Chain sequence(s) |
A: GEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALK H: RIPNYQLSPTKL B: AGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKAL |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
44 | G | A | -1.7622 | |
45 | E | A | -2.7858 | |
46 | A | A | -1.9751 | |
47 | R | A | -2.5854 | |
48 | L | A | -1.6429 | |
49 | E | A | -1.5775 | |
50 | E | A | -1.6423 | |
51 | A | A | 0.0000 | |
52 | V | A | 0.0000 | |
53 | N | A | 0.0000 | |
54 | R | A | -0.8657 | |
55 | W | A | -0.1498 | |
56 | V | A | 0.0000 | |
57 | L | A | 0.0000 | |
58 | K | A | -0.7582 | |
59 | F | A | 0.0000 | |
60 | Y | A | 0.0000 | |
61 | F | A | 0.0000 | |
62 | H | A | -1.4102 | |
63 | E | A | -1.5339 | |
64 | A | A | 0.0000 | |
65 | L | A | 0.0000 | |
66 | R | A | -3.0474 | |
67 | A | A | -2.7350 | |
68 | F | A | 0.0000 | |
69 | R | A | -3.2864 | |
70 | G | A | -2.2587 | |
71 | S | A | -2.2582 | |
72 | R | A | -3.0609 | |
73 | Y | A | -2.0203 | |
74 | G | A | -1.9137 | |
75 | D | A | -2.1414 | |
76 | F | A | 0.0000 | |
77 | R | A | -2.2844 | |
78 | Q | A | -1.0808 | |
79 | I | A | 0.0000 | |
80 | R | A | 0.0000 | |
81 | D | A | -1.4636 | |
82 | I | A | 0.0000 | |
83 | M | A | 0.0000 | |
84 | Q | A | -0.5087 | |
85 | A | A | -0.6425 | |
86 | L | A | 0.0000 | |
87 | L | A | 0.0000 | |
88 | V | A | 0.2326 | |
89 | R | A | 0.0000 | |
90 | P | A | -0.8481 | |
91 | L | A | -1.1541 | |
92 | G | A | -1.8032 | |
93 | K | A | -2.5120 | |
94 | E | A | -2.4290 | |
95 | H | A | -2.1646 | |
96 | T | A | -1.2909 | |
97 | V | A | 0.0000 | |
98 | S | A | -1.2760 | |
99 | R | A | -1.1090 | |
100 | L | A | 0.0000 | |
101 | L | A | 0.0000 | |
102 | R | A | -0.5525 | |
103 | V | A | 0.0000 | |
104 | M | A | 0.0000 | |
105 | Q | A | 0.0000 | |
106 | C | A | 0.0000 | |
107 | L | A | 0.0000 | |
108 | S | A | 0.0000 | |
109 | R | A | 0.0000 | |
110 | I | A | 0.0000 | |
111 | E | A | -1.0456 | |
112 | E | A | -1.3023 | |
113 | G | A | 0.0000 | |
114 | E | A | -1.8608 | |
115 | N | A | -1.8237 | |
116 | L | A | -1.5426 | |
117 | D | A | -2.1462 | |
118 | C | A | 0.0000 | |
119 | S | A | 0.0000 | |
120 | F | A | 0.0000 | |
121 | D | A | -1.2448 | |
122 | M | A | -0.9962 | |
123 | E | A | -1.9965 | |
124 | A | A | -1.3577 | |
125 | E | A | -1.4510 | |
126 | L | A | -0.5813 | |
127 | T | A | 0.0000 | |
128 | P | A | 0.0000 | |
129 | L | A | 0.0000 | |
130 | E | A | 0.0000 | |
131 | S | A | 0.0000 | |
132 | A | A | 0.0000 | |
133 | I | A | 0.0000 | |
134 | N | A | -1.5734 | |
135 | V | A | 0.0000 | |
136 | L | A | 0.0000 | |
137 | E | A | -2.3045 | |
138 | M | A | -1.2105 | |
139 | I | A | 0.0000 | |
140 | K | A | -1.9512 | |
141 | T | A | -1.4005 | |
142 | E | A | -1.8290 | |
