Project name: bf4d7aa068d2256

Chain sequence(s)	A: QQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTVILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7261
• Maximal score value: 2.8029
• Average score: -0.6576
• Total score value: -339.9546

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
57	Q	A	-2.1074
58	Q	A	-1.9172
59	Q	A	-1.4789
60	Q	A	0.0000
61	L	A	-0.1060
62	P	A	-0.0724
63	A	A	0.0000
64	A	A	0.2320
65	M	A	0.2591
66	A	A	0.0000
67	D	A	-1.5582
68	T	A	0.1767
69	F	A	1.9627
70	L	A	2.4183
71	E	A	0.9454
72	H	A	0.0000
73	L	A	2.8029
74	C	A	2.0609
75	L	A	1.8921
76	L	A	1.0246
77	D	A	-0.6971
78	I	A	0.1268
79	D	A	-1.9063
80	S	A	0.0000
81	E	A	-2.4207
82	P	A	-1.2974
83	V	A	0.1162
84	A	A	-0.0545
85	A	A	0.0771
86	R	A	0.0000
87	S	A	-0.2175
88	T	A	0.0000
89	S	A	0.0000
90	I	A	0.0000
91	I	A	0.0000
92	A	A	0.0000
93	T	A	0.0000
94	I	A	-0.3509
95	G	A	-0.9246
96	P	A	-0.8993
97	A	A	-1.3039
98	S	A	0.0000
99	R	A	-1.4732
100	S	A	-1.5498
101	V	A	-2.1477
102	E	A	-3.1546
103	R	A	-3.0065
104	L	A	0.0000
105	K	A	-3.0325
106	E	A	-3.3265
107	M	A	0.0000
108	I	A	0.0000
109	K	A	-2.7692
110	A	A	-1.9447
111	G	A	-1.3080
112	M	A	0.0000
113	N	A	-0.5978
114	I	A	0.0000
115	A	A	0.0000
116	R	A	0.0000
117	L	A	0.0000
118	N	A	-0.7158
119	F	A	0.0000
120	S	A	-0.9294
121	H	A	-1.1919
122	G	A	-0.8613
123	S	A	-0.7680
124	H	A	-1.4507
125	E	A	-1.7951
126	Y	A	-0.4070
127	H	A	0.0000
128	A	A	-1.1141
129	E	A	-1.7085
130	S	A	0.0000
131	I	A	0.0000
132	A	A	-1.3891
133	N	A	-2.1790
134	V	A	0.0000
135	R	A	-2.2934
136	E	A	-3.0162
137	A	A	0.0000
138	V	A	0.0000
139	E	A	-2.6458
140	S	A	-1.4815
141	F	A	-1.1156
142	A	A	-0.8284
143	G	A	-0.6683
144	S	A	-0.3375
145	P	A	-0.4014
146	L	A	-0.0166
147	S	A	-0.1342
148	Y	A	0.0000
149	R	A	-1.4234
150	P	A	0.0000
151	V	A	0.0000
152	A	A	0.0000
153	I	A	0.0000
154	A	A	0.0000
155	L	A	0.0000
156	D	A	0.0000
157	T	A	0.0000
158	K	A	-0.7817
159	G	A	-0.5335
160	P	A	-0.4863
161	E	A	-0.8391
162	I	A	0.0000
163	R	A	-1.5472
164	T	A	0.0000
165	V	A	0.0000
166	I	A	-1.5623
167	L	A	0.0000
168	Q	A	-2.6130
169	G	A	-1.8824
170	G	A	0.0000
171	P	A	-1.8232
172	E	A	-2.4719
173	S	A	-2.2220
174	E	A	-2.5722
175	V	A	-1.4398
176	E	A	-1.4850
177	L	A	0.0000
178	V	A	-0.2327
179	K	A	-2.1338
180	G	A	-1.6725
181	S	A	-1.4154
182	Q	A	-1.7744
183	V	A	0.0000
184	L	A	-0.5656
185	V	A	0.0000
186	T	A	0.0000
187	V	A	-0.6935
188	D	A	-1.0788
189	P	A	-0.8444
190	A	A	-0.8180
191	F	A	-1.3289
192	R	A	-2.4488
193	T	A	-1.9405
194	R	A	-2.7332
195	G	A	0.0000
196	N	A	-2.2824
197	A	A	-1.3493
198	N	A	-1.6252
199	T	A	-1.1874
200	V	A	0.0000
201	W	A	0.0000
202	V	A	0.0000
203	D	A	-1.5354
204	Y	A	0.0000
205	P	A	-0.7616
206	N	A	-1.0913
207	I	A	0.0000
208	V	A	-0.7005
209	R	A	-1.6018
210	V	A	-0.7253
211	V	A	0.0000
212	P	A	0.0609
213	V	A	1.0608
214	G	A	-0.1366
215	G	A	-0.2893
216	R	A	-0.9540
217	I	A	0.0000
