Project name: cf5624e7d6d231e

Chain sequence(s)	A: MKKNLRIVSAAAAALLAVAPVAASAVSTVSAATTINASSSAINTNTNAKYDVDVTPSVSAVAANTANNTPAIAGNLTGTISASYNGKTYTANLKADTENATITAAGSTTAVKPAELAAGVAYTVTVNDVSFNFGSENAGKTVTLGSANSNVKFTGTNSDNQTETNVSTLKVKLDQNGVASLTNVSIANVYAINTTDNSNVNFYDVTSGATVTNGAVSVNADNQGQVNVANVVAAINSKYFAAQYADKKLNTRTANTEDAIKAALKDQKIDVNSVGYFKAPHTFTVNVKATSNTNGKSATLPVVVTVPNVAEPTVASVSKRIMHNAYYYDKDAKRVGTDSVKRYNSVSVLPNTTTINGKTYYQVVENGKAVDKYINAANIDGTKRTLKHNAYVYASSKKRANKVVLKKGEVVTTYGASYTFKNGQKYYKIGDNTDKTYVKVANFR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8786
• Maximal score value: 3.0835
• Average score: -0.7242
• Total score value: -321.5493

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.4867
2	K	A	-2.1552
3	K	A	-2.3002
4	N	A	-1.1661
5	L	A	0.3946
6	R	A	-0.8712
7	I	A	0.7891
8	V	A	1.7548
9	S	A	0.7980
10	A	A	1.1647
11	A	A	1.6002
12	A	A	1.6800
13	A	A	1.8022
14	A	A	2.0566
15	L	A	3.0689
16	L	A	3.0454
17	A	A	2.3790
18	V	A	3.0835
19	A	A	1.9647
20	P	A	1.1947
21	V	A	1.2962
22	A	A	0.5145
23	A	A	0.5815
24	S	A	0.3284
25	A	A	0.2008
26	V	A	1.2705
27	S	A	0.4031
28	T	A	0.5140
29	V	A	1.3399
30	S	A	1.2250
31	A	A	0.4542
32	A	A	0.7587
33	T	A	0.5058
34	T	A	0.4490
35	I	A	1.1720
36	N	A	-0.2474
37	A	A	0.0495
38	S	A	0.0985
39	S	A	0.1828
40	S	A	-0.1300
41	A	A	0.6909
42	I	A	1.2901
43	N	A	-0.3051
44	T	A	-0.6542
45	N	A	-1.4290
46	T	A	-1.7494
47	N	A	-2.0122
48	A	A	-1.5051
49	K	A	-1.9969
50	Y	A	-0.8181
51	D	A	-1.6281
52	V	A	-0.5389
53	D	A	-0.8580
54	V	A	1.3648
55	T	A	0.7418
56	P	A	-0.7000
57	S	A	-0.1510
58	V	A	1.1501
59	S	A	0.1749
60	A	A	0.4630
61	V	A	-0.1095
62	A	A	-0.2465
63	A	A	-0.6516
64	N	A	-1.8266
65	T	A	-1.2109
66	A	A	-1.5599
67	N	A	-2.3378
68	N	A	-2.1902
69	T	A	-1.4459
70	P	A	-0.4781
71	A	A	0.4762
72	I	A	1.2705
73	A	A	0.2513
74	G	A	-0.5487
75	N	A	-0.8338
76	L	A	0.6029
77	T	A	-0.5026
78	G	A	-0.2395
79	T	A	0.1835
80	I	A	1.5361
81	S	A	0.8478
82	A	A	0.2947
83	S	A	-0.2896
84	Y	A	0.0437
85	N	A	-1.1792
86	G	A	-1.0861
87	K	A	-1.0202
88	T	A	-0.4454
89	Y	A	0.0532
90	T	A	0.0197
91	A	A	0.0000
92	N	A	-1.2298
93	L	A	-1.7975
94	K	A	-2.7491
95	A	A	-2.0329
96	D	A	-2.7162
97	T	A	-2.8176
98	E	A	-3.1833
99	N	A	-2.4914
100	A	A	0.0000
101	T	A	-0.4589
102	I	A	0.0000
103	T	A	-0.4578
104	A	A	-0.5107
105	A	A	-0.3324
106	G	A	-0.5551
107	S	A	-0.5471
108	T	A	-0.2691
109	T	A	-0.0582
110	A	A	-0.1985
111	V	A	0.0000
112	K	A	-1.5352
113	P	A	-1.2584
114	A	A	-0.9147
115	E	A	-1.2212
116	L	A	0.7517
117	A	A	0.0335
118	A	A	-0.3306
119	G	A	-0.7036
120	V	A	-0.3058
121	A	A	-0.8820
122	Y	A	-1.1293
123	T	A	-0.7599
124	V	A	-0.0683
125	T	A	-0.2741
