Chain sequence(s) |
A: MDTVCIAVVGAGVIGLSTAACISQLVPGCTVTVISDRFTPDTTSNVAAGMLIPHTYADTPVPTQKRWFRETFEHLSEIAKSAEAADAGVHLVSGWQIFHSVPAEEVPFWADVVLGFRKMTEAELKRFPQYVFGQAFTTLKCETSAYLPWLERRIKGSGGLLLTWRIEDLWELQPSFDIVVNCSGLGSRRLVGDPMISPVRGQVLQARAPWVKHFIRDGGGLTYVYPGMSYVTLGGTRQKGDWNRSPDAELSREIFSRCCTLEPSLHRAYDIKEKVGLRPSRPGVRLQKEILVRGQQTLPVVHNYGHGSGGISVHWGSALEATRLVMECIHTLRTPASLSKL |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | IA290L |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.392933 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.1118 | |
2 | D | A | -1.3415 | |
3 | T | A | -0.7954 | |
4 | V | A | 0.0000 | |
5 | C | A | -0.4188 | |
6 | I | A | 0.0000 | |
7 | A | A | 0.0000 | |
8 | V | A | 0.0000 | |
9 | V | A | 0.0000 | |
10 | G | A | -0.7762 | |
11 | A | A | 0.0000 | |
12 | G | A | -0.3943 | |
13 | V | A | 0.0000 | |
14 | I | A | 0.1618 | |
15 | G | A | 0.0000 | |
16 | L | A | 0.0000 | |
17 | S | A | 0.0000 | |
18 | T | A | 0.0000 | |
19 | A | A | 0.0000 | |
20 | A | A | -0.8391 | |
21 | C | A | 0.0000 | |
22 | I | A | 0.0000 | |
23 | S | A | -0.7083 | |
24 | Q | A | -1.2251 | |
25 | L | A | 0.0000 | |
26 | V | A | 0.0000 | |
27 | P | A | -0.6892 | |
28 | G | A | -0.9130 | |
29 | C | A | -0.6884 | |
30 | T | A | -0.2774 | |
31 | V | A | 0.0000 | |
32 | T | A | 0.8017 | |
33 | V | A | 0.0000 | |
34 | I | A | 0.0000 | |
35 | S | A | 0.0000 | |
36 | D | A | -3.1900 | |
37 | R | A | -2.8908 | |
38 | F | A | -1.0716 | |
39 | T | A | 0.0000 | |
40 | P | A | -0.7844 | |
41 | D | A | -1.3696 | |
42 | T | A | -1.0037 | |
43 | T | A | -0.4869 | |
44 | S | A | 0.0000 | |
45 | N | A | 0.0000 | |
46 | V | A | -0.1675 | |
47 | A | A | -0.0622 | |
48 | A | A | -0.0260 | |
49 | G | A | 0.0000 | |
50 | M | A | 0.0000 | |
51 | L | A | 0.0000 | |
52 | I | A | 0.1142 | |
53 | P | A | -0.1996 | |
54 | H | A | -0.4813 | |
55 | T | A | -0.3114 | |
56 | Y | A | 0.0155 | |
57 | A | A | -0.4543 | |
58 | D | A | -0.7818 | |
59 | T | A | -0.3496 | |
60 | P | A | -0.3150 | |
61 | V | A | -0.3031 | |
62 | P | A | -0.7121 | |
63 | T | A | -0.6900 | |
64 | Q | A | -0.8369 | |
65 | K | A | -1.2118 | |
66 | R | A | -1.4813 | |
67 | W | A | 0.0000 | |
68 | F | A | 0.0000 | |
69 | R | A | -1.9737 | |
70 | E | A | -1.6638 | |
71 | T | A | 0.0000 | |
72 | F | A | 0.0000 | |
73 | E | A | -2.7935 | |
74 | H | A | -2.1251 | |
75 | L | A | 0.0000 | |
76 | S | A | -1.9922 | |
77 | E | A | -2.8333 | |
78 | I | A | -1.9979 | |
79 | A | A | -1.8438 | |
80 | K | A | -2.3872 | |
81 | S | A | -1.6995 | |
82 | A | A | -1.4436 | |
83 | E | A | -2.5288 | |
84 | A | A | -2.0013 | |
85 | A | A | -1.6730 | |
86 | D | A | -2.4049 | |
87 | A | A | 0.0000 | |
88 | G | A | 0.0000 | |
89 | V | A | 0.0000 | |
90 | H | A | -0.7492 | |
91 | L | A | 0.4718 | |
92 | V | A | -0.0666 | |
93 | S | A | -0.0968 | |
94 | G | A | 0.0000 | |
95 | W | A | -0.2621 | |
96 | Q | A | 0.0000 | |
97 | I | A | 0.0000 | |
98 | F | A | 0.6496 | |
99 | H | A | 0.0479 | |
100 | S | A | 1.0310 | |
101 | V | A | 1.6675 | |
102 | P | A | 0.2544 | |
103 | A | A | -0.2085 | |
