Project name: 2XUB
Status: done
submitted: 2018-02-20 14:08:58, status changed: 2018-02-20 14:19:24
Settings
Chain sequence(s)
|
A: MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKEQKQVEDFAMIPAKEAKDMLYKMLSENFMVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMK
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.1495
-
Maximal score value
-
1.6472
-
Average score
-
-1.009
-
Total score value
-
-436.8849
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
0.2958 |
|
2 |
T |
A |
-0.2932 |
|
3 |
Q |
A |
-1.4875 |
|
4 |
A |
A |
-1.4625 |
|
5 |
E |
A |
-1.0638 |
|
6 |
I |
A |
0.0000 |
|
7 |
K |
A |
-1.7362 |
|
8 |
L |
A |
0.0000 |
|
9 |
C |
A |
0.0000 |
|
10 |
S |
A |
-1.2119 |
|
11 |
L |
A |
0.0000 |
|
12 |
L |
A |
0.0000 |
|
13 |
L |
A |
0.0000 |
|
14 |
Q |
A |
-2.1066 |
|
15 |
E |
A |
-1.7922 |
|
16 |
H |
A |
-1.5236 |
|
17 |
F |
A |
-0.9414 |
|
18 |
G |
A |
-1.7011 |
|
19 |
E |
A |
-2.3426 |
|
20 |
I |
A |
-1.3405 |
|
21 |
V |
A |
0.0000 |
|
22 |
E |
A |
-1.6316 |
|
23 |
K |
A |
-1.4087 |
|
24 |
I |
A |
0.0000 |
|
25 |
G |
A |
0.0000 |
|
26 |
V |
A |
0.0000 |
|
27 |
H |
A |
-1.3117 |
|
28 |
L |
A |
0.0000 |
|
29 |
I |
A |
-1.1749 |
|
30 |
R |
A |
-1.8179 |
|
31 |
T |
A |
-1.3207 |
|
32 |
G |
A |
-1.1027 |
|
33 |
S |
A |
-0.8264 |
|
34 |
Q |
A |
0.0000 |
|
35 |
P |
A |
-0.0792 |
|
36 |
L |
A |
-0.6144 |
|
37 |
R |
A |
-1.9506 |
|
38 |
V |
A |
-0.8470 |
|
39 |
I |
A |
0.0000 |
|
40 |
A |
A |
0.0000 |
|
41 |
H |
A |
-2.1093 |
|
42 |
D |
A |
-2.4360 |
|
43 |
T |
A |
-1.5826 |
|
44 |
G |
A |
-1.1961 |
|
45 |
T |
A |
0.0000 |
|
46 |
S |
A |
-1.4037 |
|
47 |
L |
A |
-1.7276 |
|
48 |
D |
A |
-2.8866 |
|
49 |
Q |
A |
-2.3700 |
|
50 |
V |
A |
0.0000 |
|
51 |
K |
A |
-2.9409 |
|
52 |
K |
A |
-2.6095 |
|
53 |
A |
A |
0.0000 |
|
54 |
L |
A |
0.0000 |
|
55 |
C |
A |
-0.2731 |
|
56 |
V |
A |
-0.1192 |
|
57 |
L |
A |
0.0000 |
|
58 |
V |
A |
0.0491 |
|
59 |
Q |
A |
-0.3342 |
|
60 |
H |
A |
-0.2500 |
|
61 |
N |
A |
-0.5963 |
|
62 |
L |
A |
0.0000 |
|
63 |
V |
A |
0.0000 |
|
64 |
S |
A |
-0.3635 |
|
65 |
Y |
A |
0.6298 |
|
66 |
Q |
A |
0.1850 |
|
67 |
V |
A |
0.6965 |
|
68 |
H |
A |
-1.3112 |
|
69 |
K |
A |
-2.5395 |
|
70 |
R |
A |
-2.6159 |
|
71 |
G |
A |
-1.4285 |
|
72 |
V |
A |
-0.4280 |
|
73 |
V |
A |
0.5206 |
|
74 |
E |
A |
-0.0181 |
|
75 |
Y |
A |
0.0487 |
