Chain sequence(s) |
A: MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS C: ARKTGGK B: MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | -0.1147 | |
2 | D | A | -1.8615 | |
3 | K | A | -2.2403 | |
4 | N | A | -2.1816 | |
5 | E | A | -2.0037 | |
6 | L | A | 0.0000 | |
7 | V | A | -1.4404 | |
8 | Q | A | -1.7261 | |
9 | K | A | -1.5879 | |
10 | A | A | 0.0000 | |
11 | K | A | -2.2849 | |
12 | L | A | 0.0000 | |
13 | A | A | 0.0000 | |
14 | E | A | -2.7049 | |
15 | Q | A | -2.3367 | |
16 | A | A | 0.0000 | |
17 | E | A | -2.9905 | |
18 | R | A | -2.0891 | |
19 | Y | A | -1.8268 | |
20 | D | A | -2.2269 | |
21 | D | A | -1.5656 | |
22 | M | A | 0.0000 | |
23 | A | A | 0.0000 | |
24 | A | A | -0.7228 | |
25 | C | A | -0.9527 | |
26 | M | A | 0.0000 | |
27 | K | A | -1.1417 | |
28 | S | A | -1.2798 | |
29 | V | A | 0.0000 | |
30 | T | A | 0.0000 | |
31 | E | A | -2.6863 | |
32 | Q | A | -2.5712 | |
33 | G | A | -1.9179 | |
34 | A | A | -1.3530 | |
35 | E | A | -1.5908 | |
36 | L | A | -1.2760 | |
37 | S | A | -1.4765 | |
38 | N | A | -2.3869 | |
39 | E | A | -2.6202 | |
40 | E | A | 0.0000 | |
41 | R | A | 0.0000 | |
42 | N | A | -1.6311 | |
43 | L | A | -1.2044 | |
44 | L | A | 0.0000 | |
45 | S | A | -0.4645 | |
46 | V | A | -0.1271 | |
47 | A | A | 0.0000 | |
48 | Y | A | 0.0000 | |
49 | K | A | -0.8964 | |
50 | N | A | -1.5589 | |
51 | V | A | -0.7715 | |
52 | V | A | 0.0000 | |
53 | G | A | -1.0216 | |
54 | A | A | -0.9965 | |
55 | R | A | -1.3352 | |
56 | R | A | -1.0920 | |
57 | S | A | -1.2058 | |
58 | S | A | 0.0000 | |
59 | W | A | -1.3146 | |
60 | R | A | -1.5133 | |
61 | V | A | -0.7860 | |
62 | V | A | 0.0000 | |
63 | S | A | -1.4453 | |
64 | S | A | -1.0845 | |
65 | I | A | -1.5766 | |
66 | E | A | 0.0000 | |
67 | Q | A | -2.7717 | |
68 | K | A | -2.9349 | |
69 | T | A | -3.0568 | |
70 | E | A | -3.6928 | |
71 | G | A | -2.5455 | |
72 | A | A | -2.7410 | |
73 | E | A | -3.5939 | |
74 | K | A | -3.4377 | |
75 | K | A | -3.1250 | |
76 | Q | A | -3.7213 | |
77 | Q | A | -3.5644 | |
78 | M | A | -2.5943 | |
79 | A | A | 0.0000 | |
80 | R | A | -3.7065 | |
81 | E | A | -3.9342 | |
82 | Y | A | 0.0000 | |
83 | R | A | -2.9410 | |
84 | E | A | -3.6711 | |
85 | K | A | -3.1335 | |
86 | I | A | 0.0000 | |
87 | E | A | 0.0000 | |
88 | T | A | -1.8828 | |
89 | E | A | -1.8172 | |
90 | L | A | 0.0000 | |
91 | R | A | -2.0338 | |
92 | D | A | -2.6924 | |
93 | I | A | -1.5761 | |
94 | C | A | 0.0000 | |
95 | N | A | -2.1993 | |
96 | D | A | -1.6060 | |
97 | V | A | 0.0000 | |
98 | L | A | 0.0000 | |
99 | S | A | -1.7691 | |
100 | L | A | 0.0000 | |
101 | L | A | 0.0000 | |
102 | E | A | -2.7109 | |
103 | K | A | -2.8281 | |
104 | F | A | -1.9777 | |
105 | L | A | 0.0000 | |
106 | I | A | -1.1302 | |
107 | P | A | -1.3128 | |
108 | N | A | -1.6397 | |
109 | A | A | -1.1908 | |
110 | S | A | -1.3484 | |
111 | Q | A | -1.7504 | |
112 | A | A | -1.6425 | |
