Chain sequence(s) |
A: GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCCKVSNKGLPSSSIEKTTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNNGQPENNYKTTPPVLDSSDGSFFLYSRLTVDKSRWQEGNVFSCCSVMHEALHNHYTQKSLSLSL B: GGPSVFLFPPKPKDTLMIISRTPEVVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCCKVSNKGLPSSIEKTTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSSCCSSVMHEALHNHYTQKSLSLS |
Distance of aggregation | 5 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
236 | G | A | -0.5526 | |
237 | G | A | -0.5660 | |
238 | P | A | -0.4089 | |
239 | S | A | -0.1270 | |
240 | V | A | 0.0000 | |
241 | F | A | 1.0943 | |
242 | L | A | 0.0000 | |
243 | F | A | 1.1563 | |
244 | P | A | -0.0398 | |
245 | P | A | 0.0000 | |
246 | K | A | -1.7075 | |
247 | P | A | -0.3976 | |
248 | K | A | -0.3201 | |
249 | D | A | -0.2665 | |
250 | T | A | 0.0000 | |
251 | L | A | 0.0000 | |
252 | M | A | 0.6783 | |
253 | I | A | 2.0298 | |
254 | S | A | -0.0119 | |
255 | R | A | -1.0070 | |
256 | T | A | -0.2407 | |
257 | P | A | 0.0000 | |
258 | E | A | -0.7853 | |
259 | V | A | 0.0000 | |
260 | T | A | -0.0124 | |
261 | C | A | 0.0000 | |
262 | V | A | 0.0000 | |
263 | V | A | 0.0000 | |
264 | V | A | -0.1727 | |
265 | D | A | -1.7414 | |
266 | V | A | 0.0000 | |
267 | S | A | -0.4160 | |
268 | Q | A | -1.5783 | |
269 | E | A | -2.1522 | |
270 | D | A | -0.9270 | |
271 | P | A | -0.5248 | |
272 | E | A | -1.7941 | |
273 | V | A | -0.3425 | |
274 | Q | A | -0.9794 | |
275 | F | A | -0.0123 | |
276 | N | A | -0.3135 | |
277 | W | A | 0.0000 | |
278 | Y | A | 0.4133 | |
279 | V | A | 0.0489 | |
280 | D | A | -1.3795 | |
281 | G | A | -0.3898 | |
282 | V | A | 1.5836 | |
283 | E | A | -0.2849 | |
284 | V | A | 0.0627 | |
285 | H | A | -1.1587 | |
286 | N | A | -1.4565 | |
287 | A | A | -0.5289 | |
288 | K | A | -1.7076 | |
289 | T | A | -0.6117 | |
290 | K | A | -1.3323 | |
291 | P | A | -0.8257 | |
292 | R | A | -2.2218 | |
293 | E | A | -2.4966 | |
294 | E | A | -2.1777 | |
295 | Q | A | -0.1644 | |
296 | F | A | 1.6677 | |
297 | N | A | -0.9481 | |
298 | S | A | -0.4517 | |
299 | T | A | -0.0239 | |
300 | Y | A | -0.2670 | |
301 | R | A | -0.7810 | |
302 | V | A | 0.0000 | |
303 | V | A | 0.1926 | |
304 | S | A | 0.0000 | |
305 | V | A | 0.0000 | |
306 | L | A | 0.0000 | |
307 | T | A | -0.1556 | |
308 | V | A | 0.0000 | |
309 | L | A | 1.2188 | |
310 | H | A | -0.0467 | |
311 | Q | A | -1.0139 | |
312 | D | A | -0.5116 | |
313 | W | A | 0.0000 | |
314 | L | A | 0.0192 | |
315 | N | A | -1.2467 | |
316 | G | A | -0.4588 | |
317 | K | A | -0.9890 | |
318 | E | A | -1.8206 | |
319 | Y | A | 0.0000 | |
320 | K | A | -0.6829 | |
321 | C | A | 0.0000 | |
322 | K | A | -0.6079 | |
323 | V | A | 0.0000 | |
324 | S | A | 0.0000 | |
325 | N | A | -0.3970 | |
326 | K | A | -1.2817 | |
