| Chain sequence(s) |
A: LVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASS C: SALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVAN |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 196 | L | A | 1.7687 | |
| 197 | V | A | 1.8758 | |
| 198 | P | A | 0.1816 | |
| 199 | G | A | -0.5344 | |
| 200 | E | A | -1.0470 | |
| 201 | E | A | -1.3301 | |
| 202 | W | A | 0.0000 | |
| 203 | E | A | 0.0000 | |
| 204 | F | A | 0.0000 | |
| 205 | E | A | -0.6219 | |
| 206 | V | A | 0.0000 | |
| 207 | T | A | 0.0000 | |
| 208 | A | A | 0.0000 | |
| 209 | F | A | -1.1744 | |
| 210 | Y | A | 0.0000 | |
| 211 | R | A | -2.0615 | |
| 212 | G | A | -1.7752 | |
| 213 | R | A | -1.9823 | |
| 214 | Q | A | -1.7048 | |
| 215 | V | A | -0.7248 | |
| 216 | F | A | -0.7402 | |
| 217 | Q | A | -1.4951 | |
| 218 | Q | A | -1.0554 | |
| 219 | T | A | -0.5506 | |
| 220 | I | A | -0.0243 | |
| 221 | S | A | -0.4814 | |
| 222 | C | A | -0.7273 | |
| 223 | P | A | -0.9843 | |
| 224 | E | A | -1.5642 | |
| 225 | G | A | 0.0000 | |
| 226 | L | A | 0.0000 | |
| 227 | R | A | 0.0000 | |
| 228 | L | A | 0.0000 | |
| 229 | V | A | 0.0000 | |
| 230 | G | A | -0.9459 | |
| 231 | S | A | -1.2788 | |
| 232 | E | A | -1.8290 | |
| 233 | V | A | -0.8851 | |
| 234 | G | A | -1.9340 | |
| 235 | D | A | -2.9559 | |
| 236 | R | A | -2.6035 | |
| 237 | T | A | -1.4683 | |
| 238 | L | A | -0.8016 | |
| 239 | P | A | -0.9895 | |
| 240 | G | A | -0.7597 | |
| 241 | W | A | 0.0027 | |
| 242 | P | A | -0.0721 | |
| 243 | V | A | 0.0000 | |
| 244 | T | A | -0.2856 | |
| 245 | L | A | 0.0000 | |
| 246 | P | A | -0.3870 | |
| 247 | D | A | -0.9430 | |
| 248 | P | A | 0.0000 | |
| 249 | G | A | -0.6580 | |
| 250 | M | A | 0.8229 | |
| 251 | S | A | -0.0659 | |
| 252 | L | A | -0.9872 | |
| 253 | T | A | -1.2404 | |
| 254 | D | A | -2.7218 | |
| 255 | R | A | -2.6760 | |
| 256 | G | A | -1.4049 | |
| 257 | V | A | -1.2225 | |
| 258 | M | A | 0.0000 | |
| 259 | S | A | -1.0278 | |
| 260 | Y | A | 0.1451 | |
| 261 | V | A | 0.0000 | |
| 262 | R | A | -1.9565 | |
| 263 | H | A | -1.3375 | |
| 264 | V | A | -0.7873 | |
| 265 | L | A | 0.0000 | |
| 266 | S | A | -1.0637 | |
| 267 | C | A | -0.8440 | |
| 268 | L | A | 0.0000 | |
| 269 | G | A | -0.8326 | |
| 270 | G | A | -0.6776 | |
| 271 | G | A | 0.0000 | |
| 272 | L | A | 0.0000 | |
| 273 | A | A | 0.0000 | |
| 274 | L | A | 0.0000 | |
| 275 | W | A | -0.5235 | |
| 276 | R | A | -0.6745 | |
| 277 | A | A | -0.1951 | |
| 278 | G | A | -0.6195 | |
| 279 | Q | A | -1.3628 | |
| 280 | W | A | -0.4382 | |
| 281 | L | A | 0.0000 | |
| 282 | W | A | -0.4208 | |
| 283 | A | A | 0.0000 | |
| 284 | Q | A | -1.9463 | |
| 285 | R | A | -2.0178 | |
| 286 | L | A | -1.2202 | |
| 287 | G | A | 0.0000 | |
| 288 | H | A | -1.4325 | |
| 289 | C | A | 0.0000 | |
| 290 | H | A | -1.7061 | |
| 291 | T | A | 0.0000 | |
| 292 | Y | A | -0.7808 | |
| 293 | W | A | -0.4675 | |
| 294 | A | A | 0.0000 | |
| 295 | V | A | -0.9796 | |
| 296 | S | A | -1.3326 | |
| 297 | E | A | -1.9335 | |
| 298 | E | A | -0.7345 | |
| 299 | L | A | 0.6420 | |
| 300 | L | A | -0.1181 | |
| 301 | P | A | -0.9415 | |
| 302 | N | A | -2.1379 | |
| 303 | S | A | -1.8739 | |
| 304 | G | A | -2.5294 | |
| 305 | H | A | -2.2087 | |
| 306 | G | A | -1.6301 | |
| 307 | P | A | -1.3897 | |
| 308 | D | A | -1.8850 | |
| 309 | G | A | -1.2601 | |
| 310 | E | A | -1.5657 | |
| 311 | V | A | 0.0000 | |
| 312 | P | A | -2.6390 | |
