Project name: b0d70f6a65d5958

Chain sequence(s)	A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0935
• Maximal score value: 2.3503
• Average score: -0.7278
• Total score value: -370.4636

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
886	S	A	0.8521
887	V	A	2.1432
888	S	A	1.5738
889	I	A	2.3503
890	Y	A	1.1652
891	P	A	0.1188
892	S	A	-0.7702
893	S	A	0.0000
894	A	A	-1.1683
895	E	A	-1.4926
896	V	A	0.0000
897	L	A	-1.1596
898	K	A	-1.9458
899	A	A	0.0000
900	C	A	-1.1038
901	R	A	-2.0873
902	N	A	-1.9930
903	L	A	-0.5907
904	G	A	-1.3789
905	K	A	-2.5498
906	N	A	-2.3362
907	G	A	-1.1536
908	L	A	-0.1400
909	S	A	-1.0742
910	N	A	-1.4100
911	S	A	-0.4766
912	S	A	0.0436
913	I	A	0.3842
914	L	A	0.3771
915	L	A	0.4786
916	D	A	-1.7859
917	K	A	-1.7691
918	C	A	-0.4071
919	P	A	-0.6332
920	P	A	-0.8805
921	P	A	-1.3615
922	R	A	-2.1675
923	P	A	-1.4296
924	P	A	-0.9051
925	S	A	-0.5164
926	S	A	-0.2601
927	P	A	0.2206
928	Y	A	0.9978
929	P	A	0.4305
930	P	A	-0.3000
931	L	A	-1.0018
932	P	A	-1.9932
933	K	A	-3.5812
934	D	A	-3.7070
935	K	A	-3.5324
936	L	A	0.0000
937	N	A	-2.6397
938	P	A	-1.6397
939	P	A	-0.8597
940	T	A	-0.3623
941	P	A	-0.2183
942	S	A	0.1520
943	I	A	0.7089
944	Y	A	0.6213
945	L	A	0.0000
946	E	A	-2.7827
947	N	A	-3.1808
948	K	A	-2.9784
949	R	A	-2.2263
950	D	A	-1.0199
951	A	A	0.0000
952	F	A	1.1625
953	F	A	1.5704
954	P	A	0.5527
955	P	A	0.1306
956	L	A	0.0000
957	H	A	-0.3620
958	Q	A	-1.0923
959	F	A	-0.4554
960	C	A	0.0000
961	T	A	-0.7753
962	N	A	-1.2377
963	P	A	-1.2306
964	N	A	-1.6126
965	N	A	-0.9545
966	P	A	0.0000
967	V	A	0.0000
968	T	A	0.0000
969	V	A	0.0000
970	I	A	0.0000
971	R	A	-0.2963
972	G	A	-1.0347
973	L	A	0.0000
974	A	A	0.0000
975	G	A	-2.1567
976	A	A	0.0000
977	L	A	0.0000
978	K	A	-2.7379
979	L	A	0.0000
980	D	A	-2.0728
981	L	A	-1.0069
982	G	A	-0.9484
983	L	A	-0.3634
984	F	A	0.0000
985	S	A	-0.9556
986	T	A	-1.2394
987	K	A	-2.1836
988	T	A	-1.4833
989	L	A	0.0000
990	V	A	-2.2260
991	E	A	-2.5655
992	A	A	-1.7190
993	N	A	-1.5830
994	N	A	-2.5764
995	E	A	-2.5005
996	H	A	-1.0780
997	M	A	-0.2128
998	V	A	0.0000
999	E	A	-1.2131
1000	V	A	0.0000
1001	R	A	-2.2363
1002	T	A	-1.5604
1003	Q	A	0.0000
1004	L	A	-0.0352
1005	L	A	0.2553
