Project name: c98ca45c439e3c5
Status: done
submitted: 2018-04-12 18:12:58, status changed: 2018-04-16 01:09:26
Settings
Chain sequence(s)
|
A: PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKYVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPF
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.8369
-
Maximal score value
-
1.7096
-
Average score
-
-0.9992
-
Total score value
-
-387.6891
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
47 |
P |
A |
-0.7590 |
|
48 |
P |
A |
-1.2072 |
|
49 |
G |
A |
-1.4976 |
|
50 |
T |
A |
-1.8982 |
|
51 |
V |
A |
0.0000 |
|
52 |
D |
A |
-2.9208 |
|
53 |
K |
A |
-2.8244 |
|
54 |
K |
A |
-2.8759 |
|
55 |
M |
A |
-2.0129 |
|
56 |
V |
A |
0.0000 |
|
57 |
E |
A |
-2.5439 |
|
58 |
K |
A |
-1.7969 |
|
59 |
C |
A |
0.0000 |
|
60 |
W |
A |
-1.5042 |
|
61 |
K |
A |
-1.8775 |
|
62 |
L |
A |
0.0000 |
|
63 |
M |
A |
0.0000 |
|
64 |
D |
A |
-2.1125 |
|
65 |
K |
A |
-2.1761 |
|
66 |
V |
A |
0.0000 |
|
67 |
V |
A |
-1.7928 |
|
68 |
R |
A |
-2.4716 |
|
69 |
L |
A |
-1.3735 |
|
70 |
C |
A |
0.0000 |
|
71 |
Q |
A |
-2.0614 |
|
72 |
N |
A |
-1.7916 |
|
73 |
P |
A |
-1.6179 |
|
74 |
K |
A |
-2.4103 |
|
75 |
L |
A |
0.0000 |
|
76 |
A |
A |
-1.5338 |
|
77 |
L |
A |
0.0000 |
|
78 |
K |
A |
-2.6808 |
|
79 |
N |
A |
-2.1823 |
|
80 |
S |
A |
-0.9611 |
|
81 |
P |
A |
-0.3066 |
|
82 |
P |
A |
-0.0924 |
|
83 |
Y |
A |
-0.7382 |
|
84 |
I |
A |
0.0000 |
|
85 |
L |
A |
-1.7002 |
|
86 |
D |
A |
-2.2080 |
|
87 |
L |
A |
-1.0328 |
|
88 |
L |
A |
0.0000 |
|
89 |
P |
A |
-1.4038 |
|
90 |
D |
A |
-2.0545 |
|
91 |
T |
A |
0.0000 |
|
92 |
Y |
A |
-1.4054 |
|
93 |
Q |
A |
-2.0607 |
|
94 |
H |
A |
-1.7182 |
|
95 |
L |
A |
0.0000 |
|
96 |
R |
A |
-2.7185 |
|
97 |
T |
A |
-1.6535 |
|
98 |
I |
A |
0.0000 |
|
99 |
L |
A |
0.0000 |
|
100 |
S |
A |
-1.9920 |
|
101 |
R |
A |
-2.0780 |
|
102 |
Y |
A |
-2.3278 |
|
103 |
E |
A |
-3.0560 |
|
104 |
G |
A |
-2.5332 |
|
105 |
K |
A |
-3.0378 |
|
106 |
M |
A |
-2.9359 |
|
107 |
E |
A |
-3.2529 |
|
108 |
T |
A |
-2.0810 |
|
109 |
L |
A |
0.0000 |
|
110 |
G |
A |
0.0000 |
|
111 |
E |
A |
