Project name: 5%_arg_2osl
Status: done
submitted: 2018-08-15 09:43:27, status changed: 2018-08-15 09:54:17
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.7939
-
Maximal score value
-
1.7504
-
Average score
-
-0.6567
-
Total score value
-
-285.6771
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-1.1388 |
|
2 |
I |
A |
0.0525 |
|
3 |
V |
A |
1.1372 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.5185 |
|
6 |
Q |
A |
-0.7226 |
|
7 |
S |
A |
-0.3865 |
|
8 |
P |
A |
0.2846 |
|
9 |
A |
A |
0.5306 |
|
10 |
I |
A |
1.5324 |
|
11 |
L |
A |
0.5750 |
|
12 |
S |
A |
-0.4629 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-2.0683 |
|
15 |
P |
A |
-2.0021 |
|
16 |
G |
A |
-2.2137 |
|
17 |
E |
A |
-3.0056 |
|
18 |
K |
A |
-2.9427 |
|
19 |
V |
A |
0.0000 |
|
20 |
T |
A |
-0.4241 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.7174 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.9072 |
|
25 |
A |
A |
0.0000 |
|
26 |
S |
A |
-0.3334 |
|
27 |
S |
A |
-0.5420 |
|
28 |
S |
A |
-0.6987 |
|
29 |
V |
A |
0.0000 |
|
30 |
S |
A |
-0.2275 |
|
31 |
Y |
A |
0.1387 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.7475 |
|
38 |
K |
A |
0.0000 |
|
39 |
P |
A |
-0.8676 |
|
40 |
G |
A |
-0.5912 |
|
41 |
S |
A |
-0.5802 |
|
42 |
S |
A |
-0.4386 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-1.2837 |
|
45 |
P |
A |
-0.5927 |
|
46 |
W |
A |
-0.4238 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-0.1042 |
|
49 |
A |
A |
-0.2349 |
|
50 |
T |
A |
-0.3292 |
|
51 |
S |
A |
-0.7109 |
|
52 |
N |
A |
-1.1239 |
|
53 |
L |
A |
-0.0145 |
|
54 |
A |
A |
-0.4738 |
|
55 |
S |
A |
-0.6324 |
|
56 |
G |
A |
-0.2067 |
|
57 |
V |
A |
0.0000 |
|
58 |
P |
A |
0.6067 |
|
59 |
V |
A |
1.3375 |
|
60 |
R |
A |
-0.4400 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.1315 |
|
63 |
G |
A |
-0.4870 |
|
64 |
S |
A |
-0.6172 |
|
65 |
G |
A |
-0.7573 |
|
66 |
S |
A |
-0.6938 |
|
67 |
G |
A |
-0.7471 |
|
68 |
T |
A |
-1.0900 |
|
69 |
S |
A |
-1.3360 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.6168 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.7621 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-2.1011 |
|
76 |
R |
A |
-3.1348 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-2.8474 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.7984 |
|
81 |
D |
A |
0.0000 |
|
82 |
A |
A |
-1.3004 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.4030 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
-0.0597 |
|
91 |
T |
A |
-0.2835 |
|
92 |
S |
A |
-0.9630 |
|
93 |
N |
A |
-1.6933 |
|
94 |
P |
A |
-1.5481 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
-0.1058 |
|
97 |
F |
A |
0.2578 |
|
98 |
G |
A |
0.0000 |
|
99 |
G |
A |
-0.6639 |
|
100 |
G |
A |
-0.3890 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
-0.4691 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
-1.1445 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-2.0808 |
|
107 |
R |
A |
-1.2220 |
|
108 |
T |
A |
-0.1693 |
|
109 |
V |
A |
0.4114 |
|
110 |
A |
A |
0.0709 |
|
111 |
A |
A |
-0.1573 |
|
112 |
P |
A |
0.0000 |
|
113 |
S |
A |
-0.1338 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
0.0000 |
|
116 |
I |
A |
0.0000 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.5036 |
|
119 |
P |
A |
-0.6986 |
|
120 |
S |
A |
-1.3540 |
|
121 |
D |
A |
-2.5710 |
|
122 |
E |
A |
-2.3115 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
-1.5177 |
|
125 |
K |
A |
-1.8700 |
|
126 |
S |
A |
-1.2681 |
|
127 |
G |
A |
-1.0483 |
|
128 |
T |
A |
-0.7819 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
0.0000 |
|
137 |
N |
A |
