Project name: b17dbade5f84198

Chain sequence(s)	A: SGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.569
• Maximal score value: 2.2833
• Average score: -0.8378
• Total score value: -250.5016

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
27	S	A	-0.9994
28	G	A	0.0000
29	V	A	0.0000
30	F	A	0.0000
31	Q	A	0.0000
32	L	A	0.0000
33	Q	A	-1.0548
34	L	A	0.0000
35	Q	A	-1.7350
36	E	A	-1.8596
37	F	A	0.0000
38	I	A	-0.8841
39	N	A	0.0000
40	E	A	-2.5858
41	R	A	-2.8442
42	G	A	0.0000
43	V	A	0.0000
44	L	A	-1.1737
45	A	A	-0.7912
46	S	A	-1.2530
47	G	A	-1.6043
48	R	A	-2.7628
49	P	A	-2.0777
50	C	A	0.0000
51	E	A	-2.3616
52	P	A	-1.5353
53	G	A	0.0000
54	C	A	0.0000
55	R	A	-0.8680
56	T	A	0.0000
57	F	A	0.0000
58	F	A	0.0000
59	R	A	-0.5052
60	V	A	0.0000
61	C	A	0.1010
62	L	A	0.0000
63	K	A	0.0000
64	H	A	-0.2739
65	F	A	0.4846
66	Q	A	0.0464
67	A	A	0.8476
68	V	A	2.2833
69	V	A	2.2610
70	S	A	0.7424
71	P	A	-0.0143
72	G	A	-0.4977
73	P	A	-0.5045
74	C	A	-0.1099
75	T	A	-0.2055
76	F	A	0.0000
77	G	A	-0.2090
78	T	A	-0.1072
79	V	A	-0.0703
80	S	A	-0.3808
81	T	A	0.0000
82	P	A	-0.1792
83	V	A	0.1352
84	L	A	0.0000
85	G	A	-0.4418
86	T	A	-0.3479
87	N	A	-1.2996
88	S	A	-1.0687
89	F	A	-0.5323
90	A	A	-1.0351
91	V	A	-1.9369
92	R	A	-3.7882
93	D	A	-4.5690
94	D	A	-4.1334
95	S	A	-2.6682
96	S	A	-1.9166
97	G	A	0.0000
98	G	A	0.0000
99	G	A	-2.8653
100	R	A	-3.9169
101	N	A	-3.5198
102	P	A	-1.9868
103	L	A	0.0000
104	Q	A	-1.2823
105	L	A	0.0000
106	P	A	-0.7360
107	F	A	0.0000
108	N	A	-1.2114
109	F	A	-0.2728
110	T	A	-0.5631
111	W	A	-0.4989
112	P	A	0.0102
113	G	A	-0.0566
114	T	A	-0.2550
115	F	A	0.0000
116	S	A	0.0000
117	L	A	0.0000
118	I	A	-0.0298
119	I	A	0.0000
120	E	A	-0.8965
121	A	A	0.0000
122	W	A	-0.2704
123	H	A	0.0000
124	A	A	0.0000
125	P	A	-1.2511
126	G	A	-1.4514
127	D	A	-2.3931
128	D	A	-2.3220
129	L	A	-1.6920
130	R	A	-2.7891
131	P	A	-2.0712
132	E	A	-2.5774
133	A	A	-1.8830
134	L	A	-1.3264
135	P	A	-1.0160
136	P	A	-1.1805
137	D	A	-1.7990
138	A	A	0.0000
139	L	A	-0.5766
140	I	A	0.0000
141	S	A	-0.8033
142	K	A	-1.7209
143	I	A	0.0000
144	A	A	-0.1882
145	I	A	0.0000
146	Q	A	-0.3423
147	G	A	-0.3953
148	S	A	-0.2999
149	L	A	0.0000
150	A	A	-0.3981
151	V	A	-0.7180
152	G	A	-1.1151
153	Q	A	-1.5991
154	N	A	-1.3504
155	W	A	-0.0812
156	L	A	0.8665
157	L	A	0.6763
158	D	A	-1.1115
159	E	A	-2.4766
160	Q	A	-1.7704
161	T	A	-0.8721
162	S	A	-0.3989
163	T	A	0.2297
164	L	A	0.2097
165	T	A	0.0000
166	R	A	-1.5370
167	L	A	0.0000
168	R	A	-2.4666
169	Y	A	0.0000
170	S	A	0.0000
171	Y	A	0.0000
