Project name: 10%_arg_2osl
Status: done
submitted: 2018-08-15 09:45:35, status changed: 2018-08-15 09:59:31
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.7843
-
Maximal score value
-
1.6861
-
Average score
-
-0.6246
-
Total score value
-
-271.6847
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-1.1188 |
|
2 |
I |
A |
0.0000 |
|
3 |
V |
A |
0.9791 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.6849 |
|
6 |
Q |
A |
-0.7425 |
|
7 |
S |
A |
-0.3644 |
|
8 |
P |
A |
0.2209 |
|
9 |
A |
A |
0.4540 |
|
10 |
I |
A |
1.4225 |
|
11 |
L |
A |
0.7419 |
|
12 |
S |
A |
-0.2529 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-1.9285 |
|
15 |
P |
A |
-1.9693 |
|
16 |
G |
A |
-2.2540 |
|
17 |
E |
A |
-2.8671 |
|
18 |
K |
A |
-2.8284 |
|
19 |
V |
A |
-1.1887 |
|
20 |
T |
A |
-0.3212 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.6999 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.8701 |
|
25 |
A |
A |
0.0000 |
|
26 |
S |
A |
-0.4335 |
|
27 |
S |
A |
-0.5587 |
|
28 |
S |
A |
-0.7038 |
|
29 |
V |
A |
0.0000 |
|
30 |
S |
A |
-0.2205 |
|
31 |
Y |
A |
0.1463 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.6723 |
|
38 |
K |
A |
0.0000 |
|
39 |
P |
A |
-0.8460 |
|
40 |
G |
A |
-0.5861 |
|
41 |
S |
A |
-0.5880 |
|
42 |
S |
A |
-0.4517 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-1.2800 |
|
45 |
P |
A |
-0.5978 |
|
46 |
W |
A |
-0.3721 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-0.0992 |
|
49 |
A |
A |
-0.0704 |
|
50 |
T |
A |
-0.2862 |
|
51 |
S |
A |
-0.6306 |
|
52 |
N |
A |
-1.0024 |
|
53 |
L |
A |
0.0660 |
|
54 |
A |
A |
0.0000 |
|
55 |
S |
A |
-0.5897 |
|
56 |
G |
A |
-0.2248 |
|
57 |
V |
A |
0.2225 |
|
58 |
P |
A |
0.7087 |
|
59 |
V |
A |
1.4062 |
|
60 |
R |
A |
-0.3144 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.0399 |
|
63 |
G |
A |
0.0000 |
|
64 |
S |
A |
-0.6320 |
|
65 |
G |
A |
-0.8509 |
|
66 |
S |
A |
-0.7359 |
|
67 |
G |
A |
-0.7066 |
|
68 |
T |
A |
-1.0047 |
|
69 |
S |
A |
-1.1629 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.6440 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.7108 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-1.9471 |
|
76 |
R |
A |
-3.0348 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-2.5126 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.5427 |
|
81 |
D |
A |
0.0000 |
|
82 |
A |
A |
-1.7359 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.2252 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
-0.2255 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
0.0000 |
|
91 |
T |
A |
-0.3740 |
|
92 |
S |
A |
-1.0401 |
|
93 |
N |
A |
-1.7030 |
|
94 |
P |
A |
-1.4609 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
0.0000 |
|
97 |
F |
A |
0.3096 |
|
98 |
G |
A |
0.0000 |
|
99 |
G |
A |
-0.6566 |
|
100 |
G |
A |
0.0000 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
-0.2328 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
-1.1768 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-1.8029 |
|
107 |
R |
A |
-1.2158 |
|
108 |
T |
A |
-0.2840 |
|
109 |
V |
A |
0.1806 |
|
110 |
A |
A |
-0.0356 |
|
111 |
A |
A |
-0.1607 |
|
112 |
P |
A |
0.0000 |
|
113 |
S |
A |
-0.1447 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
0.0258 |
|
116 |
I |
A |
0.0000 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.5977 |
|
119 |
P |
A |
0.0000 |
|
120 |
S |
A |
-1.6584 |
|
121 |
D |
A |
-2.7690 |
|
122 |
E |
A |
-2.7641 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
-1.5562 |
|
125 |
K |
A |
-1.8883 |
|
126 |
S |
A |
-1.2676 |
|
127 |
G |
A |
-0.9213 |
|
128 |
T |
A |
-0.8638 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
