Project name: bc8fbecb4248d7a

Chain sequence(s)	A: CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFRQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAKGDSGGPLSCKHNEVWHLVGITSWGEGERPGVYTNVVEYVDWILEKV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.999
• Maximal score value: 2.3361
• Average score: -0.7141
• Total score value: -416.3203

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	C	A	1.1591
3	V	A	1.8144
4	T	A	0.5657
5	Q	A	-0.9029
6	L	A	-0.5987
7	L	A	-0.8852
8	K	A	-2.1349
9	D	A	-2.1286
10	T	A	0.0000
11	C	A	-1.7673
12	F	A	0.0000
13	E	A	-2.5466
14	G	A	-1.7513
15	G	A	-1.3294
16	D	A	-1.9888
17	I	A	-0.6278
18	T	A	-0.2994
19	T	A	-0.0319
20	V	A	-0.0578
21	F	A	-0.3916
22	T	A	0.0000
23	P	A	0.0000
24	S	A	-0.5170
25	A	A	0.0000
26	K	A	-1.6604
27	Y	A	-0.6548
28	C	A	0.0000
29	Q	A	0.0000
30	V	A	0.0783
31	V	A	0.2443
32	C	A	0.0000
33	T	A	0.0000
34	Y	A	0.2882
35	H	A	-0.3319
36	P	A	-0.7002
37	R	A	-0.8204
38	C	A	0.0000
39	L	A	0.0000
40	L	A	0.0000
41	F	A	0.0000
42	T	A	0.0000
43	F	A	0.0000
44	T	A	-0.8837
45	A	A	-0.9778
46	E	A	-2.1668
47	S	A	-1.4701
48	P	A	-1.4291
49	S	A	-1.7174
50	E	A	-2.8203
51	D	A	-3.1510
52	P	A	-2.3446
53	T	A	-2.1871
54	R	A	-2.8052
55	W	A	-2.2087
56	F	A	0.0000
57	T	A	-0.8037
58	C	A	0.0000
59	V	A	-0.0955
60	L	A	0.0000
61	K	A	0.0000
62	D	A	0.0000
63	S	A	0.0986
64	V	A	1.3271
65	T	A	0.2973
66	E	A	-0.4420
67	T	A	-0.5942
68	L	A	-0.9300
69	P	A	-1.5491
70	R	A	-2.5423
71	V	A	-1.8633
72	N	A	-2.6133
73	R	A	-2.8727
74	T	A	-1.8279
75	A	A	-1.4486
76	A	A	0.0000
77	I	A	-0.7482
78	S	A	0.0000
79	G	A	0.0000
80	Y	A	0.4380
81	S	A	0.0000
82	F	A	0.2412
83	R	A	0.0000
84	Q	A	-0.8710
85	C	A	0.0000
86	S	A	-0.9361
87	H	A	-1.2973
88	Q	A	-1.1061
89	I	A	-0.3348
90	S	A	-0.3625
91	A	A	-0.0278
92	C	A	-0.6406
93	N	A	-1.6389
94	K	A	-2.1848
95	D	A	-1.3738
96	I	A	-0.0356
97	Y	A	0.7727
98	V	A	0.9607
99	D	A	-0.9118
100	L	A	0.0000
101	D	A	0.0000
102	M	A	0.0000
103	K	A	-1.2961
104	G	A	-0.4714
105	I	A	0.7275
106	N	A	-0.5171
107	Y	A	-0.5223
108	N	A	-1.0677
109	S	A	-0.2605
110	S	A	0.5807
111	V	A	1.2502
112	A	A	0.0000
113	K	A	-1.7703
114	S	A	-1.5213
115	A	A	-1.3775
116	Q	A	-2.0518
117	E	A	-2.0741
118	C	A	0.0000
119	Q	A	0.0000
120	E	A	-2.8115
121	R	A	-2.0538
122	C	A	0.0000
123	T	A	0.0000
124	D	A	-1.5289
125	D	A	-1.0122
126	V	A	0.0735
127	H	A	-0.5136
128	C	A	0.0000
129	H	A	-0.3663
130	F	A	0.0000
131	F	A	0.0000
132	T	A	0.0000
