Chain sequence(s) |
A: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT B: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | A | A | -1.1406 | |
2 | S | A | -1.5801 | |
3 | K | A | -2.1386 | |
4 | G | A | 0.0000 | |
5 | E | A | -1.5868 | |
6 | E | A | -2.1640 | |
7 | L | A | -0.7832 | |
8 | F | A | 0.0000 | |
9 | T | A | -0.3742 | |
10 | G | A | 0.2457 | |
11 | V | A | 1.0446 | |
12 | V | A | 0.0000 | |
13 | P | A | -1.0750 | |
14 | I | A | 0.0000 | |
15 | L | A | -1.1390 | |
16 | V | A | 0.0000 | |
17 | E | A | -1.9696 | |
18 | L | A | 0.0000 | |
19 | D | A | -3.2345 | |
20 | G | A | -2.6860 | |
21 | D | A | -2.2589 | |
22 | V | A | 0.0000 | |
23 | N | A | -1.7468 | |
24 | G | A | -1.3012 | |
25 | H | A | -1.7547 | |
26 | K | A | -2.6609 | |
27 | F | A | 0.0000 | |
28 | S | A | -1.7810 | |
29 | V | A | 0.0000 | |
30 | S | A | -1.1036 | |
31 | G | A | 0.0000 | |
32 | E | A | -2.4192 | |
33 | G | A | -1.7361 | |
34 | E | A | -1.8144 | |
35 | G | A | 0.0000 | |
36 | D | A | -0.3114 | |
37 | A | A | 0.0000 | |
38 | T | A | -0.1221 | |
39 | Y | A | -0.3369 | |
40 | G | A | 0.0000 | |
41 | K | A | -0.6529 | |
42 | L | A | 0.0000 | |
43 | T | A | -1.0913 | |
44 | L | A | 0.0000 | |
45 | K | A | -1.5330 | |
46 | F | A | 0.0000 | |
47 | I | A | -1.2185 | |
48 | C | A | 0.0000 | |
49 | T | A | -0.7477 | |
50 | T | A | -1.1625 | |
51 | G | A | -1.6617 | |
52 | K | A | -2.2851 | |
53 | L | A | 0.0000 | |
54 | P | A | -1.1286 | |
55 | V | A | 0.0000 | |
56 | P | A | 0.0000 | |
57 | W | A | 0.0000 | |
58 | P | A | 0.0000 | |
59 | T | A | 0.0000 | |
60 | L | A | 0.0000 | |
61 | V | A | 0.0000 | |
62 | T | A | 0.0000 | |
63 | T | A | 0.0000 | |
64 | F | A | 0.0000 | |
66 | Y | A | 0.0000 | |
67 | G | A | 0.0000 | |
68 | V | A | 0.0000 | |
69 | Q | A | 0.0000 | |
70 | C | A | 0.0000 | |
71 | F | A | 0.0000 | |
72 | S | A | 0.0000 | |
73 | R | A | -0.6722 | |
74 | Y | A | 0.0000 | |
75 | P | A | -1.6458 | |
76 | D | A | -2.7603 | |
77 | H | A | -2.3580 | |
78 | M | A | 0.0000 | |
79 | K | A | -2.3440 | |
80 | R | A | -2.7300 | |
81 | H | A | -1.6816 | |
82 | D | A | 0.0000 | |
83 | F | A | 0.0000 | |
84 | F | A | 0.0000 | |
85 | K | A | 0.0000 | |
86 | S | A | -0.9731 | |
87 | A | A | 0.0000 | |
88 | M | A | 0.0000 | |
89 | P | A | -1.0116 | |
90 | E | A | -1.5956 | |
91 | G | A | 0.0000 | |
92 | Y | A | 0.0000 | |
93 | V | A | -0.6322 | |
94 | Q | A | 0.0000 | |
95 | E | A | -2.3598 | |
96 | R | A | 0.0000 | |
97 | T | A | -0.4757 | |
98 | I | A | 0.0000 | |
99 | F | A | 0.2701 | |
100 | F | A | 0.0000 | |
101 | K | A | -2.1955 | |
102 | D | A | -2.9594 | |
103 | D | A | -2.6030 | |
104 | G | A | 0.0000 | |
105 | N | A | -0.6977 | |
106 | Y | A | 0.0000 | |
107 | K | A | -1.6372 | |
108 | T | A | 0.0000 | |
109 | R | A | -3.2618 | |
110 | A | A | 0.0000 | |
111 | E | A | -1.7787 | |
112 | V | A | 0.0000 | |
113 | K | A | -1.1616 | |
114 | F | A | -1.2838 | |