1006	Q	A	0.0000
1007	P	A	-0.3462
1008	A	A	-0.0643
1009	D	A	-0.5134
1010	E	A	-0.7177
1011	N	A	0.0000
1012	W	A	-0.6942
1013	D	A	0.0000
1014	P	A	-0.4310
1015	T	A	-0.7433
1016	G	A	0.0000
1017	T	A	-1.1689
1018	K	A	-1.7620
1019	K	A	-1.0856
1020	I	A	-0.3921
1021	W	A	0.0000
1022	H	A	-1.0291
1023	C	A	0.0000
1024	E	A	-1.0788
1025	S	A	-1.6352
1026	N	A	-2.5465
1027	R	A	-3.0888
1028	S	A	-2.0083
1029	H	A	-1.3369
1030	T	A	-0.9036
1031	T	A	0.0000
1032	I	A	0.0000
1033	A	A	-2.2472
1034	K	A	-2.3429
1035	Y	A	0.0000
1036	A	A	-1.4101
1037	Q	A	-1.6394
1038	Y	A	-0.7279
1039	Q	A	0.0000
1040	A	A	-0.5083
1041	S	A	-0.5974
1042	S	A	-0.4040
1043	F	A	0.0874
1044	Q	A	-1.2966
1045	E	A	-1.7724
1046	S	A	-1.4930
1047	L	A	-1.7787
1048	R	A	-3.6556
1049	E	A	-3.3558
1050	E	A	-3.6383
1051	N	A	-4.0935
1052	E	A	-4.0198
1053	K	A	-3.4675
1054	R	A	-3.6940
1055	S	A	-2.8155
1056	H	A	-2.7082
1057	H	A	-2.9101
1058	K	A	-3.5341
1059	D	A	-2.7603
1060	H	A	-2.0180
1061	S	A	-1.5588
1062	D	A	-1.4870
1063	S	A	-1.6546
1064	E	A	-2.2330
1065	S	A	-2.0476
1066	T	A	0.0000
1067	S	A	-1.8854
1068	S	A	-2.9511
1069	D	A	-3.0058
1070	N	A	-3.0256
1071	S	A	-1.9769
1072	G	A	-1.9135
1073	R	A	-3.5753
1074	R	A	-3.8521
1075	R	A	-3.8273
1076	K	A	-3.1687
1077	G	A	-1.6401
1078	P	A	-1.0411
1079	F	A	-0.6115
1080	K	A	-0.2031
1081	T	A	-0.2025
1082	I	A	0.0000
1083	K	A	-1.2365
1084	F	A	0.0000
1085	G	A	0.0000
1086	T	A	0.0000
1087	N	A	-0.7002
1088	I	A	0.0000
1089	D	A	-0.3373
1090	L	A	0.0000
1091	S	A	-1.3458
1092	D	A	-2.8906
1093	D	A	-3.9240
1094	K	A	-3.6074
1095	K	A	-2.7945
1096	W	A	0.0000
1097	K	A	-3.0590
1098	L	A	-0.8375
1099	Q	A	0.0000
1100	L	A	-1.3767
1101	H	A	-1.3917
1102	E	A	0.0000
1103	L	A	0.0000
1104	T	A	-0.4725
1105	K	A	-1.2576
1106	L	A	0.0000
1107	P	A	0.0000
1108	A	A	0.3465
1109	F	A	0.3011
1110	V	A	0.0000
1111	R	A	0.1699
1112	V	A	0.8169
1113	V	A	1.6210
1114	S	A	0.7091
1115	A	A	0.3036
1116	G	A	0.1161
1117	N	A	0.0000
1118	L	A	0.0000
1119	L	A	0.0000
1120	S	A	0.2890
1121	H	A	-0.3546
1122	V	A	0.0000
1123	G	A	-1.2172
1124	H	A	-1.1637
1125	T	A	-0.2118
1126	I	A	0.0000
1127	L	A	1.1356
1128	G	A	0.0000
1129	M	A	0.0000
1130	N	A	0.4741
1131	T	A	0.1889
1132	V	A	0.0000
1133	Q	A	-0.2883
1134	L	A	0.0000