133	Y	A	0.0000
134	A	A	0.0000
135	T	A	-1.9381
136	R	A	-2.6193
137	Q	A	-2.2739
138	F	A	-2.0102
139	P	A	-1.2872
140	S	A	-0.8770
141	L	A	-0.3687
142	E	A	-1.7806
143	H	A	-1.6818
144	R	A	-1.7825
145	N	A	-1.2240
146	I	A	-0.0247
147	C	A	0.0000
148	L	A	0.1502
149	L	A	0.0000
150	K	A	0.0000
151	H	A	-0.2552
152	T	A	0.0000
153	Q	A	-1.1741
154	T	A	-0.7698
155	G	A	-0.5621
156	T	A	-0.5449
157	P	A	0.0000
158	T	A	-1.0879
159	R	A	-2.2899
160	I	A	0.0000
161	T	A	-1.6831
162	K	A	-1.9871
163	L	A	-1.1760
164	D	A	-2.3732
165	K	A	-2.3754
166	V	A	0.0000
167	V	A	0.0000
168	S	A	0.0000
169	G	A	0.0000
170	F	A	0.0000
171	S	A	-0.9702
172	L	A	0.0000
173	K	A	0.0000
174	S	A	-0.3000
175	C	A	-0.1898
176	A	A	-0.1252
177	L	A	-0.6333
178	S	A	0.0000
179	N	A	-1.4586
180	L	A	-0.2687
181	A	A	-0.3692
182	C	A	-0.1672
183	I	A	0.4580
184	R	A	-0.2878
185	D	A	-0.7294
186	I	A	1.0988
187	F	A	0.1186
188	P	A	-0.7429
189	N	A	-2.4361
190	T	A	-1.6816
191	V	A	-1.0723
192	F	A	0.0000
193	A	A	-0.5400
194	D	A	-0.8892
195	S	A	-1.1169
196	N	A	-1.3653
197	I	A	-0.6923
198	D	A	-1.3308
199	S	A	-0.4745
200	V	A	-0.0172
201	M	A	-0.0023
202	A	A	0.0000
203	P	A	0.1036
204	D	A	-0.0400
205	A	A	0.6406
206	F	A	1.4916
207	V	A	0.0000
208	C	A	0.0000
209	G	A	0.6016
210	R	A	0.1512
211	I	A	0.1803
212	C	A	0.0000
213	T	A	0.0000
214	H	A	-0.4589
215	H	A	-0.6790
216	P	A	-0.6341
217	G	A	-0.8136
218	C	A	0.0000
219	L	A	0.0000
220	F	A	0.0000
221	F	A	0.0000
222	T	A	0.0000
223	F	A	0.0000
224	F	A	0.0000
225	S	A	-2.0839
226	Q	A	-2.5106
227	E	A	-3.3094
228	W	A	0.0000
229	P	A	-2.4898
230	K	A	-3.2338
231	E	A	-3.6422
232	S	A	-2.0958
233	Q	A	-2.2610
234	R	A	-2.5264
235	N	A	0.0000
236	L	A	-0.4496
237	C	A	0.0000
238	L	A	-0.2473
239	L	A	0.0000
240	K	A	0.0000
241	T	A	-0.6074
242	S	A	-0.8847
243	E	A	-1.7027
244	S	A	-0.6340
245	G	A	0.0000
246	L	A	0.9170
247	P	A	-0.1553
248	S	A	-0.5970
249	T	A	-0.6040
250	R	A	-1.8627
251	I	A	-1.2217
252	K	A	-2.6631
253	K	A	-3.0069
254	S	A	-2.4164
255	K	A	-2.4551
256	A	A	0.0000
257	L	A	-0.1528
258	S	A	0.0000
259	G	A	0.0000
260	F	A	0.0000
261	S	A	0.0317
262	L	A	0.2130
263	Q	A	-0.0399
264	S	A	0.0000
265	C	A	0.0000
266	R	A	-0.4714
267	H	A	-0.4877
268	S	A	0.0000
269	I	A	0.0000
270	P	A	-0.6922
271	V	A	0.0000
272	F	A	0.0000
273	C	A	0.1366
274	H	A	0.0000
275	S	A	-0.0667
276	S	A	0.0113
277	F	A	0.2679
278	Y	A	-0.1716
279	H	A	-1.1783
280	D	A	-1.5068
281	T	A	0.0000
282	D	A	0.0000
283	F	A	0.0000