|
76 |
E |
A |
-1.0736 |
|
77 |
A |
A |
0.0000 |
|
78 |
Q |
A |
-1.8570 |
|
79 |
C |
A |
-0.9560 |
|
80 |
S |
A |
-0.8909 |
|
81 |
R |
A |
-1.2406 |
|
82 |
V |
A |
0.0000 |
|
83 |
L |
A |
0.0000 |
|
84 |
R |
A |
0.0000 |
|
85 |
M |
A |
0.0000 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
0.0000 |
|
88 |
Y |
A |
0.3244 |
|
89 |
P |
A |
0.0120 |
|
90 |
R |
A |
-0.3979 |
|
91 |
Y |
A |
0.0000 |
|
92 |
I |
A |
-0.0060 |
|
93 |
Y |
A |
0.5592 |
|
94 |
T |
A |
0.0000 |
|
95 |
T |
A |
0.0000 |
|
96 |
K |
A |
-0.9534 |
|
97 |
T |
A |
-0.0680 |
|
98 |
L |
A |
0.4468 |
|
99 |
Y |
A |
-0.4732 |
|
100 |
S |
A |
-1.0253 |
|
101 |
D |
A |
-1.9019 |
|
102 |
T |
A |
-1.4840 |
|
103 |
G |
A |
0.0000 |
|
104 |
E |
A |
-0.9393 |
|
105 |
L |
A |
-0.8433 |
|
106 |
I |
A |
0.0000 |
|
107 |
V |
A |
0.0000 |
|
108 |
E |
A |
-0.2607 |
|
109 |
E |
A |
0.0000 |
|
110 |
L |
A |
0.0000 |
|
111 |
L |
A |
0.0000 |
|
112 |
L |
A |
0.5827 |
|
113 |
N |
A |
-0.4095 |
|
114 |
G |
A |
0.0000 |
|
115 |
K |
A |
-0.4267 |
|
116 |
L |
A |
0.1533 |
|
117 |
T |
A |
0.4369 |
|
118 |
M |
A |
0.2497 |
|
119 |
S |
A |
-0.2283 |
|
120 |
A |
A |
-0.7007 |
|
121 |
V |
A |
0.0000 |
|
122 |
V |
A |
0.0000 |
|
123 |
K |
A |
-2.4299 |
|
124 |
K |
A |
-2.2611 |
|
125 |
V |
A |
0.0000 |
|
126 |
A |
A |
0.0000 |
|
127 |
D |
A |
-3.3318 |
|
128 |
R |
A |
-2.6277 |
|
129 |
L |
A |
0.0000 |
|
130 |
T |
A |
-2.7390 |
|
131 |
E |
A |
-3.0476 |
|
132 |
T |
A |
-1.8638 |
|
133 |
M |
A |
-2.2704 |
|
134 |
E |
A |
-3.3637 |
|
135 |
D |
A |
-3.4654 |
|
136 |
G |
A |
-2.7847 |
|
137 |
K |
A |
-2.8471 |
|
138 |
T |
A |
-2.1767 |
|
139 |
M |
A |
-1.7234 |
|
140 |
D |
A |
-2.0263 |
|
141 |
Y |
A |
-0.8255 |
|
142 |
A |
A |
-0.9433 |
|
143 |
E |
A |
-1.9874 |
|
144 |
V |
A |
0.0000 |
|
145 |
S |
A |
-0.9254 |
|
146 |
N |
A |
-1.0936 |
|
147 |
T |
A |
-1.1061 |
|
148 |
F |
A |
0.0000 |
|
149 |
V |
A |
-0.9150 |
|
150 |
R |
A |
-2.2280 |
|
151 |
L |
A |
0.0000 |
|
152 |
A |
A |
-2.0742 |
|
153 |
D |
A |
-2.6290 |
|
154 |
T |
A |
-1.6573 |
|
155 |
H |
A |
-2.4565 |
|
156 |
F |
A |
0.0000 |
|
157 |
V |
A |
0.0000 |
|
158 |
Q |
A |
-2.2792 |
|
159 |
R |
A |
-2.1746 |
|
160 |
C |
A |
0.0000 |
|
161 |
P |
A |
-0.7318 |
|
162 |
S |
A |
-0.1843 |
|
163 |
V |
A |
1.3910 |
|
231 |
D |
A |
-1.1693 |
|
232 |
G |
A |
-0.4552 |
