Project name: ce38671a129645
Status: done
submitted: 2018-10-12 16:13:40, status changed: 2018-10-12 16:29:16
Settings
Chain sequence(s)
|
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKEPPEEGEPPKEGDRSGYSSPGEPGEPGSREREPELPEPPTREPKKVAVVREPPKEPEEAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGEVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVEKEPVVEGDEEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.8465
-
Maximal score value
-
2.7171
-
Average score
-
-1.1871
-
Total score value
-
-523.5331
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
0.0000 |
|
2 |
A |
A |
0.0000 |
|
3 |
E |
A |
-3.4419 |
|
4 |
P |
A |
-2.6808 |
|
5 |
R |
A |
-2.9555 |
|
6 |
Q |
A |
-2.0030 |
|
7 |
E |
A |
-1.7042 |
|
8 |
F |
A |
0.4729 |
|
9 |
E |
A |
0.0335 |
|
10 |
V |
A |
0.8622 |
|
11 |
M |
A |
0.0000 |
|
12 |
E |
A |
-0.3633 |
|
13 |
D |
A |
-0.6522 |
|
14 |
H |
A |
-0.4406 |
|
15 |
A |
A |
-0.4146 |
|
16 |
G |
A |
-0.2793 |
|
17 |
T |
A |
0.2129 |
|
18 |
Y |
A |
1.1228 |
|
19 |
G |
A |
0.1814 |
|
20 |
L |
A |
-0.3128 |
|
21 |
G |
A |
-1.3698 |
|
22 |
D |
A |
-3.2173 |
|
23 |
R |
A |
-3.8465 |
|
24 |
K |
A |
-3.4031 |
|
25 |
D |
A |
-3.4382 |
|
26 |
Q |
A |
-2.4392 |
|
27 |
G |
A |
0.0000 |
|
28 |
G |
A |
0.0000 |
|
29 |
Y |
A |
-1.2754 |
|
30 |
T |
A |
-0.5753 |
|
31 |
M |
A |
-0.1394 |
|
32 |
H |
A |
-1.3904 |
|
33 |
Q |
A |
-1.9657 |
|
34 |
D |
A |
-2.8310 |
|
35 |
Q |
A |
-2.6267 |
|
36 |
E |
A |
-2.2535 |
|
37 |
G |
A |
-2.3364 |
|
38 |
D |
A |
-2.7917 |
|
39 |
T |
A |
-2.1927 |
|
40 |
D |
A |
-2.5228 |
|
41 |
A |
A |
-1.4474 |
|
42 |
G |
A |
-0.5580 |
|
43 |
L |
A |
-0.0441 |
|
44 |
K |
A |
-1.4287 |
|
45 |
E |
A |
-1.7962 |
|
46 |
S |
A |
-1.0145 |
|
47 |
P |
A |
-0.1492 |
|
48 |
L |
A |
0.3426 |
|
49 |
Q |
A |
-0.7146 |
|
50 |
T |
A |
-0.4601 |
|
51 |
P |
A |
-1.3855 |
|
52 |
T |
A |
-2.0246 |
|
53 |
E |
A |
-3.4558 |
|
54 |
D |
A |
-3.1393 |
|
55 |
G |
A |
-2.2267 |
|
56 |
S |
A |
-2.1153 |
|
57 |
E |
A |
-2.6552 |
|
58 |
E |
A |
-2.5661 |
|
59 |
P |
A |
-1.5582 |
|
60 |
G |
A |
-1.2690 |
|
61 |
S |
A |
-1.2404 |
|
62 |
E |
A |
-1.5081 |
|
63 |
T |
A |
-0.8778 |
|
64 |
S |
A |
-1.5920 |
|
65 |
D |
A |
-2.5054 |
|
66 |
A |
A |
0.0000 |
|
67 |
K |
A |
-2.6789 |
|
68 |
S |
A |
0.0000 |
|
69 |
T |
A |
-2.2854 |
|
70 |
P |
A |
-1.4551 |
|
71 |
T |
A |
-1.0024 |
|
72 |
A |
A |
-0.9997 |
|
73 |
E |
A |
-2.3945 |
|
