Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP B: RKQLATKAARSAPATG |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.7409 | |
887 | V | A | 2.1888 | |
888 | S | A | 1.6540 | |
889 | I | A | 2.3583 | |
890 | Y | A | 1.1533 | |
891 | P | A | 0.1149 | |
892 | S | A | -0.8273 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.1293 | |
895 | E | A | -1.4165 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.1495 | |
898 | K | A | -1.8708 | |
899 | A | A | 0.0000 | |
900 | C | A | -1.2407 | |
901 | R | A | -2.2378 | |
902 | N | A | -2.2001 | |
903 | L | A | -0.9064 | |
904 | G | A | -1.5656 | |
905 | K | A | -2.6509 | |
906 | N | A | -2.4366 | |
907 | G | A | -1.2202 | |
908 | L | A | -0.2864 | |
909 | S | A | -1.2275 | |
910 | N | A | -1.6142 | |
911 | S | A | -0.5547 | |
912 | S | A | 0.0814 | |
913 | I | A | 0.5201 | |
914 | L | A | 0.3671 | |
915 | L | A | 0.5068 | |
916 | D | A | -1.7862 | |
917 | K | A | -1.7679 | |
918 | C | A | -0.4208 | |
919 | P | A | -0.6341 | |
920 | P | A | -0.9030 | |
921 | P | A | -1.3267 | |
922 | R | A | -2.1064 | |
923 | P | A | -1.2344 | |
924 | P | A | -0.9152 | |
925 | S | A | -0.5452 | |
926 | S | A | -0.2575 | |
927 | P | A | 0.2305 | |
928 | Y | A | 0.9996 | |
929 | P | A | 0.4356 | |
930 | P | A | -0.2549 | |
931 | L | A | -0.9157 | |
932 | P | A | -1.9550 | |
933 | K | A | -3.4523 | |
934 | D | A | -3.5881 | |
935 | K | A | -3.3043 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.5720 | |
938 | P | A | -1.5548 | |
939 | P | A | -0.8685 | |
940 | T | A | -0.4138 | |
941 | P | A | -0.2043 | |
942 | S | A | 0.0869 | |
943 | I | A | 0.7598 | |
944 | Y | A | 0.6779 | |
945 | L | A | 0.0000 | |
946 | E | A | -2.6905 | |
947 | N | A | -3.0437 | |
948 | K | A | -3.0176 | |
949 | R | A | -2.2276 | |
950 | D | A | -0.9454 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.2256 | |
953 | F | A | 1.7085 | |
954 | P | A | 0.6856 | |
955 | P | A | 0.1670 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.4378 | |
958 | Q | A | -1.3158 | |
959 | F | A | -0.4106 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.7189 | |
962 | N | A | -1.1867 | |
963 | P | A | -1.2104 | |
964 | N | A | -1.5765 | |
965 | N | A | -0.9329 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.3010 | |
972 | G | A | -1.0168 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -2.1015 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.7706 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.1003 | |
981 | L | A | -1.0496 | |
982 | G | A | -0.9866 | |
983 | L | A | -0.4018 | |
984 | F | A | 0.0000 | |
985 | S | A | -1.0272 | |
986 | T | A | -1.3199 | |
987 | K | A | -2.2766 | |
988 | T | A | -1.5519 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.3296 | |
991 | E | A | -2.7354 | |
992 | A | A | -1.8890 | |
993 | N | A | -1.8618 | |
994 | N | A | -2.8356 | |
995 | E | A | -2.6232 | |
996 | H | A | -1.2285 | |
997 | M | A | -0.1268 | |
998 | V | A | 0.0000 | |
999 | E | A | -0.7951 | |
1000 | V | A | 0.0000 | |
1001 | R | A | 0.0000 | |
1002 | T | A | -1.1685 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.1689 | |
1005 | L | A | 0.1861 | |
1006 | Q | A | -0.3582 | |
1007 | P | A | -0.3728 | |
1008 | A | A | -0.0804 | |
1009 | D | A | -0.6097 | |
1010 | E | A | -0.8698 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.8590 | |
1013 | D | A | -0.8605 | |
1014 | P | A | -0.6521 | |
1015 | T | A | -0.7991 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -1.2341 | |
1018 | K | A | -1.8419 | |
1019 | K | A | -1.1954 | |
1020 | I | A | -0.5918 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -0.8883 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.0492 | |
1025 | S | A | 0.0000 | |
1026 | N | A | -1.6210 | |
1027 | R | A | -2.5310 | |
1028 | S | A | -1.7374 | |
1029 | H | A | -1.2988 | |
1030 | T | A | -0.9659 | |
1031 | T | A | -1.4185 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.3347 | |
1034 | K | A | -2.4034 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | -1.4647 | |
1037 | Q | A | -1.7071 | |
1038 | Y | A | -0.7996 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.5862 | |
1041 | S | A | -0.7193 | |
1042 | S | A | -0.5840 | |
1043 | F | A | -0.0759 | |