284	L	A	0.3982
285	G	A	-1.0435
286	E	A	-2.6582
287	E	A	-2.5407
288	L	A	-1.1012
289	D	A	-1.1206
290	I	A	0.3638
291	V	A	0.3837
292	A	A	-0.6194
293	A	A	0.0000
294	K	A	-3.1716
295	S	A	-2.0264
296	H	A	-1.9311
297	E	A	-2.5406
298	A	A	-1.8665
299	C	A	0.0000
300	Q	A	0.0000
301	K	A	-2.3087
302	L	A	-0.9436
303	C	A	0.0000
304	T	A	-1.2882
305	N	A	-1.7003
306	A	A	-1.0570
307	V	A	0.0000
308	R	A	-0.5439
309	C	A	0.0000
310	Q	A	0.0000
311	F	A	0.0000
312	F	A	0.0000
313	T	A	0.0000
314	Y	A	0.0000
315	T	A	-1.2560
316	P	A	-1.8211
317	A	A	-2.2488
318	Q	A	-1.9155
319	A	A	-0.9743
320	S	A	-0.8910
321	C	A	-0.6783
322	N	A	-2.4953
323	E	A	-3.2781
324	G	A	-3.0434
325	K	A	-3.3741
326	G	A	0.0000
327	K	A	-1.0845
328	C	A	0.0000
329	Y	A	-0.0860
330	L	A	0.0000
331	K	A	0.0000
332	L	A	0.0000
333	S	A	-1.2118
334	S	A	-1.0049
335	N	A	-1.0662
336	G	A	-0.3859
337	S	A	0.0000
338	P	A	-0.0786
339	T	A	0.5347
340	K	A	0.0000
341	I	A	0.8162
342	L	A	-0.3511
343	H	A	-1.5671
344	G	A	-1.5703
345	R	A	-1.7312
346	G	A	-1.7964
347	G	A	0.0000
348	I	A	0.0000
349	S	A	0.0000
350	G	A	0.0000
351	Y	A	0.0000
352	T	A	0.0000
353	L	A	0.0475
354	R	A	0.0000
355	L	A	0.1217
356	C	A	-0.1189
357	K	A	-0.9011
358	M	A	0.0000
359	D	A	0.0000
360	N	A	-1.0081
361	E	A	-1.0712
362	C	A	0.0000
363	T	A	0.0000
364	T	A	-1.2331
365	K	A	-2.4732
366	I	A	-1.7648
367	K	A	-2.0653
368	P	A	-0.5607
369	R	A	0.3559
370	I	A	2.2819
371	V	A	2.3361
372	G	A	0.6939
373	G	A	0.0104
374	T	A	-0.1467
375	A	A	0.0862
376	S	A	0.0000
377	V	A	0.2590
378	R	A	-1.4428
379	G	A	-1.3559
380	E	A	-0.6021
381	W	A	0.0000
382	P	A	0.0000
383	W	A	0.0000
384	Q	A	0.0000
385	V	A	0.0000
386	T	A	0.0000
387	L	A	0.0000
388	H	A	0.0000
389	T	A	0.0000
390	T	A	-1.1157
391	S	A	-0.6931
392	P	A	-0.7764
393	T	A	-1.0311
394	Q	A	-1.6155
395	R	A	-2.1895
396	H	A	0.0000
397	L	A	-0.6423
398	C	A	0.0000
399	G	A	0.0000
400	G	A	0.0000
401	S	A	0.0000
402	I	A	0.0000
403	I	A	0.0842
404	G	A	-0.3143
405	N	A	-1.2425
406	Q	A	-1.2794
407	W	A	-0.4290
408	I	A	0.0000
409	L	A	0.0000
410	T	A	0.0000
411	A	A	0.0000
412	A	A	0.0000
413	H	A	0.2275
414	C	A	0.0000
415	F	A	0.0000
416	Y	A	0.9031
417	G	A	-0.2443
418	V	A	-0.6236
419	E	A	-1.8586
420	S	A	-1.6778
421	P	A	-1.7823
422	K	A	-2.2667
423	I	A	-1.1199
424	L	A	0.0000
425	R	A	-1.0250
426	V	A	0.0000
427	Y	A	0.0000
428	S	A	0.0908
429	G	A	-0.4796
430	I	A	-0.1989
431	L	A	-0.5147
432	N	A	-1.1186
433	Q	A	-1.2015
434	S	A	-1.1606
