
62	D	G	-1.2538
63	I	G	-0.7991
64	T	G	-1.0109
65	E	G	-2.1756
66	V	G	0.0000
67	P	G	-1.5075
68	D	G	-1.6264
69	F	G	0.0000
70	N	G	-1.3631
71	K	G	-2.1755
72	M	G	-1.0649
73	Y	G	0.0000
74	E	G	-1.6882
75	L	G	0.0000
76	Y	G	0.2328
77	D	G	-0.3527
78	P	G	-0.3335
79	C	G	0.0000
80	T	G	0.0000
81	V	G	0.0000
82	M	G	0.0000
83	F	G	0.0000
84	F	G	0.0000
85	F	G	0.0000
86	R	G	-3.4505
87	N	G	-2.1158
88	K	G	-1.8876
89	H	G	0.0000
90	I	G	0.0000
91	M	G	0.0000
92	I	G	0.0000
93	D	G	-0.5907
94	L	G	0.0000
95	G	G	-1.2215
96	T	G	-0.9702
97	G	G	-0.9319
98	N	G	-0.9848
99	N	G	-0.9048
100	N	G	0.0000
101	K	G	0.0000
102	I	G	0.0000
103	N	G	-0.4394
104	W	G	-0.3610
105	A	G	-0.8328
106	M	G	0.0000
107	E	G	-2.4372
108	D	G	-2.0959
109	K	G	-2.0765
110	Q	G	-1.9889
111	E	G	-1.8546
112	M	G	0.0000
113	V	G	0.0000
114	D	G	-1.6160
115	I	G	0.0000
116	I	G	0.0000
117	E	G	-1.5742
118	T	G	0.0000
119	V	G	0.0000
120	Y	G	-2.3141
121	R	G	-3.1713
122	G	G	0.0000
123	A	G	0.0000
124	R	G	-4.1943
125	K	G	-3.6796
126	G	G	-2.9379
127	R	G	-2.7003
128	G	G	-1.5577
129	L	G	-0.0832
130	V	G	0.0000
131	V	G	1.1059
132	S	G	0.0000
133	P	G	-1.2161
134	K	G	-2.5378
135	D	G	-2.5027
136	Y	G	-1.3247
137	S	G	-0.9189
238	P	H	0.5679
239	L	H	1.9449
240	F	H	1.6847
241	Q	H	-0.5287
242	Q	H	-1.4088
243	R	H	-2.0728
244	P	H	-1.2878
245	Y	H	-0.6887
246	P	H	-0.4825
247	S	H	-0.7930
248	P	H	0.0000
249	G	H	0.0000
250	A	H	-0.7670
251	V	H	0.0000
252	L	H	-1.0749
253	R	H	-2.3553
254	A	H	-1.6449
255	N	H	-2.1348
256	A	H	-2.1881
257	E	H	-3.3217
258	A	H	-2.5531
259	S	H	-2.6062
260	R	H	-3.5295
261	T	H	-2.6590
262	K	H	-3.1790
263	Q	H	-2.6708