143 | F | A | 0.0000 | |
144 | T | A | -0.7719 | |
145 | L | A | -0.6338 | |
146 | T | A | -1.0031 | |
147 | E | A | -2.2864 | |
148 | A | A | -1.0293 | |
149 | V | A | -0.4195 | |
150 | V | A | 0.0000 | |
151 | E | A | -2.6811 | |
152 | S | A | -1.3023 | |
153 | S | A | 0.0000 | |
154 | R | A | -1.5831 | |
155 | K | A | -1.0760 | |
156 | L | A | -0.6283 | |
157 | V | A | 0.0000 | |
158 | K | A | 0.0000 | |
159 | E | A | -0.3751 | |
160 | A | A | 0.0000 | |
161 | A | A | 0.0000 | |
162 | V | A | 0.0000 | |
163 | I | A | 0.0000 | |
164 | I | A | 0.0000 | |
165 | C | A | 0.0000 | |
166 | I | A | 0.0000 | |
167 | K | A | -2.5854 | |
168 | N | A | -2.5097 | |
169 | K | A | -3.4721 | |
170 | E | A | -3.1145 | |
171 | F | A | -3.0859 | |
172 | E | A | -3.0216 | |
173 | K | A | -2.2946 | |
174 | A | A | 0.0000 | |
175 | S | A | -2.2398 | |
176 | K | A | -2.8882 | |
177 | I | A | 0.0000 | |
178 | L | A | 0.0000 | |
179 | K | A | -2.7713 | |
180 | K | A | -2.8266 | |
181 | H | A | -1.8965 | |
182 | M | A | 0.0000 | |
183 | S | A | -1.7857 | |
184 | K | A | -2.2386 | |
185 | D | A | -1.7517 | |
186 | P | A | -1.6149 | |
187 | T | A | -1.3192 | |
188 | T | A | 0.0000 | |
189 | Q | A | -3.1163 | |
190 | K | A | -3.0333 | |
191 | L | A | -1.8345 | |
192 | R | A | -2.7134 | |
193 | N | A | -2.6945 | |
194 | D | A | -1.7470 | |
195 | L | A | 0.0000 | |
196 | L | A | -1.7535 | |
197 | N | A | -2.6578 | |
198 | I | A | 0.0000 | |
199 | I | A | 0.0000 | |
200 | R | A | -3.7481 | |
201 | E | A | -3.8823 | |
202 | K | A | -3.9977 | |
203 | N | A | -2.7831 | |
204 | L | A | -1.6024 | |
205 | A | A | -0.9397 | |
206 | H | A | -1.0557 | |
207 | P | A | -1.0203 | |
208 | V | A | -0.4290 | |
209 | I | A | 0.0000 | |
210 | Q | A | -1.8345 | |
211 | N | A | -1.6972 | |
212 | F | A | -0.7865 | |
213 | S | A | -0.7255 | |
214 | Y | A | -0.7826 | |
215 | E | A | -1.0670 | |
216 | T | A | -0.9184 | |
217 | F | A | 0.0000 | |
218 | Q | A | 0.0000 | |
219 | Q | A | -2.0668 | |
220 | K | A | -2.4495 | |
221 | M | A | 0.0000 | |
222 | L | A | 0.0000 | |
223 | R | A | -2.9289 | |
224 | F | A | -1.4302 | |
225 | L | A | 0.0000 | |
226 | E | A | -2.2903 | |
227 | S | A | -1.7472 | |
228 | H | A | -1.3577 | |
229 | L | A | -1.7666 | |
230 | D | A | -3.0019 | |
231 | D | A | -3.2574 | |
232 | A | A | -2.1907 | |
233 | E | A | -2.4533 | |
234 | P | A | 0.0000 | |
235 | Y | A | -0.1097 | |
236 | L | A | 0.0000 | |
237 | L | A | -0.7484 | |
238 | T | A | -0.8009 | |
239 | M | A | -0.4281 | |
240 | A | A | 0.0000 | |
241 | K | A | -2.1353 | |
242 | K | A | -2.4294 | |
243 | A | A | -1.3212 | |
244 | L | A | -1.4280 | |
245 | K | A | -2.2557 | |
43 | A | B | -1.1490 | |
44 | G | B | -1.8439 | |
