Project name: 3PS5

Chain sequence(s)	A: MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1955
• Maximal score value: 1.1762
• Average score: -0.8866
• Total score value: -468.9859

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.8427
2	V	A	0.4952
3	R	A	0.0000
4	W	A	0.0000
5	F	A	0.0000
6	H	A	0.0000
7	R	A	-1.2361
8	D	A	-2.1354
9	L	A	-1.0262
10	S	A	-0.9258
11	G	A	-0.1040
12	L	A	0.8820
13	D	A	-0.5746
14	A	A	0.0000
15	E	A	-1.2901
16	T	A	-1.0689
17	L	A	-0.7080
18	L	A	0.0000
19	K	A	-2.8022
20	G	A	-1.7049
21	R	A	-1.2923
22	G	A	0.0000
23	V	A	-1.1331
24	H	A	-1.8450
25	G	A	0.0000
26	S	A	0.0000
27	F	A	0.0000
28	L	A	0.0000
29	A	A	0.0000
30	R	A	0.0000
31	P	A	-1.9110
32	S	A	-2.9243
33	R	A	-3.6961
34	K	A	-3.8938
35	N	A	-3.6219
36	Q	A	-3.2005
37	G	A	-2.1829
38	D	A	-2.3673
39	F	A	0.0000
40	S	A	0.0000
41	L	A	0.0000
42	S	A	0.0000
43	V	A	0.0000
44	R	A	0.0000
45	V	A	-0.9117
46	G	A	-1.8523
47	D	A	-2.9581
48	Q	A	-2.4162
49	V	A	-1.2045
50	T	A	-0.8411
51	H	A	-1.1898
52	I	A	0.0000
53	R	A	-2.4898
54	I	A	0.0000
55	Q	A	-1.1584
56	N	A	-1.3994
57	S	A	-1.2594
58	G	A	-1.5666
59	D	A	-2.1738
60	F	A	-1.5269
61	Y	A	0.0000
62	D	A	0.0000
63	L	A	-0.9726
64	Y	A	-0.3094
65	G	A	-0.9173
66	G	A	-1.5505
67	E	A	-2.7522
68	K	A	-2.9016
69	F	A	-1.6346
70	A	A	-0.9647
71	T	A	-1.0498
72	L	A	0.0000
73	T	A	-0.8070
74	E	A	-1.8816
75	L	A	0.0000
76	V	A	0.0000
77	E	A	-2.0403
78	Y	A	-1.8098
79	Y	A	0.0000
80	T	A	-1.9457
81	Q	A	-2.6393
82	Q	A	-2.3544
83	Q	A	-1.9260
84	G	A	-0.8043
85	V	A	1.1762
86	L	A	0.0000
87	Q	A	-0.7997
88	D	A	-2.1508
89	R	A	-3.2116
90	D	A	-2.8189
91	G	A	-1.6071
92	T	A	-0.5565
93	I	A	1.0980
94	I	A	0.0000
95	H	A	-1.0732
96	L	A	0.0000
97	K	A	-1.6872
98	Y	A	0.0000
99	P	A	-0.1426
100	L	A	0.0000
101	N	A	0.0000
102	C	A	-0.1629
103	S	A	-0.4419
104	D	A	-0.7577
105	P	A	-0.4026
106	T	A	0.0000
107	S	A	-0.9639
108	E	A	-0.7123
109	R	A	0.0000
110	W	A	0.0000
111	Y	A	0.0000
112	H	A	0.0000
113	G	A	0.0000
114	H	A	0.2505
115	M	A	-0.0816
116	S	A	-0.5497
117	G	A	-0.9373
118	G	A	-1.2803
119	Q	A	-1.6015
120	A	A	0.0000
121	E	A	-1.4797
122	T	A	-1.0572
123	L	A	-0.7133
124	L	A	0.0000
125	Q	A	-1.5188
126	A	A	-1.2228
