Project name: WEI4-1

Chain sequence(s)	H: VQLQESGPGLVKPSQSLSLTCTVTGYSITTDYAWNWIRQFPGNKLECMGYINYSGSTSFNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCARWDYGRGGSYAMDYWGQGTSVTVSS; L: IVLTQSPASLAVSLGQRATISCRASESVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPWTFGGGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.116
• Maximal score value: 1.8747
• Average score: -0.2464
• Total score value: -56.9094

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	I	L	0.8820
3	V	L	1.8747
4	L	L	0.0000
5	T	L	-0.0890
6	Q	L	-0.1758
7	S	L	-0.2269
8	P	L	-0.1275
9	A	L	0.0038
10	S	L	-0.3206
11	L	L	0.3621
12	A	L	-0.1177
13	V	L	0.0000
14	S	L	-0.0273
15	L	L	1.4452
16	G	L	-0.3775
17	Q	L	-1.4698
18	R	L	-2.1160
19	A	L	0.0000
20	T	L	-0.0624
21	I	L	0.0000
22	S	L	-0.0775
23	C	L	0.0000
24	R	L	-1.9357
25	A	L	0.0000
26	S	L	-0.5482
27	E	L	-1.8704
28	S	L	-0.5999
29	V	L	0.0000
30	D	L	-0.9684
30A	S	L	-0.0038
30B	Y	L	1.2168
30C	G	L	-0.3332
30D	N	L	-0.6750
31	S	L	-0.2091
32	F	L	0.1986
33	M	L	0.0000
34	H	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-0.4626
40	P	L	-0.4163
41	G	L	-0.7199
42	Q	L	-1.2129
43	P	L	-0.2461
44	P	L	0.0000
45	K	L	-1.6912
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.1831
50	L	L	0.2032
51	A	L	0.0000
52	S	L	-0.4380
53	N	L	-1.1127
54	L	L	0.3538
55	E	L	0.0000
56	S	L	-0.2973
57	G	L	-0.5049
58	V	L	0.0000
59	P	L	-0.1464
60	A	L	-0.0377
61	R	L	-0.3679
62	F	L	0.0000
63	S	L	-0.1813
64	G	L	-0.1552
65	S	L	-0.2625
66	G	L	-0.2821
67	S	L	-0.5973
68	R	L	-1.8923
69	T	L	-0.5009
70	D	L	-1.0172
71	F	L	0.0000
72	T	L	-0.0352
73	L	L	0.0000
74	T	L	-0.0240
75	I	L	0.0000
76	D	L	-0.9687
77	P	L	-0.3744
78	V	L	0.0000
79	E	L	-1.1521
80	A	L	-0.4846
81	D	L	-1.7785
82	D	L	0.0000
83	A	L	0.0287
84	A	L	0.0115
85	T	L	0.0000
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	N	L	0.0000
92	N	L	-0.6544
93	E	L	-1.3720
94	D	L	-1.9928
95	P	L	-0.5301
96	W	L	0.2020
97	T	L	0.0318
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.4663
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.5351
104	L	L	0.0000
105	E	L	-1.7623
106	I	L	-0.3478
107	K	L	-1.6606
2	V	H	1.0561
3	Q	H	-0.9517
4	L	H	0.0000
5	Q	H	-0.6756
6	E	H	0.0000
7	S	H	-0.2380
8	G	H	-0.5356
9	P	H	-0.3616
10	G	H	-0.0215
11	L	H	1.4953
12	V	H	0.0000
13	K	H	-1.3091
14	P	H	-0.3466
15	S	H	-0.4809
16	Q	H	-1.2885
17	S	H	-0.4516
18	L	H	0.0000
19	S	H	-0.2303
20	L	H	0.0000
21	T	H	0.0315
22	C	H	0.0000
23	T	H	-0.0521
24	V	H	0.0000
25	T	H	-0.1474
26	G	H	-0.2079
27	Y	H	0.4132
28	S	H	0.0067
29	I	H	0.0000
30	T	H	0.0221
31	T	H	-0.1368
31A	D	H	-0.2567
32	Y	H	0.1247
33	A	H	0.0007
34	W	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	0.0000
40	F	H	0.2231
41	P	H	-0.2698
42	G	H	-0.7339
43	N	H	-1.5625
44	K	H	-1.9220
45	L	H	0.0000
46	E	H	-0.2474
47	C	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	Y	H	0.1645
51	I	H	0.0000
52	N	H	-0.0979
53	Y	H	0.3646
54	S	H	-0.1599
55	G	H	-0.2652
56	S	H	-0.2546
57	T	H	-0.0934
58	S	H	-0.0041
59	F	H	0.3975
60	N	H	-0.1141
61	P	H	-0.2475
62	S	H	-0.2456
63	L	H	0.0000
64	K	H	-1.7390
65	S	H	-0.6137
66	R	H	-0.5249
67	I	H	0.0000
68	S	H	-0.1304
69	I	H	0.0000
70	T	H	-0.1399
71	R	H	-0.4705
72	D	H	-0.4604
73	T	H	-0.1902
74	S	H	-0.5362
75	K	H	-1.7788
76	N	H	-0.5641
77	Q	H	-0.2065
78	F	H	0.0000
79	F	H	0.4050
80	L	H	0.0000
81	Q	H	-0.6435
82	L	H	0.0000
82A	N	H	-0.5649
82B	S	H	-0.4587
82C	V	H	0.0000
83	T	H	-0.0503
84	T	H	-0.4108
85	E	H	-1.8329
86	D	H	0.0000
87	T	H	-0.0165
88	A	H	0.0000
89	T	H	-0.0473
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	W	H	0.0000
96	D	H	-0.0451
97	Y	H	0.5621
98	G	H	-0.2957
99	R	H	-1.9427
100	G	H	-0.8076
100A	G	H	0.0000
100B	S	H	0.0717
100C	Y	H	0.1063
100D	A	H	0.0000
100E	M	H	0.0000
101	D	H	0.0000
102	Y	H	0.5611
103	W	H	0.2161
104	G	H	0.0000
105	Q	H	-1.1983
106	G	H	0.0000
107	T	H	-0.0496
108	S	H	-0.2171
109	V	H	0.0000
110	T	H	0.1341
111	V	H	0.0000
112	S	H	-0.1678
113	S	H	-0.2366