1135	Y	A	-0.1036
1136	M	A	0.0000
1137	K	A	0.0000
1138	V	A	0.0000
1139	P	A	0.4417
1140	G	A	0.2605
1141	S	A	0.0000
1142	R	A	0.0000
1143	T	A	-0.1707
1144	P	A	-0.2783
1145	G	A	0.0000
1146	H	A	-0.2274
1147	Q	A	-0.4999
1148	E	A	-0.4888
1149	N	A	-0.3944
1150	N	A	0.0000
1151	N	A	0.0000
1152	F	A	0.0000
1153	C	A	0.0000
1154	S	A	0.0000
1155	V	A	0.0000
1156	N	A	0.0000
1157	I	A	0.0000
1158	N	A	0.0000
1159	I	A	0.0000
1160	G	A	0.0000
1161	P	A	-0.5655
1162	G	A	-0.3844
1163	D	A	-0.5008
1164	C	A	0.0000
1165	E	A	0.0759
1166	W	A	0.0000
1167	F	A	0.0000
1168	V	A	0.0000
1169	V	A	0.0000
1170	P	A	-0.5419
1171	E	A	-0.7261
1172	G	A	-0.3353
1173	Y	A	0.0000
1174	W	A	0.0000
1175	G	A	0.0000
1176	V	A	-0.3532
1177	L	A	0.0000
1178	N	A	-1.1648
1179	D	A	-2.0266
1180	F	A	-1.5706
1181	C	A	0.0000
1182	E	A	-3.0305
1183	K	A	-3.1883
1184	N	A	-2.5702
1185	N	A	-2.8943
1186	L	A	0.0000
1187	N	A	-1.2794
1188	F	A	0.0000
1189	L	A	0.3012
1190	M	A	0.9514
1191	G	A	-0.2188
1192	S	A	-0.3756
1193	W	A	0.0000
1194	W	A	0.0000
1195	P	A	0.0000
1196	N	A	0.0000
1197	L	A	0.0000
1198	E	A	-1.9880
1199	D	A	-1.7164
1200	L	A	0.0000
1201	Y	A	-2.2537
1202	E	A	-2.5790
1203	A	A	-1.4099
1204	N	A	-2.0550
1205	V	A	0.0000
1206	P	A	0.0000
1207	V	A	0.0000
1208	Y	A	-0.5997
1209	R	A	-0.7544
1210	F	A	0.1170
1211	I	A	0.3811
1212	Q	A	0.0000
1213	R	A	-1.0990
1214	P	A	-0.8779
1215	G	A	0.0000
1216	D	A	0.0000
1217	L	A	0.0000
1218	V	A	0.0000
1219	W	A	0.0000
1220	I	A	0.0000
1221	N	A	0.0000
1222	A	A	0.0000
1223	G	A	0.0000
1224	T	A	0.0000
1225	V	A	0.0000
1226	H	A	0.0000
1227	W	A	0.0000
1228	V	A	0.0000
1229	Q	A	0.0000
1230	A	A	0.0000
1231	I	A	1.0365
1232	G	A	0.3431
1233	W	A	0.3892
1234	C	A	0.0000
1235	N	A	0.0000
1236	N	A	0.0000
1237	I	A	0.0000
1238	A	A	0.0000
1239	W	A	0.0000
1240	N	A	0.0000
1241	V	A	0.0000
1242	G	A	0.0000
1243	P	A	0.0000
1244	L	A	0.3616
1245	T	A	-0.1738
1246	A	A	0.0000
1247	C	A	-0.0674
1248	Q	A	0.0000
1249	Y	A	0.0000
1250	K	A	-1.1177
1251	L	A	-0.7449
1252	A	A	0.0000
1253	V	A	-0.9485
1254	E	A	-2.3176
1255	R	A	0.0000
1256	Y	A	0.0000
1257	E	A	-0.9944
1258	W	A	0.0000
1259	N	A	0.0000
1260	K	A	-0.5233
1261	L	A	0.5940
1262	Q	A	-0.2694
1263	S	A	-0.0758
1264	V	A	-0.0040
