Project name: c76393101e21078

Chain sequence(s)	A: NGVCIAYYITDGRNPTFKLKDIPDKVDMVILFGLKYWSLQDTTKLPGGTGMMGSFKSYKDLDTQIRSLQSRGIKVLQNIDDDVSWQSSKPGGFASAAAYGDAIKSIVIDKWKLDGISLDIEHSGAKPNPIPTFPGYAATGYNGWYSGSMAATPAFLNVISELTKYFGTTAPNNKQLQIASGIDVYAWNKIMENFRNNFNYIQLQSYGANVSRTQLMMNYATGTNKIPASKMVFGAYAEGGTNQANDVEVAKWTPTQGAKGGMMIYTYNSNVSYANAVRDAVK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4605
• Maximal score value: 0.8353
• Average score: -0.6866
• Total score value: -193.6241

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
8	N	A	-2.0977
9	G	A	-1.3373
10	V	A	0.0000
11	C	A	0.0000
12	I	A	0.0000
13	A	A	0.0000
14	Y	A	0.0000
15	Y	A	0.0000
16	I	A	0.0000
17	T	A	0.0000
18	D	A	-0.9194
19	G	A	-1.2223
20	R	A	-1.2042
21	N	A	-1.2183
22	P	A	-0.9517
23	T	A	-0.5802
24	F	A	-0.7313
25	K	A	-1.1198
26	L	A	0.0000
27	K	A	-1.8327
28	D	A	-1.5011
29	I	A	0.0000
30	P	A	-1.9330
31	D	A	-3.1147
32	K	A	-3.2716
33	V	A	0.0000
34	D	A	-1.8993
35	M	A	0.0000
36	V	A	0.0000
37	I	A	0.0000
38	L	A	0.0000
39	F	A	-0.0488
40	G	A	-0.4162
41	L	A	0.0000
42	K	A	-1.0737
43	Y	A	-0.3842
44	W	A	-0.1579
45	S	A	0.0000
46	L	A	0.0000
47	Q	A	-0.9065
48	D	A	-0.8940
49	T	A	-0.7352
50	T	A	-1.0833
51	K	A	-1.7471
52	L	A	-0.9371
53	P	A	-0.9734
54	G	A	-1.3910
55	G	A	-1.3007
56	T	A	-0.8187
57	G	A	-0.6242
58	M	A	-0.4839
59	M	A	0.0000
60	G	A	-1.1039
61	S	A	0.0000
62	F	A	0.0000
63	K	A	-2.2806
64	S	A	-1.7472
65	Y	A	-1.4028
66	K	A	-2.2877
67	D	A	-1.8675
68	L	A	0.0000
69	D	A	-1.6302
70	T	A	-1.2222
71	Q	A	0.0000
72	I	A	0.0000
73	R	A	-1.5557
74	S	A	-1.3395
75	L	A	0.0000
76	Q	A	-1.7936
77	S	A	-1.4295
78	R	A	-2.4452
79	G	A	-1.9032
80	I	A	0.0000
81	K	A	-1.7104
82	V	A	0.0000
83	L	A	0.0000
84	Q	A	0.0000
85	N	A	0.0000
86	I	A	0.0000
87	D	A	-0.8430
88	D	A	0.0000
89	D	A	-0.6623
90	V	A	0.8353
91	S	A	-0.2511
92	W	A	0.0000
93	Q	A	-0.4101
94	S	A	-0.7554
95	S	A	-1.3114
96	K	A	-1.9516
97	P	A	0.0000
98	G	A	-0.5895
99	G	A	-0.9952
100	F	A	-0.7464
101	A	A	-0.5897
102	S	A	-1.0969
103	A	A	-1.1941
104	A	A	-1.1506
105	A	A	-0.8903
106	Y	A	0.0000
107	G	A	0.0000
108	D	A	-2.0321
109	A	A	-0.9576
110	I	A	0.0000
111	K	A	-1.7993
112	S	A	-1.6730
113	I	A	0.0000
114	V	A	0.0000
115	I	A	-1.7349
116	D	A	-2.2096
117	K	A	-2.3729
118	W	A	0.0000
119	K	A	-2.5819
120	L	A	0.0000
121	D	A	-1.4875
122	G	A	0.0000
123	I	A	0.0000
124	S	A	0.0000
125	L	A	0.0000
126	D	A	0.0000
127	I	A	0.0000
128	E	A	-0.8490
129	H	A	-0.6674
130	S	A	-0.4807
131	G	A	-0.2820
132	A	A	-0.5489
133	K	A	-1.4487
