Project name: Gevokizumab_Fab

Chain sequence(s)	H: QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP; L: DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5536
• Maximal score value: 1.0898
• Average score: -0.7302
• Total score value: -316.1582

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4780
2	V	H	-1.1210
3	Q	H	-1.8748
4	L	H	0.0000
5	Q	H	-1.3251
6	E	H	0.0000
7	S	H	-0.5338
8	G	H	-0.4680
9	P	H	-0.3651
10	G	H	-0.3599
11	L	H	-0.3173
12	V	H	0.0000
13	K	H	-2.0764
14	P	H	-1.3067
15	S	H	-1.1300
16	Q	H	-1.4584
17	T	H	-1.0896
18	L	H	0.0000
19	S	H	-0.8091
20	L	H	0.0000
21	T	H	-0.6646
22	C	H	0.0000
23	S	H	-1.2589
24	F	H	0.0000
25	S	H	-1.3604
26	G	H	-1.1066
27	F	H	-0.5183
28	S	H	-0.3280
29	L	H	0.0000
30	S	H	-0.6871
31	T	H	-0.4667
32	S	H	-0.4329
33	G	H	0.0000
34	M	H	0.0000
35	G	H	0.0000
36	V	H	0.0000
37	G	H	0.0000
38	W	H	0.0000
39	I	H	0.0000
40	R	H	0.0000
41	Q	H	-0.7661
42	P	H	-0.8458
43	S	H	-0.9591
44	G	H	-1.4385
45	K	H	-2.3632
46	G	H	-1.6122
47	L	H	0.0000
48	E	H	-0.9007
49	W	H	0.0000
50	L	H	0.0000
51	A	H	0.0000
52	H	H	0.0000
53	I	H	0.0000
54	W	H	-1.6338
55	W	H	-1.1775
56	D	H	-2.4756
57	G	H	-2.3547
58	D	H	-3.1735
59	E	H	-2.8649
60	S	H	-1.2442
61	Y	H	-0.6763
62	N	H	0.0000
63	P	H	-0.9655
64	S	H	-0.7543
65	L	H	0.0000
66	K	H	-1.9471
67	S	H	-1.2327
68	R	H	-1.2987
69	L	H	0.0000
70	T	H	-1.1479
71	I	H	0.0000
72	S	H	-1.2633
73	K	H	-1.3312
74	D	H	-1.7852
75	T	H	-1.4896
76	S	H	-1.5665
77	K	H	-2.5601
78	N	H	-2.2072
79	Q	H	-1.8205
80	V	H	0.0000
81	S	H	-0.7803
82	L	H	0.0000
83	K	H	-1.3249
84	I	H	0.0000
85	T	H	-0.8484
86	S	H	-0.8688
87	V	H	0.0000
88	T	H	-0.5244
89	A	H	-0.2397
90	A	H	0.0519
91	D	H	0.0000
92	T	H	0.0906
93	A	H	0.0000
94	V	H	0.1967
95	Y	H	0.0000
96	F	H	0.0000
97	C	H	0.0000
98	A	H	0.0000
99	R	H	-0.4922
100	N	H	0.0000
101	R	H	-0.7086
102	Y	H	-0.0222
103	D	H	-1.4026
104	P	H	-0.5994
105	P	H	0.0000
106	W	H	0.1216
107	F	H	0.0000
108	V	H	-0.0815
109	D	H	-0.7776
110	W	H	0.0000
111	G	H	0.0000
112	Q	H	-1.9359
113	G	H	0.0000
114	T	H	-0.2418
115	L	H	0.1541
116	V	H	0.0000
117	T	H	0.0000
118	V	H	0.0000
119	S	H	-0.7508
120	S	H	-0.8472
121	A	H	-0.5293
122	S	H	-0.6197
123	T	H	-0.7337
124	K	H	-1.1924
125	G	H	-1.3767
126	P	H	0.0000
127	S	H	-0.5468
128	V	H	0.0000
129	F	H	-0.6830
130	P	H	-1.1044
131	L	H	0.0000