126	V	A	0.0039
127	N	A	-1.5468
128	D	A	-1.9062
129	V	A	-0.5988
130	S	A	-0.5362
131	F	A	-0.3587
132	N	A	-1.1750
133	F	A	0.0000
134	G	A	-1.4239
135	S	A	-1.6450
136	E	A	-2.4995
137	N	A	-2.1430
138	A	A	-1.7433
139	G	A	-1.6737
140	K	A	-2.3287
141	T	A	-1.2895
142	V	A	-0.7443
143	T	A	-0.4187
144	L	A	-0.2662
145	G	A	-0.6667
146	S	A	-0.5326
147	A	A	-0.7512
148	N	A	-1.4999
149	S	A	-0.8396
150	N	A	-0.7483
151	V	A	-0.4420
152	K	A	-1.2782
153	F	A	-1.1714
154	T	A	-1.5091
155	G	A	-2.0772
156	T	A	-2.6356
157	N	A	-3.1484
158	S	A	-2.3199
159	D	A	-3.2949
160	N	A	-3.4719
161	Q	A	-3.3389
162	T	A	-2.6611
163	E	A	-2.8378
164	T	A	-1.7319
165	N	A	-1.6247
166	V	A	-0.3152
167	S	A	-0.1937
168	T	A	-0.5917
169	L	A	-0.5765
170	K	A	-1.1264
171	V	A	0.2005
172	K	A	-0.4296
173	L	A	0.0841
174	D	A	-1.2209
175	Q	A	-1.9768
176	N	A	-2.3068
177	G	A	-1.3691
178	V	A	-0.5572
179	A	A	-0.0158
180	S	A	-0.0797
181	L	A	0.4972
182	T	A	0.0000
183	N	A	-1.2976
184	V	A	0.0000
185	S	A	-0.3309
186	I	A	-0.0511
187	A	A	-0.2960
188	N	A	-0.7302
189	V	A	0.0000
190	Y	A	1.6663
191	A	A	1.7209
192	I	A	1.5520
193	N	A	-0.6401
194	T	A	-0.6168
195	T	A	-1.0494
196	D	A	-1.8425
197	N	A	-1.9137
198	S	A	-1.0777
199	N	A	-1.0280
200	V	A	0.7830
201	N	A	1.0925
202	F	A	1.9983
203	Y	A	0.8476
204	D	A	-0.8079
205	V	A	-0.2234
206	T	A	-0.2314
207	S	A	-0.3004
208	G	A	-0.5205
209	A	A	-0.2100
210	T	A	-0.2992
211	V	A	0.0577
212	T	A	-0.0150
213	N	A	-0.9537
214	G	A	-0.5432
215	A	A	-0.4229
216	V	A	-0.1694
217	S	A	-0.9192
218	V	A	-1.2820
219	N	A	-2.2645
220	A	A	-2.5395
221	D	A	-3.0834
222	N	A	-2.7480
223	Q	A	-1.8906
224	G	A	-1.9851
225	Q	A	-1.7050
226	V	A	-0.5084
227	N	A	-0.6409
228	V	A	-0.4031
229	A	A	-0.3340
230	N	A	-1.1609
231	V	A	0.0000
232	V	A	0.0000
233	A	A	-0.5554
234	A	A	-0.6867
235	I	A	0.0000
236	N	A	-0.7601
237	S	A	-0.7675
238	K	A	-1.2102
239	Y	A	0.2560
240	F	A	0.6525
241	A	A	0.0000
242	A	A	0.0000
243	Q	A	-1.1252
244	Y	A	-0.9323
245	A	A	-1.4352
246	D	A	-2.7223
247	K	A	-3.4787
248	K	A	-3.5291
249	L	A	-2.6206
250	N	A	-2.4032
251	T	A	-2.3800
252	R	A	-2.7089
253	T	A	-1.6743
254	A	A	-1.0643
255	N	A	0.0000
256	T	A	0.0000
257	E	A	-2.9389
258	D	A	-2.0901
259	A	A	0.0000
260	I	A	-1.6183
261	K	A	-2.0528
262	A	A	-2.2792
263	A	A	-2.2166
264	L	A	-2.3097
265	K	A	-3.6483
266	D	A	-3.4881
267	Q	A	-3.1690
268	K	A	-3.4317
269	I	A	-2.2440
270	D	A	-2.4564
271	V	A	-0.8298
272	N	A	-0.6784
273	S	A	0.3461
274	V	A	1.6117
275	G	A	0.4860
276	Y	A	1.0621
277	F	A	0.1287
278	K	A	-1.8078
279	A	A	-0.6313
280	P	A	-0.4708
281	H	A	-0.8273
282	T	A	-0.3095
283	F	A	0.0000
284	T	A	0.5434