74 |
D |
A |
-1.8640 |
|
75 |
V |
A |
0.5039 |
|
76 |
T |
A |
0.1355 |
|
77 |
A |
A |
-0.1248 |
|
78 |
P |
A |
0.3783 |
|
79 |
L |
A |
1.5951 |
|
80 |
V |
A |
0.2304 |
|
81 |
D |
A |
-2.0339 |
|
82 |
E |
A |
-2.7594 |
|
83 |
G |
A |
-1.7915 |
|
84 |
A |
A |
-1.1299 |
|
85 |
P |
A |
-1.4649 |
|
86 |
G |
A |
-2.1869 |
|
87 |
K |
A |
-2.4457 |
|
88 |
Q |
A |
-2.5179 |
|
89 |
A |
A |
-1.4836 |
|
90 |
A |
A |
0.0000 |
|
91 |
A |
A |
-1.1946 |
|
92 |
Q |
A |
-1.7716 |
|
93 |
P |
A |
-1.5230 |
|
94 |
H |
A |
-1.2487 |
|
95 |
T |
A |
-0.6729 |
|
96 |
E |
A |
-0.6886 |
|
97 |
I |
A |
0.7756 |
|
98 |
P |
A |
-0.8212 |
|
99 |
E |
A |
-2.0419 |
|
100 |
G |
A |
-1.2124 |
|
101 |
T |
A |
-1.4926 |
|
102 |
T |
A |
-1.5908 |
|
103 |
A |
A |
0.0000 |
|
104 |
E |
A |
-3.7420 |
|
105 |
E |
A |
-3.4045 |
|
106 |
A |
A |
-2.3501 |
|
107 |
G |
A |
-1.7051 |
|
108 |
I |
A |
0.0000 |
|
109 |
G |
A |
-2.0253 |
|
110 |
D |
A |
-1.7139 |
|
111 |
T |
A |
-0.8804 |
|
112 |
P |
A |
-0.1031 |
|
113 |
S |
A |
0.0441 |
|
114 |
L |
A |
0.1474 |
|
115 |
E |
A |
-1.8946 |
|
116 |
D |
A |
-2.9150 |
|
117 |
E |
A |
-2.9801 |
|
118 |
A |
A |
-1.3992 |
|
119 |
A |
A |
-0.9040 |
|
120 |
G |
A |
-0.7866 |
|
121 |
H |
A |
-0.9440 |
|
122 |
V |
A |
-1.1404 |
|
123 |
T |
A |
-1.2750 |
|
124 |
Q |
A |
-2.0706 |
|
125 |
A |
A |
0.0000 |
|
126 |
R |
A |
-2.2406 |
|
127 |
M |
A |
-0.8975 |
|
128 |
V |
A |
0.3810 |
|
129 |
S |
A |
-1.0096 |
|
130 |
K |
A |
-2.2620 |
|
131 |
S |
A |
-1.8061 |
|
132 |
K |
A |
-1.5306 |
|
133 |
D |
A |
-2.7275 |
|
134 |
G |
A |
-1.4658 |
|
135 |
T |
A |
-1.5369 |
|
136 |
G |
A |
-2.3211 |
|
137 |
S |
A |
-1.9952 |
|
138 |
D |
A |
0.0000 |
|
139 |
D |
A |
-2.0083 |
|
140 |
K |
A |
-2.4759 |
|
141 |
K |
A |
0.0000 |
|
142 |
A |
A |
-2.6086 |
|
143 |
K |
A |
-3.4359 |
|
144 |
G |
A |
-2.6487 |
|
145 |
A |
A |
-1.9872 |
|
146 |
D |
A |
-2.8985 |
|
147 |
G |
A |
-2.3993 |
|
148 |
K |
A |
-3.0388 |
|
149 |
T |
A |
-1.9937 |
|
150 |
K |
A |
-1.4516 |
|
151 |
I |
A |
-0.8119 |
|
152 |
A |
A |
0.0000 |
|
153 |
T |
A |
-0.5279 |
|
154 |
P |
A |
-1.1378 |
|
155 |
R |
A |
-2.0620 |
|
156 |
G |
A |
-1.3962 |
|
157 |
A |
A |
-0.7135 |
|
158 |
A |
A |
-0.5550 |
|
159 |
P |
A |
0.0000 |
|
160 |
P |
A |
-0.7115 |
|
161 |
G |
A |
-1.5212 |
|
162 |
Q |
A |
0.0000 |
|
163 |
K |
A |
-2.3538 |
|
164 |
G |
A |
-1.8524 |
|
165 |
Q |
A |
-2.1057 |
|
166 |
A |
A |