218	Y	A	-0.1748
219	I	A	0.0000
220	D	A	-0.9937
221	D	A	-1.6123
222	G	A	-0.3696
223	L	A	0.9578
224	I	A	0.0000
225	S	A	0.0000
226	L	A	0.0000
227	V	A	0.0000
228	V	A	0.0000
229	Q	A	-0.9884
230	K	A	-0.9733
231	I	A	0.1027
232	G	A	-0.6085
233	P	A	-1.0979
234	E	A	-1.6781
235	G	A	0.0000
236	L	A	0.0000
237	V	A	-0.5318
238	T	A	0.0000
239	Q	A	-2.2047
240	V	A	0.0000
241	E	A	-1.7791
242	N	A	-1.2204
243	G	A	-0.7364
244	G	A	0.3260
245	V	A	0.9116
246	L	A	0.0000
247	G	A	-1.4153
248	S	A	-1.8586
249	R	A	-2.3360
250	K	A	-1.9696
251	G	A	-1.6162
252	V	A	0.0000
253	N	A	-0.7030
254	L	A	0.0000
255	P	A	-0.8269
256	G	A	-1.0224
257	A	A	-1.0036
258	Q	A	-1.5613
259	V	A	-0.8920
260	D	A	-1.7170
261	L	A	-0.6582
262	P	A	-0.6432
263	G	A	-0.5398
264	L	A	-0.5357
265	S	A	-1.3080
266	E	A	-2.4868
267	Q	A	-2.3204
268	D	A	0.0000
269	V	A	-1.6123
270	R	A	-2.8852
271	D	A	0.0000
272	L	A	0.0000
273	R	A	-2.8195
274	F	A	0.0000
275	G	A	0.0000
276	V	A	-2.0028
277	E	A	-2.6150
278	H	A	-1.4443
279	G	A	-1.3082
280	V	A	0.0000
281	D	A	0.0000
282	I	A	0.0000
283	V	A	0.0000
284	F	A	0.0000
285	A	A	0.0000
286	S	A	0.0000
287	F	A	-0.3294
288	V	A	0.0000
289	R	A	-1.6716
290	K	A	-2.0615
291	A	A	-1.3355
292	S	A	-0.6766
293	D	A	-0.6530
294	V	A	0.0000
295	A	A	-0.3662
296	A	A	-0.2216
297	V	A	0.0000
298	R	A	-1.0548
299	A	A	-0.4368
300	A	A	0.0000
301	L	A	0.0000
302	G	A	-1.3474
303	P	A	-1.5951
304	E	A	-2.7010
305	G	A	0.0000
306	H	A	-1.8640
307	G	A	-1.4259
308	I	A	-1.0655
309	K	A	-0.8735
310	I	A	0.0000
311	I	A	0.0000
312	S	A	0.0000
313	K	A	0.0000
314	I	A	0.0000
315	E	A	0.0000
316	N	A	-1.2613
317	H	A	-2.2638
318	E	A	-2.6183
319	G	A	0.0000
320	V	A	-1.9056
321	K	A	-3.1375
322	R	A	-3.0030
323	F	A	0.0000
324	D	A	-3.3722
325	E	A	-2.7796
326	I	A	0.0000
327	L	A	0.0000
328	E	A	-2.3622
329	V	A	-1.0082
330	S	A	0.0000
331	D	A	-0.9334
332	G	A	0.0000
333	I	A	0.0000
334	M	A	0.0000
335	V	A	0.0000
336	A	A	0.0000
337	R	A	-0.3718
338	G	A	-1.0457
339	D	A	-0.9164
340	L	A	0.0000
341	G	A	-0.8423
342	I	A	-0.3498
343	E	A	-0.8059
344	I	A	0.0000
345	P	A	-1.1990
346	A	A	-1.0282
347	E	A	-1.7833
348	K	A	-0.9721
349	V	A	0.2457
350	F	A	1.6415
351	L	A	1.4988
352	A	A	0.0000
353	Q	A	0.0000
354	K	A	-0.6255
355	M	A	-0.0855
356	M	A	0.0000
357	I	A	0.0000
358	G	A	-0.9228
359	R	A	-1.5279
360	C	A	0.0000
361	N	A	0.0000
362	L	A	0.4716
363	A	A	-0.3386
364	G	A	-0.1816
365	K	A	-0.7627
366	P	A	0.0000
367	V	A	0.0000
368	V	A	0.0000
369	C	A	0.0000
370	A	A	0.0000
371	T	A	-0.9711
372	Q	A	-1.7493
373	M	A	0.0000
374	L	A	0.0000
375	E	A	-1.7942
376	S	A	-1.6135
377	M	A	0.0000
378	I	A	-1.5671
379	T	A	-1.7328
380	K	A	-2.7421
381	P	A	-2.1516
382	R	A	-2.7534
383	P	A	-2.0761
384	T	A	-1.8526
385	R	A	-2.2024
386	A	A	-1.0870
387	E	A	-1.6581
388	T	A	-1.1950
389	S	A	-1.1352
390	D	A	-1.1615
391	V	A	0.0000
392	A	A	-0.9613
393	N	A	-1.2695
394	A	A	0.0000