127	K	A	-2.3096
128	G	A	-2.1829
129	E	A	-2.9901
130	P	A	-2.3464
131	W	A	-1.2452
132	T	A	0.0000
133	F	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	R	A	0.0000
137	E	A	0.0000
138	S	A	0.0000
139	L	A	-0.3489
140	S	A	-0.6374
141	Q	A	-1.2894
142	P	A	-0.6918
143	G	A	-0.9563
144	D	A	-0.9423
145	F	A	0.0000
146	V	A	0.0000
147	L	A	0.0000
148	S	A	0.0000
149	V	A	0.0000
150	L	A	0.0000
151	S	A	-1.9251
152	D	A	-3.0042
153	Q	A	-2.8901
154	P	A	-2.4123
155	K	A	-2.7518
156	A	A	-1.3862
157	G	A	-1.0182
158	P	A	-0.9962
159	G	A	-0.8648
160	S	A	-1.2047
161	P	A	-1.5354
162	L	A	-2.4563
163	R	A	-2.8554
164	V	A	-1.5504
165	T	A	-0.6405
166	H	A	-0.9098
167	I	A	0.0000
168	K	A	-1.3532
169	V	A	0.0000
170	M	A	-1.0625
171	C	A	-1.5651
172	E	A	-2.4854
173	G	A	-1.8827
174	G	A	-2.2981
175	R	A	-2.5771
176	Y	A	0.0000
177	T	A	0.0000
178	V	A	-0.3296
179	G	A	-0.8375
180	G	A	-0.4950
181	L	A	0.7642
182	E	A	-0.5923
183	T	A	-1.3520
184	F	A	-1.7335
185	D	A	-2.4977
186	S	A	-1.6969
187	L	A	0.0000
188	T	A	-1.7293
189	D	A	-2.8242
190	L	A	0.0000
191	V	A	0.0000
192	E	A	-3.3320
193	H	A	-2.5172
194	F	A	0.0000
195	K	A	-3.3335
196	K	A	-2.9812
197	T	A	-1.6011
198	G	A	0.0000
199	I	A	0.0000
200	E	A	-2.5019
201	E	A	-2.7215
202	A	A	-1.3945
203	S	A	-1.1403
204	G	A	-1.3760
205	A	A	-0.7829
206	F	A	-0.2333
207	V	A	-0.4060
208	Y	A	-0.5778
209	L	A	0.0000
210	R	A	-2.5899
211	Q	A	-1.6614
212	P	A	-0.2945
213	Y	A	0.3616
214	Y	A	0.7189
215	A	A	0.0000
216	T	A	-0.5958
217	R	A	-1.2530
218	V	A	0.0000
219	N	A	0.0000
220	A	A	0.0000
221	A	A	-0.9681
222	D	A	-1.4469
223	I	A	0.0000
224	E	A	-2.2253
225	N	A	-1.8223
226	R	A	0.0000
227	V	A	0.0000
228	L	A	-0.2586
229	E	A	-1.3626
230	L	A	0.0000
231	N	A	-1.6200
232	K	A	-2.7656
233	K	A	-4.1817
234	Q	A	-4.0564
235	E	A	-4.1955
236	S	A	-2.8878
237	E	A	-3.4018
238	D	A	-3.9209
239	T	A	-2.6288
240	A	A	-3.0866
241	K	A	-3.2238
242	A	A	-2.8135
243	G	A	-2.1782
244	F	A	0.0000
245	W	A	-1.6823
246	E	A	-2.2959
247	E	A	0.0000
248	F	A	0.0000
249	E	A	-2.2755
250	S	A	-1.7266
251	L	A	0.0000
252	Q	A	-2.0590
253	K	A	-2.4626
254	Q	A	-1.9947
255	E	A	-1.2896
256	V	A	0.2290
257	K	A	-1.2506
258	N	A	-0.4749
259	L	A	0.5290