-1.4110 |
|
167 |
N |
A |
-1.8432 |
|
168 |
A |
A |
-1.0689 |
|
169 |
T |
A |
-1.3563 |
|
170 |
R |
A |
-2.5554 |
|
171 |
I |
A |
-1.4969 |
|
172 |
P |
A |
0.0000 |
|
173 |
A |
A |
-0.9664 |
|
174 |
K |
A |
-1.4554 |
|
175 |
T |
A |
-0.8713 |
|
176 |
P |
A |
-0.7140 |
|
177 |
P |
A |
-1.1267 |
|
178 |
A |
A |
-1.2216 |
|
179 |
P |
A |
-1.9408 |
|
180 |
K |
A |
-3.5152 |
|
181 |
E |
A |
-3.5134 |
|
182 |
P |
A |
-3.0525 |
|
183 |
P |
A |
-2.3687 |
|
184 |
E |
A |
-3.1656 |
|
185 |
E |
A |
-3.0839 |
|
186 |
G |
A |
-2.3013 |
|
187 |
E |
A |
-2.5402 |
|
188 |
P |
A |
-2.1835 |
|
189 |
P |
A |
-2.1044 |
|
190 |
K |
A |
-2.2857 |
|
191 |
E |
A |
-2.6507 |
|
192 |
G |
A |
-2.8712 |
|
193 |
D |
A |
-2.8718 |
|
194 |
R |
A |
-2.4515 |
|
195 |
S |
A |
-1.6539 |
|
196 |
G |
A |
-2.2163 |
|
197 |
Y |
A |
0.0000 |
|
198 |
S |
A |
0.0000 |
|
199 |
S |
A |
-1.2586 |
|
200 |
P |
A |
-0.9832 |
|
201 |
G |
A |
-1.1432 |
|
202 |
E |
A |
0.0000 |
|
203 |
P |
A |
-1.2327 |
|
204 |
G |
A |
-1.1448 |
|
205 |
E |
A |
-1.2575 |
|
206 |
P |
A |
-0.8947 |
|
207 |
G |
A |
-0.8557 |
|
208 |
S |
A |
-1.1904 |
|
209 |
R |
A |
-2.0028 |
|
210 |
E |
A |
-2.9245 |
|
211 |
R |
A |
-3.0561 |
|
212 |
E |
A |
-2.5364 |
|
213 |
P |
A |
-2.5260 |
|
214 |
E |
A |
-3.3639 |
|
215 |
L |
A |
-2.6151 |
|
216 |
P |
A |
0.0000 |
|
217 |
E |
A |
-2.8904 |
|
218 |
P |
A |
0.0000 |
|
219 |
P |
A |
-1.3590 |
|
220 |
T |
A |
-1.1419 |
|
221 |
R |
A |
-1.2417 |
|
222 |
E |
A |
-1.4177 |
|
223 |
P |
A |
0.0000 |
|
224 |
K |
A |
-2.4569 |
|
225 |
K |
A |
-2.4185 |
|
226 |
V |
A |
-1.2287 |
|
227 |
A |
A |
-0.1579 |
|
228 |
V |
A |
0.8164 |
|
229 |
V |
A |
1.2392 |
|
230 |
R |
A |
-0.6452 |
|
231 |
E |
A |
-2.1415 |
|
232 |
P |
A |
-1.8506 |
|
233 |
P |
A |
-2.1141 |
|
234 |
K |
A |
-2.9876 |
|
235 |
E |
A |
-3.0125 |
|
236 |
P |
A |
-2.0728 |
|
237 |
E |
A |
-1.9890 |
|
238 |
E |
A |
-2.4947 |
|
239 |
A |
A |
-1.6164 |
|
240 |
K |
A |
-1.7210 |
|
241 |
S |
A |
-0.5481 |
|
242 |
R |
A |
0.6335 |
|
243 |
L |
A |
2.0308 |
|
244 |
Q |
A |
0.0000 |
|
245 |
T |
A |
-0.2177 |
|
246 |
A |
A |
0.2758 |
|
247 |
P |
A |
-0.4417 |
|
248 |
V |
A |
-0.3244 |
|
249 |
P |
A |
-0.9234 |
|
250 |
M |
A |
-0.8142 |
|
251 |
P |
A |
-1.0339 |
|
252 |
D |
A |
-0.7651 |
|
253 |
L |
A |
-1.4621 |
|
254 |
K |
A |
-1.8144 |
|
255 |
N |
A |
-1.4843 |
|
256 |
V |
A |
0.0000 |
|
257 |
K |
A |
-1.7514 |
|
258 |
