Project name: pg_5p_6fxn
Status: done
submitted: 2018-08-14 19:28:11, status changed: 2018-08-14 19:37:45
Settings
Chain sequence(s)
|
A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.1115
-
Maximal score value
-
2.9666
-
Average score
-
-0.6902
-
Total score value
-
-297.4682
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
2 |
S |
A |
-1.6142 |
|
3 |
E |
A |
-2.4181 |
|
4 |
L |
A |
0.0000 |
|
5 |
T |
A |
-1.6067 |
|
6 |
Q |
A |
-1.6896 |
|
7 |
D |
A |
-2.3873 |
|
8 |
P |
A |
-1.7604 |
|
9 |
A |
A |
-1.3670 |
|
10 |
V |
A |
-1.0196 |
|
11 |
S |
A |
-0.2744 |
|
12 |
V |
A |
0.0000 |
|
13 |
A |
A |
0.1779 |
|
14 |
L |
A |
0.0967 |
|
15 |
G |
A |
-0.7435 |
|
16 |
Q |
A |
-1.0569 |
|
17 |
T |
A |
-1.0725 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-1.8934 |
|
20 |
V |
A |
0.0000 |
|
21 |
T |
A |
-1.1242 |
|
22 |
C |
A |
0.0000 |
|
23 |
Q |
A |
-2.1550 |
|
24 |
G |
A |
0.0000 |
|
25 |
D |
A |
-3.0264 |
|
26 |
S |
A |
0.0000 |
|
27 |
L |
A |
0.0000 |
|
28 |
R |
A |
-2.7045 |
|
29 |
S |
A |
-1.3725 |
|
30 |
Y |
A |
-0.5776 |
|
31 |
Y |
A |
-0.0563 |
|
32 |
A |
A |
0.0000 |
|
33 |
S |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
Y |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-1.2026 |
|
38 |
K |
A |
-1.7846 |
|
39 |
P |
A |
-1.7479 |
|
40 |
G |
A |
-1.6435 |
|
41 |
Q |
A |
-1.9230 |
|
42 |
A |
A |
-1.0450 |
|
43 |
P |
A |
0.0000 |
|
44 |
V |
A |
1.1010 |
|
45 |
L |
A |
0.0000 |
|
46 |
V |
A |
0.0000 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-1.0474 |
|
49 |
G |
A |
0.0000 |
|
50 |
K |
A |
-2.5199 |
|
51 |
N |
A |
-2.4670 |
|
52 |
N |
A |
-2.3141 |
|
53 |
R |
A |
-2.2193 |
|
54 |
P |
A |
-1.1677 |
|
55 |
S |
A |
-0.9212 |
|
56 |
G |
A |
-0.8868 |
|
57 |
I |
A |
-0.6851 |
|
58 |
P |
A |
-1.3102 |
|
59 |
D |
A |
-2.2499 |
|
60 |
R |
A |
-1.3684 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-1.3694 |
|
63 |
G |
A |
-1.3963 |
|
64 |
S |
A |
-1.0925 |
|
65 |
S |
A |
-1.2115 |
|
66 |
S |
A |
-1.1511 |
|
67 |
G |
A |
-1.9353 |
|
68 |
N |
A |
-2.3684 |
|
69 |
T |
A |
-1.5056 |
|
70 |
A |
A |
0.0000 |
|
71 |
S |
A |
0.0000 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.9377 |
|
74 |
I |
A |
0.0000 |
|
75 |
T |
A |
-1.1817 |
|
76 |
G |
A |
-0.8844 |
|
77 |
A |
A |
0.0000 |
|
78 |
Q |
A |
-1.2152 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.1689 |
|
81 |
D |
A |
0.0000 |
|
82 |
E |
A |
-2.0514 |
|
83 |
A |
A |
0.0000 |
|
84 |
D |
A |
-2.2423 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
S |
A |
-0.3969 |
|
89 |
S |
A |
0.0000 |
|
90 |
R |
A |
-0.6715 |
|
91 |
D |
A |
-1.3821 |
|
92 |
S |
A |
-1.5411 |
|
93 |
S |
A |
-0.7706 |
|
94 |
G |
A |
-0.9212 |
|
95 |
N |
A |
-1.0769 |
|
96 |
H |
A |
-0.8989 |
|
97 |
W |
A |
-0.5353 |
|
98 |
V |
A |
-0.7040 |
|
99 |
F |
A |
0.0000 |
|
100 |
G |
A |
0.0000 |
|
101 |
G |
A |
-1.7914 |
|
102 |
G |
A |
-1.7171 |
|
103 |
T |
A |
0.0000 |
|
104 |
E |
A |
-2.7789 |
|
105 |
L |
A |
0.0000 |
|
106 |
T |
A |
-0.5441 |
|
107 |
V |
A |
0.0000 |
|
108 |
L |
A |
1.0348 |
|
109 |
G |
A |
-0.0022 |
|
110 |
Q |
A |
0.0000 |
|
111 |
P |
A |
-1.0937 |
|
112 |
K |
A |
-2.2410 |
|
113 |
A |
A |
-1.3749 |
|
114 |
A |
A |
-0.8912 |
|
115 |
P |
A |
-0.1715 |
|
116 |
S |
A |
-0.3667 |
|
117 |
V |
A |
-0.2572 |
|
118 |
T |
A |
-0.1488 |
|
119 |
L |
A |
0.0000 |
|
120 |
F |
A |
0.0000 |
|
121 |
P |
A |
-0.2327 |
|
122 |
P |
A |
-0.3839 |
|
123 |
S |
A |
-0.8598 |
|
124 |
S |
A |
-1.2002 |
|
125 |
E |
A |
-1.6349 |
|
126 |
E |
A |
0.0000 |
|
127 |
L |
A |
-1.6798 |
|
128 |
Q |
A |
-2.1112 |
|
129 |
A |
A |
-1.8322 |
|
130 |
N |
A |
-2.6980 |
|
131 |
K |
A |
-2.8100 |
|
132 |
A |
A |
0.0000 |
|
133 |
T |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
V |
A |
0.0000 |
|
136 |
C |
A |
0.0000 |
|
137 |
L |
A |
0.0000 |
|
138 |
I |
A |
0.0000 |
|
139 |
S |
A |
-0.5922 |
|
140 |
D |
A |
-1.4184 |
|
141 |
F |
A |
0.0000 |
|
142 |
Y |
A |
-1.2602 |
|
143 |
P |
A |
-1.1814 |
|
144 |
G |
A |
-1.0570 |
|
145 |
A |
A |
-0.4203 |
|
146 |
V |
A |
-0.2209 |
|
147 |
T |
A |
-0.1607 |
|
148 |
V |
A |
0.1978 |
|
149 |
A |
A |
-0.3443 |
|
150 |
W |
A |
0.0000 |
|
151 |
K |
A |
-1.0158 |
|
152 |
A |
A |
0.0000 |
|
153 |
D |
A |
-1.3747 |
|
154 |
S |
A |
-0.8967 |
|
155 |
S |
A |
-0.5653 |
|
156 |
P |
A |
-0.8386 |
|
157 |
V |
A |
-0.6846 |
|
158 |
K |
A |
-1.4805 |
|
159 |
A |
A |
-0.5957 |
|
160 |
G |
A |
-0.2618 |
|
161 |
V |
A |
0.0022 |
|
162 |
E |
A |
0.0072 |
|
163 |
T |
A |
0.2284 |
|
164 |
T |
A |
0.0000 |
|
165 |
T |
A |
-0.1236 |
|
166 |
P |
A |
-0.2828 |
|
167 |
S |
A |
-0.5669 |
|
168 |
K |
A |
-1.0018 |
|
169 |
Q |
A |
-1.1188 |
|
170 |
S |
A |
-1.1796 |
|
171 |
N |
A |
-1.4701 |
|
172 |
N |
A |
-1.5486 |
|
173 |
K |
A |
-1.5182 |
|
174 |
Y |
A |
-0.8302 |
|
175 |
A |
A |
0.0000 |
|
176 |
A |
A |
0.0000 |
|
177 |
S |
A |
0.0000 |
|
178 |
S |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
L |
A |
0.9321 |
|
181 |
S |
A |
0.1080 |
|
182 |
L |
A |
-0.7623 |
|
183 |
T |
A |
-1.7933 |
|
184 |
P |
A |
-2.4563 |
|
185 |
E |
A |
-3.1115 |
|
186 |
Q |
A |
-2.0671 |
|
187 |
W |
A |
0.0000 |
|
188 |
K |
A |
-3.0421 |
|
189 |
S |
A |
0.0000 |
|
190 |
H |
A |
-2.3336 |
|
191 |
R |
A |
-2.5670 |
|
192 |
S |
A |
-1.5922 |
|
193 |
Y |
A |
0.0000 |
|
194 |
S |
A |
0.0000 |
|
195 |
C |
A |
0.0000 |
|
196 |
Q |
A |
-0.7860 |
|
197 |
V |
A |
0.0000 |
|
198 |
T |
A |
-0.4196 |
|
199 |
H |
A |
0.0000 |
|
200 |
E |
A |
-2.2804 |
|
201 |
G |
A |
-1.4434 |
|
202 |
S |
A |
-0.6420 |
|
203 |
T |
A |
-0.1415 |
|
204 |
V |
A |
0.3844 |
|
205 |
E |
A |
-1.6144 |
|
206 |
K |
A |
-1.5748 |
|
207 |
T |
A |
-1.1283 |
|
208 |
V |
A |
0.0000 |
|
209 |
A |
A |
-1.0272 |
|
210 |
P |
A |
-1.0927 |
|
2 |
V |
A |
0.8068 |
|
3 |
Q |
A |
-1.1436 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.8458 |
|
6 |
Q |
A |
-1.4206 |
|
7 |
S |
A |
-1.0354 |
|
8 |
G |
A |
-1.0209 |
|
9 |
A |
A |
-0.9799 |
|
10 |
E |
A |
-1.4261 |
|
11 |
V |
A |
-1.0399 |
|
12 |
K |
A |
-1.8207 |
|
13 |
K |
A |
-2.4721 |
|
14 |
P |
A |
-2.0294 |
|
15 |
G |
A |
-1.5112 |
|
16 |
S |
A |
-1.2246 |
|
17 |
S |
A |
-1.4374 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-2.3660 |
|
20 |
V |
A |
0.0000 |
|
21 |
S |
A |
-0.9562 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.1687 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.7733 |
|
26 |
G |
A |
-0.4926 |
|
27 |
G |
A |
-0.5816 |
|
28 |
T |
A |
-0.6984 |
|
29 |
F |
A |
-0.4755 |
|
30 |
N |
A |
-0.8537 |
|
31 |
N |
A |
0.0779 |
|
32 |
N |
A |
-0.2061 |
|
33 |
A |
A |
0.1442 |
|
34 |
I |
A |
0.0000 |
|
35 |
N |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
R |
A |
-0.4570 |
|
39 |
Q |
A |
-0.7480 |
|
40 |
A |
A |
-1.0105 |
|
41 |
P |
A |
-1.0697 |
|
42 |
G |
A |
-1.2825 |
|
43 |
Q |
A |
-1.7663 |
|
44 |
G |
A |
-1.1493 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-0.7801 |
|
47 |
W |
A |
0.0000 |
|
48 |
M |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
G |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
I |
A |
0.3277 |
|
53 |
P |
A |
0.0000 |
|
54 |
M |
A |
0.0535 |
|
55 |
F |
A |
1.3444 |
|
56 |
G |
A |
0.5024 |
|
57 |
T |
A |
0.0124 |
|
58 |
A |
A |
-0.2183 |
|
59 |
K |
A |
-1.1077 |
|
60 |
Y |
A |
-0.6034 |
|
61 |
S |
A |
-1.3501 |
|
62 |
Q |
A |
-2.2397 |
|
63 |
N |
A |
-2.2224 |
|
64 |
F |
A |
-1.5184 |
|
65 |
Q |
A |
-2.1128 |
|
66 |
G |
A |
-1.4837 |
|
67 |
R |
A |
-1.1167 |
|
68 |
V |
A |
-0.8522 |
|
69 |
A |
A |
-0.5449 |
|
70 |
I |
A |
-0.3681 |
|
71 |
T |
A |
-0.2413 |
|
72 |
A |
A |
-0.3366 |
|
73 |
D |
A |
-1.1337 |
|
74 |
E |
A |
-1.6609 |
|
75 |
S |
A |
-1.2348 |
|
76 |
T |
A |
-0.8494 |
|
77 |
G |
A |
0.0000 |
|
78 |
T |
A |
-0.7239 |
|
79 |
A |
A |
0.0000 |
|
80 |
S |
A |
0.0000 |
|
81 |
M |
A |
0.0000 |
|
82 |
E |
A |
-1.7949 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-1.0723 |
|
85 |
S |
A |
-1.0267 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
-2.3126 |
|
88 |
S |
A |
-2.0627 |
|
89 |
E |
A |
-2.2931 |
|
90 |
D |
A |
0.0000 |
|
91 |
T |
A |
-0.9272 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
-0.0721 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
-0.2724 |
|
100 |
R |
A |
-0.2621 |
|
101 |
D |
A |
0.0000 |
|
102 |
L |
A |
2.4757 |
|
103 |
L |
A |
2.9666 |
|
104 |
L |
A |
2.7429 |
|
105 |
F |
A |
1.7385 |
|
106 |
P |
A |
1.0811 |
|
107 |
H |
A |
-0.2751 |
|
108 |
H |
A |
-0.0454 |
|
109 |
A |
A |
0.0000 |
|
110 |
L |
A |
0.0000 |
|
111 |
S |
A |
-0.0016 |
|
112 |
P |
A |
0.2521 |
|
113 |
W |
A |
-0.4205 |
|
114 |
G |
A |
-1.5540 |
|
115 |
R |
A |
-2.5097 |
|
116 |
G |
A |
-1.3233 |
|
117 |
T |
A |
0.0000 |
|
118 |
M |
A |
-0.3027 |
|
119 |
V |
A |
0.0000 |
|
120 |
T |
A |
-0.9343 |
|
121 |
V |
A |
0.0000 |
|
122 |
S |
A |
-1.1402 |
|
123 |
S |
A |
-1.0132 |
|
124 |
A |
A |
-0.5942 |
|
125 |
S |
A |
-0.6959 |
|
126 |
T |
A |
-0.7442 |
|
127 |
K |
A |
-1.0737 |
|
128 |
G |
A |
-1.1633 |
|
129 |
P |
A |
-0.6085 |
|
130 |
S |
A |
-0.5778 |
|
131 |
V |
A |
0.0000 |
|
132 |
F |
A |
-0.6620 |
|
133 |
P |
A |
-1.0918 |
|
134 |
L |
A |
0.0000 |
|
135 |
A |
A |
-0.7989 |
|
136 |
P |
A |
