Chain sequence(s) |
A: VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR C: VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR B: HLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH D: HLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | V | A | 1.4259 | |
2 | L | A | 0.0000 | |
3 | S | A | 0.0820 | |
4 | P | A | -0.2220 | |
5 | A | A | -0.3831 | |
6 | D | A | 0.0000 | |
7 | K | A | -1.0529 | |
8 | T | A | -0.7967 | |
9 | N | A | -0.8206 | |
10 | V | A | 0.0000 | |
11 | K | A | -1.8764 | |
12 | A | A | -1.4227 | |
13 | A | A | 0.0000 | |
14 | W | A | 0.0000 | |
15 | G | A | -1.8382 | |
16 | K | A | -2.4443 | |
17 | V | A | 0.0000 | |
18 | G | A | -1.3774 | |
19 | A | A | -1.0971 | |
20 | H | A | -1.9604 | |
21 | A | A | -2.1475 | |
22 | G | A | -2.8842 | |
23 | E | A | -2.5775 | |
24 | Y | A | -1.4620 | |
25 | G | A | 0.0000 | |
26 | A | A | 0.0000 | |
27 | E | A | -1.1608 | |
28 | A | A | 0.0000 | |
29 | L | A | 0.0000 | |
30 | E | A | -0.4719 | |
31 | R | A | 0.0000 | |
32 | M | A | 0.0000 | |
33 | F | A | 0.0000 | |
34 | L | A | 0.7715 | |
35 | S | A | 0.4852 | |
36 | F | A | 0.3456 | |
37 | P | A | -0.0353 | |
38 | T | A | -0.1988 | |
39 | T | A | 0.0000 | |
40 | K | A | -0.2274 | |
41 | T | A | 0.0000 | |
42 | Y | A | 0.0601 | |
43 | F | A | -0.4763 | |
44 | P | A | -1.2508 | |
45 | H | A | -1.2799 | |
46 | F | A | -1.1662 | |
47 | D | A | -2.0822 | |
48 | L | A | -1.1841 | |
49 | S | A | -1.1483 | |
50 | H | A | -1.5734 | |
51 | G | A | -1.5263 | |
52 | S | A | -1.4740 | |
53 | A | A | -1.2075 | |
54 | Q | A | -1.7144 | |
55 | V | A | 0.0000 | |
56 | K | A | -2.6208 | |
57 | G | A | -2.1296 | |
58 | H | A | -2.0151 | |
59 | G | A | 0.0000 | |
60 | K | A | -3.8599 | |
61 | K | A | -3.2847 | |
62 | V | A | -1.9744 | |
63 | A | A | 0.0000 | |
64 | D | A | -3.0915 | |
65 | A | A | -1.8105 | |
66 | L | A | 0.0000 | |
67 | T | A | -1.6551 | |
68 | N | A | -1.5788 | |
69 | A | A | 0.0000 | |
70 | V | A | 0.0000 | |
71 | A | A | -1.2019 | |
72 | H | A | -1.9886 | |
73 | V | A | -1.8070 | |
74 | D | A | -2.7537 | |
75 | D | A | -2.8066 | |
76 | M | A | 0.0000 | |
77 | P | A | -1.4995 | |
78 | N | A | -1.9767 | |
79 | A | A | -1.4630 | |
80 | L | A | 0.0000 | |
81 | S | A | -0.8273 | |
82 | A | A | -0.3758 | |
83 | L | A | -0.1233 | |
84 | S | A | 0.0000 | |
85 | D | A | -1.6090 | |
86 | L | A | -0.9450 | |
87 | H | A | -0.8752 | |
88 | A | A | 0.0000 | |
89 | H | A | -2.0339 | |
90 | K | A | -2.0293 | |
91 | L | A | -0.5457 | |
92 | R | A | -0.7517 | |
93 | V | A | 0.0201 | |
94 | D | A | 0.0000 | |
95 | P | A | -0.1791 | |
96 | V | A | -0.0984 | |
97 | N | A | 0.0000 | |
98 | F | A | -0.3623 | |
99 | K | A | -1.4057 | |
100 | L | A | -0.3502 | |
101 | L | A | -0.1078 | |
102 | S | A | -0.4959 | |
103 | H | A | -0.4964 | |
104 | C | A | 0.0000 | |
105 | L | A | 0.0000 | |
106 | L | A | 0.0000 | |
107 | V | A | 0.0000 | |