260	H	A	-1.0348
261	Q	A	-1.3751
262	R	A	-0.9372
263	L	A	0.1809
264	E	A	0.0000
265	G	A	0.0000
266	Q	A	-2.1852
267	R	A	-1.9105
268	P	A	-2.1889
269	E	A	-2.2411
270	N	A	0.0000
271	K	A	-3.2930
272	G	A	-2.1775
273	K	A	-1.7983
274	N	A	-1.6618
275	R	A	-1.4079
276	Y	A	-1.3202
277	K	A	-2.8121
278	N	A	-2.0594
279	I	A	-0.8839
280	L	A	0.0000
281	P	A	0.0000
282	F	A	0.0000
283	D	A	-1.2374
284	H	A	-1.6215
285	S	A	0.0000
286	R	A	0.0000
287	V	A	0.0000
288	I	A	0.4521
289	L	A	0.0000
290	Q	A	-1.8400
291	G	A	-1.8932
292	R	A	-2.1830
293	D	A	-2.4441
294	S	A	-1.5889
295	N	A	-1.2491
296	I	A	0.1444
297	P	A	-0.4796
298	G	A	0.0000
299	S	A	-0.8826
300	D	A	-0.7614
301	Y	A	0.0000
302	I	A	0.0000
303	N	A	0.0000
304	A	A	0.0000
305	N	A	0.0000
306	Y	A	0.0609
307	I	A	0.0000
308	K	A	-1.1045
309	N	A	-0.8296
310	Q	A	-0.7536
311	L	A	0.7625
312	L	A	-0.2202
313	G	A	-1.0050
314	P	A	-1.5927
315	D	A	-2.6663
316	E	A	-2.4045
317	N	A	-2.1740
318	A	A	-1.4120
319	K	A	0.0000
320	T	A	-0.5713
321	Y	A	0.0000
322	I	A	0.0000
323	A	A	0.0000
324	S	A	0.0000
325	Q	A	0.0000
326	G	A	0.0000
327	C	A	0.0000
328	L	A	-1.0472
329	E	A	-1.7045
330	A	A	-1.0274
331	T	A	0.0000
332	V	A	-0.6596
333	N	A	-1.0050
334	D	A	-0.7025
335	F	A	0.0000
336	W	A	0.0000
337	Q	A	-0.6878
338	M	A	0.0000
339	A	A	0.0000
340	W	A	-0.4567
341	Q	A	-0.6546
342	E	A	-0.6843
343	N	A	-0.7655
344	S	A	0.0000
345	R	A	-0.9073
346	V	A	0.0000
347	I	A	0.0000
348	V	A	0.0000
349	M	A	0.0000
350	T	A	0.0000
351	T	A	0.0000
352	R	A	-0.2980
353	E	A	-0.2186
354	V	A	-0.0235
355	E	A	0.0000
356	K	A	-2.4681
357	G	A	-2.0442
358	R	A	-2.8589
359	N	A	-2.2261
360	K	A	-1.3780
361	C	A	0.0000
362	V	A	-0.0554
363	P	A	-0.3610
364	Y	A	0.0000
365	W	A	0.0000
366	P	A	0.0000
367	E	A	-1.4346
368	V	A	0.5479
369	G	A	-0.0864
370	M	A	-0.7504
371	Q	A	-1.9965
372	R	A	-2.5211
373	A	A	-1.1075
374	Y	A	-0.7844
375	G	A	-0.7365
376	P	A	-0.4733
377	Y	A	0.0000
378	S	A	-0.7301
379	V	A	0.0000
380	T	A	-1.0277
381	N	A	0.0000
382	C	A	0.1287
383	G	A	-0.1562
384	E	A	-1.4126
385	H	A	-2.2458
386	D	A	-2.6149
387	T	A	-1.3164
388	T	A	-0.6743
389	E	A	-0.6967
390	Y	A	0.0000
391	K	A	-1.3929
392	L	A	-0.9945
393	R	A	0.0000
394	T	A	-0.1800