|
233 |
I |
A |
1.1722 |
|
234 |
Y |
A |
0.2045 |
|
235 |
W |
A |
0.0000 |
|
236 |
Q |
A |
-1.0032 |
|
237 |
A |
A |
0.0000 |
|
238 |
N |
A |
-1.4854 |
|
239 |
L |
A |
-1.2142 |
|
240 |
D |
A |
-2.0634 |
|
241 |
R |
A |
-1.5624 |
|
242 |
F |
A |
0.0000 |
|
243 |
H |
A |
-1.0616 |
|
244 |
Q |
A |
0.0000 |
|
245 |
H |
A |
-1.0043 |
|
246 |
F |
A |
0.0000 |
|
247 |
R |
A |
0.0000 |
|
248 |
D |
A |
-1.1758 |
|
249 |
Q |
A |
-1.3545 |
|
250 |
A |
A |
-0.5229 |
|
251 |
I |
A |
0.0000 |
|
252 |
V |
A |
0.0000 |
|
253 |
S |
A |
-1.2996 |
|
254 |
A |
A |
0.0000 |
|
255 |
V |
A |
0.0000 |
|
256 |
A |
A |
-1.8561 |
|
257 |
N |
A |
-2.4359 |
|
258 |
R |
A |
-2.5806 |
|
259 |
M |
A |
-1.4587 |
|
260 |
D |
A |
-1.9029 |
|
261 |
Q |
A |
-1.8845 |
|
262 |
T |
A |
-0.6839 |
|
263 |
S |
A |
0.0000 |
|
264 |
S |
A |
0.0000 |
|
265 |
E |
A |
0.0000 |
|
266 |
I |
A |
0.0000 |
|
267 |
V |
A |
0.0000 |
|
268 |
R |
A |
-1.6502 |
|
269 |
T |
A |
0.0000 |
|
270 |
M |
A |
0.0000 |
|
271 |
L |
A |
0.0000 |
|
272 |
R |
A |
-0.9908 |
|
273 |
M |
A |
-0.2959 |
|
274 |
S |
A |
0.0000 |
|
275 |
E |
A |
0.1699 |
|
276 |
I |
A |
1.6472 |
|
277 |
T |
A |
0.5461 |
|
278 |
T |
A |
0.4069 |
|
279 |
S |
A |
-0.0556 |
|
280 |
S |
A |
-0.9402 |
|
281 |
S |
A |
-0.6724 |
|
282 |
A |
A |
-0.1114 |
|
283 |
P |
A |
0.0418 |
|
284 |
F |
A |
1.1561 |
|
285 |
T |
A |
0.0000 |
|
286 |
Q |
A |
-0.2782 |
|
287 |
P |
A |
-0.3694 |
|
288 |
L |
A |
0.0000 |
|
289 |
S |
A |
0.0000 |
|
290 |
S |
A |
0.0000 |
|
291 |
N |
A |
-1.8468 |
|
292 |
E |
A |
-1.4714 |
|
293 |
I |
A |
0.0000 |
|
294 |
F |
A |
-1.0823 |
|
295 |
R |
A |
-1.9187 |
|
296 |
S |
A |
-0.8026 |
|
297 |
L |
A |
-0.2141 |
|
298 |
P |
A |
0.3378 |
|
299 |
V |
A |
1.2160 |
|
300 |
G |
A |
0.2368 |
|
301 |
Y |
A |
0.0810 |
|
302 |
N |
A |
-0.8080 |
|
303 |
I |
A |
-0.2478 |
|
304 |
S |
A |
-1.0385 |
|
305 |
K |
A |
-2.1152 |
|
306 |
Q |
A |
-1.8324 |
|
307 |
V |
A |
-0.7502 |
|
308 |
L |
A |
0.0000 |
|
309 |
D |
A |
-1.5966 |
|
310 |
Q |
A |
-1.1181 |
|
311 |
Y |
A |
-0.3794 |
|
312 |
L |
A |
0.0000 |
|
313 |
T |
A |
-0.7643 |
|
314 |
L |
A |
-0.0210 |
|
315 |
L |
A |
0.0000 |
|
316 |
A |
A |
-1.3974 |
|
317 |
D |
A |
-2.1401 |
|
318 |
D |
A |
-1.5045 |
|
319 |
P |
A |
-1.2055 |
|
320 |
L |
A |
-1.4639 |
|
321 |
E |
A |
-2.5036 |
|
322 |
F |
A |