108 | T | A | 0.0000 | |
109 | L | A | 0.0000 | |
110 | A | A | 0.0000 | |
111 | A | A | -1.1164 | |
112 | H | A | -1.0327 | |
113 | L | A | 0.0000 | |
114 | P | A | -0.6141 | |
115 | A | A | -0.3063 | |
116 | E | A | -0.7139 | |
117 | F | A | 0.0000 | |
118 | T | A | -0.1660 | |
119 | P | A | -0.2745 | |
120 | A | A | -0.2320 | |
121 | V | A | -0.0416 | |
122 | H | A | 0.0000 | |
123 | A | A | -0.1094 | |
124 | S | A | 0.0000 | |
125 | L | A | 0.0000 | |
126 | D | A | -0.4368 | |
127 | K | A | -0.1007 | |
128 | F | A | 0.0000 | |
129 | L | A | 0.0000 | |
130 | A | A | -0.4299 | |
131 | S | A | 0.2085 | |
132 | V | A | 0.0000 | |
133 | S | A | -0.2220 | |
134 | T | A | -0.3098 | |
135 | V | A | -0.2317 | |
136 | L | A | -0.1709 | |
137 | T | A | -0.4501 | |
138 | S | A | -0.5445 | |
139 | K | A | -1.3323 | |
140 | Y | A | 0.0000 | |
141 | R | A | -0.8226 | |
2 | H | B | -1.4998 | |
3 | L | B | -1.5254 | |
4 | T | B | -1.3672 | |
5 | P | B | -1.8310 | |
6 | E | B | -2.5071 | |
7 | E | B | -2.0723 | |
8 | K | B | -2.1656 | |
9 | S | B | -1.5603 | |
10 | A | B | -1.0803 | |
11 | V | B | 0.0000 | |
12 | T | B | -0.7419 | |
13 | A | B | -0.6669 | |
14 | L | B | 0.0000 | |
15 | W | B | -0.8304 | |
16 | G | B | -1.3906 | |
17 | K | B | -2.1187 | |
18 | V | B | 0.0000 | |
19 | N | B | -2.7471 | |
20 | V | B | -2.3151 | |
21 | D | B | -3.5010 | |
22 | E | B | -3.3029 | |
23 | V | B | 0.0000 | |
24 | G | B | 0.0000 | |
25 | G | B | -2.3039 | |
26 | E | B | -1.2994 | |
27 | A | B | 0.0000 | |
28 | L | B | 0.0000 | |
29 | G | B | 0.0000 | |
30 | R | B | 0.0000 | |
31 | L | B | 0.0000 | |
32 | L | B | 0.0000 | |
33 | V | B | -0.1167 | |
34 | V | B | 0.0000 | |
35 | Y | B | 0.0210 | |
36 | P | B | -0.3146 | |
37 | W | B | 0.0000 | |
38 | T | B | 0.0000 | |
39 | Q | B | -0.5409 | |
40 | R | B | -1.0566 | |
41 | F | B | -0.0941 | |
42 | F | B | -0.9018 | |
43 | E | B | -2.0517 | |
44 | S | B | -1.4759 | |
45 | F | B | -1.4312 | |
46 | G | B | -1.9205 | |
47 | D | B | -2.6142 | |
48 | L | B | -1.3827 | |
49 | S | B | -1.0201 | |
50 | T | B | -0.9374 | |
51 | P | B | -0.9742 | |
52 | D | B | -2.0880 | |
53 | A | B | -1.5602 | |
54 | V | B | 0.0000 | |
55 | M | B | -1.3010 | |
56 | G | B | -1.5767 | |
57 | N | B | 0.0000 | |
58 | P | B | -1.7265 | |
59 | K | B | -2.5158 | |
60 | V | B | 0.0000 | |
61 | K | B | -2.7423 | |
62 | A | B | -2.3374 | |
63 | H | B | -1.9014 | |
64 | G | B | 0.0000 | |
65 | K | B | -3.3350 | |
66 | K | B | -2.3890 | |
67 | V | B | -0.9330 | |
68 | L | B | 0.0000 | |
69 | G | B | -1.6706 | |
70 | A | B | -0.9242 | |
71 | F | B | -0.5699 | |
72 | S | B | -0.9159 | |
73 | D | B | -1.8172 | |
74 | G | B | 0.0000 | |
75 | L | B | -0.9942 | |
76 | A | B | -1.0289 | |
77 | H | B | -2.0067 | |
78 | L | B | -1.9137 | |
79 | D | B | -2.8148 | |
80 | N | B | -2.7857 | |
81 | L | B | -1.9291 | |
82 | K | B | -2.6489 | |
83 | G | B | -1.8983 | |
84 | T | B | -1.4283 | |
