Project name: AG_10p_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1722
• Maximal score value: 2.4333
• Average score: -0.7147
• Total score value: -308.0449

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.5646
3	E	A	-2.4318
4	L	A	0.0000
5	T	A	-1.4676
6	Q	A	-1.7061
7	D	A	-2.3740
8	P	A	-1.7055
9	A	A	0.0000
10	V	A	-1.0041
11	S	A	-0.3384
12	V	A	0.0000
13	A	A	-0.0462
14	L	A	-0.0627
15	G	A	-0.9064
16	Q	A	-1.4022
17	T	A	-1.2171
18	V	A	0.0000
19	R	A	-1.9006
20	V	A	0.0000
21	T	A	-1.1459
22	C	A	0.0000
23	Q	A	-2.2347
24	G	A	0.0000
25	D	A	-3.1359
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.7701
29	S	A	-1.3511
30	Y	A	-0.7116
31	Y	A	-0.5163
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	K	A	-1.8207
39	P	A	-1.4073
40	G	A	-1.3267
41	Q	A	-1.8233
42	A	A	-1.0088
43	P	A	0.0000
44	V	A	0.9937
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.1081
49	G	A	0.0000
50	K	A	-2.6433
51	N	A	-2.5005
52	N	A	-2.1465
53	R	A	-1.8548
54	P	A	-0.5473
55	S	A	-0.6269
56	G	A	-0.7953
57	I	A	-0.5995
58	P	A	-1.2633
59	D	A	-2.1507
60	R	A	-1.3647
61	F	A	0.0000
62	S	A	-1.5881
63	G	A	-1.4409
64	S	A	-1.1862
65	S	A	-1.1256
66	S	A	-1.0574
67	G	A	-1.7992
68	N	A	-2.0801
69	T	A	-1.4532
70	A	A	0.0000
71	S	A	-0.8086
72	L	A	0.0000
73	T	A	-0.9271
74	I	A	0.0000
75	T	A	-1.2438
76	G	A	-0.9116
77	A	A	0.0000
78	Q	A	-1.4928
79	A	A	0.0000
80	E	A	-2.6481
81	D	A	0.0000
82	E	A	-2.2174
83	A	A	0.0000
84	D	A	-1.8973
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.1021
89	S	A	0.0000
90	R	A	-0.7640
91	D	A	-1.4694
92	S	A	-1.5675
93	S	A	-0.7732
94	G	A	-0.7699
95	N	A	-1.3621
96	H	A	-1.0977
97	W	A	0.0000
98	V	A	-0.5229
99	F	A	-0.4666
100	G	A	0.0000
101	G	A	-1.5731
102	G	A	0.0000
103	T	A	0.0000
104	E	A	-2.3887
105	L	A	0.0000
106	T	A	-0.5255
107	V	A	0.0000
108	L	A	0.6568
109	G	A	-0.1428
110	Q	A	0.0000
111	P	A	-0.9938
112	K	A	-2.1610
113	A	A	-1.1915
114	A	A	-0.6685
115	P	A	0.0000
116	S	A	-0.1710
117	V	A	0.0000
118	T	A	-0.3826
119	L	A	-0.3441
120	F	A	0.0000
121	P	A	-0.0543
122	P	A	-0.6461
123	S	A	-1.1753
124	S	A	-1.6026
125	E	A	-2.3915
126	E	A	0.0000
127	L	A	-2.0640
128	Q	A	-2.3780
129	A	A	-1.8980
130	N	A	-2.6088
131	K	A	-2.4905
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.4024
140	D	A	-0.8498
141	F	A	0.0000
142	Y	A	-1.1004
143	P	A	-0.9490
144	G	A	-0.8816
145	A	A	-0.2726
146	V	A	-0.0278
147	T	A	-0.0803
148	V	A	0.1606
149	A	A	-0.3013
150	W	A	0.0000
151	K	A	-1.3042
152	A	A	0.0000
153	D	A	-1.5986
154	S	A	-1.0580
155	S	A	-0.9177
156	P	A	-0.9967
157	V	A	-0.5977
158	K	A	-1.4413
159	A	A	-0.4763
160	G	A	0.0801
161	V	A	0.5539
162	E	A	0.3852
163	T	A	0.3369
164	T	A	0.0545
165	T	A	-0.1040
166	P	A	-0.2437
167	S	A	-0.5689
168	K	A	-1.1321
169	Q	A	-1.1564
170	S	A	-1.3635
171	N	A	-1.8908
172	N	A	-1.9092
173	K	A	-1.3699
174	Y	A	-0.6588
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.2525
181	S	A	0.1995
182	L	A	0.0000
183	T	A	-1.8220
184	P	A	-2.3889
185	E	A	-3.1722
186	Q	A	-2.3253
187	W	A	0.0000
188	K	A	-3.1069
189	S	A	0.0000
190	H	A	-2.4313
191	R	A	-2.5998
192	S	A	-1.6631
193	Y	A	0.0000
194	S	A	-1.2434
195	C	A	0.0000
196	Q	A	-1.3237
197	V	A	0.0000
198	T	A	-0.6899
199	H	A	0.0000
200	E	A	-2.2874
201	G	A	-1.4339
202	S	A	-0.9056
203	T	A	-0.7725
204	V	A	-0.7632
205	E	A	-2.2323
206	K	A	-1.9312
207	T	A	-1.1802
208	V	A	0.0000
209	A	A	-0.9648
210	P	A	-0.9909
2	V	A	1.0798