0.0000 |
|
323 |
V |
A |
0.0000 |
|
324 |
G |
A |
-1.3128 |
|
325 |
K |
A |
-2.0582 |
|
326 |
S |
A |
-1.4303 |
|
327 |
G |
A |
-1.8457 |
|
328 |
D |
A |
-2.5737 |
|
329 |
S |
A |
-1.8112 |
|
330 |
G |
A |
-1.5241 |
|
331 |
G |
A |
-1.5815 |
|
332 |
G |
A |
0.0000 |
|
333 |
M |
A |
-1.5031 |
|
334 |
Y |
A |
0.0000 |
|
335 |
V |
A |
-0.0610 |
|
336 |
I |
A |
0.0000 |
|
337 |
N |
A |
-0.3726 |
|
338 |
L |
A |
0.0000 |
|
339 |
H |
A |
-0.6429 |
|
340 |
K |
A |
-1.3961 |
|
341 |
A |
A |
0.0000 |
|
342 |
L |
A |
0.0000 |
|
343 |
A |
A |
-0.2137 |
|
344 |
S |
A |
-0.3708 |
|
345 |
L |
A |
-0.0900 |
|
346 |
A |
A |
0.0000 |
|
347 |
T |
A |
-0.2752 |
|
348 |
A |
A |
-0.4754 |
|
349 |
T |
A |
-0.3284 |
|
350 |
L |
A |
0.0000 |
|
351 |
E |
A |
-2.1037 |
|
352 |
S |
A |
-1.6222 |
|
353 |
V |
A |
-1.5381 |
|
354 |
V |
A |
0.0000 |
|
355 |
Q |
A |
-3.3055 |
|
356 |
E |
A |
-3.3226 |
|
357 |
R |
A |
-3.0458 |
|
358 |
F |
A |
-1.9285 |
|
359 |
G |
A |
-2.2479 |
|
360 |
S |
A |
-2.2915 |
|
361 |
R |
A |
-2.2747 |
|
362 |
C |
A |
0.0000 |
|
363 |
A |
A |
0.0000 |
|
364 |
R |
A |
-2.4048 |
|
365 |
I |
A |
0.0000 |
|
366 |
F |
A |
0.0000 |
|
367 |
R |
A |
-2.4903 |
|
368 |
L |
A |
-1.1873 |
|
369 |
V |
A |
-0.8991 |
|
370 |
L |
A |
-1.2140 |
|
371 |
Q |
A |
-2.0808 |
|
372 |
K |
A |
-2.2967 |
|
376 |
E |
A |
-3.4925 |
|
377 |
Q |
A |
-3.7292 |
|
378 |
K |
A |
-3.8188 |
|
379 |
Q |
A |
-3.3418 |
|
380 |
V |
A |
-2.3428 |
|
381 |
E |
A |
-2.6780 |
|
382 |
D |
A |
-2.1235 |
|
383 |
F |
A |
0.3216 |
|
384 |
A |
A |
0.0000 |
|
385 |
M |
A |
1.1708 |
|
386 |
I |
A |
0.0428 |
|
387 |
P |
A |
-0.6591 |
|
388 |
A |
A |
-1.7235 |
|
389 |
K |
A |
-2.5911 |
|
390 |
E |
A |
-2.1262 |
|
391 |
A |
A |
-1.9361 |
|
392 |
K |
A |
-2.8094 |
|
393 |
D |
A |
-2.5920 |
|
394 |
M |
A |
-1.2919 |
|
395 |
L |
A |
-0.2267 |
|
396 |
Y |
A |
0.0461 |
|
397 |
K |
A |
-1.0552 |
|
398 |
M |
A |
0.0000 |
|
399 |
L |
A |
0.4985 |
|
400 |
S |
A |
-0.5872 |
|
401 |
E |
A |
-1.5494 |
|
402 |
N |
A |
-1.6768 |
|
403 |
F |
A |
0.0000 |
|
404 |
M |
A |
0.1327 |
|
426 |
V |
A |
-0.2784 |
|
427 |
N |
A |
-0.7545 |
|
428 |
I |
A |
0.1110 |
|
429 |
L |
A |
-0.0516 |
|
430 |
S |
A |
-0.7811 |
|
431 |
A |
A |
0.0000 |
|
432 |
A |
A |
0.0000 |
|
433 |
R |
A |
-1.5186 |
|
434 |
M |
A |
-0.9636 |
|
435 |
L |
A |
0.0000 |
