Project name: 1l6x:A

Chain sequence(s)	A: GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4702
• Maximal score value: 1.6157
• Average score: -0.9786
• Total score value: -202.5654

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
237	G	A	-1.0926
238	P	A	0.0000
239	S	A	-0.2447
240	V	A	0.0000
241	F	A	1.3299
242	L	A	0.9907
243	F	A	1.2618
244	P	A	-0.1145
245	P	A	-1.1008
246	K	A	-2.1388
247	P	A	-1.3878
248	K	A	-1.0844
249	D	A	-0.9306
250	T	A	0.0000
251	L	A	0.0000
252	M	A	0.3988
253	I	A	1.6157
254	S	A	0.2328
255	R	A	-0.8843
256	T	A	-0.4396
257	P	A	0.0000
258	E	A	-0.8781
259	V	A	0.0000
260	T	A	0.3358
261	C	A	0.0000
262	V	A	0.0000
263	V	A	0.0000
264	V	A	-0.9184
265	D	A	-2.1006
266	V	A	0.0000
267	S	A	-2.4532
268	H	A	-2.5586
269	E	A	-2.9385
270	D	A	-2.6519
271	P	A	-2.5776
272	E	A	-2.9811
273	V	A	-1.7940
274	K	A	-2.2549
275	F	A	-1.2211
276	N	A	-1.1729
277	W	A	0.0000
278	Y	A	-0.6593
279	V	A	-0.8457
280	D	A	-1.9464
281	G	A	-0.7549
282	V	A	0.6893
283	E	A	-0.5603
284	V	A	-0.5320
285	H	A	-1.8725
286	N	A	-2.1796
287	A	A	-1.9083
288	K	A	-2.4825
289	T	A	-1.7804
290	K	A	-2.3758
291	P	A	-1.9777
292	R	A	-2.7411
293	E	A	-3.4702
294	E	A	-3.3930
295	Q	A	-1.8088
296	Y	A	-0.0207
297	N	A	-1.2370
298	S	A	-1.5878
299	T	A	-2.1266
300	Y	A	-2.4120
301	R	A	-2.6911
302	V	A	0.0000
303	V	A	-0.8449
304	S	A	0.0000
305	V	A	0.0000
306	L	A	0.0000
307	T	A	-0.5644
308	V	A	0.0000
309	L	A	0.9607
310	H	A	0.0650
311	Q	A	-0.9177
312	D	A	-1.4042
313	W	A	0.0000
314	L	A	-1.0209
315	N	A	-2.1333
316	G	A	-2.2381
317	K	A	-2.3128
318	E	A	-2.4151
319	Y	A	0.0000
320	K	A	-1.7006
321	C	A	0.0000
322	K	A	-1.6468
323	V	A	0.0000
324	S	A	-1.5887
325	N	A	-1.8935
326	K	A	-2.6762
327	A	A	-1.6843
328	L	A	-0.7043
329	P	A	-0.5245
330	A	A	-0.4921
331	P	A	-1.0244
332	I	A	-0.8790
333	E	A	-2.1311
334	K	A	-1.2276
335	T	A	-1.0288
336	I	A	-0.3443
337	S	A	-1.2972
338	K	A	-1.4384
339	A	A	-1.2350
340	K	A	-2.3866
341	G	A	-1.9548
342	Q	A	-2.1071
343	P	A	-1.7203
344	R	A	-2.0181
345	E	A	-2.6731
346	P	A	0.0000
347	Q	A	-1.2400
348	V	A	0.0000
349	Y	A	0.3166
350	T	A	0.2465
351	L	A	0.6706
352	P	A	0.0898
353	P	A	-0.8510
354	S	A	-1.7425
355	R	A	-2.9057
356	D	A	-3.1083
357	E	A	-2.6709
358	L	A	-2.3004
359	T	A	-2.0500
360	K	A	-3.0933
361	N	A	-2.9825
362	Q	A	-2.7575
363	V	A	0.0000
364	S	A	-0.6802
365	L	A	0.0000
366	T	A	0.0000
367	C	A	0.0000
368	L	A	0.3977
369	V	A	0.0000
370	K	A	-0.6457
371	G	A	-1.2211
372	F	A	0.0000
373	Y	A	-1.0311
374	P	A	0.0000
375	S	A	-0.0108
376	D	A	-1.1895
377	I	A	-0.6022
378	A	A	0.0000
379	V	A	0.0000
380	E	A	-1.5478
381	W	A	0.0000
382	E	A	-1.7800
383	S	A	0.0000
384	N	A	-1.8312
385	G	A	-1.7441
386	Q	A	-2.2859
387	P	A	-2.0841
388	E	A	-2.0806
389	N	A	-2.5864
390	N	A	-2.3631
391	Y	A	-2.0956
392	K	A	-2.4029
393	T	A	-1.0961
394	T	A	-0.3838
395	P	A	-0.0360
396	P	A	0.5177
397	V	A	1.4279
398	L	A	1.2679
399	D	A	-0.5192
400	S	A	-1.0688
401	D	A	-1.9732
402	G	A	-0.7810
403	S	A	0.0000
404	F	A	0.3595
405	F	A	0.6407
406	L	A	0.0000
407	Y	A	0.2119
408	S	A	0.0000
409	K	A	-1.5001
410	L	A	0.0000
411	T	A	-1.5157
412	V	A	0.0000
413	D	A	-2.5311
414	K	A	-2.6643
415	S	A	-2.1430
416	R	A	-2.0026
417	W	A	0.0000
418	Q	A	-1.7526
419	Q	A	-1.8054
420	G	A	-0.6950
421	N	A	-0.6223
422	V	A	0.5515
423	F	A	0.0000
424	S	A	-1.0458
425	C	A	0.0000
426	S	A	0.0000
427	V	A	0.0000
428	M	A	0.0000
429	H	A	0.0000
430	E	A	-1.1595
431	A	A	-1.4938
432	L	A	-1.4315
433	H	A	-1.7736
434	N	A	-1.6827
435	H	A	-1.1647
436	Y	A	-0.5388
437	T	A	-0.9164
438	Q	A	-1.3827
439	K	A	-1.3185
440	S	A	-0.4913
441	L	A	0.0000
442	S	A	0.6253
443	L	A	1.1153