-0.5760 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
0.0000 |
|
140 |
P |
A |
-1.9017 |
|
141 |
R |
A |
-3.1117 |
|
142 |
E |
A |
-3.3486 |
|
143 |
A |
A |
-2.4847 |
|
144 |
K |
A |
-2.5604 |
|
145 |
V |
A |
-1.2872 |
|
146 |
Q |
A |
-0.4588 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.6131 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-2.2792 |
|
151 |
N |
A |
-1.6924 |
|
152 |
A |
A |
-0.3623 |
|
153 |
L |
A |
0.7140 |
|
154 |
Q |
A |
-0.1128 |
|
155 |
S |
A |
-0.5116 |
|
156 |
G |
A |
-1.0189 |
|
157 |
N |
A |
-0.8564 |
|
158 |
S |
A |
-1.0210 |
|
159 |
Q |
A |
-2.1202 |
|
160 |
E |
A |
-2.2777 |
|
161 |
S |
A |
-1.2613 |
|
162 |
V |
A |
0.0000 |
|
163 |
T |
A |
-1.1848 |
|
164 |
E |
A |
-2.2292 |
|
165 |
Q |
A |
-2.0377 |
|
166 |
D |
A |
-2.1777 |
|
167 |
S |
A |
-2.5105 |
|
168 |
K |
A |
-2.8245 |
|
169 |
D |
A |
-1.8991 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.2153 |
|
178 |
L |
A |
0.6635 |
|
179 |
T |
A |
0.3242 |
|
180 |
L |
A |
-0.1299 |
|
181 |
S |
A |
-1.1451 |
|
182 |
K |
A |
-2.0262 |
|
183 |
A |
A |
-1.9789 |
|
184 |
D |
A |
-2.8895 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-3.7939 |
|
187 |
K |
A |
-3.7652 |
|
188 |
H |
A |
-3.0446 |
|
189 |
K |
A |
-3.0548 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-0.6635 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.2975 |
|
197 |
H |
A |
-1.6686 |
|
198 |
Q |
A |
-1.8438 |
|
199 |
G |
A |
-0.4604 |
|
200 |
L |
A |
-0.2638 |
|
201 |
S |
A |
-0.4660 |
|
202 |
S |
A |
-0.4517 |
|
203 |
P |
A |
-0.6003 |
|
204 |
V |
A |
0.0850 |
|
205 |
T |
A |
-0.2953 |
|
206 |
K |
A |
-0.4543 |
|
207 |
S |
A |
-0.6230 |
|
208 |
F |
A |
-0.9821 |
|
209 |
N |
A |
-1.9764 |
|
210 |
R |
A |
-2.5532 |
|
211 |
G |
A |
-2.1521 |
|
212 |
E |
A |
-2.4805 |
|
1 |
Q |
A |
-0.9913 |
|
2 |
V |
A |
-0.0457 |
|
3 |
Q |
A |
-0.8672 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.3249 |
|
6 |
Q |
A |
-0.8303 |
|
7 |
P |
A |
-0.7316 |
|
8 |
G |
A |
-0.8858 |
|
9 |
A |
A |
-0.7186 |
|
10 |
E |
A |
-0.6222 |
|
11 |
L |
A |
-0.2010 |
|
12 |
V |
A |
0.0000 |
|
13 |
K |
A |
-1.5062 |
|
14 |
P |
A |
-1.1855 |
|
15 |
G |
A |
-1.0622 |
|
16 |
A |
A |
-0.8480 |
|
17 |
S |
A |
-1.0478 |
|
18 |
V |
A |
0.0000 |
|
19 |
K |
A |
-1.5921 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.6950 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.3919 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.7440 |
|
26 |
G |
A |
-0.5460 |
|
27 |
Y |
A |
-0.1088 |
|
28 |
T |
A |
-0.1235 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.6140 |
|
31 |
S |
A |
-0.0757 |
|
32 |
Y |
A |
0.3255 |
|
33 |
N |
A |
-0.2390 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
0.0000 |
|
39 |
Q |
A |
-0.5834 |
|
40 |
T |
A |
0.0000 |
|
41 |
P |
A |
-0.9754 |
|
42 |
G |
A |
-1.4072 |
|
43 |
R |
A |
-2.0635 |
|
44 |
G |
A |
-1.3034 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-1.1865 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.6909 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.4266 |
|
55 |
N |
A |
-2.1459 |
|
56 |
G |
A |
-2.1340 |
|
57 |
D |
A |
-2.3452 |
|
58 |
T |
A |
-1.1292 |
|
59 |
S |
A |
-0.9338 |
|
60 |
Y |
A |
-1.2460 |
|
61 |
N |
A |
-2.1480 |
|
62 |
Q |
A |
-2.9651 |
|
63 |
K |
A |
-2.9554 |
|
64 |
F |
A |
0.0000 |
|
65 |
K |
A |
-2.8561 |
|
66 |
G |
A |
-1.9790 |
|
67 |
K |
A |
-1.6457 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.8215 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.5042 |
|
72 |
A |
A |
-1.2795 |
|
73 |
D |
A |
-1.8855 |
|
74 |
K |
A |
-2.4707 |
|
75 |
S |
A |
-1.3507 |
|
76 |
S |
A |
-1.1759 |
|
77 |
S |
A |