-3.1836 |
|
112 |
N |
A |
-2.3011 |
|
113 |
E |
A |
-2.7465 |
|
114 |
Y |
A |
0.0000 |
|
115 |
F |
A |
0.0000 |
|
116 |
R |
A |
-1.8967 |
|
117 |
V |
A |
0.0000 |
|
118 |
F |
A |
0.0000 |
|
119 |
M |
A |
0.0000 |
|
120 |
E |
A |
-1.2656 |
|
121 |
N |
A |
0.0000 |
|
122 |
L |
A |
0.0000 |
|
123 |
M |
A |
-0.7746 |
|
124 |
K |
A |
-0.8899 |
|
125 |
K |
A |
0.0000 |
|
126 |
T |
A |
0.0000 |
|
127 |
K |
A |
-0.4882 |
|
128 |
Q |
A |
-0.7230 |
|
129 |
T |
A |
0.0000 |
|
130 |
I |
A |
0.0000 |
|
131 |
S |
A |
-1.3123 |
|
132 |
L |
A |
0.0000 |
|
133 |
F |
A |
0.0000 |
|
134 |
K |
A |
-3.3569 |
|
135 |
E |
A |
-3.5853 |
|
136 |
G |
A |
-3.4705 |
|
137 |
K |
A |
-4.4387 |
|
138 |
E |
A |
-4.3026 |
|
139 |
R |
A |
-4.8369 |
|
140 |
M |
A |
0.0000 |
|
141 |
Y |
A |
-3.3030 |
|
142 |
E |
A |
-4.6081 |
|
143 |
E |
A |
-4.0832 |
|
144 |
N |
A |
-3.2556 |
|
145 |
S |
A |
-2.9967 |
|
146 |
Q |
A |
-2.5539 |
|
147 |
P |
A |
0.0000 |
|
148 |
R |
A |
-2.3206 |
|
149 |
R |
A |
-1.6293 |
|
150 |
N |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
T |
A |
0.0000 |
|
153 |
K |
A |
0.0000 |
|
154 |
L |
A |
0.0000 |
|
155 |
S |
A |
0.0000 |
|
156 |
L |
A |
0.0000 |
|
157 |
I |
A |
0.0000 |
|
158 |
F |
A |
0.0000 |
|
159 |
S |
A |
-0.1865 |
|
160 |
H |
A |
0.0000 |
|
161 |
M |
A |
0.0000 |
|
162 |
L |
A |
0.0000 |
|
163 |
A |
A |
-0.2510 |
|
164 |
E |
A |
0.0000 |
|
165 |
L |
A |
0.0000 |
|
166 |
K |
A |
-0.9592 |
|
167 |
G |
A |
-0.5485 |
|
168 |
I |
A |
0.0000 |
|
169 |
F |
A |
0.0000 |
|
170 |
P |
A |
-0.2267 |
|
171 |
S |
A |
-0.2976 |
|
172 |
G |
A |
0.0000 |
|
173 |
L |
A |
0.7196 |
|
174 |
F |
A |
0.2357 |
|
175 |
Q |
A |
-0.7276 |
|
176 |
G |
A |
0.0000 |
|
177 |
D |
A |
-2.7756 |
|
178 |
T |
A |
-1.8473 |
|
179 |
F |
A |
-1.6745 |
|
180 |
R |
A |
-2.0348 |
|
181 |
I |
A |
0.0000 |
|
182 |
T |
A |
-1.0600 |
|
183 |
K |
A |
-1.6414 |
|
184 |
A |
A |
-1.7544 |
|
185 |
D |
A |
-2.5647 |
|
186 |
A |
A |
0.0000 |
|
187 |
A |
A |
-2.4034 |
|
188 |
E |
A |
-3.3049 |
|
189 |
F |
A |
0.0000 |
|
190 |
W |
A |
0.0000 |
|
191 |
R |
A |
-3.2985 |
|
192 |
K |
A |