0.0000 |
|
137 |
N |
A |
-0.5795 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
-0.9401 |
|
140 |
P |
A |
-1.3844 |
|
141 |
R |
A |
-2.1703 |
|
142 |
E |
A |
-2.9009 |
|
143 |
A |
A |
-2.2324 |
|
144 |
K |
A |
-2.3609 |
|
145 |
V |
A |
-1.2977 |
|
146 |
Q |
A |
-0.6754 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.5916 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-1.8446 |
|
151 |
N |
A |
-1.5233 |
|
152 |
A |
A |
-0.2908 |
|
153 |
L |
A |
0.5955 |
|
154 |
Q |
A |
-0.1208 |
|
155 |
S |
A |
-0.5288 |
|
156 |
G |
A |
-0.9797 |
|
157 |
N |
A |
-0.8587 |
|
158 |
S |
A |
-0.8930 |
|
159 |
Q |
A |
-1.6866 |
|
160 |
E |
A |
-1.4666 |
|
161 |
S |
A |
-0.6737 |
|
162 |
V |
A |
-0.6445 |
|
163 |
T |
A |
-1.0189 |
|
164 |
E |
A |
-2.1248 |
|
165 |
Q |
A |
-2.0435 |
|
166 |
D |
A |
-2.2600 |
|
167 |
S |
A |
-2.4971 |
|
168 |
K |
A |
-2.7939 |
|
169 |
D |
A |
-2.0009 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.0836 |
|
178 |
L |
A |
0.7817 |
|
179 |
T |
A |
0.1362 |
|
180 |
L |
A |
-0.1909 |
|
181 |
S |
A |
-1.1589 |
|
182 |
K |
A |
-2.1488 |
|
183 |
A |
A |
-1.8678 |
|
184 |
D |
A |
-2.5634 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-3.7843 |
|
187 |
K |
A |
-3.6730 |
|
188 |
H |
A |
-3.0383 |
|
189 |
K |
A |
-3.5536 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-0.6248 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.2701 |
|
197 |
H |
A |
0.0000 |
|
198 |
Q |
A |
-1.5922 |
|
199 |
G |
A |
-0.5448 |
|
200 |
L |
A |
-0.3273 |
|
201 |
S |
A |
-0.5035 |
|
202 |
S |
A |
-0.4845 |
|
203 |
P |
A |
-0.5943 |
|
204 |
V |
A |
-0.0367 |
|
205 |
T |
A |
-0.3383 |
|
206 |
K |
A |
-0.4766 |
|
207 |
S |
A |
-0.7197 |
|
208 |
F |
A |
0.0000 |
|
209 |
N |
A |
-2.5094 |
|
210 |
R |
A |
-2.9821 |
|
211 |
G |
A |
-2.5291 |
|
212 |
E |
A |
-2.7014 |
|
1 |
Q |
A |
-1.0268 |
|
2 |
V |
A |
-0.0384 |
|
3 |
Q |
A |
-0.8523 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.7820 |
|
6 |
Q |
A |
-1.1156 |
|
7 |
P |
A |
-0.8317 |
|
8 |
G |
A |
-0.9590 |
|
9 |
A |
A |
-0.7106 |
|
10 |
E |
A |
-0.5224 |
|
11 |
L |
A |
-0.0992 |
|
12 |
V |
A |
0.0000 |
|
13 |
K |
A |
-1.7108 |
|
14 |
P |
A |
-1.1386 |
|
15 |
G |
A |
-1.0544 |
|
16 |
A |
A |
-0.8756 |
|
17 |
S |
A |
-0.9001 |
|
18 |
V |
A |
-0.8386 |
|
19 |
K |
A |
-1.2678 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.7183 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.5219 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.8614 |
|
26 |
G |
A |
-0.6043 |
|
27 |
Y |
A |
-0.1218 |
|
28 |
T |
A |
-0.1905 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.6979 |
|
31 |
S |
A |
-0.1489 |
|
32 |
Y |
A |
0.4312 |
|
33 |
N |
A |
-0.0909 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
0.0000 |
|
39 |
Q |
A |
-0.5426 |
|
40 |
T |
A |
0.0000 |
|
41 |
P |
A |
-0.9480 |
|
42 |
G |
A |
-1.5857 |
|
43 |
R |
A |
-2.5181 |
|
44 |
G |
A |
-1.3560 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-0.8189 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.7897 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.3644 |
|
55 |
N |
A |
-2.0979 |
|
56 |
G |
A |
-2.0020 |
|
57 |
D |
A |
-2.4243 |
|
58 |
T |
A |
-1.1316 |
|
59 |
S |
A |
-0.9000 |
|
60 |
Y |
A |
-0.9617 |
|
61 |
N |
A |
0.0000 |
|
62 |
Q |
A |
-2.7906 |
|
63 |
K |
A |
-2.8912 |
|
64 |
F |
A |
0.0000 |
|
65 |
K |
A |
-2.8503 |
|
66 |
G |
A |
-2.0119 |
|
67 |
K |
A |
-1.6495 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.7808 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.4839 |
|
72 |
A |
A |
-1.0882 |
|
73 |
D |
A |
-1.8674 |
|
74 |
K |
A |
-2.3072 |
|
75 |
S |
A |
-1.3891 |
|
76 |
S |
A |
-1.2384 |
|
77 |