115 | E | A | -1.5841 | |
116 | G | A | -1.7118 | |
117 | D | A | -2.1363 | |
118 | T | A | -1.6119 | |
119 | L | A | 0.0000 | |
120 | V | A | 0.0000 | |
121 | N | A | 0.0000 | |
122 | R | A | -2.2695 | |
123 | I | A | 0.0000 | |
124 | E | A | -3.8366 | |
125 | L | A | 0.0000 | |
126 | K | A | -2.2184 | |
127 | G | A | 0.0000 | |
128 | I | A | -1.0944 | |
129 | D | A | -2.4720 | |
130 | F | A | 0.0000 | |
131 | K | A | -3.7750 | |
132 | E | A | -3.8652 | |
133 | D | A | -3.5290 | |
134 | G | A | -2.7794 | |
135 | N | A | -2.2212 | |
136 | I | A | 0.0000 | |
137 | L | A | -1.9515 | |
138 | G | A | -2.2760 | |
139 | H | A | -2.0927 | |
140 | K | A | -2.3370 | |
141 | L | A | 0.0000 | |
142 | E | A | -1.2538 | |
143 | Y | A | -0.3129 | |
144 | N | A | 0.0000 | |
145 | Y | A | 0.0000 | |
146 | N | A | 0.0000 | |
147 | S | A | 0.0000 | |
148 | H | A | 0.0000 | |
149 | N | A | -0.3536 | |
150 | V | A | 0.0000 | |
151 | Y | A | 0.2663 | |
152 | I | A | 0.0000 | |
153 | M | A | -0.8487 | |
154 | A | A | -1.7834 | |
155 | D | A | -2.3686 | |
156 | K | A | -3.2489 | |
157 | Q | A | -3.1938 | |
158 | K | A | -3.4002 | |
159 | N | A | -2.7522 | |
160 | G | A | 0.0000 | |
161 | I | A | 0.0000 | |
162 | K | A | -1.1910 | |
163 | V | A | 0.0000 | |
164 | N | A | -0.3270 | |
165 | F | A | 0.0000 | |
166 | K | A | -1.3817 | |
167 | I | A | 0.0000 | |
168 | R | A | -0.6807 | |
169 | H | A | 0.0000 | |
170 | N | A | -0.8572 | |
171 | I | A | 0.0000 | |
172 | E | A | -3.1398 | |
173 | D | A | -2.9623 | |
174 | G | A | -1.8590 | |
175 | S | A | -0.7872 | |
176 | V | A | 0.0110 | |
177 | Q | A | 0.0000 | |
178 | L | A | -0.6659 | |
179 | A | A | 0.0000 | |
180 | D | A | -0.6747 | |
181 | H | A | 0.0000 | |
182 | Y | A | -0.0575 | |
183 | Q | A | 0.0000 | |
184 | Q | A | -1.2776 | |
185 | N | A | 0.0000 | |
186 | T | A | -0.7511 | |
187 | P | A | -0.6360 | |
188 | I | A | 0.0001 | |
189 | G | A | -1.0814 | |
190 | D | A | -1.9767 | |
191 | G | A | -1.2607 | |
192 | P | A | -0.7501 | |
193 | V | A | -0.4359 | |
194 | L | A | -0.4241 | |
195 | L | A | -0.9022 | |
196 | P | A | 0.0000 | |
197 | D | A | -2.3770 | |
198 | N | A | -1.6349 | |
199 | H | A | 0.0000 | |
200 | Y | A | -0.0154 | |
201 | L | A | 0.0000 | |
202 | S | A | -0.0838 | |
203 | T | A | 0.0000 | |
204 | Q | A | 0.0000 | |
205 | S | A | 0.0000 | |
206 | A | A | 0.0000 | |
207 | L | A | 0.0000 | |
208 | S | A | -0.5786 | |
209 | K | A | -1.5163 | |
210 | D | A | -1.7378 | |
211 | P | A | -1.5516 | |
212 | N | A | -2.2814 | |
213 | E | A | -2.5579 | |
214 | K | A | -3.1251 | |
215 | R | A | -3.1556 | |
216 | D | A | -2.1307 | |
217 | H | A | 0.0000 | |
218 | M | A | 0.0000 | |
219 | V | A | 0.0000 | |
220 | L | A | 0.0000 | |
221 | L | A | -0.0406 | |
222 | E | A | 0.0000 | |
223 | F | A | 0.0000 | |
224 | V | A | 0.0000 | |
225 | T | A | -0.1952 | |
226 | A | A | 0.0000 | |
227 | A | A | -0.2016 | |