-2.9673 |
|
193 |
A |
A |
-1.9445 |
|
194 |
F |
A |
0.0000 |
|
195 |
G |
A |
-2.9377 |
|
196 |
E |
A |
-3.6202 |
|
197 |
K |
A |
-3.2817 |
|
198 |
T |
A |
0.0000 |
|
199 |
I |
A |
-0.9904 |
|
200 |
V |
A |
0.0000 |
|
201 |
P |
A |
-1.1141 |
|
202 |
W |
A |
0.0000 |
|
203 |
K |
A |
-2.4676 |
|
204 |
S |
A |
-1.4044 |
|
205 |
F |
A |
0.0000 |
|
206 |
R |
A |
-1.9386 |
|
207 |
Q |
A |
-2.3547 |
|
208 |
A |
A |
-1.6795 |
|
209 |
L |
A |
0.0000 |
|
210 |
H |
A |
-1.6919 |
|
211 |
E |
A |
-2.0437 |
|
212 |
V |
A |
-0.5348 |
|
213 |
H |
A |
-0.7569 |
|
214 |
P |
A |
-0.9762 |
|
215 |
I |
A |
0.0000 |
|
216 |
S |
A |
-0.4822 |
|
217 |
S |
A |
-0.6021 |
|
218 |
G |
A |
-0.5432 |
|
219 |
L |
A |
-0.7733 |
|
220 |
E |
A |
0.0000 |
|
221 |
A |
A |
-0.2241 |
|
222 |
M |
A |
-0.0294 |
|
223 |
A |
A |
0.0000 |
|
224 |
L |
A |
0.0000 |
|
225 |
K |
A |
-0.3119 |
|
226 |
S |
A |
-0.4216 |
|
227 |
T |
A |
0.0516 |
|
228 |
I |
A |
0.0000 |
|
229 |
D |
A |
0.0000 |
|
230 |
L |
A |
0.0064 |
|
231 |
T |
A |
0.0000 |
|
232 |
C |
A |
-0.4001 |
|
233 |
N |
A |
-1.0901 |
|
234 |
D |
A |
-2.0366 |
|
235 |
Y |
A |
-0.9320 |
|
236 |
I |
A |
0.0000 |
|
237 |
S |
A |
0.0000 |
|
238 |
V |
A |
0.0000 |
|
239 |
F |
A |
-0.0077 |
|
240 |
E |
A |
0.0000 |
|
241 |
F |
A |
0.0000 |
|
242 |
D |
A |
0.0000 |
|
243 |
I |
A |
0.0000 |
|
244 |
F |
A |
0.0000 |
|
245 |
T |
A |
0.0000 |
|
246 |
R |
A |
-0.5536 |
|
247 |
L |
A |
0.0000 |
|
248 |
F |
A |
0.0000 |
|
249 |
Q |
A |
-0.8135 |
|
250 |
P |
A |
-0.7357 |
|
251 |
W |
A |
-0.7318 |
|
252 |
S |
A |
-0.5431 |
|
253 |
S |
A |
0.0000 |
|
254 |
L |
A |
0.0000 |
|
255 |
L |
A |
0.0000 |
|
256 |
R |
A |
-0.7505 |
|
257 |
N |
A |
0.0000 |
|
258 |
W |
A |
0.0000 |
|
259 |
N |
A |
0.0000 |
|
260 |
S |
A |
-0.3958 |
|
261 |
L |
A |
0.0000 |
|
262 |
A |
A |
0.0000 |
|
263 |
V |
A |
0.0000 |
|
264 |
T |
A |
0.0318 |
|
265 |
H |
A |
0.0000 |
|
266 |
P |
A |
-0.5370 |
|
267 |
G |
A |
0.0000 |
|
268 |
Y |
A |
0.1917 |
|
269 |
M |
A |
0.0000 |
|
270 |
A |
A |
0.1448 |
|
271 |
F |
A |
0.4293 |
|
272 |
L |
A |
0.2397 |
|
273 |
T |
A |
0.0000 |
