Project name: ARG_5p_6FXN

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1768
• Maximal score value: 2.6111
• Average score: -0.7131
• Total score value: -307.3252

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.4549
3	E	A	-2.2255
4	L	A	0.0000
5	T	A	-1.3628
6	Q	A	-1.4993
7	D	A	-2.2980
8	P	A	-1.6322
9	A	A	0.0000
10	V	A	-0.7001
11	S	A	-0.2948
12	V	A	0.0000
13	A	A	-0.1011
14	L	A	-0.1633
15	G	A	-0.9765
16	Q	A	-1.4635
17	T	A	-1.1837
18	V	A	0.0000
19	R	A	-1.8669
20	V	A	0.0000
21	T	A	-1.1834
22	C	A	0.0000
23	Q	A	-1.9105
24	G	A	0.0000
25	D	A	-2.3199
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.6378
29	S	A	-1.4193
30	Y	A	-0.6545
31	Y	A	-0.6784
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	-0.3373
37	Q	A	0.0000
38	K	A	-1.6761
39	P	A	-1.4868
40	G	A	-1.5029
41	Q	A	-1.8115
42	A	A	-1.0411
43	P	A	0.0000
44	V	A	1.0612
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.1112
49	G	A	0.0000
50	K	A	-2.5817
51	N	A	-2.4181
52	N	A	-2.1561
53	R	A	-1.8638
54	P	A	-0.5761
55	S	A	-0.6380
56	G	A	-0.7982
57	I	A	-0.5801
58	P	A	-1.2702
59	D	A	-2.1667
60	R	A	-1.4103
61	F	A	0.0000
62	S	A	-1.5336
63	G	A	-1.3195
64	S	A	-0.8682
65	S	A	-1.2142
66	S	A	-1.0866
67	G	A	-1.8037
68	N	A	-2.0185
69	T	A	-1.3770
70	A	A	0.0000
71	S	A	0.0000
72	L	A	0.0000
73	T	A	-0.9531
74	I	A	0.0000
75	T	A	-1.2646
76	G	A	-1.0279
77	A	A	0.0000
78	Q	A	-1.6346
79	A	A	0.0000
80	E	A	-2.6115
81	D	A	0.0000
82	E	A	-2.6793
83	A	A	0.0000
84	D	A	-1.9532
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.0944
89	S	A	0.0000
90	R	A	-0.6690
91	D	A	-1.2337
92	S	A	-1.3784
93	S	A	-0.7604
94	G	A	-0.7763
95	N	A	-1.0093
96	H	A	-0.8053
97	W	A	0.0000
98	V	A	-0.3694
99	F	A	-0.3826
100	G	A	0.0000
101	G	A	-1.6155
102	G	A	0.0000
103	T	A	0.0000
104	E	A	-2.1562
105	L	A	0.0000
106	T	A	-0.6051
107	V	A	0.0000
108	L	A	0.4961
109	G	A	-0.2474
110	Q	A	-0.6511
111	P	A	-1.1342
112	K	A	-2.2522
113	A	A	-1.3539
114	A	A	-0.7821
115	P	A	-0.4443
116	S	A	-0.3000
117	V	A	0.0000
118	T	A	-0.4217
119	L	A	-0.3567
120	F	A	0.0000
121	P	A	-0.1662
122	P	A	0.0000
123	S	A	-1.2425
124	S	A	-1.7740
125	E	A	-2.7189
126	E	A	0.0000
127	L	A	-2.3056
128	Q	A	-2.5510
129	A	A	-2.1059
130	N	A	-2.8951
131	K	A	-2.9969
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.5360
140	D	A	-1.1442
141	F	A	0.0000
142	Y	A	-1.2386
143	P	A	-1.1529
144	G	A	-0.9485
145	A	A	-0.3094
146	V	A	-0.1124
147	T	A	-0.0403
148	V	A	0.1151
149	A	A	-0.2071
150	W	A	0.0000
151	K	A	-1.0872
152	A	A	0.0000
153	D	A	-1.5691
154	S	A	-1.0119
155	S	A	-0.6972
156	P	A	-0.8954
157	V	A	-0.5042
158	K	A	-1.3794
159	A	A	-0.4382
160	G	A	0.1708
161	V	A	0.5817
162	E	A	0.3924
163	T	A	0.3277
164	T	A	0.0000
165	T	A	-0.1498
166	P	A	-0.2518
167	S	A	-0.6061
168	K	A	-1.3039
169	Q	A	-1.1946
170	S	A	-1.3084
171	N	A	-1.7275
172	N	A	-1.9385
173	K	A	-1.8415
174	Y	A	-0.8518
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.3668
181	S	A	0.2212
182	L	A	0.0000
183	T	A	-1.9679
184	P	A	-2.5257
185	E	A	-3.1768
186	Q	A	-2.5476
187	W	A	0.0000
188	K	A	-3.0740
189	S	A	0.0000
190	H	A	-2.4992
191	R	A	-2.6929
192	S	A	-1.6382
193	Y	A	0.0000
194	S	A	-1.1617
195	C	A	0.0000
196	Q	A	-1.2295
197	V	A	0.0000
198	T	A	-0.7151
199	H	A	0.0000
200	E	A	-2.3443
201	G	A	-1.4467
202	S	A	-0.9436
203	T	A	-0.7842
204	V	A	-0.8769
205	E	A	-2.2551
206	K	A	-2.0109
207	T	A	-1.1524
208	V	A	0.0000
209	A	A	-0.9706