113 | E | A | -1.4970 | |
114 | S | A | 0.0000 | |
115 | K | A | -1.4374 | |
116 | V | A | 0.0000 | |
117 | F | A | -0.2770 | |
118 | Y | A | 0.0000 | |
119 | L | A | 0.0000 | |
120 | K | A | -0.7747 | |
121 | M | A | 0.0000 | |
122 | K | A | -0.9150 | |
123 | G | A | 0.0000 | |
124 | D | A | 0.0000 | |
125 | Y | A | 0.0000 | |
126 | Y | A | -0.4743 | |
127 | R | A | 0.0000 | |
128 | Y | A | 0.0000 | |
129 | L | A | 0.0000 | |
130 | A | A | 0.0000 | |
131 | E | A | -0.6316 | |
132 | V | A | 0.0000 | |
133 | A | A | -0.6213 | |
139 | K | A | -1.8559 | |
140 | G | A | -1.4758 | |
141 | I | A | -0.9509 | |
142 | V | A | -1.0532 | |
143 | D | A | -2.1140 | |
144 | Q | A | -2.0515 | |
145 | S | A | 0.0000 | |
146 | Q | A | -1.9393 | |
147 | Q | A | -2.7669 | |
148 | A | A | 0.0000 | |
149 | Y | A | 0.0000 | |
150 | Q | A | -2.5504 | |
151 | E | A | -2.9887 | |
152 | A | A | 0.0000 | |
153 | F | A | -2.1649 | |
154 | E | A | -3.3294 | |
155 | I | A | -2.7574 | |
156 | S | A | 0.0000 | |
157 | K | A | -3.6826 | |
158 | K | A | -3.8592 | |
159 | E | A | -3.6338 | |
160 | M | A | 0.0000 | |
161 | Q | A | -2.4100 | |
162 | P | A | 0.0000 | |
163 | T | A | 0.0000 | |
164 | H | A | -0.8051 | |
165 | P | A | -0.6416 | |
166 | I | A | -0.3492 | |
167 | R | A | -0.8667 | |
168 | L | A | 0.0000 | |
169 | G | A | 0.0000 | |
170 | L | A | 0.0000 | |
171 | A | A | 0.0000 | |
172 | L | A | 0.0000 | |
173 | N | A | 0.0000 | |
174 | F | A | 0.0000 | |
175 | S | A | 0.0000 | |
176 | V | A | 0.0000 | |
177 | F | A | 0.0000 | |
178 | Y | A | -0.7061 | |
179 | Y | A | -0.9683 | |
180 | E | A | -0.8830 | |
181 | I | A | -0.4745 | |
182 | L | A | -0.4620 | |
183 | N | A | -1.5546 | |
184 | S | A | -1.5737 | |
185 | P | A | -1.6902 | |
186 | E | A | -2.7490 | |
187 | K | A | -2.5844 | |
188 | A | A | 0.0000 | |
189 | C | A | -1.6558 | |
190 | S | A | -1.6577 | |
191 | L | A | -1.2268 | |
192 | A | A | 0.0000 | |
193 | K | A | -2.6084 | |
194 | T | A | -1.5446 | |
195 | A | A | -1.2337 | |
196 | F | A | -1.6455 | |
197 | D | A | -2.4750 | |
198 | E | A | -1.8213 | |
199 | A | A | 0.0000 | |
200 | I | A | 0.0395 | |
201 | A | A | -0.5671 | |
202 | E | A | -1.2195 | |
203 | L | A | -0.1378 | |
204 | D | A | -1.4875 | |
205 | T | A | -0.8823 | |
206 | L | A | -1.4005 | |
207 | S | A | -1.8248 | |
208 | E | A | -3.0795 | |
209 | E | A | -3.1886 | |
210 | S | A | -2.2783 | |
211 | Y | A | -1.6466 | |
212 | K | A | -2.5569 | |
213 | D | A | -2.4326 | |
214 | S | A | 0.0000 | |
215 | T | A | -0.2621 | |
216 | L | A | 0.1479 | |
217 | I | A | 0.0000 | |
218 | M | A | 0.0000 | |
219 | Q | A | -1.3542 | |
220 | L | A | -0.9670 | |
221 | L | A | 0.0000 | |
222 | R | A | -2.8211 | |
223 | D | A | -1.5895 | |
224 | N | A | 0.0000 | |
225 | L | A | 0.0000 | |
226 | T | A | -0.3623 | |
227 | L | A | 0.2525 | |
228 | W | A | -0.0958 | |
229 | T | A | 0.1300 | |
230 | S | A | 0.0538 | |
1 | M | B | -0.1567 | |