327 | G | A | -0.4160 | |
328 | L | A | 1.2913 | |
329 | P | A | -0.0354 | |
330 | S | A | -0.2765 | |
331 | S | A | 0.0325 | |
332 | I | A | 0.5974 | |
333 | E | A | -1.5819 | |
334 | K | A | -1.0245 | |
335 | T | A | -0.2416 | |
336 | I | A | 0.3049 | |
337 | S | A | -0.2183 | |
338 | K | A | -0.1681 | |
339 | A | A | -0.2918 | |
340 | K | A | -1.7771 | |
341 | G | A | -1.0037 | |
342 | Q | A | -1.3000 | |
343 | P | A | -0.5856 | |
344 | R | A | -2.0015 | |
345 | E | A | -2.1260 | |
346 | P | A | 0.0000 | |
347 | Q | A | -0.5613 | |
348 | V | A | 0.0663 | |
349 | Y | A | 0.0000 | |
350 | T | A | -0.0075 | |
351 | L | A | 0.0000 | |
352 | P | A | -0.1480 | |
353 | P | A | -0.0534 | |
354 | S | A | 0.0000 | |
355 | Q | A | -1.5292 | |
356 | E | A | -2.0377 | |
357 | E | A | 0.0000 | |
358 | M | A | 0.1318 | |
359 | T | A | -0.2178 | |
360 | K | A | -1.1992 | |
361 | N | A | -1.5529 | |
362 | Q | A | -1.0116 | |
363 | V | A | 0.0000 | |
364 | S | A | 0.0000 | |
365 | L | A | 0.0000 | |
366 | T | A | 0.0000 | |
367 | C | A | 0.0000 | |
368 | L | A | 0.0000 | |
369 | V | A | 0.0000 | |
370 | K | A | -0.2165 | |
371 | G | A | -0.1114 | |
372 | F | A | 0.0000 | |
373 | Y | A | 0.0349 | |
374 | P | A | 0.0000 | |
375 | S | A | -0.2285 | |
376 | D | A | -0.9130 | |
377 | I | A | 0.0259 | |
378 | A | A | 0.0000 | |
379 | V | A | 0.0000 | |
380 | E | A | -0.7389 | |
381 | W | A | 0.0000 | |
382 | E | A | -0.3712 | |
383 | S | A | -0.3160 | |
384 | N | A | -1.3628 | |
385 | G | A | -0.9175 | |
386 | Q | A | -1.3300 | |
387 | P | A | -0.5566 | |
388 | E | A | -0.5010 | |
389 | N | A | -1.4527 | |
390 | N | A | -0.9269 | |
391 | Y | A | 0.0933 | |
392 | K | A | -0.6972 | |
393 | T | A | -0.1568 | |
394 | T | A | 0.0000 | |
395 | P | A | -0.1473 | |
396 | P | A | -0.0775 | |
397 | V | A | 0.4761 | |
398 | L | A | 1.5549 | |
399 | D | A | -0.1130 | |
400 | S | A | -0.6053 | |
401 | D | A | -1.8860 | |
402 | G | A | -0.6431 | |
403 | S | A | 0.0000 | |
404 | F | A | 0.4619 | |
405 | F | A | 0.0000 | |
406 | L | A | 0.0000 | |
407 | Y | A | 0.0000 | |
408 | S | A | 0.0000 | |
409 | R | A | 0.0000 | |
410 | L | A | 0.0000 | |
411 | T | A | -0.0081 | |
412 | V | A | 0.0000 | |
413 | D | A | -1.1178 | |
414 | K | A | -0.7570 | |
415 | S | A | -0.5272 | |
416 | R | A | -0.6218 | |
417 | W | A | 0.0000 | |
418 | Q | A | -1.5579 | |
419 | E | A | -2.1011 | |
420 | G | A | -0.7751 | |
421 | N | A | -0.4412 | |
422 | V | A | 1.3407 | |
423 | F | A | 0.0000 | |
424 | S | A | -0.0512 | |
425 | C | A | 0.0000 | |
426 | S | A | 0.0000 | |
427 | V | A | 0.0000 | |
428 | M | A | 0.0000 | |
429 | H | A | 0.0000 | |
430 | E | A | -0.3045 | |
431 | A | A | -0.2275 | |
432 | L | A | -0.0522 | |
433 | H | A | -1.1900 | |
434 | N | A | -1.4989 | |
435 | H | A | -0.3553 | |