132	A	H	-0.8315
133	P	H	0.0000
134	S	H	-0.9782
135	S	H	-1.1983
136	K	H	-1.9335
137	S	H	-1.0983
138	T	H	-0.9492
139	S	H	-0.9396
140	G	H	-0.8069
141	G	H	-0.6210
142	T	H	-0.4337
143	A	H	0.0000
144	A	H	0.0000
145	L	H	0.0000
146	G	H	0.0000
147	C	H	0.0000
148	L	H	0.0000
149	V	H	0.0000
150	K	H	0.0000
151	D	H	-0.3647
152	Y	H	0.0000
153	F	H	0.0000
154	P	H	0.0000
155	E	H	-0.3993
156	P	H	-0.6524
157	V	H	-0.6542
158	T	H	-0.5908
159	V	H	-0.1190
160	S	H	-0.3251
161	W	H	0.0000
162	N	H	-0.7614
163	S	H	-0.6289
164	G	H	-0.5616
165	A	H	-0.2425
166	L	H	-0.0234
167	T	H	-0.1780
168	S	H	-0.2079
169	G	H	-0.2736
170	V	H	0.1332
171	H	H	-0.3198
172	T	H	0.0404
173	F	H	0.0000
174	P	H	-0.3139
175	A	H	0.2748
176	V	H	0.5739
177	L	H	1.0898
178	Q	H	0.2426
179	S	H	-0.0953
180	S	H	-0.2374
181	G	H	0.0227
182	L	H	0.1100
183	Y	H	0.4112
184	S	H	0.0000
185	L	H	0.0000
186	S	H	0.0000
187	S	H	0.0000
188	V	H	0.0000
189	V	H	0.0000
190	T	H	-0.1383
191	V	H	0.0000
192	P	H	-0.5583
193	S	H	-0.6350
194	S	H	-0.7277
195	S	H	-0.6943
196	L	H	-0.9179
197	G	H	-1.0850
198	T	H	-0.7011
199	Q	H	-1.1556
200	T	H	-1.1497
201	Y	H	0.0000
202	I	H	-1.3658
203	C	H	0.0000
204	N	H	-1.3886
205	V	H	0.0000
206	N	H	-1.9707
207	H	H	0.0000
208	K	H	-2.7570
209	P	H	-1.6424
210	S	H	-1.8323
211	N	H	-2.6056
212	T	H	-2.0726
213	K	H	-2.7165
214	V	H	-1.6812
215	D	H	-2.3443
216	K	H	-2.2669
217	R	H	-2.7326
218	V	H	0.0000
219	E	H	-2.5824
220	P	H	-1.2365
1	D	L	-1.8780
2	I	L	0.0000
3	Q	L	-2.1113
4	M	L	0.0000
5	T	L	-1.3941
6	Q	L	0.0000
7	S	L	-0.7283
8	T	L	-0.5066
9	S	L	-0.7617
10	S	L	-0.5379
11	L	L	-0.1451
12	S	L	-0.5802
13	A	L	-0.9665
14	S	L	-1.1686
15	V	L	-0.7766
16	G	L	-1.1449
17	D	L	-1.8532
18	R	L	-2.3873
19	V	L	0.0000
20	T	L	-0.6342
21	I	L	0.0000
22	T	L	-0.7284
23	C	L	0.0000
24	R	L	-2.6272
25	A	L	0.0000
26	S	L	-2.0266
27	Q	L	-2.3780
28	D	L	-2.5439
29	I	L	0.0000
30	S	L	-0.8810
31	N	L	-0.6076
32	Y	L	-0.1118
33	L	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.1823
39	K	L	-1.9202
40	P	L	-1.5721
41	G	L	-1.8690
42	K	L	-2.5680
43	A	L	-1.8344
44	V	L	0.0000
45	K	L	-1.3063
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.3713
50	Y	L	0.5823
51	T	L	0.0000
52	S	L	-0.6027
53	K	L	-0.9286
54	L	L	-0.1738
55	H	L	-0.4416
56	S	L	-0.5125
57	G	L	-0.5738
58	V	L	0.0000
59	P	L	-0.3962
60	S	L	-0.4377