172	R	A	-0.3285
173	V	A	0.0000
174	I	A	-0.6733
175	C	A	-0.9036
176	S	A	-0.7666
177	D	A	-1.7028
178	N	A	-1.2285
179	Y	A	-0.7160
180	Y	A	-1.3592
181	G	A	-2.0850
182	D	A	-2.7522
183	N	A	-2.3625
184	C	A	0.0000
185	S	A	-1.0223
186	R	A	-1.0252
187	L	A	0.4532
188	C	A	0.0000
189	K	A	-2.4550
190	K	A	-2.8943
191	R	A	-2.4243
192	N	A	-2.2435
193	D	A	-1.8949
194	H	A	-1.0690
195	F	A	0.5286
196	G	A	0.0000
197	H	A	-1.1177
198	Y	A	0.0000
199	V	A	-0.5483
200	C	A	-0.9650
201	Q	A	-1.4461
202	P	A	-1.3079
203	D	A	-2.5323
204	G	A	0.0000
205	N	A	-1.0461
206	L	A	-0.5425
207	S	A	0.2251
208	C	A	-0.0415
209	L	A	0.0552
210	P	A	0.1340
211	G	A	-0.0402
212	W	A	-0.3673
213	T	A	-0.5981
214	G	A	-1.2828
215	E	A	-1.7557
216	Y	A	-0.1422
217	C	A	0.0000
218	Q	A	-1.7827
219	Q	A	-1.5542
220	P	A	-0.6019
221	I	A	0.9181
222	C	A	0.4751
223	L	A	0.1601
224	S	A	0.0151
225	G	A	-1.0413
226	C	A	-0.8516
227	H	A	-2.1346
228	E	A	-2.5531
229	Q	A	-2.4381
230	N	A	-1.9441
231	G	A	0.0000
232	Y	A	0.1581
233	C	A	0.2282
234	S	A	-0.8559
235	K	A	-1.6369
236	P	A	-0.5105
237	A	A	0.0147
238	E	A	-0.2092
239	C	A	-0.1316
240	L	A	0.0454
241	C	A	-0.9561
242	R	A	-1.3766
243	P	A	-0.7558
244	G	A	0.0000
245	W	A	-1.2890
246	Q	A	-1.8366
247	G	A	-2.0660
248	R	A	-2.3117
249	L	A	-1.5072
250	C	A	0.0000
251	N	A	-2.9109
252	E	A	-2.7652
253	C	A	0.0000
254	I	A	-0.3872
255	P	A	-0.5639
256	H	A	-0.6682
257	N	A	-1.4453
258	G	A	-0.8793
259	C	A	-1.0662
260	R	A	-2.6852
261	H	A	-2.5873
262	G	A	-1.6841
263	T	A	-0.7996
264	C	A	-0.3437
265	S	A	-0.5032
266	T	A	-0.3304
267	P	A	-0.1701
268	W	A	0.0757
269	Q	A	-0.2171
270	C	A	-0.3577
271	T	A	-0.6721
272	C	A	-1.6761
273	D	A	-3.1510
274	E	A	-2.6325
275	G	A	-1.6158
276	W	A	-1.6367
277	G	A	-1.0966
278	G	A	-0.2698
279	L	A	1.0467
280	F	A	-0.0768
281	C	A	0.0000
282	D	A	-2.4452
283	Q	A	-1.8507
284	D	A	-1.3086
285	L	A	-0.1874
286	N	A	-0.8224
287	Y	A	-0.6434
288	C	A	-0.5954
289	T	A	-0.6873
290	H	A	-0.8902
291	H	A	-1.1237
292	S	A	-0.8757
293	P	A	-0.5965
294	C	A	-1.0156
295	K	A	-2.2014
296	N	A	-2.3294
297	G	A	-1.6874
298	A	A	-1.5193
299	T	A	-0.7355
300	C	A	-0.3844
301	S	A	-0.6550
302	N	A	-1.5259
303	S	A	-1.6274
304	G	A	-1.6791
305	Q	A	-2.4537
306	R	A	-2.7283
307	S	A	-1.7313
308	Y	A	-1.0938
309	T	A	-0.2992
310	C	A	-0.2853
311	T	A	-0.4191
312	C	A	-1.1806
313	R	A	-2.4673
314	P	A	-1.2080
315	G	A	-0.5221
316	Y	A	-0.8227
317	T	A	-0.0293
318	G	A	0.5997
319	V	A	1.4176
320	D	A	-0.0629
321	C	A	0.0000
322	E	A	-0.8250
323	L	A	0.3215
324	E	A	-0.8904
325	L	A	0.8364