1044 | Q | A | -1.4583 | |
1045 | E | A | -2.2719 | |
1046 | S | A | -1.7254 | |
1047 | L | A | -1.9303 | |
1048 | R | A | -3.8505 | |
1049 | E | A | -3.4684 | |
1050 | E | A | -3.7047 | |
1051 | N | A | -4.1690 | |
1052 | E | A | -4.0086 | |
1053 | K | A | -3.5522 | |
1054 | R | A | -3.7020 | |
1055 | S | A | -2.8347 | |
1056 | H | A | -2.7274 | |
1057 | H | A | -2.9379 | |
1058 | K | A | -3.5894 | |
1059 | D | A | -2.8638 | |
1060 | H | A | -2.0654 | |
1061 | S | A | -1.6736 | |
1062 | D | A | -1.7282 | |
1063 | S | A | -1.8205 | |
1064 | E | A | -2.4104 | |
1065 | S | A | -2.2787 | |
1066 | T | A | -1.9682 | |
1067 | S | A | -2.0155 | |
1068 | S | A | 0.0000 | |
1069 | D | A | -2.8568 | |
1070 | N | A | -2.9958 | |
1071 | S | A | -1.9655 | |
1072 | G | A | -1.9055 | |
1073 | R | A | -3.5383 | |
1074 | R | A | -3.8211 | |
1075 | R | A | -3.7925 | |
1076 | K | A | -3.1822 | |
1077 | G | A | -1.7704 | |
1078 | P | A | -1.2197 | |
1079 | F | A | -0.9330 | |
1080 | K | A | -0.8822 | |
1081 | T | A | -0.4985 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -1.0248 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | 0.0000 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.2435 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.4466 | |
1092 | D | A | -2.7265 | |
1093 | D | A | -3.8818 | |
1094 | K | A | -3.7131 | |
1095 | K | A | -3.1809 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -2.9911 | |
1098 | L | A | -0.6377 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.3514 | |
1101 | H | A | -1.3562 | |
1102 | E | A | -1.1795 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.5653 | |
1105 | K | A | -1.3874 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.3389 | |
1109 | F | A | 0.3119 | |
1110 | V | A | 0.0000 | |
1111 | R | A | 0.1409 | |
1112 | V | A | 0.8058 | |
1113 | V | A | 1.6343 | |
1114 | S | A | 0.7375 | |
1115 | A | A | 0.2221 | |
1116 | G | A | 0.1988 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.2203 | |
1121 | H | A | -0.4779 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -0.9844 | |
1124 | H | A | 0.0000 | |
1125 | T | A | -0.2824 | |
1126 | I | A | 0.0000 | |
1127 | L | A | 0.0078 | |
1128 | G | A | 0.0000 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.1831 | |
1131 | T | A | -0.0854 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | 0.0000 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | 0.0973 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4429 | |
1140 | G | A | 0.2679 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.0228 | |
1144 | P | A | 0.0000 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.1664 | |
1147 | Q | A | -0.4974 | |
1148 | E | A | -0.6049 | |
1149 | N | A | -0.7469 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | 0.0000 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5892 | |
1162 | G | A | -0.4356 | |
1163 | D | A | -0.6011 | |
1164 | C | A | 0.0000 | |
1165 | E | A | -0.0295 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.5374 | |
1171 | E | A | -0.7757 | |
1172 | G | A | -0.3239 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | 0.0000 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.3798 | |
1177 | L | A | 0.0000 | |
1178 | N | A | -1.2521 | |
1179 | D | A | -2.1885 | |
1180 | F | A | -1.6860 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -2.9916 | |
1183 | K | A | -3.1755 | |
1184 | N | A | -2.4921 | |
1185 | N | A | -2.7514 | |
1186 | L | A | -1.6453 | |
1187 | N | A | -1.2009 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.2626 | |
1190 | M | A | 0.9898 | |
1191 | G | A | -0.0705 | |
1192 | S | A | 0.0000 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | -1.0695 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -2.5760 | |
1199 | D | A | -2.1327 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -2.1831 | |
1202 | E | A | -2.6582 | |
1203 | A | A | -1.4568 | |
1204 | N | A | -2.0323 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.8027 | |
1209 | R | A | -0.8040 | |
1210 | F | A | 0.0000 | |
1211 | I | A | 0.2279 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.3353 | |
1214 | P | A | -0.9286 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0663 | |
1232 | G | A | 0.2824 | |