|
436 |
L |
A |
0.0000 |
|
437 |
H |
A |
-1.2110 |
|
438 |
R |
A |
-1.1380 |
|
439 |
C |
A |
0.0000 |
|
440 |
Y |
A |
0.0000 |
|
441 |
K |
A |
-2.2946 |
|
442 |
S |
A |
-1.3941 |
|
443 |
I |
A |
0.0000 |
|
444 |
A |
A |
0.0000 |
|
445 |
N |
A |
-2.3912 |
|
446 |
L |
A |
-1.8148 |
|
447 |
I |
A |
0.0000 |
|
448 |
E |
A |
-2.6307 |
|
449 |
R |
A |
-2.5125 |
|
450 |
R |
A |
0.0000 |
|
451 |
Q |
A |
-1.7706 |
|
452 |
F |
A |
-1.0782 |
|
453 |
E |
A |
-1.9974 |
|
454 |
T |
A |
-2.2742 |
|
455 |
K |
A |
-3.3277 |
|
456 |
E |
A |
-3.2049 |
|
457 |
N |
A |
-3.1298 |
|
458 |
K |
A |
-4.1495 |
|
459 |
R |
A |
-3.9143 |
|
460 |
L |
A |
0.0000 |
|
461 |
L |
A |
-3.0227 |
|
462 |
E |
A |
-4.1453 |
|
463 |
K |
A |
-3.2491 |
|
464 |
S |
A |
-3.0895 |
|
465 |
Q |
A |
-3.3551 |
|
466 |
R |
A |
-3.3960 |
|
467 |
V |
A |
0.0000 |
|
468 |
E |
A |
-2.8996 |
|
469 |
A |
A |
-1.3555 |
|
470 |
I |
A |
-0.2584 |
|
471 |
I |
A |
0.0208 |
|
472 |
A |
A |
0.2811 |
|
473 |
S |
A |
0.4644 |
|
474 |
M |
A |
1.2200 |
|
483 |
Q |
A |
-1.8133 |
|
484 |
L |
A |
-1.1295 |
|
485 |
Q |
A |
-2.8545 |
|
486 |
E |
A |
-3.3629 |
|
487 |
I |
A |
-2.0357 |
|
488 |
E |
A |
-3.2003 |
|
489 |
E |
A |
-3.2197 |
|
490 |
M |
A |
-1.7008 |
|
491 |
I |
A |
0.0000 |
|
492 |
T |
A |
-1.2826 |
|
493 |
A |
A |
-1.0910 |
|
494 |
P |
A |
-1.2133 |
|
495 |
E |
A |
-1.6636 |
|
496 |
R |
A |
-2.5526 |
|
497 |
Q |
A |
-2.7322 |
|
498 |
Q |
A |
-2.4678 |
|
499 |
L |
A |
0.0000 |
|
500 |
E |
A |
-3.5316 |
|
501 |
T |
A |
-2.7973 |
|
502 |
L |
A |
0.0000 |
|
503 |
K |
A |
-3.7819 |
|
504 |
R |
A |
-4.1299 |
|
505 |
N |
A |
-3.1555 |
|
506 |
V |
A |
-2.8736 |
|
507 |
N |
A |
-3.5093 |
|
508 |
K |
A |
-3.3446 |
|
509 |
L |
A |
-2.4411 |
|
510 |
D |
A |
-2.3873 |
|
511 |
A |
A |
-1.6380 |
|
512 |
S |
A |
-1.4439 |
|
513 |
E |
A |
-1.3329 |
|
514 |
I |
A |
-0.9327 |
|
515 |
Q |
A |
-1.7159 |
|
516 |
V |
A |
-0.8258 |
|
517 |
D |
A |
0.0000 |
|
518 |
E |
A |
-2.0812 |
|
519 |
T |
A |
-0.9572 |
|
520 |
I |
A |
0.0000 |
|
521 |
F |
A |
0.0000 |
|
522 |
L |
A |
-0.3109 |
|
523 |
L |
A |
0.0000 |
|
524 |
E |
A |
-0.9504 |
|
525 |
S |
A |
-0.7394 |
|
526 |
Y |
A |
0.0000 |
|
527 |
I |
A |
0.0000 |
|
528 |
E |
A |
-1.8394 |
|
529 |
C |
A |
0.0000 |
|
530 |
T |
A |
-0.6026 |
|
531 |
M |
A |
-0.3737 |
|
532 |
K |
A |
-1.4570 |
|