-0.7676 |
|
137 |
S |
A |
-0.6684 |
|
138 |
S |
A |
-1.0267 |
|
139 |
K |
A |
-1.7299 |
|
140 |
S |
A |
-1.2094 |
|
141 |
T |
A |
-0.9048 |
|
142 |
S |
A |
-0.9410 |
|
143 |
G |
A |
-1.0335 |
|
144 |
G |
A |
-1.1355 |
|
145 |
T |
A |
-0.9341 |
|
146 |
A |
A |
0.0000 |
|
147 |
A |
A |
0.0000 |
|
148 |
L |
A |
0.0000 |
|
149 |
G |
A |
0.0000 |
|
150 |
C |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
V |
A |
0.0000 |
|
153 |
K |
A |
-0.3620 |
|
154 |
D |
A |
-0.6475 |
|
155 |
Y |
A |
0.0000 |
|
156 |
F |
A |
-0.2768 |
|
157 |
P |
A |
0.0000 |
|
158 |
E |
A |
-0.9120 |
|
159 |
P |
A |
-0.8451 |
|
160 |
V |
A |
-0.3889 |
|
161 |
T |
A |
-0.3456 |
|
162 |
V |
A |
-0.2170 |
|
163 |
S |
A |
-0.5005 |
|
164 |
W |
A |
0.0000 |
|
165 |
N |
A |
-0.8183 |
|
166 |
S |
A |
-0.7300 |
|
167 |
G |
A |
-0.5493 |
|
168 |
A |
A |
-0.2115 |
|
169 |
L |
A |
0.0974 |
|
170 |
T |
A |
-0.1147 |
|
171 |
S |
A |
-0.2117 |
|
172 |
G |
A |
-0.2592 |
|
173 |
V |
A |
0.1474 |
|
174 |
H |
A |
-0.1860 |
|
175 |
T |
A |
-0.0403 |
|
176 |
F |
A |
0.0000 |
|
177 |
P |
A |
-0.0709 |
|
178 |
A |
A |
0.2664 |
|
179 |
V |
A |
0.7338 |
|
180 |
L |
A |
1.1115 |
|
181 |
Q |
A |
0.1851 |
|
182 |
S |
A |
-0.1745 |
|
183 |
S |
A |
-0.2870 |
|
184 |
G |
A |
-0.0632 |
|
185 |
L |
A |
0.0316 |
|
186 |
Y |
A |
0.3342 |
|
187 |
S |
A |
0.0000 |
|
188 |
L |
A |
0.2967 |
|
189 |
S |
A |
0.0000 |
|
190 |
S |
A |
0.0000 |
|
191 |
V |
A |
0.1276 |
|
192 |
V |
A |
0.0000 |
|
193 |
T |
A |
-0.1949 |
|
194 |
V |
A |
0.0000 |
|
195 |
P |
A |
-0.8295 |
|
196 |
S |
A |
-1.0386 |
|
197 |
S |
A |
-0.7730 |
|
198 |
S |
A |
-0.7403 |
|
199 |
L |
A |
-1.0676 |
|
200 |
G |
A |
-1.0542 |
|
201 |
T |
A |
-0.8766 |
|
202 |
Q |
A |
-1.6254 |
|
203 |
T |
A |
-1.2683 |
|
204 |
Y |
A |
0.0000 |
|
205 |
I |
A |
-1.2924 |
|
206 |
C |
A |
0.0000 |
|
207 |
N |
A |
-1.6955 |
|
208 |
V |
A |
0.0000 |
|
209 |
N |
A |
-1.6525 |
|
210 |
H |
A |
0.0000 |
|
211 |
K |
A |
-2.3156 |
|
212 |
P |
A |
0.0000 |
|
213 |
S |
A |
-1.6161 |
|
214 |
N |
A |
-2.4076 |
|
215 |
T |
A |
-1.8958 |
|
216 |
K |
A |
-2.6021 |
|
217 |
V |
A |
-1.7713 |
|
218 |
D |
A |
-2.6071 |
|
219 |
K |
A |
-1.8761 |
|
220 |
K |
A |
-2.4737 |
|
221 |
V |
A |
0.0000 |
|
222 |
E |
A |
-2.3928 |
|
223 |
P |
A |
-1.4375 |
|