| 313 | K | A | -3.7387 | |
| 314 | D | A | -3.7250 | |
| 315 | K | A | -3.6547 | |
| 316 | E | A | -2.7431 | |
| 317 | G | A | -1.6382 | |
| 318 | G | A | -0.5160 | |
| 319 | V | A | 0.0000 | |
| 320 | F | A | 0.0000 | |
| 321 | D | A | -0.8265 | |
| 322 | L | A | 0.0000 | |
| 323 | G | A | -0.4540 | |
| 324 | P | A | -0.3406 | |
| 325 | F | A | 0.0000 | |
| 326 | I | A | 0.0000 | |
| 327 | V | A | 0.9174 | |
| 328 | D | A | -1.3194 | |
| 329 | L | A | 0.0000 | |
| 330 | I | A | -0.2797 | |
| 331 | T | A | -1.1287 | |
| 332 | F | A | 0.0000 | |
| 333 | T | A | 0.0000 | |
| 334 | E | A | -2.4579 | |
| 335 | G | A | -1.8484 | |
| 336 | S | A | -1.6954 | |
| 337 | G | A | -1.7325 | |
| 338 | R | A | -2.6259 | |
| 339 | S | A | -2.2429 | |
| 340 | P | A | -1.9278 | |
| 341 | R | A | -2.8630 | |
| 342 | Y | A | 0.0000 | |
| 343 | A | A | 0.0000 | |
| 344 | L | A | 0.0000 | |
| 345 | W | A | 0.0000 | |
| 346 | F | A | 0.0000 | |
| 347 | C | A | 0.0000 | |
| 348 | V | A | 0.0000 | |
| 349 | G | A | -0.8163 | |
| 350 | E | A | -0.8595 | |
| 351 | S | A | -0.8647 | |
| 352 | W | A | 0.0000 | |
| 353 | P | A | 0.0000 | |
| 354 | Q | A | -2.6756 | |
| 355 | D | A | -3.1424 | |
| 356 | Q | A | -2.7657 | |
| 357 | P | A | -2.0765 | |
| 358 | W | A | -1.5830 | |
| 359 | T | A | -1.7903 | |
| 360 | K | A | -2.3038 | |
| 361 | R | A | -1.5381 | |
| 362 | L | A | -0.8023 | |
| 363 | V | A | 0.0000 | |
| 364 | M | A | 0.0000 | |
| 365 | V | A | 0.0000 | |
| 366 | K | A | -0.1025 | |
| 367 | V | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | P | A | 0.0000 | |
| 370 | T | A | 0.0000 | |
| 371 | C | A | 0.0000 | |
| 372 | L | A | 0.0000 | |
| 373 | R | A | -0.7930 | |
| 374 | A | A | 0.0000 | |
| 375 | L | A | 0.0000 | |
| 376 | V | A | 0.0000 | |
| 377 | E | A | -1.0531 | |
| 378 | M | A | 0.0000 | |
| 379 | A | A | 0.0000 | |
| 380 | R | A | -0.9496 | |
| 381 | V | A | -0.4117 | |
| 382 | G | A | -0.5081 | |
| 383 | G | A | -1.2626 | |
| 384 | A | A | 0.0000 | |
| 385 | S | A | -1.0162 | |
| 386 | S | A | -1.1979 | |
| 2065 | S | C | -1.0134 | |
| 2066 | A | C | -0.6337 | |
| 2067 | L | C | -0.7010 | |
| 2068 | Q | C | -2.0728 | |
| 2069 | D | C | -2.2289 | |
| 2070 | L | C | 0.0000 | |
| 2071 | L | C | 0.0000 | |
| 2072 | R | C | -2.8063 | |
| 2073 | T | C | -1.7934 | |
| 2074 | L | C | -1.5739 | |
| 2075 | K | C | -2.0961 | |
| 2076 | S | C | -1.3748 | |
| 2077 | P | C | -0.7626 | |
| 2078 | S | C | -0.8259 | |
| 2079 | S | C | -0.8946 | |
| 2080 | P | C | -1.1973 | |
| 2081 | Q | C | -1.5942 | |
| 2082 | Q | C | 0.0000 | |
| 2083 | Q | C | -1.5435 | |
| 2084 | Q | C | -1.9241 | |
| 2085 | Q | C | 0.0000 | |
| 2086 | V | C | 0.0000 | |
| 2087 | L | C | -1.0768 | |
| 2088 | N | C | -1.6046 | |
| 2089 | I | C | 0.0000 | |
| 2090 | L | C | 0.0000 | |
| 2091 | K | C | -2.1251 | |
| 2092 | S | C | -1.4070 | |
| 2093 | N | C | -1.2877 | |
| 2094 | P | C | -1.2989 | |
| 2095 | Q | C | -1.0047 | |
| 2096 | L | C | 0.0000 | |
| 2097 | M | C | -0.4515 | |
| 2098 | A | C | -0.4696 | |
| 2099 | A | C | 0.0000 | |
| 2100 | F | C | 0.0000 | |
| 2101 | I | C | 0.0016 | |
| 2102 | K | C | -1.7741 | |
| 2103 | Q | C | 0.0000 | |
| 2104 | R | C | -1.1704 | |
| 2105 | T | C | -0.9871 | |
| 2106 | A | C | -1.3167 | |
| 2107 | K | C | -1.0449 | |
| 2108 | Y | C | 1.2378 | |
| 2109 | V | C | 1.8044 | |
| 2110 | A | C | 0.4198 | |
| 2111 | N | C | -0.7427 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine