Project name: 5WTQ

Chain sequence(s)	A: GDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMSSRYDSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF; C: DVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQSNFALLVENRIKEEMEAFPEKF; B: VSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF; D: VSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4948
• Maximal score value: 1.7573
• Average score: -0.6658
• Total score value: -288.2921

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
10	G	A	-1.1101
11	D	A	-1.6884
12	V	A	-0.4833
13	S	A	-0.3548
14	L	A	0.4217
15	H	A	-0.3718
16	N	A	-1.1386
17	F	A	0.0000
18	S	A	-0.6562
19	A	A	-0.7000
20	R	A	-1.8239
21	L	A	-0.6539
22	W	A	-0.3407
23	E	A	-1.7775
24	Q	A	-1.2067
25	L	A	-0.5238
26	V	A	0.0000
27	H	A	-0.5977
28	F	A	0.0000
29	H	A	0.0000
30	V	A	0.0000
31	M	A	0.0000
32	R	A	-1.0152
33	L	A	0.0000
34	T	A	-1.2780
35	D	A	-2.0195
36	S	A	0.0000
37	L	A	0.0000
38	F	A	0.0000
39	L	A	0.0000
40	W	A	0.0000
41	V	A	0.0000
42	G	A	0.0000
43	A	A	0.0372
44	T	A	0.0578
45	P	A	-0.2326
46	H	A	-0.0497
47	L	A	0.3589
48	R	A	-1.7820
49	N	A	-1.0790
50	L	A	0.0000
51	A	A	0.0000
52	V	A	0.0000
53	A	A	0.0000
54	M	A	-0.5325
55	S	A	-1.1112
56	S	A	-0.5945
57	R	A	-1.2743
58	Y	A	-1.1359
59	D	A	-1.5771
60	S	A	-0.8239
61	I	A	-0.0091
62	P	A	0.0000
63	V	A	1.3836
64	S	A	0.6986
65	T	A	0.2242
66	S	A	-1.0455
67	L	A	0.0000
68	L	A	0.0000
69	G	A	-1.3340
70	D	A	-2.3990
71	T	A	-1.7065
72	S	A	-1.4298
73	D	A	-1.9653
74	T	A	-1.0238
75	T	A	-0.4390
76	S	A	0.0000
77	T	A	-0.3602
78	G	A	0.0000
79	L	A	0.0000
80	A	A	0.0000
81	Q	A	-1.1305
82	R	A	-2.6349
83	L	A	0.0000
84	A	A	0.0000
85	R	A	-3.3664
86	K	A	-3.4948
87	T	A	-2.3024
88	N	A	-2.8447
89	K	A	-1.9252
90	Q	A	-1.0937
91	V	A	0.0000
92	F	A	0.0000
93	V	A	0.0000
94	S	A	-0.5881
95	Y	A	0.0000
96	N	A	-1.4922
97	L	A	0.0000
98	Q	A	-1.7328
99	N	A	-1.5318
100	T	A	-1.5571
101	D	A	-1.6212
102	S	A	-0.9388
103	N	A	-1.0837
104	F	A	0.0000
105	A	A	-0.1310
106	L	A	0.7378
107	L	A	0.3343
108	V	A	0.0000
109	E	A	-0.8959
110	N	A	-1.4079
111	R	A	-1.7985
112	I	A	0.0000
113	K	A	-2.6658
114	E	A	-3.1019
115	E	A	0.0000
116	M	A	0.0000
117	E	A	-2.6277
118	A	A	-1.3659
119	F	A	-0.8382
120	P	A	-1.5642
121	E	A	-1.9830
122	K	A	-1.2753
123	F	A	-0.8602
12	V	B	1.7403
13	S	B	0.6501
14	L	B	0.5955
15	H	B	-0.4897
16	N	B	-1.1846
17	F	B	0.0000
18	S	B	-0.6791
19	A	B	-0.6909
20	R	B	-1.8122
21	L	B	0.0000
22	W	B	-0.0797
23	E	B	-1.6694
24	Q	B	-1.1379
25	L	B	-0.5061
26	V	B	0.0000
27	H	B	-0.6377
28	F	B	0.0000
29	H	B	0.0000
30	V	B	0.0000
31	M	B	0.0000
32	R	B	-0.4000
33	L	B	0.0000
34	T	B	-0.5719
35	D	B	-1.6923
36	S	B	0.0000
37	L	B	0.0000
38	F	B	0.0000
39	L	B	0.0000
40	W	B	0.0000
41	V	B	0.0000
42	G	B	0.0000
43	A	B	-0.1966
44	T	B	0.0598
45	P	B	-0.0931
46	H	B	0.1668
47	L	B	0.7030
48	R	B	-1.1313
49	N	B	-0.7890
50	L	B	0.0000
51	A	B	0.0000
52	V	B	0.0000
53	A	B	0.0000
54	M	B	0.1998
55	S	B	0.2934
61	I	B	1.6239
62	P	B	0.0000
63	V	B	1.7573
64	S	B	0.7162
65	T	B	0.3812
66	S	B	-0.8290
67	L	B	0.0000
68	L	B	0.0000
69	G	B	-1.2419
70	D	B	-2.2585
71	T	B	-1.4119
72	S	B	-1.0927
73	D	B	-1.3292
74	T	B	-0.7672
75	T	B	0.0000
76	S	B	0.0000
77	T	B	-0.3140
78	G	B	-0.4218
79	L	B	0.0000
80	A	B	0.0000
81	Q	B	-0.9561
82	R	B	-2.1763
83	L	B	0.0000
84	A	B	0.0000
85	R	B	-2.7475
86	K	B	-2.9125
87	T	B	-2.2306
88	N	B	-2.4642
89	K	B	-1.9059
90	Q	B	-1.0143
91	V	B	0.0000
92	F	B	0.0000
93	V	B	0.0000
94	S	B	-0.3513
95	Y	B	0.0000
96	N	B	-0.8239
97	L	B	-0.8227
98	Q	B	-1.4578
99	N	B	-1.2174
100	T	B	-1.1141
101	D	B	-1.2821
102	S	B	-0.9253
103	N	B	-1.1141
104	F	B	0.0000
105	A	B	-0.3466
106	L	B	0.0340
107	L	B	0.0221
108	V	B	0.0000
109	E	B	0.0000
110	N	B	-1.6039
111	R	B	-1.6589
112	I	B	0.0000
113	K	B	-2.6115
114	E	B	-3.0282
115	E	B	0.0000
116	M	B	0.0000
117	E	B	-2.6160
118	A	B	-1.3278
119	F	B	-0.7866
120	P	B	-1.6293
121	E	B	-2.1663
122	K	B	-1.4328
123	F	B	-1.0560
11	D	C	-1.9921
12	V	C	-0.8173
13	S	C	-1.1173
14	L	C	-0.6171
15	H	C	-0.9163
16	N	C	-1.2714
17	F	C	0.0000
18	S	C	-0.7026
19	A	C	-0.8169
20	R	C	-1.9987
21	L	C	0.0000
22	W	C	-0.2624
23	E	C	-1.8329
24	Q	C	-1.3150
25	L	C	-0.6671
26	V	C	0.0000
27	H	C	-0.6270
28	F	C	0.0000
29	H	C	0.0000
30	V	C	0.0000
31	M	C	0.0000
32	R	C	-1.3409
33	L	C	0.0000
34	T	C	-1.4558
35	D	C	-2.4019
36	S	C	-1.2327
37	L	C	0.0000
38	F	C	0.0000
39	L	C	0.0000
40	W	C	0.0000
41	V	C	0.0000
42	G	C	0.0000
43	A	C	0.0071
44	T	C	0.0119
45	P	C	-0.2302
46	H	C	0.0232
47	L	C	0.4551
48	R	C	-1.6333
49	N	C	-0.9602
50	L	C	0.0000
51	A	C	0.0000
52	V	C	0.0000
53	A	C	0.0000
54	M	C	-0.0471
60	S	C	-0.3282
61	I	C	-0.1728
62	P	C	0.0000
63	V	C	0.9861
64	S	C	0.5642
65	T	C	0.0000
66	S	C	0.0000
67	L	C	0.0000
68	L	C	0.0000
69	G	C	-1.4859
70	D	C	-2.5820
71	T	C	-1.7534
72	S	C	-1.6431