2 | D | B | -1.9030 | |
3 | K | B | -2.1921 | |
4 | N | B | -2.1639 | |
5 | E | B | -1.9095 | |
6 | L | B | -1.2719 | |
7 | V | B | -1.5272 | |
8 | Q | B | -1.8697 | |
9 | K | B | -1.7629 | |
10 | A | B | 0.0000 | |
11 | K | B | -2.4969 | |
12 | L | B | 0.0000 | |
13 | A | B | 0.0000 | |
14 | E | B | -2.7990 | |
15 | Q | B | -2.4138 | |
16 | A | B | 0.0000 | |
17 | E | B | -2.9782 | |
18 | R | B | -2.3104 | |
19 | Y | B | -1.9782 | |
20 | D | B | -2.2873 | |
21 | D | B | -1.6770 | |
22 | M | B | 0.0000 | |
23 | A | B | 0.0000 | |
24 | A | B | -0.7241 | |
25 | C | B | 0.0000 | |
26 | M | B | 0.0000 | |
27 | K | B | -1.1876 | |
28 | S | B | -1.3136 | |
29 | V | B | 0.0000 | |
30 | T | B | 0.0000 | |
31 | E | B | -2.6956 | |
32 | Q | B | -2.5816 | |
33 | G | B | -1.9753 | |
34 | A | B | -1.4538 | |
35 | E | B | -1.7857 | |
36 | L | B | 0.0000 | |
37 | S | B | -1.6843 | |
38 | N | B | -2.6120 | |
39 | E | B | -2.7584 | |
40 | E | B | 0.0000 | |
41 | R | B | 0.0000 | |
42 | N | B | -1.6903 | |
43 | L | B | 0.0000 | |
44 | L | B | 0.0000 | |
45 | S | B | -0.7463 | |
46 | V | B | -0.3986 | |
47 | A | B | 0.0000 | |
48 | Y | B | 0.0000 | |
49 | K | B | -1.6127 | |
50 | N | B | -1.5931 | |
51 | V | B | 0.0000 | |
52 | V | B | 0.0000 | |
53 | G | B | -1.0156 | |
54 | A | B | -1.1184 | |
55 | R | B | -1.2763 | |
56 | R | B | -1.2166 | |
57 | S | B | -1.2596 | |
58 | S | B | 0.0000 | |
59 | W | B | -1.4518 | |
60 | R | B | -1.7943 | |
61 | V | B | -1.0836 | |
62 | V | B | 0.0000 | |
63 | S | B | -1.4209 | |
64 | S | B | -1.1276 | |
65 | I | B | -1.5383 | |
66 | E | B | 0.0000 | |
67 | Q | B | -2.6263 | |
68 | K | B | -2.9032 | |
69 | T | B | -3.0950 | |
70 | E | B | -3.6730 | |
71 | G | B | -2.5848 | |
72 | A | B | -2.8799 | |
73 | E | B | -3.7485 | |
74 | K | B | -3.7813 | |
75 | K | B | -3.5355 | |
76 | Q | B | 0.0000 | |
77 | Q | B | -3.6115 | |
78 | M | B | 0.0000 | |
79 | A | B | 0.0000 | |
80 | R | B | -3.4912 | |
81 | E | B | -3.7798 | |
82 | Y | B | 0.0000 | |
83 | R | B | -2.9482 | |
84 | E | B | -3.5781 | |
85 | K | B | -2.8419 | |
86 | I | B | 0.0000 | |
87 | E | B | -2.1690 | |
88 | T | B | -1.9329 | |
89 | E | B | -2.0446 | |
90 | L | B | 0.0000 | |
91 | R | B | -2.0838 | |
92 | D | B | -2.8443 | |
93 | I | B | 0.0000 | |
94 | C | B | 0.0000 | |
95 | N | B | -2.2909 | |
96 | D | B | -1.7048 | |
97 | V | B | 0.0000 | |
98 | L | B | 0.0000 | |
99 | S | B | -1.6913 | |
100 | L | B | 0.0000 | |
101 | L | B | 0.0000 | |
102 | E | B | -2.7323 | |
103 | K | B | -2.8574 | |
104 | F | B | -2.0857 | |
105 | L | B | 0.0000 | |
106 | I | B | -1.2451 | |
107 | P | B | -1.4765 | |
108 | N | B | -1.7896 | |
109 | A | B | -1.2147 | |
110 | S | B | -1.3368 | |
111 | Q | B | -1.6568 | |
112 | A | B | -1.4845 | |
113 | E | B | -1.3742 | |
114 | S | B | -1.2041 | |
115 | K | B | -1.1165 | |
116 | V | B | 0.0000 | |
117 | F | B | -0.2419 | |
118 | Y | B | 0.0000 | |