45 | E | B | -2.7062 | |
46 | A | B | -1.9326 | |
47 | R | B | -2.6518 | |
48 | L | B | -1.6321 | |
49 | E | B | 0.0000 | |
50 | E | B | -1.5112 | |
51 | A | B | 0.0000 | |
52 | V | B | 0.0000 | |
53 | N | B | 0.0000 | |
54 | R | B | -0.5707 | |
55 | W | B | -0.0586 | |
56 | V | B | 0.0000 | |
57 | L | B | 0.0000 | |
58 | K | B | -0.7279 | |
59 | F | B | 0.0000 | |
60 | Y | B | 0.0000 | |
61 | F | B | 0.0000 | |
62 | H | B | -1.4116 | |
63 | E | B | -1.2185 | |
64 | A | B | 0.0000 | |
65 | L | B | 0.0000 | |
66 | R | B | -2.6725 | |
67 | A | B | 0.0000 | |
68 | F | B | 0.0000 | |
69 | R | B | -2.6617 | |
70 | G | B | -2.0956 | |
71 | S | B | -2.2551 | |
72 | R | B | -2.8771 | |
73 | Y | B | -1.7759 | |
74 | G | B | -1.7071 | |
75 | D | B | -2.0941 | |
76 | F | B | 0.0000 | |
77 | R | B | -2.6188 | |
78 | Q | B | -1.8063 | |
79 | I | B | 0.0000 | |
80 | R | B | -2.1518 | |
81 | D | B | -2.8942 | |
82 | I | B | 0.0000 | |
83 | M | B | 0.0000 | |
84 | Q | B | -1.5336 | |
85 | A | B | -0.7263 | |
86 | L | B | 0.0000 | |
87 | L | B | 0.7369 | |
88 | V | B | 1.5220 | |
89 | R | B | 0.0000 | |
90 | P | B | -0.2024 | |
91 | L | B | -0.6306 | |
92 | G | B | -1.8569 | |
93 | K | B | -2.4782 | |
94 | E | B | -2.3855 | |
95 | H | B | -2.2106 | |
96 | T | B | -1.5153 | |
97 | V | B | 0.0000 | |
98 | S | B | -1.5058 | |
99 | R | B | -1.5867 | |
100 | L | B | 0.0000 | |
101 | L | B | -0.7313 | |
102 | R | B | -1.2105 | |
103 | V | B | 0.0000 | |
104 | M | B | 0.0000 | |
105 | Q | B | -0.6189 | |
106 | C | B | 0.0000 | |
107 | L | B | 0.0000 | |
108 | S | B | 0.0000 | |
109 | R | B | 0.0000 | |
110 | I | B | 0.0000 | |
111 | E | B | 0.0000 | |
112 | E | B | -1.3368 | |
113 | G | B | 0.0000 | |
114 | E | B | -2.6933 | |
115 | N | B | -2.4382 | |
116 | L | B | -1.7675 | |
117 | D | B | -2.1036 | |
118 | C | B | -1.0269 | |
119 | S | B | -0.5882 | |
120 | F | B | 0.0738 | |
121 | D | B | -0.6323 | |
122 | M | B | -0.4181 | |
123 | E | B | -1.7905 | |
124 | A | B | -1.2841 | |
125 | E | B | -1.6931 | |
126 | L | B | -0.4549 | |
127 | T | B | 0.0000 | |
128 | P | B | 0.0000 | |
129 | L | B | 0.0000 | |
130 | E | B | 0.0000 | |
131 | S | B | 0.0000 | |
132 | A | B | 0.0000 | |
133 | I | B | 0.0000 | |
134 | N | B | -1.7029 | |
135 | V | B | 0.0000 | |
136 | L | B | 0.0000 | |
137 | E | B | -2.1709 | |
138 | M | B | -1.3318 | |
139 | I | B | 0.0000 | |
140 | K | B | -1.5821 | |
141 | T | B | -1.2366 | |
142 | E | B | -1.7120 | |
143 | F | B | -0.9040 | |
144 | T | B | -0.6331 | |
145 | L | B | -0.6102 | |
146 | T | B | -0.8676 | |
147 | E | B | -2.2157 | |
148 | A | B | -0.8956 | |
149 | V | B | -0.0532 | |
150 | V | B | 0.0000 | |
151 | E | B | -2.4058 | |