395	V	A	0.0000
396	L	A	0.1813
397	D	A	-0.5823
398	G	A	0.0000
399	A	A	0.0000
400	D	A	0.0000
401	C	A	0.0000
402	I	A	0.0000
403	M	A	0.0000
404	L	A	0.0000
405	S	A	-0.7350
406	G	A	-1.1077
407	E	A	0.0000
408	T	A	0.0000
409	A	A	-1.0490
410	K	A	-2.0104
411	G	A	0.0000
412	N	A	-1.8862
413	F	A	-1.5093
414	P	A	0.0000
415	V	A	0.0000
416	E	A	-1.9638
417	A	A	0.0000
418	V	A	0.0000
419	K	A	-2.0553
420	M	A	-1.0940
421	Q	A	0.0000
422	H	A	-1.1719
423	A	A	-0.9977
424	I	A	0.0000
425	A	A	0.0000
426	R	A	-1.5598
427	E	A	-2.0495
428	A	A	0.0000
429	E	A	-0.7611
430	A	A	0.0000
431	A	A	-0.0689
432	V	A	-0.0587
433	Y	A	0.0000
434	H	A	-1.2869
435	R	A	-2.4042
436	Q	A	-2.1146
437	L	A	-1.7026
438	F	A	0.0000
439	E	A	-3.2950
440	E	A	-3.0445
441	L	A	0.0000
442	R	A	-1.8655
443	R	A	-2.7999
444	A	A	-1.2181
445	A	A	-0.3671
446	P	A	-0.0977
447	L	A	0.8326
448	S	A	-0.1798
449	R	A	-1.5958
450	D	A	-1.0803
451	P	A	-0.6297
452	T	A	0.0000
453	E	A	-0.1602
454	V	A	0.9455
455	T	A	0.3663
456	A	A	0.0000
457	I	A	0.1964
458	G	A	-0.0108
459	A	A	0.0000
460	V	A	0.0000
461	E	A	-1.6594
462	A	A	0.0000
463	A	A	0.0000
464	F	A	-0.7068
465	K	A	-1.4650
466	C	A	-0.1346
467	C	A	0.3566
468	A	A	0.0000
469	A	A	0.0075
470	A	A	0.0000
471	I	A	0.0000
472	I	A	0.0000
473	V	A	0.0000
474	L	A	0.0000
475	T	A	0.0000
476	T	A	-0.8465
477	T	A	-0.9977
478	G	A	0.0000
479	R	A	-1.5491
480	S	A	-0.9307
481	A	A	0.0000
482	Q	A	-0.9437
483	L	A	0.0000
484	L	A	0.0000
485	S	A	0.0000
486	R	A	-0.1254
487	Y	A	0.0000
488	R	A	0.0000
489	P	A	-0.2285
490	R	A	-0.1875
491	A	A	0.0000
492	A	A	-0.0076
493	V	A	0.0000
494	I	A	0.0000
495	A	A	0.0000
496	V	A	0.0000
497	T	A	0.0000
498	R	A	-1.5223
499	S	A	-0.9301
500	A	A	-0.8720
501	Q	A	-1.1916
502	A	A	0.0000
503	A	A	0.0000
504	R	A	-0.7927
505	Q	A	-0.6250
506	V	A	0.0000
507	H	A	0.0000
508	L	A	0.0000
509	C	A	0.0000
510	R	A	0.0000
511	G	A	-0.1562
512	V	A	0.0000
513	F	A	0.0690
514	P	A	0.0000
515	L	A	0.0000
516	L	A	-0.8186
517	Y	A	0.0000
518	R	A	-2.3633
519	E	A	-2.9159
520	P	A	-1.8729
521	P	A	-1.6934
522	E	A	-1.6428
523	A	A	0.1458
524	I	A	1.3862
525	W	A	0.2437
526	A	A	-0.6403
527	D	A	-2.0215
528	D	A	0.0000
529	V	A	0.0000
530	D	A	-3.2977
531	R	A	-3.7261
532	R	A	-2.5523
533	V	A	0.0000
534	Q	A	-2.0762
535	F	A	-1.4214
536	G	A	0.0000
537	I	A	-1.0257
538	E	A	-1.2950
539	S	A	0.0000
540	G	A	0.0000
541	K	A	-1.2205
542	L	A	0.2034
543	R	A	-0.4438
544	G	A	-0.7229
545	F	A	-0.4333
546	L	A	0.0000
547	R	A	-1.4136
548	V	A	0.2833
549	G	A	-0.2536
550	D	A	-0.3495
551	L	A	0.4927
552	V	A	0.0000
553	I	A	0.0000
554	V	A	0.0000
555	V	A	0.0000
556	T	A	0.0000
557	G	A	0.1196
558	W	A	0.6294
559	R	A	-0.6583
560	P	A	-0.6104
561	G	A	-0.7683
562	S	A	-0.8574
563	G	A	-0.8903
564	Y	A	0.0357
565	T	A	-0.1598
566	N	A	-0.0875
567	I	A	0.5026
568	M	A	0.2225
569	R	A	0.0228
570	V	A	0.9318
571	L	A	0.7016
572	S	A	0.2245
573	S	A	-0.3067