1233 | W | A | 0.3560 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.3437 | |
1245 | T | A | -0.2877 | |
1246 | A | A | -0.7880 | |
1247 | C | A | -0.3337 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.3365 | |
1251 | L | A | 0.0000 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -1.0138 | |
1254 | E | A | -2.3949 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -0.9451 | |
1258 | W | A | -0.8102 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -0.5095 | |
1261 | L | A | 0.4431 | |
1262 | Q | A | -0.2166 | |
1263 | S | A | -0.0525 | |
1264 | V | A | 0.0227 | |
1265 | K | A | -0.4786 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.0000 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.0000 | |
1272 | H | A | 0.0000 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -0.8795 | |
1277 | M | A | 0.0000 | |
1278 | A | A | 0.0000 | |
1279 | R | A | -2.0540 | |
1280 | N | A | -1.9581 | |
1281 | I | A | 0.0000 | |
1282 | K | A | -2.0517 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.1550 | |
1285 | D | A | -1.8473 | |
1286 | P | A | -1.5194 | |
1287 | K | A | -2.1987 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -0.9810 | |
1290 | E | A | -0.7543 | |
1291 | M | A | -0.4902 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.7360 | |
1295 | C | A | 0.0000 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.1096 | |
1299 | T | A | -0.6797 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.3230 | |
1302 | Q | A | -1.6916 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -0.6940 | |
1306 | L | A | -0.4214 | |
1307 | R | A | -0.3979 | |
1308 | E | A | -0.4437 | |
1309 | A | A | 0.0324 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 0.9610 | |
1312 | A | A | 0.5361 | |
1313 | A | A | -0.1753 | |
1314 | G | A | -0.2799 | |
1315 | K | A | -1.0576 | |
1316 | E | A | -1.2953 | |
1317 | I | A | 0.2328 | |
1318 | I | A | 0.9923 | |
1319 | W | A | 0.7522 | |
1320 | H | A | 0.0000 | |
1321 | G | A | 0.0000 | |
1322 | R | A | -0.9851 | |
1323 | T | A | -1.3384 | |
1324 | K | A | -2.2507 | |
1325 | E | A | -1.7485 | |
1326 | E | A | 0.0000 | |
1327 | P | A | -0.8808 | |
1328 | A | A | -0.3192 | |
1329 | H | A | 0.0000 | |
1330 | Y | A | 0.0000 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.6689 | |
1333 | I | A | 1.5874 | |
1334 | C | A | 0.5222 | |
1335 | E | A | 0.1177 | |
1336 | V | A | 0.3892 | |
1337 | E | A | 0.0000 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.1949 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -1.0807 | |
1346 | N | A | -2.2998 | |
1347 | E | A | -2.0358 | |
1348 | S | A | -1.7098 | |
1349 | N | A | -2.2687 | |
1350 | S | A | -2.4879 | |
1351 | R | A | -3.5235 | |
1352 | K | A | -3.5894 | |
1353 | T | A | -2.2546 | |
1354 | Y | A | -1.2441 | |
1355 | I | A | -0.0626 | |
1356 | V | A | 0.0000 | |
1357 | H | A | 0.0000 | |
1358 | C | A | -0.4471 | |
1359 | Q | A | -1.6473 | |
1360 | D | A | -2.4597 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -2.9522 | |
1364 | K | A | -2.8803 | |
1365 | T | A | -2.0893 | |
1366 | S | A | -2.4397 | |
1367 | G | A | -2.5194 | |
1368 | N | A | -2.5698 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.1417 | |
1371 | N | A | -2.3707 | |
1372 | F | A | 0.0000 | |
1373 | V | A | -0.6051 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.1453 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | 0.0000 | |
1379 | K | A | -2.1534 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.7341 | |
1382 | D | A | -2.2089 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.8493 | |
1385 | Q | A | -2.5662 | |
1386 | V | A | 0.0000 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -1.7169 | |
1389 | Q | A | -1.9240 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.5879 | |
1392 | L | A | 0.0271 | |
1393 | A | A | -0.4464 | |
1394 | P | A | -0.4975 | |
17 | R | B | -2.5055 | |
18 | K | B | -2.6682 | |
19 | Q | B | -2.5105 | |
20 | L | B | -0.9819 | |
21 | A | B | -0.7818 | |
22 | T | B | -0.8645 | |
23 | K | B | -1.7280 | |
24 | A | B | -0.8650 | |
25 | A | B | 0.0000 | |
26 | R | B | -0.6897 | |
28 | S | B | -0.4061 | |
29 | A | B | -0.3067 | |
30 | P | B | -0.1885 | |
31 | A | B | -0.6878 | |
32 | T | B | -0.8351 |