85 | F | B | 0.0000 | |
86 | A | B | -0.9984 | |
87 | T | B | -0.4950 | |
88 | L | B | 0.0169 | |
89 | S | B | 0.0000 | |
90 | E | B | -1.9335 | |
91 | L | B | -0.7703 | |
92 | H | B | -0.6794 | |
93 | C | B | 0.0000 | |
94 | D | B | -2.2708 | |
95 | K | B | -1.9510 | |
96 | L | B | -0.1843 | |
97 | H | B | -0.6170 | |
98 | V | B | -0.0423 | |
99 | D | B | 0.0000 | |
100 | P | B | 0.0000 | |
101 | E | B | -0.3985 | |
102 | N | B | 0.0000 | |
103 | F | B | -0.2301 | |
104 | R | B | -0.7971 | |
105 | L | B | -0.2078 | |
106 | L | B | -0.0134 | |
107 | G | B | 0.0000 | |
108 | N | B | -0.4567 | |
109 | V | B | 0.0000 | |
110 | L | B | 0.0000 | |
111 | V | B | 0.0000 | |
112 | C | B | 0.0000 | |
113 | V | B | 0.0000 | |
114 | L | B | 0.0000 | |
115 | A | B | 0.0000 | |
116 | H | B | -0.8991 | |
117 | H | B | -1.2919 | |
118 | F | B | -1.4358 | |
119 | G | B | -1.7556 | |
120 | K | B | -2.7264 | |
121 | E | B | -2.6439 | |
122 | F | B | 0.0000 | |
123 | T | B | -1.1201 | |
124 | P | B | 0.0000 | |
125 | P | B | -0.1931 | |
126 | V | B | -0.5136 | |
127 | Q | B | 0.0000 | |
128 | A | B | 0.0000 | |
129 | A | B | 0.0000 | |
130 | Y | B | 0.0000 | |
131 | Q | B | 0.0000 | |
132 | K | B | -0.8522 | |
133 | V | B | 0.0000 | |
134 | V | B | 0.0000 | |
135 | A | B | -0.6088 | |
136 | G | B | -1.1515 | |
137 | V | B | 0.0000 | |
138 | A | B | 0.0000 | |
139 | N | B | -1.3279 | |
140 | A | B | 0.0000 | |
141 | L | B | -0.8236 | |
142 | A | B | -1.3022 | |
143 | H | B | -1.9878 | |
144 | K | B | -1.9898 | |
145 | Y | B | -1.4965 | |
146 | H | B | -1.5480 | |
1 | V | C | 1.3871 | |
2 | L | C | 0.0000 | |
3 | S | C | 0.1139 | |
4 | P | C | -0.4031 | |
5 | A | C | -0.3382 | |
6 | D | C | 0.0000 | |
7 | K | C | -0.9723 | |
8 | T | C | -0.6684 | |
9 | N | C | -0.7354 | |
10 | V | C | 0.0000 | |
11 | K | C | -1.5316 | |
12 | A | C | -1.2264 | |
13 | A | C | 0.0000 | |
14 | W | C | 0.0000 | |
15 | G | C | -1.7582 | |
16 | K | C | -2.4035 | |
17 | V | C | 0.0000 | |
18 | G | C | -1.3935 | |
19 | A | C | -0.9582 | |
20 | H | C | -1.5456 | |
21 | A | C | 0.0000 | |
22 | G | C | -2.2027 | |
23 | E | C | -1.9189 | |
24 | Y | C | 0.0000 | |
25 | G | C | 0.0000 | |
26 | A | C | 0.0000 | |
27 | E | C | -1.0225 | |
28 | A | C | 0.0000 | |
29 | L | C | 0.0000 | |
30 | E | C | -0.6009 | |
31 | R | C | 0.0000 | |
32 | M | C | 0.0000 | |
33 | F | C | 0.0000 | |
34 | L | C | 0.3325 | |
35 | S | C | 0.2366 | |
36 | F | C | 0.2146 | |
37 | P | C | -0.1855 | |
38 | T | C | -0.2554 | |
39 | T | C | 0.0000 | |
40 | K | C | -0.3916 | |
41 | T | C | 0.0000 | |
42 | Y | C | 0.0973 | |
43 | F | C | -0.3116 | |
44 | P | C | -0.9512 | |
45 | H | C | -1.1795 | |
46 | F | C | -1.0048 | |
47 | D | C | -2.0006 | |
48 | L | C | -1.2801 | |
49 | S | C | -1.2418 | |
50 | H | C | -1.7205 | |
51 | G | C | -1.7103 | |
52 | S | C | -1.4471 | |
53 | A | C | -1.2381 | |
54 | Q | C | -1.6968 | |