1265	K	A	-0.6005
1266	S	A	0.0000
1267	I	A	0.9624
1268	V	A	0.0000
1269	P	A	0.0000
1270	M	A	0.0000
1271	V	A	0.0000
1272	H	A	0.0000
1273	L	A	0.0000
1274	S	A	0.0000
1275	W	A	0.0000
1276	N	A	-0.8216
1277	M	A	0.0000
1278	A	A	0.0000
1279	R	A	-2.0351
1280	N	A	-1.9990
1281	I	A	-1.3340
1282	K	A	-2.0680
1283	V	A	0.0000
1284	S	A	-1.1669
1285	D	A	-1.7266
1286	P	A	-1.6346
1287	K	A	-2.1992
1288	L	A	0.0000
1289	F	A	-1.1041
1290	E	A	-0.9255
1291	M	A	-0.5650
1292	I	A	0.0000
1293	K	A	0.0000
1294	Y	A	0.6411
1295	C	A	0.0000
1296	L	A	0.0000
1297	L	A	0.0000
1298	R	A	-1.0410
1299	T	A	-0.6660
1300	L	A	0.0000
1301	K	A	-1.2981
1302	Q	A	-1.6841
1303	C	A	0.0000
1304	Q	A	0.0000
1305	T	A	-0.4244
1306	L	A	-0.2320
1307	R	A	-0.2764
1308	E	A	-0.0943
1309	A	A	0.3685
1310	L	A	0.0000
1311	I	A	1.2067
1312	A	A	0.5302
1313	A	A	-0.1298
1314	G	A	-0.4199
1315	K	A	-1.0133
1316	E	A	-1.0418
1317	I	A	0.3267
1318	I	A	1.1732
1319	W	A	1.0221
1320	H	A	0.3943
1321	G	A	0.0000
1322	R	A	-1.2041
1323	T	A	-1.8291
1324	K	A	-2.9013
1325	E	A	-3.0660
1326	E	A	-2.0905
1327	P	A	-1.3023
1328	A	A	-0.4267
1329	H	A	-0.0657
1330	Y	A	0.3246
1331	C	A	0.0000
1332	S	A	0.9242
1333	I	A	1.5958
1334	C	A	0.3200
1335	E	A	-0.0684
1336	V	A	0.2002
1337	E	A	-0.1460
1338	V	A	0.0000
1339	F	A	0.2141
1340	D	A	0.0000
1341	L	A	0.0000
1342	L	A	0.0000
1343	F	A	0.0000
1344	V	A	0.0000
1345	T	A	-1.4579
1346	N	A	-2.6821
1347	E	A	-2.4601
1348	S	A	0.0000
1349	N	A	-2.0192
1350	S	A	-2.3877
1351	R	A	-3.1085
1352	K	A	-2.7678
1353	T	A	-1.2364
1354	Y	A	-0.3470
1355	I	A	0.6613
1356	V	A	0.0000
1357	H	A	0.0000
1358	C	A	-0.5055
1359	Q	A	-1.5478
1360	D	A	-2.4452
1361	C	A	0.0000
1362	A	A	0.0000
1363	R	A	-3.0948
1364	K	A	-2.8642
1365	T	A	-2.0528
1366	S	A	0.0000
1367	G	A	-2.5224
1368	N	A	-2.6604
1369	L	A	0.0000
1370	E	A	-3.0434
1371	N	A	-2.5623
1372	F	A	0.0000
1373	V	A	0.0000
1374	V	A	0.0000
1375	L	A	0.0000
1376	E	A	0.0000
1377	Q	A	0.0000
1378	Y	A	0.0000
1379	K	A	-2.1145
1380	M	A	-1.8162
1381	E	A	-2.8293
1382	D	A	-2.4737
1383	L	A	0.0000
1384	M	A	-1.8896
1385	Q	A	-2.6032
1386	V	A	0.0000
1387	Y	A	0.0000
1388	D	A	-1.5692
1389	Q	A	-2.0997
1390	F	A	0.0000
1391	T	A	-0.8795
1392	L	A	-0.6319
1393	A	A	-0.6710
1394	P	A	-0.5891