|
274 |
Y |
A |
0.5756 |
|
275 |
D |
A |
-0.6503 |
|
276 |
E |
A |
-0.8401 |
|
277 |
V |
A |
0.0000 |
|
278 |
K |
A |
-1.3239 |
|
279 |
A |
A |
-1.3200 |
|
280 |
R |
A |
-1.7258 |
|
281 |
L |
A |
0.0000 |
|
282 |
Q |
A |
-2.4447 |
|
283 |
K |
A |
-2.4539 |
|
284 |
F |
A |
-1.4470 |
|
285 |
I |
A |
-1.6554 |
|
286 |
H |
A |
-1.8642 |
|
287 |
K |
A |
-1.2456 |
|
288 |
P |
A |
-0.7285 |
|
289 |
G |
A |
0.0000 |
|
290 |
S |
A |
0.0000 |
|
291 |
Y |
A |
0.0000 |
|
292 |
I |
A |
0.0000 |
|
293 |
F |
A |
0.0000 |
|
294 |
R |
A |
0.0000 |
|
295 |
L |
A |
0.2228 |
|
296 |
S |
A |
0.0000 |
|
297 |
C |
A |
-0.1673 |
|
298 |
T |
A |
-0.7414 |
|
299 |
R |
A |
-1.6995 |
|
300 |
L |
A |
-0.7506 |
|
301 |
G |
A |
0.0000 |
|
302 |
Q |
A |
-1.1347 |
|
303 |
W |
A |
0.0000 |
|
304 |
A |
A |
0.0000 |
|
305 |
I |
A |
0.0000 |
|
306 |
G |
A |
0.0000 |
|
307 |
Y |
A |
0.3880 |
|
308 |
V |
A |
0.0000 |
|
309 |
T |
A |
-0.7662 |
|
310 |
A |
A |
-1.1385 |
|
311 |
D |
A |
-2.2690 |
|
312 |
G |
A |
-1.8400 |
|
313 |
N |
A |
-1.9144 |
|
314 |
I |
A |
0.0000 |
|
315 |
L |
A |
0.1578 |
|
316 |
Q |
A |
0.3490 |
|
317 |
T |
A |
0.1804 |
|
318 |
I |
A |
-0.2345 |
|
319 |
P |
A |
-1.0512 |
|
320 |
H |
A |
-1.9033 |
|
321 |
N |
A |
-2.3590 |
|
322 |
K |
A |
-2.5509 |
|
323 |
P |
A |
-1.5665 |
|
324 |
L |
A |
0.0000 |
|
325 |
F |
A |
0.0000 |
|
326 |
Q |
A |
-1.6787 |
|
327 |
A |
A |
0.0000 |
|
328 |
L |
A |
0.0000 |
|
329 |
I |
A |
-1.5824 |
|
330 |
D |
A |
-2.6693 |
|
331 |
G |
A |
-1.2891 |
|
332 |
F |
A |
-0.8769 |
|
333 |
R |
A |
-2.6138 |
|
334 |
E |
A |
-2.5874 |
|
335 |
G |
A |
-0.9741 |
|
336 |
F |
A |
0.5886 |
|
337 |
Y |
A |
0.0000 |
|
338 |
L |
A |
-0.1919 |
|
339 |
F |
A |
-0.7384 |
|
340 |
P |
A |
0.0000 |
|
341 |
D |
A |
0.0000 |
|
342 |
G |
A |
-1.5344 |
|
343 |
R |
A |
-2.6915 |
|
344 |
N |
A |
-2.6145 |
|
345 |
Q |
A |
-2.5394 |
|
346 |
N |
A |
-1.5751 |
|
347 |
P |
A |
-1.5776 |
|
348 |
D |
A |
-1.8733 |
|
349 |
L |
A |
0.0000 |
|
350 |
T |
A |
-1.1177 |
|
351 |
G |
A |
-1.1479 |
|
352 |
L |
A |
0.0000 |
|
353 |
C |
A |
-0.8045 |
|
354 |
E |
A |
-1.8904 |