285	V	A	0.3593
286	N	A	-0.2378
287	V	A	-0.3845
288	K	A	-1.6223
289	A	A	-1.4335
290	T	A	-1.5867
291	S	A	-1.6757
292	N	A	-2.2650
293	T	A	-1.9191
294	N	A	-2.4512
295	G	A	-2.3225
296	K	A	-2.6817
297	S	A	-1.8296
298	A	A	-0.8593
299	T	A	-0.7061
300	L	A	-0.0487
301	P	A	0.2674
302	V	A	0.0000
303	V	A	0.8468
304	V	A	0.5217
305	T	A	0.3802
306	V	A	0.0737
307	P	A	-0.2721
308	N	A	-0.2062
309	V	A	0.9491
310	A	A	-0.1158
311	E	A	-1.3960
312	P	A	-0.7670
313	T	A	-0.3044
314	V	A	0.7012
315	A	A	0.6367
316	S	A	0.5627
317	V	A	1.2055
318	S	A	-0.2534
319	K	A	-1.3681
320	R	A	-0.6593
321	I	A	0.7530
322	M	A	-0.1080
323	H	A	-1.4068
324	N	A	-1.7631
325	A	A	-0.7893
326	Y	A	-0.1177
327	Y	A	-0.1634
328	Y	A	-1.1796
329	D	A	-2.8392
330	K	A	-3.4499
331	D	A	-3.5971
332	A	A	-2.4045
333	K	A	-2.3306
334	R	A	0.0000
335	V	A	-0.6550
336	G	A	-0.8649
337	T	A	-0.8728
338	D	A	-0.7353
339	S	A	0.0615
340	V	A	0.7590
341	K	A	-0.8305
342	R	A	-1.6684
343	Y	A	0.0000
344	N	A	-1.4172
345	S	A	-1.2742
346	V	A	0.0000
347	S	A	-0.2477
348	V	A	0.0540
349	L	A	-0.0595
350	P	A	-0.4775
351	N	A	-1.1365
352	T	A	-0.3601
353	T	A	0.0000
354	T	A	-0.2084
355	I	A	0.0000
356	N	A	-1.5954
357	G	A	-2.1891
358	K	A	-1.5378
359	T	A	-0.4287
360	Y	A	-0.0556
361	Y	A	0.1064
362	Q	A	-0.2389
363	V	A	-0.1640
364	V	A	-0.2810
365	E	A	-2.0398
366	N	A	-2.3912
367	G	A	-1.8410
368	K	A	-2.4403
369	A	A	-1.5836
370	V	A	-1.3973
371	D	A	-2.1860
372	K	A	-1.8173
373	Y	A	-0.2721
374	I	A	-0.0194
375	N	A	-0.2477
376	A	A	0.0257
377	A	A	-0.4501
378	N	A	-1.3947
379	I	A	-1.2584
380	D	A	-2.1927
381	G	A	-1.7751
382	T	A	-1.7451
383	K	A	-2.5532
384	R	A	-2.2311
385	T	A	-1.0618
386	L	A	-0.2750
387	K	A	-2.0468
388	H	A	-1.8454
389	N	A	-1.3578
390	A	A	0.5476
391	Y	A	2.3711
392	V	A	2.9544
393	Y	A	2.1274
394	A	A	0.7043
395	S	A	-0.8148
396	S	A	-1.9612
397	K	A	-3.4204
398	K	A	-3.7063
399	R	A	-3.8786
400	A	A	-2.9336
401	N	A	-3.0149
402	K	A	-1.6113
403	V	A	0.1476
404	V	A	1.0889
405	L	A	-0.6226
406	K	A	-2.3239
407	K	A	-2.4995
408	G	A	-1.3155
409	E	A	-0.6434
410	V	A	0.4431
411	V	A	0.0000
412	T	A	-0.4131
413	T	A	-0.8793
414	Y	A	0.1498
415	G	A	-0.1237
416	A	A	-0.0283
417	S	A	-0.3062
418	Y	A	-0.3316
419	T	A	-0.7056
420	F	A	-1.4542
421	K	A	-2.4888
422	N	A	-2.7660
423	G	A	-2.2940
424	Q	A	-2.6041
425	K	A	-2.1594
426	Y	A	-0.1880
427	Y	A	0.1463
428	K	A	-0.5289
429	I	A	0.7662
430	G	A	-0.9830
431	D	A	-2.4417
432	N	A	-2.7061
433	T	A	-2.5380
434	D	A	-3.0312
435	K	A	-2.4930
436	T	A	-0.3377
437	Y	A	1.3143
438	V	A	2.0227
439	K	A	0.3711
440	V	A	1.5787
441	A	A	0.3734
442	N	A	-0.4777
443	F	A	0.6254
444	R	A	-1.3156