435	E	A	-1.3655
436	I	A	-1.7965
437	K	A	-3.2893
438	E	A	-3.5701
439	D	A	-3.1577
440	T	A	-2.0234
441	S	A	-0.8882
442	F	A	0.0902
443	F	A	-0.3380
444	G	A	-1.4573
445	V	A	0.0000
446	Q	A	-2.6786
447	E	A	-2.1276
448	I	A	-0.4299
449	I	A	0.1408
450	I	A	0.3724
451	H	A	-0.9349
452	D	A	-2.2897
453	Q	A	-2.2296
454	Y	A	0.0000
455	K	A	-1.8840
456	M	A	-0.3249
457	A	A	0.0000
458	E	A	-0.9044
459	S	A	-1.0578
460	G	A	0.0000
461	Y	A	-0.5103
462	D	A	0.0000
463	I	A	0.0000
464	A	A	0.0000
465	L	A	0.0000
466	L	A	0.0000
467	K	A	-1.7277
468	L	A	0.0000
469	E	A	-2.4533
470	T	A	-1.4104
471	T	A	-1.2351
472	V	A	0.0000
473	N	A	-1.3913
474	Y	A	-1.0043
475	T	A	-1.1606
476	D	A	-2.3596
477	S	A	-1.2667
478	Q	A	-1.0023
479	R	A	0.0000
480	P	A	0.0000
481	I	A	0.0000
482	C	A	0.0000
483	L	A	0.3044
484	P	A	0.0000
485	S	A	-0.4751
486	K	A	-1.1175
487	G	A	0.0000
488	D	A	0.0000
489	R	A	-2.2060
490	N	A	-1.4044
491	V	A	0.0981
492	I	A	1.5247
493	Y	A	0.0000
494	T	A	0.0721
495	D	A	-0.6484
496	C	A	0.0000
497	W	A	-0.5483
498	V	A	-0.1902
499	T	A	0.0000
500	G	A	0.0000
501	W	A	0.0000
502	G	A	-1.5216
509	K	A	-1.8980
510	I	A	-1.2847
511	Q	A	-1.4977
512	N	A	-1.5147
513	T	A	-0.9642
514	L	A	0.0000
515	Q	A	-0.9661
516	K	A	0.0000
517	A	A	-0.7961
518	K	A	-1.5263
519	I	A	-0.3649
520	P	A	-0.1338
521	L	A	0.7854
522	V	A	-0.1804
523	T	A	-1.0045
524	N	A	-2.0674
525	E	A	-3.1969
526	E	A	-3.2785
527	C	A	0.0000
528	Q	A	-3.5176
529	K	A	-3.9354
530	R	A	-3.9990
531	Y	A	0.0000
532	R	A	-3.4543
533	G	A	-2.3728
534	H	A	-2.8676
535	K	A	-2.9581
536	I	A	0.0000
537	T	A	-1.4428
538	H	A	-1.6928
539	K	A	-0.9208
540	M	A	0.0000
541	I	A	-0.3056
542	C	A	0.0000
543	A	A	-0.0587
554	K	A	-2.0930
555	G	A	0.0000
556	D	A	-1.1682
557	S	A	-0.8422
558	G	A	0.0000
559	G	A	0.0000
560	P	A	0.0000
561	L	A	0.0000
562	S	A	0.0000
563	C	A	0.0000
564	K	A	-1.6726
565	H	A	-1.4479
566	N	A	-2.0016
567	E	A	-2.7484
568	V	A	0.0000
569	W	A	-0.9636
570	H	A	0.0000
571	L	A	0.0000
572	V	A	0.0000
573	G	A	0.0000
574	I	A	0.0000
575	T	A	-0.3235
576	S	A	0.0000
577	W	A	-0.6123
578	G	A	-1.6653
579	E	A	-2.4025
580	G	A	-1.9489
585	E	A	-3.5785
586	R	A	-3.7159
587	P	A	-2.1275
588	G	A	-1.2777
589	V	A	0.0000
590	Y	A	0.0192
591	T	A	0.0000
592	N	A	-0.4898
593	V	A	0.0000
594	V	A	-0.8116
595	E	A	-1.3639
596	Y	A	0.0000
597	V	A	0.0000
598	D	A	-1.4054
599	W	A	-1.0189
600	I	A	0.0000
601	L	A	-0.5614
602	E	A	-1.7360
603	K	A	-0.9592
604	V	A	0.6386