-1.3015 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.4679 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.2286 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-0.8404 |
|
85 |
S |
A |
-0.8509 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.1715 |
|
88 |
S |
A |
-1.1506 |
|
89 |
E |
A |
-1.9445 |
|
90 |
D |
A |
0.0000 |
|
91 |
S |
A |
-0.5519 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.2727 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.8680 |
|
101 |
Y |
A |
1.7504 |
|
102 |
Y |
A |
1.6215 |
|
103 |
G |
A |
0.3380 |
|
104 |
G |
A |
0.0289 |
|
105 |
D |
A |
0.4421 |
|
106 |
W |
A |
0.9136 |
|
107 |
Y |
A |
0.0000 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.2486 |
|
110 |
V |
A |
-0.1132 |
|
111 |
W |
A |
-0.2347 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.4813 |
|
114 |
G |
A |
-0.2772 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.2256 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.4445 |
|
119 |
V |
A |
-0.6699 |
|
120 |
S |
A |
-0.4120 |
|
121 |
A |
A |
-0.4984 |
|
122 |
A |
A |
-0.4050 |
|
123 |
S |
A |
-0.5626 |
|
124 |
T |
A |
-0.7320 |
|
125 |
K |
A |
-1.2344 |
|
126 |
G |
A |
-1.3448 |
|
127 |
P |
A |
-0.6143 |
|
128 |
S |
A |
-0.4168 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
-0.6131 |
|
131 |
P |
A |
-1.0192 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-1.1607 |
|
134 |
P |
A |
0.0000 |
|
135 |
S |
A |
-1.3649 |
|
136 |
S |
A |
-1.1683 |
|
137 |
K |
A |
-1.2007 |
|
138 |
S |
A |
-0.7133 |
|
139 |
T |
A |
-0.6701 |
|
140 |
S |
A |
-0.7318 |
|
141 |
G |
A |
-0.7923 |
|
142 |
G |
A |
-0.7629 |
|
143 |
T |
A |
-0.5547 |
|
144 |
A |
A |
0.0000 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
0.0000 |
|
152 |
D |
A |
-0.6895 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
0.0000 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-0.6640 |
|
157 |
P |
A |
-0.7949 |
|
158 |
V |
A |
-0.3531 |
|
159 |
T |
A |
-0.5085 |
|
160 |
V |
A |
-0.0714 |
|
161 |
S |
A |
-0.3490 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.9001 |
|
164 |
S |
A |
-0.6860 |
|
165 |
G |
A |
-0.5946 |
|
166 |
A |
A |
-0.2712 |
|
167 |
L |
A |
-0.0752 |
|
168 |
T |
A |
-0.2218 |
|
169 |
S |
A |
-0.2286 |
|
170 |
G |
A |
-0.2744 |
|
171 |
V |
A |
0.0749 |
|
172 |
H |
A |
-0.3855 |
|
173 |
T |
A |
-0.2425 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.4354 |
|
176 |
A |
A |
0.3775 |
|
177 |
V |
A |
0.5107 |
|
178 |
L |
A |
1.2464 |
|
179 |
Q |
A |
0.0392 |
|
180 |
S |
A |
-0.1863 |
|
181 |
S |
A |
-0.3907 |
|
182 |
G |
A |
-0.2685 |
|
183 |
L |
A |
-0.0544 |
|
184 |
Y |
A |
0.3304 |
|
185 |
S |
A |
0.0000 |
|
186 |
L |
A |
0.3726 |
|
187 |
S |
A |
0.0528 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1968 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.4951 |
|
194 |
S |
A |
-0.5777 |
|
195 |
S |
A |
-0.5972 |
|
196 |
S |
A |
0.0000 |
|
197 |
L |
A |
-0.9195 |
|
198 |
G |
A |
-0.9275 |
|
199 |
T |
A |
-0.7972 |
|
200 |
Q |
A |
-1.1989 |
|
201 |
T |
A |
-1.2233 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-1.2954 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.5309 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
-1.7755 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.7154 |
|
210 |
P |
A |
-1.6169 |
|
211 |
S |
A |
-1.8149 |
|
212 |
N |
A |
-2.5610 |
|
213 |
T |
A |
-2.0336 |
|
214 |
K |
A |
-2.6667 |
|
215 |
V |
A |
-1.6200 |
|
216 |
D |
A |
-2.5554 |
|
217 |
K |
A |
-2.2065 |
|
218 |
K |
A |
-2.5330 |
|
219 |
V |
A |
0.0000 |
|
220 |
E |
A |
-2.7534 |
|
221 |
P |
A |
-2.1116 |
|
222 |
K |
A |
-2.4395 |
|
223 |
S |
A |
-1.4392 |
|