228 | G | A | -0.5892 | |
229 | I | A | -0.6059 | |
230 | T | A | -0.2060 | |
1 | A | B | -1.1729 | |
2 | S | B | -1.6155 | |
3 | K | B | -2.2100 | |
4 | G | B | 0.0000 | |
5 | E | B | -1.6895 | |
6 | E | B | -2.2366 | |
7 | L | B | -0.8378 | |
8 | F | B | 0.0000 | |
9 | T | B | -0.3895 | |
10 | G | B | 0.2048 | |
11 | V | B | 1.0265 | |
12 | V | B | 0.0000 | |
13 | P | B | -1.0960 | |
14 | I | B | 0.0000 | |
15 | L | B | -1.1443 | |
16 | V | B | 0.0000 | |
17 | E | B | -1.9479 | |
18 | L | B | 0.0000 | |
19 | D | B | -3.1843 | |
20 | G | B | 0.0000 | |
21 | D | B | -2.1783 | |
22 | V | B | 0.0000 | |
23 | N | B | -1.7251 | |
24 | G | B | -1.2947 | |
25 | H | B | -1.7561 | |
26 | K | B | -2.6717 | |
27 | F | B | 0.0000 | |
28 | S | B | -1.7447 | |
29 | V | B | 0.0000 | |
30 | S | B | -1.0812 | |
31 | G | B | 0.0000 | |
32 | E | B | -2.4393 | |
33 | G | B | -1.7836 | |
34 | E | B | -1.8461 | |
35 | G | B | 0.0000 | |
36 | D | B | -0.3222 | |
37 | A | B | 0.0000 | |
38 | T | B | -0.1946 | |
39 | Y | B | -0.4908 | |
40 | G | B | 0.0000 | |
41 | K | B | -0.7850 | |
42 | L | B | 0.0000 | |
43 | T | B | -1.1161 | |
44 | L | B | 0.0000 | |
45 | K | B | -1.5076 | |
46 | F | B | 0.0000 | |
47 | I | B | -1.2335 | |
48 | C | B | 0.0000 | |
49 | T | B | -0.7845 | |
50 | T | B | -1.1986 | |
51 | G | B | -1.7294 | |
52 | K | B | -2.3471 | |
53 | L | B | 0.0000 | |
54 | P | B | -1.1833 | |
55 | V | B | 0.0000 | |
56 | P | B | 0.0000 | |
57 | W | B | 0.0000 | |
58 | P | B | 0.0000 | |
59 | T | B | 0.0000 | |
60 | L | B | 0.0000 | |
61 | V | B | 0.0000 | |
62 | T | B | 0.0000 | |
63 | T | B | 0.0000 | |
64 | F | B | 0.0000 | |
66 | Y | B | 0.0000 | |
67 | G | B | 0.0000 | |
68 | V | B | 0.0000 | |
69 | Q | B | 0.0000 | |
70 | C | B | 0.0000 | |
71 | F | B | 0.0000 | |
72 | S | B | 0.0000 | |
73 | R | B | -1.0212 | |
74 | Y | B | 0.0000 | |
75 | P | B | -1.7203 | |
76 | D | B | -2.8276 | |
77 | H | B | -2.3879 | |
78 | M | B | 0.0000 | |
79 | K | B | -2.5001 | |
80 | R | B | -2.7810 | |
81 | H | B | -1.7177 | |
82 | D | B | 0.0000 | |
83 | F | B | 0.0000 | |
84 | F | B | 0.0000 | |
85 | K | B | 0.0000 | |
86 | S | B | -0.9944 | |
87 | A | B | 0.0000 | |
88 | M | B | 0.0000 | |
89 | P | B | -1.1618 | |
90 | E | B | -1.5914 | |
91 | G | B | 0.0000 | |
92 | Y | B | 0.0000 | |
93 | V | B | -0.8105 | |
94 | Q | B | 0.0000 | |
95 | E | B | -2.9006 | |
96 | R | B | 0.0000 | |
97 | T | B | -0.5240 | |
98 | I | B | 0.0000 | |
99 | F | B | 0.4160 | |
100 | F | B | 0.0000 | |
101 | K | B | -1.8340 | |
102 | D | B | -2.8187 | |
103 | D | B | -2.5230 | |
104 | G | B | 0.0000 | |
105 | N | B | -0.5806 | |
106 | Y | B | 0.0000 | |
107 | K | B | -1.5933 | |
108 | T | B | 0.0000 | |
109 | R | B | -3.6142 | |
110 | A | B | 0.0000 | |
111 | E | B | -1.8332 | |
112 | V | B | 0.0000 | |
113 | K | B | -1.1250 | |
114 | F | B | -1.2666 | |
115 | E | B | -1.5686 | |
116 | G | B | -1.7020 | |