S |
A |
-0.9845 |
|
259 |
K |
A |
-1.3548 |
|
260 |
I |
A |
-1.6969 |
|
261 |
G |
A |
-1.4747 |
|
262 |
S |
A |
-1.4565 |
|
263 |
T |
A |
-1.4075 |
|
264 |
E |
A |
-2.0159 |
|
265 |
N |
A |
-1.7371 |
|
266 |
L |
A |
-0.7369 |
|
267 |
K |
A |
-1.6226 |
|
268 |
H |
A |
-1.8618 |
|
269 |
Q |
A |
-1.4354 |
|
270 |
P |
A |
-0.7950 |
|
271 |
G |
A |
-1.0777 |
|
272 |
G |
A |
0.0000 |
|
273 |
G |
A |
0.0000 |
|
274 |
K |
A |
-0.8050 |
|
275 |
V |
A |
1.6719 |
|
276 |
Q |
A |
0.0000 |
|
277 |
I |
A |
2.7171 |
|
278 |
I |
A |
1.9454 |
|
279 |
N |
A |
-0.9680 |
|
280 |
K |
A |
-2.3356 |
|
281 |
K |
A |
-2.7604 |
|
282 |
L |
A |
0.0000 |
|
283 |
D |
A |
-1.8907 |
|
284 |
L |
A |
0.0974 |
|
285 |
S |
A |
-0.7405 |
|
286 |
N |
A |
0.0000 |
|
287 |
V |
A |
-0.6732 |
|
288 |
Q |
A |
-1.0808 |
|
289 |
S |
A |
-0.5841 |
|
290 |
K |
A |
0.0000 |
|
291 |
C |
A |
0.0000 |
|
292 |
G |
A |
-1.2384 |
|
293 |
S |
A |
-1.5958 |
|
294 |
K |
A |
-1.8262 |
|
295 |
D |
A |
-2.5182 |
|
296 |
N |
A |
-1.8253 |
|
297 |
I |
A |
-1.0061 |
|
298 |
K |
A |
-2.0689 |
|
299 |
H |
A |
0.0000 |
|
300 |
V |
A |
0.0000 |
|
301 |
P |
A |
-0.4829 |
|
302 |
G |
A |
-0.0335 |
|
303 |
G |
A |
0.0000 |
|
304 |
G |
A |
-1.4439 |
|
305 |
E |
A |
-2.4418 |
|
306 |
V |
A |
-0.5662 |
|
307 |
Q |
A |
-0.4126 |
|
308 |
I |
A |
0.2832 |
|
309 |
V |
A |
1.6591 |
|
310 |
Y |
A |
0.2208 |
|
311 |
K |
A |
-1.5868 |
|
312 |
P |
A |
0.0000 |
|
313 |
V |
A |
-0.6425 |
|
314 |
D |
A |
-0.6533 |
|
315 |
L |
A |
-0.4808 |
|
316 |
S |
A |
-0.4746 |
|
317 |
K |
A |
-1.3722 |
|
318 |
V |
A |
-1.8952 |
|
319 |
T |
A |
0.0000 |
|
320 |
S |
A |
-2.1497 |
|
321 |
K |
A |
-2.0160 |
|
322 |
C |
A |
-1.0563 |
|
323 |
G |
A |
0.0000 |
|
324 |
S |
A |
-1.2403 |
|
325 |
L |
A |
-0.3560 |
|
326 |
G |
A |
0.0000 |
|
327 |
N |
A |
0.0000 |
|
328 |
I |
A |
0.6888 |
|
329 |
H |
A |
0.1433 |
|
330 |
H |
A |
0.1572 |
|
331 |
K |
A |
0.0000 |
|
332 |
P |
A |
-0.9469 |
|
333 |
G |
A |
-1.5704 |
|
334 |
G |
A |
-1.3623 |
|
335 |
G |
A |
-1.2591 |
|
336 |
Q |
A |
-2.0563 |
|
337 |
V |
A |
-1.7474 |
|
338 |
E |
A |
-2.2145 |
|
339 |
V |
A |
-0.9670 |
|
340 |
K |
A |
-1.2166 |
|
341 |
S |
A |
-1.6508 |
|
342 |
E |
A |
-1.4426 |
|
343 |
K |
A |
-2.3194 |
|
344 |
L |
A |
-1.0995 |
|
345 |
D |
A |
-1.1488 |
|
346 |
F |
A |
-0.7549 |
|
347 |
K |
A |
-1.2895 |
|
348 |
D |
A |
-2.0706 |
|
349 |
R |
A |
-1.9048 |
|
350 |