S |
A |
-1.3594 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.4138 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.0541 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-0.7931 |
|
85 |
S |
A |
-0.8365 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.1219 |
|
88 |
S |
A |
-1.0979 |
|
89 |
E |
A |
-2.1256 |
|
90 |
D |
A |
0.0000 |
|
91 |
S |
A |
-0.5456 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.2734 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.0000 |
|
101 |
Y |
A |
1.6861 |
|
102 |
Y |
A |
1.5819 |
|
103 |
G |
A |
0.3678 |
|
104 |
G |
A |
0.0751 |
|
105 |
D |
A |
0.4045 |
|
106 |
W |
A |
0.7834 |
|
107 |
Y |
A |
0.0000 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.3132 |
|
110 |
V |
A |
-0.0728 |
|
111 |
W |
A |
-0.3010 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.4245 |
|
114 |
G |
A |
-0.2972 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.1839 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.4160 |
|
119 |
V |
A |
-0.6087 |
|
120 |
S |
A |
-0.4813 |
|
121 |
A |
A |
-0.5441 |
|
122 |
A |
A |
-0.3566 |
|
123 |
S |
A |
-0.5420 |
|
124 |
T |
A |
-0.5361 |
|
125 |
K |
A |
-0.9909 |
|
126 |
G |
A |
-1.1971 |
|
127 |
P |
A |
-0.4765 |
|
128 |
S |
A |
-0.4373 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
0.0000 |
|
131 |
P |
A |
-1.0322 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-1.1696 |
|
134 |
P |
A |
0.0000 |
|
135 |
S |
A |
-1.3219 |
|
136 |
S |
A |
-1.2388 |
|
137 |
K |
A |
-1.2533 |
|
138 |
S |
A |
-0.7787 |
|
139 |
T |
A |
-0.7464 |
|
140 |
S |
A |
-0.8170 |
|
141 |
G |
A |
-1.0565 |
|
142 |
G |
A |
-0.9036 |
|
143 |
T |
A |
-0.6568 |
|
144 |
A |
A |
-0.4483 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
0.0000 |
|
152 |
D |
A |
-0.4460 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
-0.1751 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-0.7673 |
|
157 |
P |
A |
-0.8304 |
|
158 |
V |
A |
-0.5738 |
|
159 |
T |
A |
-0.4496 |
|
160 |
V |
A |
-0.0443 |
|
161 |
S |
A |
-0.2818 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.8041 |
|
164 |
S |
A |
-0.6452 |
|
165 |
G |
A |
-0.3991 |
|
166 |
A |
A |
-0.1983 |
|
167 |
L |
A |
0.0563 |
|
168 |
T |
A |
-0.1465 |
|
169 |
S |
A |
-0.1954 |
|
170 |
G |
A |
-0.2644 |
|
171 |
V |
A |
0.1561 |
|
172 |
H |
A |
-0.1285 |
|
173 |
T |
A |
0.0366 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.3204 |
|
176 |
A |
A |
0.4825 |
|
177 |
V |
A |
0.8245 |
|
178 |
L |
A |
1.5511 |
|
179 |
Q |
A |
0.0995 |
|
180 |
S |
A |
-0.1348 |
|
181 |
S |
A |
-0.2888 |
|
182 |
G |
A |
0.0253 |
|
183 |
L |
A |
0.1779 |
|
184 |
Y |
A |
0.4938 |
|
185 |
S |
A |
0.4281 |
|
186 |
L |
A |
0.4143 |
|
187 |
S |
A |
0.0000 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1693 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.5317 |
|
194 |
S |
A |
-0.6117 |
|
195 |
S |
A |
-0.6465 |
|
196 |
S |
A |
-0.6247 |
|
197 |
L |
A |
-0.7178 |
|
198 |
G |
A |
-0.7689 |
|
199 |
T |
A |
-0.8374 |
|
200 |
Q |
A |
-1.2720 |
|
201 |
T |
A |
-1.1135 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-0.9246 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.3296 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
0.0000 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.6496 |
|
210 |
P |
A |
-1.4887 |
|
211 |
S |
A |
-1.7050 |
|
212 |
N |
A |
-2.4583 |
|
213 |
T |
A |
-1.9141 |
|
214 |
K |
A |
-2.5149 |
|
215 |
V |
A |
-1.3962 |
|
216 |
D |
A |
-2.3099 |
|
217 |
K |
A |
-1.8572 |
|
218 |
K |
A |
-1.9404 |
|
219 |
V |
A |
0.0000 |
|
220 |
E |
A |
-2.5724 |
|
221 |
P |
A |
-2.1162 |
|
222 |
K |
A |
-2.4327 |
|
223 |
S |
A |
-1.4296 |
|