61	R	L	-0.8100
62	F	L	0.0000
63	S	L	-0.4815
64	G	L	-0.3779
65	S	L	-0.7359
66	G	L	-1.0571
67	S	L	-1.2332
68	G	L	-1.6648
69	T	L	-2.0620
70	D	L	-2.1919
71	Y	L	0.0000
72	T	L	-0.6901
73	L	L	0.0000
74	T	L	-0.6227
75	I	L	0.0000
76	S	L	-1.3364
77	S	L	-1.2659
78	L	L	0.0000
79	Q	L	-1.1716
80	Q	L	-2.2055
81	E	L	-2.4724
82	D	L	0.0000
83	F	L	-1.3996
84	A	L	0.0000
85	T	L	-0.8922
86	Y	L	0.0000
87	F	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	G	L	-0.1329
92	K	L	-0.7259
93	M	L	0.3384
94	L	L	1.0276
95	P	L	0.0000
96	W	L	0.0000
97	T	L	-0.6150
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.7918
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.3440
104	L	L	0.0000
105	E	L	-1.0645
106	I	L	0.0000
107	K	L	-1.4532
108	R	L	-1.0578
109	T	L	-0.2104
110	V	L	0.0731
111	A	L	0.0009
112	A	L	-0.1813
113	P	L	0.0000
114	S	L	-0.1837
115	V	L	0.0000
116	F	L	0.0958
117	I	L	0.1031
118	F	L	0.0000
119	P	L	-0.5333
120	P	L	0.0000
121	S	L	-1.5751
122	D	L	-2.8858
123	E	L	-2.8632
124	Q	L	0.0000
125	L	L	-2.1886
126	K	L	-2.7856
127	S	L	-1.7130
128	G	L	-1.1987
129	T	L	-1.0241
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.9804
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.7938
142	R	L	-2.7866
143	E	L	-3.1315
144	A	L	-2.3431
145	K	L	-2.3004
146	V	L	-1.3078
147	Q	L	-0.9575
148	W	L	0.0000
149	K	L	-0.9350
150	V	L	0.0000
151	D	L	-2.0691
152	N	L	-1.6667
153	A	L	-0.5138
154	L	L	0.1692
155	Q	L	-0.4070
156	S	L	-0.5471
157	G	L	-0.8831
158	N	L	-0.7873
159	S	L	-1.0067
160	Q	L	-1.1344
161	E	L	-1.4161
162	S	L	-0.7790
163	V	L	-0.7584
164	T	L	-1.1948
165	E	L	-2.2850
166	Q	L	0.0000
167	D	L	-2.1721
168	S	L	-2.3651
169	K	L	-2.7161
170	D	L	-2.0750
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.5245
179	L	L	0.0000
180	T	L	-0.4385
181	L	L	-0.6929
182	S	L	-1.0871
183	K	L	-2.0348
184	A	L	-1.8698
185	D	L	-2.6290
186	Y	L	0.0000
187	E	L	-3.2868
188	K	L	-3.5536
189	H	L	-3.1277
190	K	L	-3.4610
191	V	L	-1.7071
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.7970
196	V	L	0.0000
197	T	L	-1.2356
198	H	L	0.0000
199	Q	L	-1.7497
200	G	L	-0.4773
201	L	L	-0.2345
202	S	L	-0.4493
203	S	L	-0.4378
204	P	L	-0.5610
205	V	L	-0.0097
206	T	L	-0.4575
207	K	L	-0.5433
208	S	L	-0.6433
209	F	L	-1.2010
210	N	L	-2.5838
211	R	L	-2.8532
212	G	L	-2.4732
213	E	L	-2.6811