55 | V | C | 0.0000 | |
56 | K | C | -2.6128 | |
57 | G | C | -1.9905 | |
58 | H | C | -1.8555 | |
59 | G | C | 0.0000 | |
60 | K | C | -2.9639 | |
61 | K | C | -2.7234 | |
62 | V | C | -1.4440 | |
63 | A | C | 0.0000 | |
64 | D | C | -1.8431 | |
65 | A | C | -1.0407 | |
66 | L | C | 0.0000 | |
67 | T | C | -1.0659 | |
68 | N | C | -0.8354 | |
69 | A | C | 0.0000 | |
70 | V | C | 0.0000 | |
71 | A | C | -1.1588 | |
72 | H | C | -2.0380 | |
73 | V | C | 0.0000 | |
74 | D | C | -2.8335 | |
75 | D | C | -2.6986 | |
76 | M | C | 0.0000 | |
77 | P | C | -1.5214 | |
78 | N | C | -2.0168 | |
79 | A | C | -1.4085 | |
80 | L | C | 0.0000 | |
81 | S | C | -0.6944 | |
82 | A | C | -0.1834 | |
83 | L | C | 0.1306 | |
84 | S | C | 0.0000 | |
85 | D | C | -1.2327 | |
86 | L | C | -0.4327 | |
87 | H | C | -0.6029 | |
88 | A | C | 0.0000 | |
89 | H | C | -1.8363 | |
90 | K | C | -1.8796 | |
91 | L | C | -0.4273 | |
92 | R | C | -0.6864 | |
93 | V | C | 0.0734 | |
94 | D | C | 0.0000 | |
95 | P | C | 0.0665 | |
96 | V | C | 0.3879 | |
97 | N | C | 0.0000 | |
98 | F | C | -0.1822 | |
99 | K | C | -1.2245 | |
100 | L | C | -0.1504 | |
101 | L | C | 0.0168 | |
102 | S | C | -0.4603 | |
103 | H | C | -0.4516 | |
104 | C | C | 0.0000 | |
105 | L | C | 0.0000 | |
106 | L | C | 0.0000 | |
107 | V | C | 0.0000 | |
108 | T | C | 0.0000 | |
109 | L | C | 0.0000 | |
110 | A | C | 0.0000 | |
111 | A | C | -1.0745 | |
112 | H | C | -0.9821 | |
113 | L | C | 0.0000 | |
114 | P | C | -0.6288 | |
115 | A | C | -0.3688 | |
116 | E | C | -0.8369 | |
117 | F | C | 0.0000 | |
118 | T | C | -0.3933 | |
119 | P | C | -0.3241 | |
120 | A | C | -0.2655 | |
121 | V | C | -0.0645 | |
122 | H | C | 0.0000 | |
123 | A | C | -0.1444 | |
124 | S | C | 0.0000 | |
125 | L | C | 0.0000 | |
126 | D | C | -0.4580 | |
127 | K | C | -0.1063 | |
128 | F | C | 0.0000 | |
129 | L | C | 0.0000 | |
130 | A | C | -0.2889 | |
131 | S | C | 0.1676 | |
132 | V | C | 0.0000 | |
133 | S | C | -0.2130 | |
134 | T | C | -0.3548 | |
135 | V | C | 0.0000 | |
136 | L | C | -0.1083 | |
137 | T | C | -0.3049 | |
138 | S | C | -0.4454 | |
139 | K | C | -0.9791 | |
140 | Y | C | 0.0000 | |
141 | R | C | -0.6911 | |
2 | H | D | -1.4242 | |
3 | L | D | -1.3409 | |
4 | T | D | -1.1832 | |
5 | P | D | -1.5628 | |
6 | E | D | -2.3225 | |
7 | E | D | -1.7437 | |
8 | K | D | -1.5064 | |
9 | S | D | -1.2565 | |
10 | A | D | -0.8646 | |
11 | V | D | 0.0000 | |
12 | T | D | -0.7463 | |
13 | A | D | -0.5802 | |
14 | L | D | 0.0000 | |
15 | W | D | -0.7550 | |
16 | G | D | -1.3249 | |
17 | K | D | -1.9978 | |
18 | V | D | -1.8237 | |
19 | N | D | -2.6558 | |
20 | V | D | -2.4026 | |
21 | D | D | -3.8214 | |
22 | E | D | -3.4441 | |
23 | V | D | 0.0000 | |
24 | G | D | 0.0000 | |
25 | G | D | 0.0000 | |
26 | E | D | -1.5003 | |
27 | A | D | 0.0000 | |
28 | L | D | 0.0000 | |
29 | G | D | 0.0000 | |
30 | R | D | 0.0000 | |