73	D	C	-2.4502
74	T	C	-1.4454
75	T	C	-0.6380
76	S	C	0.0000
77	T	C	-0.7929
78	G	C	-0.5621
79	L	C	0.0000
80	A	C	0.0000
81	Q	C	-1.1269
82	R	C	-2.2265
83	L	C	0.0000
84	A	C	0.0000
85	R	C	-3.3221
86	K	C	-3.4185
87	T	C	-2.3367
88	N	C	-2.7985
89	K	C	-2.1352
90	Q	C	-1.1779
91	V	C	0.0000
92	F	C	0.0000
93	V	C	0.0000
94	S	C	-0.4537
95	Y	C	0.0000
96	N	C	-1.0202
97	L	C	-0.8173
98	Q	C	-1.2601
102	S	C	-0.7574
103	N	C	-0.8283
104	F	C	-0.1209
105	A	C	-0.2676
106	L	C	0.0280
107	L	C	-0.0222
108	V	C	0.0000
109	E	C	0.0000
110	N	C	-1.5846
111	R	C	-1.7907
112	I	C	0.0000
113	K	C	-2.6713
114	E	C	-3.1089
115	E	C	0.0000
116	M	C	0.0000
117	E	C	-2.7097
118	A	C	-1.3929
119	F	C	-0.9476
120	P	C	-1.7441
121	E	C	-2.3028
122	K	C	-1.7311
123	F	C	0.0000
12	V	D	1.6625
13	S	D	0.4283
14	L	D	0.4494
15	H	D	-0.5397
16	N	D	-1.0900
17	F	D	-0.5272
18	S	D	-0.5943
19	A	D	-0.7781
20	R	D	-1.9312
21	L	D	0.0000
22	W	D	-0.2005
23	E	D	-1.7836
24	Q	D	-1.2950
25	L	D	-0.5813
26	V	D	0.0000
27	H	D	-0.5732
28	F	D	0.0000
29	H	D	0.0000
30	V	D	0.0000
31	M	D	0.0000
32	R	D	-0.7772
33	L	D	-0.1405
34	T	D	-0.8384
35	D	D	-2.2551
36	S	D	-1.2269
37	L	D	0.0000
38	F	D	0.0000
39	L	D	0.0000
40	W	D	0.0000
41	V	D	0.0000
42	G	D	0.0000
43	A	D	0.0042
44	T	D	0.0575
45	P	D	-0.1881
46	H	D	0.0317
47	L	D	0.5974
48	R	D	-1.2167
49	N	D	-0.8161
50	L	D	0.0000
51	A	D	0.0000
52	V	D	0.0000
53	A	D	0.0000
54	M	D	0.4768
60	S	D	0.3133
61	I	D	0.9173
62	P	D	0.0000
63	V	D	1.7348
64	S	D	0.7885
65	T	D	0.3943
66	S	D	-0.8007
67	L	D	0.0000
68	L	D	0.0000
69	G	D	-1.2625
70	D	D	-2.2415
71	T	D	-1.3984
72	S	D	-1.0477
73	D	D	-1.2296
74	T	D	-0.5290
75	T	D	0.0000
76	S	D	0.0000
77	T	D	-0.2032
78	G	D	-0.3303
79	L	D	0.0000
80	A	D	0.0000
81	Q	D	-0.7663
82	R	D	-1.9663
83	L	D	0.0000
84	A	D	0.0000
85	R	D	-2.6989
86	K	D	-2.6486
87	T	D	-2.1335
88	N	D	-2.4466
89	K	D	-1.8671
90	Q	D	-0.9395
91	V	D	0.0000
92	F	D	0.0000
93	V	D	0.0000
94	S	D	-0.3529
95	Y	D	0.0000
96	N	D	-0.7972
97	L	D	-0.8050
98	Q	D	-1.4677
99	N	D	-1.2917
100	T	D	-1.1669
101	D	D	-1.3998
102	S	D	-1.0100
103	N	D	-1.2871
104	F	D	0.0000
105	A	D	-0.4346
106	L	D	-0.0244
107	L	D	0.1912
108	V	D	0.0000
109	E	D	0.0000
110	N	D	-1.3867
111	R	D	-1.5312
112	I	D	0.0000
113	K	D	-2.3234
114	E	D	-2.8788
115	E	D	0.0000
116	M	D	0.0000
117	E	D	-2.5382
118	A	D	-1.2363
119	F	D	-0.6452
120	P	D	-1.5492
121	E	D	-2.1440
122	K	D	-1.6151
123	F	D	-0.9738