104 | E | A | -1.2806 | |
105 | E | A | 0.0000 | |
106 | V | A | -0.1729 | |
107 | P | A | -0.4309 | |
108 | F | A | -0.2794 | |
109 | W | A | 0.0000 | |
110 | A | A | -0.0243 | |
111 | D | A | -1.1456 | |
112 | V | A | 0.0000 | |
113 | V | A | 0.0000 | |
114 | L | A | 1.0716 | |
115 | G | A | 0.4037 | |
116 | F | A | 0.8763 | |
117 | R | A | -0.9521 | |
118 | K | A | -1.7132 | |
119 | M | A | 0.0000 | |
120 | T | A | -1.6741 | |
121 | E | A | -2.3990 | |
122 | A | A | -2.0163 | |
123 | E | A | -2.1453 | |
124 | L | A | -1.8279 | |
125 | K | A | -3.0779 | |
126 | R | A | -3.1713 | |
127 | F | A | 0.0000 | |
128 | P | A | -1.5097 | |
129 | Q | A | -1.4142 | |
130 | Y | A | -0.2474 | |
131 | V | A | 1.3018 | |
132 | F | A | 1.1085 | |
133 | G | A | 0.0000 | |
134 | Q | A | 0.0000 | |
135 | A | A | 0.0000 | |
136 | F | A | 0.0000 | |
137 | T | A | 0.7628 | |
138 | T | A | 0.0000 | |
139 | L | A | 0.0000 | |
140 | K | A | 0.0000 | |
141 | C | A | 0.0000 | |
142 | E | A | -0.5248 | |
143 | T | A | 0.0000 | |
144 | S | A | -0.3552 | |
145 | A | A | -0.5101 | |
146 | Y | A | 0.0000 | |
147 | L | A | 0.0000 | |
148 | P | A | -1.0632 | |
149 | W | A | -1.7741 | |
150 | L | A | 0.0000 | |
151 | E | A | -2.0029 | |
152 | R | A | -3.5346 | |
153 | R | A | -3.5612 | |
154 | I | A | 0.0000 | |
155 | K | A | -3.0084 | |
156 | G | A | -2.5198 | |
157 | S | A | -1.8998 | |
158 | G | A | -1.0587 | |
159 | G | A | -0.6758 | |
160 | L | A | 1.1925 | |
161 | L | A | 1.0672 | |
162 | L | A | 0.8236 | |
163 | T | A | -0.6831 | |
164 | W | A | -1.3029 | |
165 | R | A | -2.9069 | |
166 | I | A | 0.0000 | |
167 | E | A | -2.1744 | |
168 | D | A | -1.8684 | |
169 | L | A | 0.0000 | |
170 | W | A | -0.2742 | |
171 | E | A | -1.6663 | |
172 | L | A | 0.0000 | |
173 | Q | A | -0.7666 | |
174 | P | A | -0.6337 | |
175 | S | A | -0.5841 | |
176 | F | A | -0.1424 | |
177 | D | A | -0.4514 | |
178 | I | A | 0.0000 | |
179 | V | A | 0.0000 | |
180 | V | A | 0.0000 | |
181 | N | A | 0.0000 | |
182 | C | A | 0.0000 | |
183 | S | A | -0.6901 | |
184 | G | A | -0.3147 | |
185 | L | A | -0.4408 | |
186 | G | A | -1.0122 | |
187 | S | A | 0.0000 | |
188 | R | A | -1.9641 | |
189 | R | A | -2.5985 | |
190 | L | A | 0.0000 | |
191 | V | A | -0.9224 | |
192 | G | A | -1.1147 | |
193 | D | A | 0.0000 | |
194 | P | A | -0.3197 | |
195 | M | A | 0.0186 | |
196 | I | A | 0.0000 | |
197 | S | A | -0.6465 | |
198 | P | A | 0.0000 | |
199 | V | A | -1.0693 | |
200 | R | A | 0.0000 | |
201 | G | A | 0.0000 | |
202 | Q | A | 0.0000 | |
203 | V | A | 0.0000 | |
204 | L | A | 0.0000 | |
205 | Q | A | -0.9531 | |
206 | A | A | 0.0000 | |
207 | R | A | -0.7547 | |
208 | A | A | 0.0000 | |
209 | P | A | -0.2784 | |
210 | W | A | -0.0185 | |
211 | V | A | -0.6010 | |
212 | K | A | -1.6927 | |
213 | H | A | -1.0647 | |
214 | F | A | 0.0000 | |
215 | I | A | 0.0000 | |
216 | R | A | 0.0000 | |
217 | D | A | 0.0000 | |
218 | G | A | -0.3648 | |
219 | G | A | -0.5641 | |
220 | G | A | -0.6081 | |
221 | L | A | -0.2065 | |
222 | T | A | 0.0000 | |