V |
A |
-1.7497 |
|
351 |
Q |
A |
-1.5499 |
|
352 |
S |
A |
-0.3767 |
|
353 |
K |
A |
-0.2517 |
|
354 |
I |
A |
1.0850 |
|
355 |
G |
A |
-0.3016 |
|
356 |
S |
A |
-0.6816 |
|
357 |
L |
A |
-1.0971 |
|
358 |
D |
A |
-1.3373 |
|
359 |
N |
A |
-1.8558 |
|
360 |
I |
A |
-0.9016 |
|
361 |
T |
A |
-1.3446 |
|
362 |
H |
A |
-1.7721 |
|
363 |
V |
A |
-1.2099 |
|
364 |
P |
A |
-0.5605 |
|
365 |
G |
A |
-0.6495 |
|
366 |
G |
A |
0.1682 |
|
367 |
G |
A |
-0.3978 |
|
368 |
N |
A |
0.0000 |
|
369 |
K |
A |
-1.0006 |
|
370 |
K |
A |
-1.1199 |
|
371 |
I |
A |
0.0000 |
|
372 |
E |
A |
-0.8201 |
|
373 |
T |
A |
0.0000 |
|
374 |
H |
A |
-0.6914 |
|
375 |
K |
A |
-1.3925 |
|
376 |
L |
A |
-0.9335 |
|
377 |
T |
A |
-0.7039 |
|
378 |
F |
A |
-0.4493 |
|
379 |
R |
A |
-1.9434 |
|
380 |
E |
A |
-1.7251 |
|
381 |
N |
A |
-1.7373 |
|
382 |
A |
A |
-1.4583 |
|
383 |
K |
A |
-1.4055 |
|
384 |
A |
A |
0.0000 |
|
385 |
K |
A |
-1.7064 |
|
386 |
T |
A |
-1.3826 |
|
387 |
D |
A |
-1.0805 |
|
388 |
H |
A |
-1.5936 |
|
389 |
G |
A |
-1.1480 |
|
390 |
A |
A |
-0.8458 |
|
391 |
E |
A |
-1.5632 |
|
392 |
I |
A |
-0.2994 |
|
393 |
V |
A |
0.4055 |
|
394 |
E |
A |
-1.3747 |
|
395 |
K |
A |
-2.4613 |
|
396 |
E |
A |
-2.5595 |
|
397 |
P |
A |
-1.7517 |
|
398 |
V |
A |
-0.7794 |
|
399 |
V |
A |
-0.9283 |
|
400 |
E |
A |
-1.5428 |
|
401 |
G |
A |
-1.4793 |
|
402 |
D |
A |
-2.1938 |
|
403 |
E |
A |
-2.8410 |
|
404 |
E |
A |
-3.1006 |
|
405 |
P |
A |
-2.1598 |
|
406 |
R |
A |
0.0000 |
|
407 |
H |
A |
-1.4658 |
|
408 |
L |
A |
-0.3605 |
|
409 |
S |
A |
-0.5938 |
|
410 |
N |
A |
-1.5795 |
|
411 |
V |
A |
-0.6089 |
|
412 |
S |
A |
0.0000 |
|
413 |
S |
A |
0.0000 |
|
414 |
T |
A |
-1.3269 |
|
415 |
G |
A |
-1.1243 |
|
416 |
S |
A |
-0.7466 |
|
417 |
I |
A |
0.0000 |
|
418 |
D |
A |
-0.8697 |
|
419 |
M |
A |
0.0000 |
|
420 |
V |
A |
-0.7653 |
|
421 |
D |
A |
-1.3624 |
|
422 |
S |
A |
-1.1217 |
|
423 |
P |
A |
-0.7094 |
|
424 |
Q |
A |
-0.3612 |
|
425 |
L |
A |
1.0537 |
|
426 |
A |
A |
0.8116 |
|
427 |
T |
A |
0.7248 |
|
428 |
L |
A |
1.0113 |
|
429 |
A |
A |
-0.3613 |
|
430 |
D |
A |
-1.8735 |
|
431 |
E |
A |
-1.6981 |
|
432 |
V |
A |
0.5070 |
|
433 |
S |
A |
0.1164 |
|
434 |
A |
A |
0.5805 |
|
435 |
S |
A |
0.4711 |
|
436 |
L |
A |
0.8162 |
|
437 |
A |
A |
-0.9173 |
|
438 |
K |
A |
-2.5371 |
|
439 |
Q |
A |
-2.4279 |
|
440 |
G |
A |
-1.8367 |
|
441 |
L |
A |
-0.9490 |
|