395	L	A	0.0000
396	Q	A	-0.6064
397	V	A	0.0000
398	S	A	-0.1233
399	P	A	-0.4565
400	L	A	-0.5088
401	D	A	-2.2279
402	N	A	-2.0802
403	G	A	-1.3100
404	D	A	-1.4717
405	L	A	0.5964
406	I	A	0.6179
407	R	A	-0.2653
408	E	A	-0.9569
409	I	A	0.0000
410	W	A	-0.3496
411	H	A	0.0000
412	Y	A	0.0000
413	Q	A	0.0000
414	Y	A	0.0000
415	L	A	0.1030
416	S	A	-0.1338
417	W	A	0.0000
418	P	A	-0.7930
419	D	A	-1.6746
420	H	A	-1.4849
421	G	A	-1.0790
422	V	A	-0.7634
423	P	A	0.0000
424	S	A	-1.1112
425	E	A	-1.9570
426	P	A	-1.0147
427	G	A	-0.8861
428	G	A	0.0000
429	V	A	0.0000
430	L	A	0.0000
431	S	A	-0.8111
432	F	A	0.0000
433	L	A	0.0000
434	D	A	-2.0081
435	Q	A	-1.6258
436	I	A	0.0000
437	N	A	-2.0698
438	Q	A	-2.6350
439	R	A	-2.0599
440	Q	A	-1.8958
441	E	A	-2.6529
442	S	A	-1.6788
443	L	A	-1.2100
444	P	A	-1.1958
445	H	A	-1.3875
446	A	A	-1.0897
447	G	A	-0.6348
448	P	A	-0.4469
449	I	A	0.0000
450	I	A	0.0000
451	V	A	0.0000
452	H	A	0.0000
453	S	A	0.0000
454	S	A	-0.4372
455	A	A	0.0000
456	G	A	0.0000
457	I	A	0.0000
458	G	A	0.0000
459	R	A	-0.3149
460	T	A	0.0000
461	G	A	0.0000
462	T	A	0.0000
463	I	A	0.0000
464	I	A	0.0000
465	V	A	0.0000
466	I	A	0.0000
467	D	A	0.0000
468	M	A	0.0000
469	L	A	0.0000
470	M	A	0.0000
471	E	A	-0.5365
472	N	A	-0.5099
473	I	A	0.0000
474	S	A	-0.4728
475	T	A	-0.5533
476	K	A	-0.8870
477	G	A	0.0000
478	L	A	0.0000
479	D	A	0.0000
480	C	A	0.0000
481	D	A	-0.4823
482	I	A	0.0000
483	D	A	-1.1251
484	I	A	0.0000
485	Q	A	-0.9137
486	K	A	-1.1322
487	T	A	0.0000
488	I	A	0.0000
489	Q	A	-1.1108
490	M	A	0.0000
491	V	A	0.0000
492	R	A	0.0000
493	A	A	-0.4595
494	Q	A	0.0000
495	R	A	0.0000
496	S	A	-0.1290
497	G	A	0.0000
498	M	A	0.0000
499	V	A	0.0000
500	Q	A	-1.1657
501	T	A	-1.1677
502	E	A	-1.8232
503	A	A	-1.0037
504	Q	A	0.0000
505	Y	A	0.0000
506	K	A	-0.8208
507	F	A	0.0000
508	I	A	0.0000
509	Y	A	0.0000
510	V	A	-0.3067
511	A	A	0.0000
512	I	A	0.0000
513	A	A	0.0000
514	Q	A	-1.4622
515	F	A	-0.5785
516	I	A	0.0000
517	E	A	-2.7680
518	T	A	-2.2233
519	T	A	0.0000
520	K	A	-2.8827
521	K	A	-3.3471
522	K	A	-2.6647
523	L	A	-1.6046
524	E	A	-2.1706
525	V	A	0.3386
526	L	A	0.3999
527	Q	A	-1.5360
528	S	A	-1.1044
529	Q	A	-1.2594