223 | Y | A | 0.0000 | |
224 | V | A | 0.0000 | |
225 | Y | A | 0.0000 | |
226 | P | A | 0.0000 | |
227 | G | A | -0.2573 | |
228 | M | A | 0.1428 | |
229 | S | A | 0.0553 | |
230 | Y | A | 0.1100 | |
231 | V | A | 0.0000 | |
232 | T | A | 0.0000 | |
233 | L | A | 0.0000 | |
234 | G | A | 0.0000 | |
235 | G | A | 0.0000 | |
236 | T | A | 0.0000 | |
237 | R | A | -1.3275 | |
238 | Q | A | -1.7291 | |
239 | K | A | -2.1936 | |
240 | G | A | -1.3956 | |
241 | D | A | -1.2054 | |
242 | W | A | -0.2996 | |
243 | N | A | -1.5468 | |
244 | R | A | -2.2185 | |
245 | S | A | -1.4721 | |
246 | P | A | -1.4202 | |
247 | D | A | -1.7436 | |
248 | A | A | -1.6700 | |
249 | E | A | -2.5954 | |
250 | L | A | -1.5474 | |
251 | S | A | -1.7599 | |
252 | R | A | -2.6673 | |
253 | E | A | -1.7301 | |
254 | I | A | 0.0000 | |
255 | F | A | -0.9062 | |
256 | S | A | -1.0566 | |
257 | R | A | -1.0058 | |
258 | C | A | 0.0000 | |
259 | C | A | 0.0000 | |
260 | T | A | -0.7429 | |
261 | L | A | 0.0000 | |
262 | E | A | -0.8616 | |
263 | P | A | -1.1077 | |
264 | S | A | -1.0688 | |
265 | L | A | 0.0000 | |
266 | H | A | -1.7831 | |
267 | R | A | -2.3010 | |
268 | A | A | -1.0835 | |
269 | Y | A | -0.2424 | |
270 | D | A | -1.2870 | |
271 | I | A | -0.9132 | |
272 | K | A | -2.1807 | |
273 | E | A | -1.9042 | |
274 | K | A | -1.3811 | |
275 | V | A | 0.0000 | |
276 | G | A | -0.6442 | |
277 | L | A | 0.0000 | |
278 | R | A | -0.7057 | |
279 | P | A | 0.0000 | |
280 | S | A | -0.5882 | |
281 | R | A | -0.3515 | |
282 | P | A | -0.3337 | |
283 | G | A | -0.1860 | |
284 | V | A | -0.0662 | |
285 | R | A | -0.3276 | |
286 | L | A | -0.3734 | |
287 | Q | A | -1.0214 | |
288 | K | A | -1.0186 | |
289 | E | A | -0.0542 | |
290 | L | A | 1.4559 | mutated: IA290L |
291 | L | A | 1.3633 | |
292 | V | A | 1.3100 | |
293 | R | A | -0.3456 | |
294 | G | A | -1.1221 | |
295 | Q | A | -1.5955 | |
296 | Q | A | -1.2671 | |
297 | T | A | 0.0929 | |
298 | L | A | 0.0000 | |
299 | P | A | 0.0000 | |
300 | V | A | 0.0000 | |
301 | V | A | 0.0000 | |
302 | H | A | 0.0000 | |
303 | N | A | 0.0000 | |
304 | Y | A | 0.0000 | |
305 | G | A | 0.0000 | |
306 | H | A | 0.0000 | |
307 | G | A | -0.4346 | |
308 | S | A | -0.4697 | |
309 | G | A | -0.2984 | |
310 | G | A | -0.1381 | |
311 | I | A | 0.0000 | |
312 | S | A | 0.0000 | |
313 | V | A | 0.0000 | |
314 | H | A | 0.0000 | |
315 | W | A | -0.1916 | |
316 | G | A | 0.0000 | |
317 | S | A | 0.0000 | |
318 | A | A | 0.0000 | |
319 | L | A | -0.0205 | |
320 | E | A | 0.0000 | |
321 | A | A | 0.0000 | |
322 | T | A | 0.0000 | |
323 | R | A | -0.9800 | |
324 | L | A | 0.0000 | |
325 | V | A | 0.0000 | |
326 | M | A | -0.4312 | |
327 | E | A | -0.9288 | |
328 | C | A | 0.0000 | |
329 | I | A | 0.0000 | |
330 | H | A | -0.8763 | |
331 | T | A | -0.5329 | |
332 | L | A | -0.3896 | |
333 | R | A | -1.7107 | |
334 | T | A | -0.8919 | |
335 | P | A | -0.8727 | |
336 | A | A | -0.5758 | |
337 | S | A | -0.5299 | |
338 | L | A | -0.7522 | |
339 | S | A | -0.9710 | |
340 | K | A | -1.7210 | |
341 | L | A | -0.8864 |