134	P	A	-0.9871
135	N	A	-1.3874
136	P	A	-0.7629
137	I	A	0.2244
138	P	A	0.0827
139	T	A	0.1224
140	F	A	0.0326
141	P	A	-0.1796
142	G	A	-0.1728
143	Y	A	0.3358
144	A	A	0.2262
145	A	A	0.1227
146	T	A	0.0000
147	G	A	0.0000
148	Y	A	0.0000
149	N	A	-0.8990
150	G	A	-0.4111
151	W	A	0.2275
152	Y	A	0.4301
153	S	A	-0.1695
154	G	A	-0.3359
155	S	A	0.0000
156	M	A	0.0000
157	A	A	0.0000
158	A	A	0.0000
159	T	A	-0.7509
160	P	A	-0.6972
161	A	A	-0.8956
162	F	A	0.0000
163	L	A	-1.0467
164	N	A	-1.5106
165	V	A	0.0000
166	I	A	0.0000
167	S	A	-1.3740
168	E	A	-1.8051
169	L	A	0.0000
170	T	A	-1.2638
171	K	A	-2.1706
172	Y	A	-1.6050
173	F	A	0.0000
174	G	A	0.0000
175	T	A	-1.1708
176	T	A	-1.0770
177	A	A	-1.3275
178	P	A	-1.5622
179	N	A	-2.0967
180	N	A	-2.1804
181	K	A	-1.5332
182	Q	A	-0.9499
183	L	A	0.0000
184	Q	A	0.0000
185	I	A	0.0000
186	A	A	0.0000
187	S	A	0.0000
188	G	A	0.0000
189	I	A	0.0000
190	D	A	-0.2926
191	V	A	0.0000
192	Y	A	0.0000
193	A	A	0.0000
194	W	A	0.0000
195	N	A	-1.8338
196	K	A	-2.2402
197	I	A	0.0000
198	M	A	0.0000
199	E	A	-3.4605
200	N	A	-2.8059
201	F	A	0.0000
202	R	A	-2.3588
203	N	A	-2.2629
204	N	A	-1.3968
205	F	A	0.0000
206	N	A	-0.7635
207	Y	A	-0.2865
208	I	A	0.0000
209	Q	A	0.0000
210	L	A	0.0000
211	Q	A	-0.2799
212	S	A	0.0000
213	Y	A	-0.1098
214	G	A	-0.7381
215	A	A	0.0000
216	N	A	-1.4073
217	V	A	-0.9086
218	S	A	-0.4873
219	R	A	-0.6072
220	T	A	0.0000
221	Q	A	-0.4652
222	L	A	0.0720
223	M	A	0.0000
224	M	A	0.0000
225	N	A	-0.9682
226	Y	A	-0.5913
227	A	A	0.0000
228	T	A	-1.2454
229	G	A	-1.2829
230	T	A	-1.1527
231	N	A	0.0000
232	K	A	-2.4996
233	I	A	0.0000
234	P	A	-1.0422
235	A	A	-0.7457
236	S	A	-0.4673
237	K	A	-0.5484
238	M	A	0.0000
239	V	A	0.0000
240	F	A	0.0000
241	G	A	0.0000
242	A	A	0.0000
243	Y	A	-0.1560
244	A	A	0.0000
245	E	A	-0.7304
246	G	A	-0.7342
247	G	A	-0.8529
248	T	A	-0.6733
249	N	A	-0.8811
250	Q	A	-1.1223
251	A	A	-0.9705
252	N	A	-1.4639
253	D	A	0.0000
254	V	A	-1.6308
255	E	A	-2.4326
256	V	A	0.0000
257	A	A	0.0000
258	K	A	-2.7283
259	W	A	-1.3041
260	T	A	-0.8751
261	P	A	0.0000
262	T	A	-0.4903
263	Q	A	-0.8572
264	G	A	-0.4742
265	A	A	-0.5094
266	K	A	-0.7413
267	G	A	0.0000
268	G	A	0.0000
269	M	A	0.0000
270	M	A	0.0000
271	I	A	0.0000
272	Y	A	0.0668
273	T	A	0.0000
274	Y	A	0.0000
275	N	A	0.0000
276	S	A	-0.6753
277	N	A	-0.6417
278	V	A	-0.2190
279	S	A	-0.4193
280	Y	A	0.0000
281	A	A	0.0000
282	N	A	-1.3420
283	A	A	-0.9609
284	V	A	0.0000
285	R	A	-2.2025
286	D	A	-2.7606
287	A	A	-2.1498
288	V	A	0.0000
289	K	A	-2.6397