|
355 |
P |
A |
-1.2433 |
|
356 |
T |
A |
-1.1706 |
|
357 |
P |
A |
-1.7199 |
|
358 |
Q |
A |
-2.4355 |
|
359 |
D |
A |
-2.8589 |
|
360 |
H |
A |
-2.0608 |
|
361 |
I |
A |
-0.8003 |
|
362 |
K |
A |
-1.6879 |
|
363 |
V |
A |
-1.0240 |
|
364 |
T |
A |
-1.3322 |
|
365 |
Q |
A |
-2.2214 |
|
366 |
E |
A |
-1.8881 |
|
367 |
Q |
A |
-1.3693 |
|
368 |
Y |
A |
0.0000 |
|
369 |
E |
A |
-2.1088 |
|
370 |
L |
A |
-0.4152 |
|
371 |
Y |
A |
0.0000 |
|
372 |
C |
A |
-0.9287 |
|
373 |
E |
A |
-1.5914 |
|
374 |
M |
A |
-0.4493 |
|
375 |
G |
A |
-0.1796 |
|
376 |
S |
A |
-0.1615 |
|
377 |
T |
A |
-0.8289 |
|
378 |
F |
A |
-0.3391 |
|
379 |
Q |
A |
0.0000 |
|
380 |
L |
A |
-0.8117 |
|
381 |
C |
A |
0.0000 |
|
382 |
K |
A |
-1.5821 |
|
383 |
I |
A |
-0.3440 |
|
384 |
C |
A |
-0.6587 |
|
385 |
A |
A |
-1.2400 |
|
386 |
E |
A |
-2.1132 |
|
387 |
N |
A |
-1.6092 |
|
388 |
D |
A |
-1.1766 |
|
389 |
K |
A |
-0.6673 |
|
390 |
Y |
A |
-0.0893 |
|
391 |
V |
A |
-0.6286 |
|
392 |
K |
A |
-1.3562 |
|
393 |
I |
A |
0.0000 |
|
394 |
E |
A |
-2.6096 |
|
395 |
P |
A |
-1.5142 |
|
396 |
C |
A |
-0.9632 |
|
397 |
G |
A |
-0.9178 |
|
398 |
H |
A |
-0.5561 |
|
399 |
L |
A |
-0.8124 |
|
400 |
M |
A |
0.0000 |
|
401 |
C |
A |
0.0000 |
|
402 |
T |
A |
-0.1414 |
|
403 |
S |
A |
-0.1584 |
|
404 |
C |
A |
-0.4175 |
|
405 |
L |
A |
0.0000 |
|
406 |
T |
A |
-1.1254 |
|
407 |
S |
A |
-1.2319 |
|
408 |
W |
A |
-1.5777 |
|
409 |
Q |
A |
-2.9251 |
|
410 |
E |
A |
-3.0194 |
|
411 |
S |
A |
-2.4451 |
|
412 |
E |
A |
-3.2957 |
|
413 |
G |
A |
-2.6317 |
|
414 |
Q |
A |
-2.7215 |
|
415 |
G |
A |
-2.5245 |
|
416 |
C |
A |
0.0000 |
|
417 |
P |
A |
0.0000 |
|
418 |
F |
A |
-0.1238 |
|
419 |
C |
A |
-0.7373 |
|
420 |
R |
A |
-2.2131 |
|
421 |
C |
A |
-1.7201 |
|
422 |
E |
A |
-2.8351 |
|
423 |
I |
A |
-2.1867 |
|
424 |
K |
A |
-2.4393 |
|
425 |
G |
A |
-2.0672 |
|
426 |
T |
A |
-1.8191 |
|
427 |
E |
A |
-1.9224 |
|
428 |
P |
A |
-0.7223 |
|
429 |
I |
A |
-0.3033 |
|
430 |
V |
A |
0.0000 |
|
431 |
V |
A |
0.7279 |
|
432 |
D |
A |
0.0393 |
|
433 |
P |
A |
0.2164 |
|
434 |
F |
A |
1.7096 |
|