436 | Y | A | 0.5817 | |
437 | T | A | -0.0305 | |
438 | Q | A | -0.8775 | |
439 | K | A | -0.9116 | |
440 | S | A | -0.3321 | |
441 | L | A | 0.0000 | |
442 | S | A | 0.2099 | |
443 | L | A | 0.5507 | |
444 | S | A | 0.1830 | |
445 | L | A | 1.5084 | |
236 | G | B | -0.5522 | |
237 | G | B | -0.5699 | |
238 | P | B | -0.4279 | |
239 | S | B | -0.1342 | |
240 | V | B | 0.0000 | |
241 | F | B | 0.9717 | |
242 | L | B | 0.5690 | |
243 | F | B | 1.2270 | |
244 | P | B | 0.0585 | |
245 | P | B | 0.0000 | |
246 | K | B | -1.7079 | |
247 | P | B | -0.4263 | |
248 | K | B | -0.4596 | |
249 | D | B | -0.2993 | |
250 | T | B | 0.0000 | |
251 | L | B | 0.0000 | |
252 | M | B | 0.6168 | |
253 | I | B | 2.0194 | |
254 | S | B | -0.0917 | |
255 | R | B | -1.4002 | |
256 | T | B | -0.3124 | |
257 | P | B | 0.0000 | |
258 | E | B | -0.6534 | |
259 | V | B | 0.0000 | |
260 | T | B | -0.0124 | |
261 | C | B | 0.0000 | |
262 | V | B | 0.0000 | |
263 | V | B | 0.0000 | |
264 | V | B | -0.2071 | |
265 | D | B | -1.7614 | |
266 | V | B | 0.0000 | |
267 | S | B | -0.4232 | |
268 | Q | B | -1.5695 | |
269 | E | B | -2.1619 | |
270 | D | B | -1.0147 | |
271 | P | B | -0.5261 | |
272 | E | B | -1.7870 | |
273 | V | B | -0.2251 | |
274 | Q | B | -0.5139 | |
275 | F | B | 0.0723 | |
276 | N | B | -0.2942 | |
277 | W | B | 0.0000 | |
278 | Y | B | 0.3200 | |
279 | V | B | -0.0528 | |
280 | D | B | -1.8322 | |
281 | G | B | -0.4708 | |
282 | V | B | 1.5373 | |
283 | E | B | -0.5052 | |
284 | V | B | 0.0314 | |
285 | H | B | -1.1597 | |
286 | N | B | -1.4577 | |
287 | A | B | -0.5327 | |
288 | K | B | -1.7056 | |
289 | T | B | -0.5961 | |
290 | K | B | -1.3445 | |
291 | P | B | -0.5824 | |
292 | R | B | -0.8970 | |
293 | E | B | -2.2488 | |
294 | E | B | -2.1642 | |
295 | Q | B | -0.1355 | |
296 | F | B | 1.6854 | |
297 | N | B | -0.9150 | |
298 | S | B | -0.4397 | |
299 | T | B | -0.0224 | |
300 | Y | B | -0.2330 | |
301 | R | B | -0.6983 | |
302 | V | B | 0.0000 | |
303 | V | B | 0.2862 | |
304 | S | B | 0.0000 | |
305 | V | B | 0.0000 | |
306 | L | B | 0.0000 | |
307 | T | B | -0.1483 | |
308 | V | B | 0.0000 | |
309 | L | B | 1.5477 | |
310 | H | B | 0.0000 | |
311 | Q | B | -1.1395 | |
312 | D | B | -0.4989 | |
313 | W | B | 0.0000 | |
314 | L | B | -0.0633 | |
315 | N | B | -1.2352 | |
316 | G | B | -0.4237 | |
317 | K | B | -0.8154 | |
318 | E | B | -1.0724 | |
319 | Y | B | 0.0000 | |
320 | K | B | -0.4680 | |
321 | C | B | 0.0000 | |
322 | K | B | -0.5475 | |
323 | V | B | 0.0000 | |
324 | S | B | 0.0000 | |
325 | N | B | -0.3617 | |
326 | K | B | -1.1376 | |
327 | G | B | -0.4163 | |
328 | L | B | 1.1506 | |
329 | P | B | -0.0588 | |
330 | S | B | -0.2870 | |
331 | S | B | -0.0562 | |
332 | I | B | 0.3080 | |
333 | E | B | -1.8797 | |
334 | K | B | -1.1224 | |