119 | L | B | 0.0000 | |
120 | K | B | -0.7657 | |
121 | M | B | 0.0000 | |
122 | K | B | -0.8499 | |
123 | G | B | 0.0000 | |
124 | D | B | 0.0000 | |
125 | Y | B | 0.0000 | |
126 | Y | B | -0.2889 | |
127 | R | B | 0.0000 | |
128 | Y | B | 0.0780 | |
129 | L | B | -0.2468 | |
130 | A | B | -0.6047 | |
131 | E | B | -0.7690 | |
132 | V | B | 0.0000 | |
133 | A | B | -0.5534 | |
139 | K | B | -1.8753 | |
140 | G | B | -1.5557 | |
141 | I | B | -0.9683 | |
142 | V | B | -1.1523 | |
143 | D | B | -2.3989 | |
144 | Q | B | -2.1154 | |
145 | S | B | 0.0000 | |
146 | Q | B | -1.9070 | |
147 | Q | B | -2.7829 | |
148 | A | B | 0.0000 | |
149 | Y | B | 0.0000 | |
150 | Q | B | -2.4400 | |
151 | E | B | -2.9604 | |
152 | A | B | 0.0000 | |
153 | F | B | -2.1584 | |
154 | E | B | -3.5044 | |
155 | I | B | -2.7124 | |
156 | S | B | 0.0000 | |
157 | K | B | -3.7039 | |
158 | K | B | -3.8926 | |
159 | E | B | -3.6577 | |
160 | M | B | 0.0000 | |
161 | Q | B | -2.5178 | |
162 | P | B | -1.7915 | |
163 | T | B | 0.0000 | |
164 | H | B | -0.9077 | |
165 | P | B | -0.6027 | |
166 | I | B | -0.3593 | |
167 | R | B | -0.8486 | |
168 | L | B | 0.0000 | |
169 | G | B | -0.0255 | |
170 | L | B | 0.0000 | |
171 | A | B | 0.0000 | |
172 | L | B | -0.0892 | |
173 | N | B | -0.0566 | |
174 | F | B | 0.0000 | |
175 | S | B | 0.0000 | |
176 | V | B | -0.3746 | |
177 | F | B | 0.0000 | |
178 | Y | B | -0.8863 | |
179 | Y | B | -1.2775 | |
180 | E | B | -1.7108 | |
181 | I | B | -0.9286 | |
182 | L | B | -0.7512 | |
183 | N | B | -1.8340 | |
184 | S | B | 0.0000 | |
185 | P | B | -1.7784 | |
186 | E | B | -2.7324 | |
187 | K | B | -2.5510 | |
188 | A | B | 0.0000 | |
189 | C | B | -1.6439 | |
190 | S | B | -1.6443 | |
191 | L | B | -0.9858 | |
192 | A | B | 0.0000 | |
193 | K | B | -2.5430 | |
194 | T | B | -1.5626 | |
195 | A | B | -1.4572 | |
196 | F | B | -1.6959 | |
197 | D | B | -2.6590 | |
198 | E | B | -2.1803 | |
199 | A | B | 0.0000 | |
200 | I | B | -0.1562 | |
201 | A | B | -0.7892 | |
202 | E | B | -1.5205 | |
203 | L | B | -0.0343 | |
204 | D | B | -1.3917 | |
205 | T | B | -1.0469 | |
206 | L | B | -1.3189 | |
207 | S | B | -1.6089 | |
208 | E | B | -2.8988 | |
209 | E | B | -3.0536 | |
210 | S | B | -2.0765 | |
211 | Y | B | -1.5018 | |
212 | K | B | -2.4237 | |
213 | D | B | -2.3355 | |
214 | S | B | 0.0000 | |
215 | T | B | -0.1935 | |
216 | L | B | 0.1680 | |
217 | I | B | -0.3241 | |
218 | M | B | 0.0000 | |
219 | Q | B | -1.5020 | |
220 | L | B | -0.8260 | |
221 | L | B | 0.0000 | |
222 | R | B | -3.1479 | |
223 | D | B | -2.4493 | |
224 | N | B | -1.2362 | |
225 | L | B | 0.0000 | |
226 | T | B | -0.4794 | |
227 | L | B | 0.6831 | |
228 | W | B | 0.1441 | |
229 | T | B | 0.2019 | |
230 | S | B | 0.3557 | |
7 | A | C | -0.1729 | |
8 | R | C | -0.6440 | |
9 | K | C | -1.4536 | |
11 | T | C | -0.5991 | |
12 | G | C | -0.9820 | |
13 | G | C | -1.7593 | |
14 | K | C | -2.1704 |