210	P	A	-1.0701
2	V	A	1.0717
3	Q	A	-0.9474
4	L	A	0.0000
5	Q	A	-1.8114
6	Q	A	-1.3363
7	S	A	-0.9806
8	G	A	-0.9900
9	A	A	0.0000
10	E	A	-1.2233
11	V	A	-0.7927
12	K	A	-1.7037
13	K	A	-2.4190
14	P	A	-2.0843
15	G	A	-1.4931
16	S	A	-1.2441
17	S	A	-1.5225
18	V	A	0.0000
19	R	A	-2.6587
20	V	A	0.0000
21	S	A	-1.0957
22	C	A	0.0000
23	K	A	-1.4219
24	A	A	0.0000
25	S	A	-0.7283
26	G	A	-0.6158
27	G	A	-1.0183
28	T	A	-1.5098
29	F	A	0.0000
30	N	A	-1.6876
31	N	A	-0.4929
32	N	A	-0.5314
33	A	A	-0.0503
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.6122
39	Q	A	-0.8177
40	A	A	-1.0784
41	P	A	-0.9421
42	G	A	-1.2579
43	Q	A	-1.8270
44	G	A	-1.3710
45	L	A	0.0000
46	E	A	-0.8052
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.3842
52	I	A	0.1277
53	P	A	-0.4753
54	M	A	0.4340
55	F	A	1.4229
56	G	A	0.3096
57	T	A	-0.0126
58	A	A	-0.2375
59	K	A	-1.1298
60	Y	A	-0.5791
61	S	A	-1.2449
62	Q	A	-2.1796
63	N	A	-2.2098
64	F	A	0.0000
65	Q	A	-2.0988
66	G	A	-1.4456
67	R	A	0.0000
68	V	A	0.0000
69	A	A	-0.8640
70	I	A	0.0000
71	T	A	-0.5765
72	A	A	-1.2526
73	D	A	-2.6933
74	E	A	-2.6732
75	S	A	-1.6588
76	T	A	-1.4799
77	G	A	0.0000
78	T	A	-1.4388
79	A	A	0.0000
80	S	A	-1.1505
81	M	A	0.0000
82	E	A	-2.4268
83	L	A	0.0000
84	S	A	-1.2952
85	S	A	-1.1316
86	L	A	0.0000
87	R	A	-2.7798
88	S	A	-2.2567
89	E	A	-2.4988
90	D	A	0.0000
91	T	A	-0.8992
92	A	A	0.0000
93	V	A	-0.0624
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.3867
99	S	A	0.0000
100	R	A	-0.6295
101	D	A	0.0000
102	L	A	1.6611
103	L	A	2.6111
104	L	A	2.4429
105	F	A	1.3803
106	P	A	0.8003
107	H	A	-0.4261
108	H	A	-0.5792
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.0140
112	P	A	0.0219
113	W	A	-0.3575
114	G	A	0.0000
115	R	A	-2.3805
116	G	A	-1.2179
117	T	A	0.0000
118	M	A	-0.1703
119	V	A	0.0000
120	T	A	-0.8847
121	V	A	0.0000
122	S	A	-1.0537
123	S	A	-0.9374
124	A	A	-0.6160
125	S	A	-0.6754
126	T	A	-0.6594
127	K	A	-1.1384
128	G	A	-1.2352
129	P	A	0.0000
130	S	A	-0.3855
131	V	A	0.0000
132	F	A	0.0000
133	P	A	-1.2133
134	L	A	0.0000
135	A	A	-0.9398
136	P	A	-0.8787
137	S	A	-0.9289
138	S	A	-1.2375
139	K	A	-1.9973
140	S	A	-1.4386
141	T	A	-0.8831
142	S	A	-0.9032
143	G	A	-0.8700
144	G	A	-1.1816
145	T	A	-0.9137
146	A	A	0.0000
147	A	A	0.0000
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.3845
154	D	A	-0.5377
155	Y	A	0.0000
156	F	A	-0.3728
157	P	A	0.0000
158	E	A	-0.9585
159	P	A	-0.8944
160	V	A	0.0000
161	T	A	-0.5958
162	V	A	-0.2104
163	S	A	-0.4036
164	W	A	0.0000
165	N	A	-0.6964
166	S	A	-0.6380
167	G	A	-0.5909
168	A	A	-0.2433
169	L	A	-0.0606
170	T	A	-0.1857
171	S	A	-0.2830
172	G	A	-0.3885
173	V	A	0.0948
174	H	A	-0.2037
175	T	A	-0.0671
176	F	A	0.0000
177	P	A	-0.0833
178	A	A	0.1796
179	V	A	0.0000
180	L	A	1.1675
181	Q	A	0.2841
182	S	A	-0.1239
183	S	A	-0.2236
184	G	A	0.0202
185	L	A	0.1527
186	Y	A	0.2516
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.3130
194	V	A	0.0000
195	P	A	-0.5385
196	S	A	-0.9941
197	S	A	-0.7531
198	S	A	-0.4673
199	L	A	-0.8344
200	G	A	-0.9386
201	T	A	-0.6351
202	Q	A	-1.1356
203	T	A	-1.1206
204	Y	A	0.0000
205	I	A	-1.1779
206	C	A	0.0000
207	N	A	-1.4472
208	V	A	0.0000
209	N	A	-1.7177
210	H	A	0.0000
211	K	A	-2.4895
212	P	A	-1.5668
213	S	A	-1.6673
214	N	A	-2.3869
215	T	A	-1.9826
216	K	A	-2.5326
217	V	A	-1.4539
218	D	A	-2.3726
219	K	A	-2.0636
220	K	A	-2.5868
221	V	A	0.0000
222	E	A	-2.4907
223	P	A	-1.2268