3	Q	A	-1.0628
4	L	A	0.0000
5	Q	A	-2.3192
6	Q	A	-1.5824
7	S	A	-1.3856
8	G	A	-1.1891
9	A	A	0.0000
10	E	A	-1.3200
11	V	A	-0.8003
12	K	A	-1.7477
13	K	A	-2.4495
14	P	A	-2.0868
15	G	A	-1.5871
16	S	A	-1.2771
17	S	A	-1.2753
18	V	A	0.0000
19	R	A	-2.4088
20	V	A	0.0000
21	S	A	-1.1654
22	C	A	0.0000
23	K	A	-1.7855
24	A	A	0.0000
25	S	A	-0.9473
26	G	A	-0.7574
27	G	A	-1.2965
28	T	A	-1.5849
29	F	A	0.0000
30	N	A	-1.6715
31	N	A	-0.6063
32	N	A	-0.5951
33	A	A	-0.0449
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.5570
39	Q	A	-0.7816
40	A	A	-1.0504
41	P	A	-0.9154
42	G	A	-1.2394
43	Q	A	-1.8210
44	G	A	-1.3622
45	L	A	0.0000
46	E	A	-0.7420
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.4017
52	I	A	0.4033
53	P	A	-0.2521
54	M	A	0.7067
55	F	A	1.5846
56	G	A	0.3689
57	T	A	-0.0252
58	A	A	-0.3448
59	K	A	-1.4545
60	Y	A	-0.8151
61	S	A	-1.3063
62	Q	A	-2.2084
63	N	A	-2.2397
64	F	A	0.0000
65	Q	A	-2.1005
66	G	A	-1.4944
67	R	A	-1.2439
68	V	A	-1.1165
69	A	A	-0.7155
70	I	A	0.0000
71	T	A	-0.4615
72	A	A	-1.2137
73	D	A	-2.6371
74	E	A	-2.5824
75	S	A	-1.6605
76	T	A	-1.4818
77	G	A	0.0000
78	T	A	-1.6401
79	A	A	0.0000
80	S	A	0.0000
81	M	A	0.0000
82	E	A	-1.8794
83	L	A	0.0000
84	S	A	-1.2485
85	S	A	-1.2364
86	L	A	0.0000
87	R	A	-2.8954
88	S	A	-2.3095
89	E	A	-2.5306
90	D	A	0.0000
91	T	A	-0.9774
92	A	A	0.0000
93	V	A	-0.0976
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.3937
99	S	A	0.0000
100	R	A	-0.8466
101	D	A	0.4129
102	L	A	1.3061
103	L	A	2.4333
104	L	A	2.2948
105	F	A	1.0610
106	P	A	0.4977
107	H	A	-0.8726
108	H	A	-0.8204
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.0219
112	P	A	0.0346
113	W	A	-0.3367
114	G	A	0.0000
115	R	A	-2.3960
116	G	A	0.0000
117	T	A	0.0000
118	M	A	-0.2630
119	V	A	0.0000
120	T	A	-0.6425
121	V	A	0.0000
122	S	A	-1.1496
123	S	A	-0.9595
124	A	A	-0.6119
125	S	A	-0.7375
126	T	A	-0.6965
127	K	A	-0.9753
128	G	A	-1.2089
129	P	A	-0.5855
130	S	A	-0.2534
131	V	A	-0.4856
132	F	A	0.0000
133	P	A	-1.3142
134	L	A	0.0000
135	A	A	-0.9949
136	P	A	0.0000
137	S	A	-0.9129
138	S	A	-1.2039
139	K	A	-2.0364
140	S	A	-1.3825
141	T	A	-0.8123
142	S	A	-0.8483
143	G	A	-1.0268
144	G	A	-1.1311
145	T	A	-0.7830
146	A	A	0.0000
147	A	A	0.0000
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.3005
154	D	A	-0.3627
155	Y	A	0.0000
156	F	A	-0.1991
157	P	A	0.0000
158	E	A	-0.4111
159	P	A	-0.6223
160	V	A	0.0000
161	T	A	-0.4816
162	V	A	-0.3256
163	S	A	-0.3773
164	W	A	0.0000
165	N	A	-0.8000
166	S	A	-0.6409
167	G	A	-0.5594
168	A	A	-0.1919
169	L	A	0.0705
170	T	A	-0.1305
171	S	A	-0.2619
172	G	A	-0.3374
173	V	A	0.1211
174	H	A	-0.2057
175	T	A	-0.0037
176	F	A	0.0000
177	P	A	-0.2235
178	A	A	0.2188
179	V	A	0.0000
180	L	A	1.1996
181	Q	A	0.3233
182	S	A	-0.1150
183	S	A	-0.1859
184	G	A	0.0894
185	L	A	0.2321
186	Y	A	0.4339
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.1486
192	V	A	0.0000
193	T	A	-0.1130
194	V	A	-0.0534
195	P	A	-0.3844
196	S	A	-0.8755
197	S	A	-0.7690
198	S	A	-0.5724
199	L	A	-1.0159
200	G	A	-1.2000
201	T	A	-0.8456
202	Q	A	-1.5525
203	T	A	-1.2997
204	Y	A	0.0000
205	I	A	-1.3361
206	C	A	0.0000
207	N	A	-1.3815
208	V	A	0.0000
209	N	A	-1.6285
210	H	A	0.0000
211	K	A	-2.3153
212	P	A	-1.5091
213	S	A	-1.6884
214	N	A	-2.3485
215	T	A	-1.8997
216	K	A	-2.4581
217	V	A	-1.3946
218	D	A	-2.3884
219	K	A	-2.1740
220	K	A	-2.6490
221	V	A	0.0000
222	E	A	-2.5471
223	P	A	-1.2313