152 | S | B | -1.3057 | |
153 | S | B | 0.0000 | |
154 | R | B | -1.5309 | |
155 | K | B | -1.5981 | |
156 | L | B | -0.9593 | |
157 | V | B | 0.0000 | |
158 | K | B | -0.9294 | |
159 | E | B | -0.6521 | |
160 | A | B | 0.0000 | |
161 | A | B | 0.0000 | |
162 | V | B | 0.0000 | |
163 | I | B | 0.0000 | |
164 | I | B | 0.0000 | |
165 | C | B | 0.0000 | |
166 | I | B | 0.0000 | |
167 | K | B | -2.2680 | |
168 | N | B | -2.4069 | |
169 | K | B | -3.2171 | |
170 | E | B | -2.6030 | |
171 | F | B | -2.8810 | |
172 | E | B | -2.9433 | |
173 | K | B | -2.1201 | |
174 | A | B | 0.0000 | |
175 | S | B | -2.4412 | |
176 | K | B | -3.2780 | |
177 | I | B | 0.0000 | |
178 | L | B | 0.0000 | |
179 | K | B | -3.3986 | |
180 | K | B | -3.1041 | |
181 | H | B | -2.1797 | |
182 | M | B | 0.0000 | |
183 | S | B | -2.1874 | |
184 | K | B | -2.8374 | |
185 | D | B | -2.2205 | |
186 | P | B | -1.7951 | |
187 | T | B | -1.3238 | |
188 | T | B | -2.0121 | |
189 | Q | B | -3.0641 | |
190 | K | B | -2.7718 | |
191 | L | B | -1.6644 | |
192 | R | B | -2.5235 | |
193 | N | B | -2.1939 | |
194 | D | B | -1.9537 | |
195 | L | B | 0.0000 | |
196 | L | B | -1.8516 | |
197 | N | B | -2.5434 | |
198 | I | B | 0.0000 | |
199 | I | B | 0.0000 | |
200 | R | B | -3.7533 | |
201 | E | B | -3.9153 | |
202 | K | B | -3.9854 | |
203 | N | B | -2.8924 | |
204 | L | B | -1.6662 | |
205 | A | B | -0.9515 | |
206 | H | B | -1.1882 | |
207 | P | B | -1.0118 | |
208 | V | B | -0.5741 | |
209 | I | B | 0.0000 | |
210 | Q | B | -1.7971 | |
211 | N | B | -1.7383 | |
212 | F | B | -1.0286 | |
213 | S | B | -1.1544 | |
214 | Y | B | 0.0000 | |
215 | E | B | -2.1689 | |
216 | T | B | -1.5111 | |
217 | F | B | 0.0000 | |
218 | Q | B | 0.0000 | |
219 | Q | B | -2.2011 | |
220 | K | B | -2.7282 | |
221 | M | B | 0.0000 | |
222 | L | B | 0.0000 | |
223 | R | B | -2.7360 | |
224 | F | B | -1.2498 | |
225 | L | B | 0.0000 | |
226 | E | B | -1.9132 | |
227 | S | B | -1.4484 | |
228 | H | B | -1.2508 | |
229 | L | B | -1.5432 | |
230 | D | B | -2.9661 | |
231 | D | B | -3.2102 | |
232 | A | B | -2.2349 | |
233 | E | B | -2.4324 | |
234 | P | B | 0.0000 | |
235 | Y | B | 0.0627 | |
236 | L | B | 0.0000 | |
237 | L | B | -0.6278 | |
238 | T | B | -0.9851 | |
239 | M | B | -0.4584 | |
240 | A | B | 0.0000 | |
241 | K | B | -2.0873 | |
242 | K | B | -1.8104 | |
243 | A | B | -0.3956 | |
244 | L | B | 0.4386 | |
425 | R | H | -1.3624 | |
426 | I | H | 0.5030 | |
427 | P | H | -0.5293 | |
428 | N | H | -1.2947 | |
429 | Y | H | 0.0000 | |
430 | Q | H | -0.6148 | |
431 | L | H | 0.0000 | |
432 | S | H | -0.7210 | |
433 | P | H | -0.5939 | |
434 | T | H | -0.7140 | |
435 | K | H | -1.4136 | |
436 | L | H | 0.1126 |