335 | T | B | -0.1949 | |
336 | I | B | 0.2820 | |
337 | S | B | -0.1030 | |
338 | K | B | 0.0000 | |
339 | A | B | -0.2784 | |
340 | K | B | -1.7786 | |
341 | G | B | -1.0036 | |
342 | Q | B | -1.2978 | |
343 | P | B | -0.5390 | |
344 | R | B | -1.8230 | |
345 | E | B | -2.0949 | |
346 | P | B | 0.0000 | |
347 | Q | B | -0.3634 | |
348 | V | B | 0.0000 | |
349 | Y | B | 0.0000 | |
350 | T | B | 0.0000 | |
351 | L | B | 0.0000 | |
352 | P | B | -0.1380 | |
353 | P | B | -0.0522 | |
354 | S | B | 0.0000 | |
355 | Q | B | -1.5277 | |
356 | E | B | -2.0368 | |
357 | E | B | 0.0000 | |
358 | M | B | 0.1330 | |
359 | T | B | -0.1714 | |
360 | K | B | -0.9434 | |
361 | N | B | -1.5140 | |
362 | Q | B | -1.0865 | |
363 | V | B | 0.0000 | |
364 | S | B | 0.0000 | |
365 | L | B | 0.0000 | |
366 | T | B | 0.0000 | |
367 | C | B | 0.0000 | |
368 | L | B | 0.0000 | |
369 | V | B | 0.0000 | |
370 | K | B | -0.2070 | |
371 | G | B | -0.1693 | |
372 | F | B | 0.0000 | |
373 | Y | B | 0.0291 | |
374 | P | B | 0.0000 | |
375 | S | B | -0.2076 | |
376 | D | B | -0.8020 | |
377 | I | B | 0.0689 | |
378 | A | B | 0.0000 | |
379 | V | B | -0.0028 | |
380 | E | B | -0.9173 | |
381 | W | B | 0.0000 | |
382 | E | B | -0.4987 | |
383 | S | B | 0.0000 | |
384 | N | B | -1.3602 | |
385 | G | B | -0.9237 | |
386 | Q | B | -1.3307 | |
387 | P | B | -0.5462 | |
388 | E | B | 0.0000 | |
389 | N | B | -1.5085 | |
390 | N | B | -1.4604 | |
391 | Y | B | -0.0870 | |
392 | K | B | -0.5598 | |
393 | T | B | -0.1350 | |
394 | T | B | 0.0000 | |
395 | P | B | -0.1570 | |
396 | P | B | -0.0975 | |
397 | V | B | 0.4048 | |
398 | L | B | 1.3807 | |
399 | D | B | -0.0634 | |
400 | S | B | -0.5905 | |
401 | D | B | -1.8898 | |
402 | G | B | -0.6639 | |
403 | S | B | 0.0000 | |
404 | F | B | 0.4409 | |
405 | F | B | 0.0000 | |
406 | L | B | 0.0000 | |
407 | Y | B | 0.0000 | |
408 | S | B | 0.0000 | |
409 | R | B | 0.0000 | |
410 | L | B | 0.0000 | |
411 | T | B | -0.0101 | |
412 | V | B | 0.0000 | |
413 | D | B | -1.4526 | |
414 | K | B | -0.8229 | |
415 | S | B | -0.5396 | |
416 | R | B | -0.6567 | |
417 | W | B | 0.0000 | |
418 | Q | B | -1.5565 | |
419 | E | B | -2.0962 | |
420 | G | B | -0.6908 | |
421 | N | B | -0.1525 | |
422 | V | B | 1.1023 | |
423 | F | B | 0.0000 | |
424 | S | B | 0.0000 | |
425 | C | B | 0.0000 | |
426 | S | B | 0.0000 | |
427 | V | B | 0.0000 | |
428 | M | B | 0.0000 | |
429 | H | B | 0.0000 | |
430 | E | B | -0.2875 | |
431 | A | B | -0.2238 | |
432 | L | B | -0.0442 | |
433 | H | B | -1.1970 | |
434 | N | B | -1.4973 | |
435 | H | B | -0.3121 | |
436 | Y | B | 0.5813 | |
437 | T | B | -0.0947 | |
438 | Q | B | -1.2185 | |
439 | K | B | -0.9181 | |
440 | S | B | -0.3378 | |
441 | L | B | 0.0000 | |
442 | S | B | 0.1780 | |
443 | L | B | 0.6197 | |
444 | S | B | -0.0901 |