117 | D | B | -2.1377 | |
118 | T | B | -1.4337 | |
119 | L | B | 0.0000 | |
120 | V | B | 0.0000 | |
121 | N | B | 0.0000 | |
122 | R | B | -2.2261 | |
123 | I | B | 0.0000 | |
124 | E | B | -3.8713 | |
125 | L | B | 0.0000 | |
126 | K | B | -2.0369 | |
127 | G | B | 0.0000 | |
128 | I | B | -0.9579 | |
129 | D | B | -2.4277 | |
130 | F | B | 0.0000 | |
131 | K | B | -3.8668 | |
132 | E | B | -3.9232 | |
133 | D | B | -3.5584 | |
134 | G | B | 0.0000 | |
135 | N | B | -2.1077 | |
136 | I | B | 0.0000 | |
137 | L | B | -1.9814 | |
138 | G | B | -2.2796 | |
139 | H | B | -2.0780 | |
140 | K | B | -2.3043 | |
141 | L | B | 0.0000 | |
142 | E | B | -1.2245 | |
143 | Y | B | -0.2903 | |
144 | N | B | 0.0000 | |
145 | Y | B | 0.0000 | |
146 | N | B | 0.0000 | |
147 | S | B | 0.0000 | |
148 | H | B | 0.0000 | |
149 | N | B | -0.7065 | |
150 | V | B | 0.0000 | |
151 | Y | B | 0.1123 | |
152 | I | B | 0.0000 | |
153 | M | B | -0.7894 | |
154 | A | B | -1.6504 | |
155 | D | B | 0.0000 | |
156 | K | B | -3.1050 | |
157 | Q | B | -3.1423 | |
158 | K | B | -3.4342 | |
159 | N | B | -2.6660 | |
160 | G | B | 0.0000 | |
161 | I | B | 0.0000 | |
162 | K | B | -1.1978 | |
163 | V | B | 0.0000 | |
164 | N | B | -0.5912 | |
165 | F | B | 0.0000 | |
166 | K | B | -1.2912 | |
167 | I | B | 0.0000 | |
168 | R | B | -0.6129 | |
169 | H | B | 0.0000 | |
170 | N | B | -0.8106 | |
171 | I | B | 0.0000 | |
172 | E | B | -3.1315 | |
173 | D | B | -2.9555 | |
174 | G | B | -1.8234 | |
175 | S | B | -0.7917 | |
176 | V | B | 0.0871 | |
177 | Q | B | 0.0000 | |
178 | L | B | -0.4506 | |
179 | A | B | 0.0000 | |
180 | D | B | -0.5318 | |
181 | H | B | 0.0000 | |
182 | Y | B | -0.0622 | |
183 | Q | B | 0.0000 | |
184 | Q | B | -1.7769 | |
185 | N | B | 0.0000 | |
186 | T | B | -0.8505 | |
187 | P | B | -0.6336 | |
188 | I | B | -0.0037 | |
189 | G | B | -1.0686 | |
190 | D | B | -1.9679 | |
191 | G | B | -1.2447 | |
192 | P | B | -0.7173 | |
193 | V | B | -0.3833 | |
194 | L | B | -0.4045 | |
195 | L | B | -0.7767 | |
196 | P | B | 0.0000 | |
197 | D | B | -2.3336 | |
198 | N | B | -1.5670 | |
199 | H | B | 0.0000 | |
200 | Y | B | 0.0022 | |
201 | L | B | 0.0000 | |
202 | S | B | -0.2216 | |
203 | T | B | 0.0000 | |
204 | Q | B | 0.0000 | |
205 | S | B | 0.0000 | |
206 | A | B | 0.0000 | |
207 | L | B | 0.0000 | |
208 | S | B | 0.0000 | |
209 | K | B | -1.1390 | |
210 | D | B | -1.6802 | |
211 | P | B | -1.5058 | |
212 | N | B | -2.2889 | |
213 | E | B | -2.5510 | |
214 | K | B | -3.1433 | |
215 | R | B | -3.3897 | |
216 | D | B | -2.2834 | |
217 | H | B | 0.0000 | |
218 | M | B | 0.0000 | |
219 | V | B | 0.0000 | |
220 | L | B | 0.0000 | |
221 | L | B | -0.0442 | |
222 | E | B | 0.0000 | |
223 | F | B | 0.0000 | |
224 | V | B | 0.0000 | |
225 | T | B | -0.4358 | |
226 | A | B | 0.0000 | |
227 | A | B | -0.2147 | |
228 | G | B | -0.5231 | |
229 | I | B | -0.5519 | |
230 | T | B | -0.2004 |