31 | L | D | 0.0000 | |
32 | L | D | 0.0000 | |
33 | V | D | -0.1685 | |
34 | V | D | 0.0000 | |
35 | Y | D | 0.0000 | |
36 | P | D | -0.3755 | |
37 | W | D | 0.0000 | |
38 | T | D | 0.0000 | |
39 | Q | D | -0.7558 | |
40 | R | D | -0.9766 | |
41 | F | D | -0.0651 | |
42 | F | D | -1.0617 | |
43 | E | D | -2.0619 | |
44 | S | D | -1.4123 | |
45 | F | D | -1.4275 | |
46 | G | D | -1.9199 | |
47 | D | D | -2.6155 | |
48 | L | D | -1.4138 | |
49 | S | D | -1.0306 | |
50 | T | D | -1.0130 | |
51 | P | D | -0.9896 | |
52 | D | D | -2.1107 | |
53 | A | D | -1.5736 | |
54 | V | D | 0.0000 | |
55 | M | D | -1.1074 | |
56 | G | D | -1.5647 | |
57 | N | D | 0.0000 | |
58 | P | D | -1.5672 | |
59 | K | D | -2.2821 | |
60 | V | D | 0.0000 | |
61 | K | D | -2.6440 | |
62 | A | D | -2.3351 | |
63 | H | D | -1.9425 | |
64 | G | D | 0.0000 | |
65 | K | D | -3.5635 | |
66 | K | D | -2.5040 | |
67 | V | D | -0.9035 | |
68 | L | D | 0.0000 | |
69 | G | D | -1.6530 | |
70 | A | D | -0.9575 | |
71 | F | D | 0.0000 | |
72 | S | D | -0.9352 | |
73 | D | D | -1.8758 | |
74 | G | D | 0.0000 | |
75 | L | D | -0.9894 | |
76 | A | D | -1.0914 | |
77 | H | D | -2.0944 | |
78 | L | D | -1.8991 | |
79 | D | D | -2.8848 | |
80 | N | D | -2.8848 | |
81 | L | D | -2.1395 | |
82 | K | D | -2.9031 | |
83 | G | D | -1.9812 | |
84 | T | D | -1.5089 | |
85 | F | D | 0.0000 | |
86 | A | D | -1.0012 | |
87 | T | D | -0.4139 | |
88 | L | D | -0.1953 | |
89 | S | D | 0.0000 | |
90 | E | D | -1.8504 | |
91 | L | D | -0.8702 | |
92 | H | D | -0.8512 | |
93 | C | D | 0.0000 | |
94 | D | D | -2.8408 | |
95 | K | D | -2.3812 | |
96 | L | D | -0.7550 | |
97 | H | D | -0.8864 | |
98 | V | D | -0.2206 | |
99 | D | D | 0.0000 | |
100 | P | D | 0.0000 | |
101 | E | D | -0.5429 | |
102 | N | D | 0.0000 | |
103 | F | D | -0.1881 | |
104 | R | D | -0.6013 | |
105 | L | D | -0.1190 | |
106 | L | D | 0.0187 | |
107 | G | D | 0.0000 | |
108 | N | D | -0.3455 | |
109 | V | D | 0.0000 | |
110 | L | D | 0.0000 | |
111 | V | D | 0.0000 | |
112 | C | D | 0.0000 | |
113 | V | D | 0.0000 | |
114 | L | D | 0.0000 | |
115 | A | D | 0.0000 | |
116 | H | D | -0.9203 | |
117 | H | D | -1.1913 | |
118 | F | D | -1.4013 | |
119 | G | D | -1.6952 | |
120 | K | D | -2.6224 | |
121 | E | D | -2.4422 | |
122 | F | D | 0.0000 | |
123 | T | D | -1.0481 | |
124 | P | D | -0.4856 | |
125 | P | D | -0.3085 | |
126 | V | D | -0.4680 | |
127 | Q | D | 0.0000 | |
128 | A | D | 0.0000 | |
129 | A | D | 0.0000 | |
130 | Y | D | 0.0000 | |
131 | Q | D | 0.0000 | |
132 | K | D | -0.8802 | |
133 | V | D | 0.0000 | |
134 | V | D | 0.0000 | |
135 | A | D | -0.6649 | |
136 | G | D | -1.3135 | |
137 | V | D | 0.0000 | |
138 | A | D | 0.0000 | |
139 | N | D | -1.8386 | |
140 | A | D | 0.0000 | |
141 | L | D | -0.9787 | |
142 | A | D | -1.4990 | |
143 | H | D | -2.2631 | |
144 | K | D | -2.1406 | |
145 | Y | D | -1.5696 | |
146 | H | D | -1.5628 |