| Chain sequence(s) |
A: MGMSYSMCTGKFKIVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKK B: VKLLEQSGAELVKPGASVRRLSCTASGFNIKDTYMSWVKQRPEQQGLEWIGRIDPANGDTKYDPKFQGKATITADTSSNTAYLHLSSLTSGDTAVYYCSRGWEGFAYWGQGTLVTVSASELVMTQTPASLAVSLGQRATISCRASENVDRYGNSFMHWYQQKAGQPPKLLIYRASNLESGIPARFSGSGSRTDFTLTINPVEADDVATYFCQRSNEVPWTFGGGTKLEIKR |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 295 | M | A | 1.0940 | |
| 296 | G | A | 0.5414 | |
| 297 | M | A | 1.1091 | |
| 298 | S | A | 0.4247 | |
| 299 | Y | A | 0.2806 | |
| 300 | S | A | 0.0416 | |
| 301 | M | A | 0.4897 | |
| 302 | C | A | 0.0000 | |
| 303 | T | A | -0.8269 | |
| 304 | G | A | -1.1560 | |
| 305 | K | A | -1.0757 | |
| 306 | F | A | 0.0000 | |
| 307 | K | A | 0.0000 | |
| 308 | I | A | 0.0000 | |
| 309 | V | A | 0.0000 | |
| 310 | K | A | 0.0000 | |
| 311 | E | A | -1.3433 | |
| 312 | I | A | 0.0000 | |
| 313 | A | A | -1.0480 | |
| 314 | E | A | -2.5060 | |
| 315 | T | A | -1.9631 | |
| 316 | Q | A | -2.1472 | |
| 317 | H | A | -2.1075 | |
| 318 | G | A | -1.7371 | |
| 319 | T | A | 0.0000 | |
| 320 | I | A | 0.0000 | |
| 321 | V | A | -0.7039 | |
| 322 | I | A | 0.0000 | |
| 323 | R | A | -0.8324 | |
| 324 | V | A | 0.0000 | |
| 325 | Q | A | 0.0000 | |
| 326 | Y | A | 0.0000 | |
| 327 | E | A | 0.0000 | |
| 328 | G | A | -1.5735 | |
| 329 | D | A | -2.4861 | |
| 330 | G | A | -1.6630 | |
| 331 | S | A | -1.4172 | |
| 332 | P | A | -0.9247 | |
| 333 | C | A | 0.0000 | |
| 334 | K | A | -0.3006 | |
| 335 | I | A | 0.0000 | |
| 336 | P | A | 0.1473 | |
| 337 | F | A | -0.1069 | |
| 338 | E | A | -0.6799 | |
| 339 | I | A | 0.0000 | |
| 340 | M | A | -0.2440 | |
| 341 | D | A | -0.6861 | |
| 342 | L | A | 0.5479 | |
| 346 | H | A | -0.4036 | |
| 347 | V | A | 0.4669 | |
| 348 | L | A | 0.1603 | |
| 349 | G | A | 0.0000 | |
| 350 | R | A | -1.5377 | |
| 351 | L | A | 0.0369 | |
| 352 | I | A | 1.1461 | |
| 353 | T | A | 0.8699 | |
| 354 | V | A | 1.9021 | |
| 355 | N | A | 0.3810 | |
| 356 | P | A | 0.0000 | |
| 357 | I | A | 0.1565 | |
| 358 | V | A | 0.0000 | |
| 359 | T | A | -0.8179 | |
| 360 | E | A | -1.8397 | |
| 361 | K | A | -1.7290 | |
| 362 | D | A | 0.0000 | |
| 363 | S | A | -0.8595 | |
| 364 | P | A | -0.9040 | |
| 365 | V | A | -0.4529 | |
| 366 | N | A | -1.0204 | |
| 367 | I | A | 0.0000 | |
| 368 | E | A | -0.4340 | |
| 369 | A | A | 0.0000 | |
| 370 | E | A | -1.6812 | |
| 371 | P | A | 0.0000 | |
| 372 | P | A | 0.3807 | |
| 373 | F | A | 1.3540 | |
| 374 | G | A | 0.4445 | |
| 375 | D | A | -0.2171 | |
| 376 | S | A | 0.0000 | |
| 377 | Y | A | 0.0162 | |
| 378 | I | A | 0.0000 | |
| 379 | I | A | -0.3313 | |
| 380 | I | A | 0.0000 | |
| 381 | G | A | 0.0000 | |
| 382 | V | A | -0.4342 | |
| 383 | E | A | -2.0320 | |
| 384 | P | A | -1.5314 | |
| 385 | G | A | -1.3084 | |
| 386 | Q | A | -1.5433 | |
| 387 | L | A | 0.0000 | |
| 388 | K | A | -0.9254 | |
| 389 | L | A | 0.0000 | |
| 390 | N | A | -0.3500 | |
| 391 | W | A | 0.0000 | |
| 392 | F | A | 1.2428 | |
| 393 | K | A | -0.2128 | |
| 394 | K | A | -1.0668 | |
| 2 | V | B | 1.5155 | |
| 3 | K | B | 0.3123 | |
| 4 | L | B | 0.0870 | |
| 5 | L | B | 0.0000 | |
| 6 | E | B | -2.0871 | |
| 7 | Q | B | 0.0000 | |
| 8 | S | B | -1.0238 | |
| 9 | G | B | -0.7686 | |
| 10 | A | B | 0.2855 | |
| 11 | E | B | -0.1396 | |
| 12 | L | B | 0.9710 | |
| 13 | V | B | 0.0000 | |
| 14 | K | B | -1.7003 | |
| 15 | P | B | -1.1245 | |
| 16 | G | B | -1.1322 | |
| 17 | A | B | -0.9594 | |
| 18 | S | B | -1.1881 | |
| 19 | V | B | 0.0000 | |
| 20 | R | B | -2.1721 | |
| 21 | L | B | 0.0000 | |
| 22 | S | B | -0.8369 | |
| 23 | C | B | 0.0000 | |
| 24 | T | B | -0.9483 | |
| 25 | A | B | 0.0000 | |
| 26 | S | B | -0.4988 | |
| 27 | G | B | -0.1793 | |
| 28 | F | B | 0.0000 | |
| 29 | N | B | -2.1026 | |
| 30 | I | B | 0.0000 | |
| 31 | K | B | -2.4913 | |
| 32 | D | B | -1.5254 | |
| 33 | T | B | 0.0000 | |
| 34 | Y | B | 0.0000 | |
| 35 | M | B | 0.0000 | |
| 36 | S | B | 0.0000 | |
| 37 | W | B | 0.0000 | |
| 38 | V | B | 0.0000 | |
| 39 | K | B | 0.0000 | |
| 40 | Q | B | -1.2803 | |
| 41 | R | B | -1.8848 | |
| 42 | P | B | -1.8790 | |
| 43 | E | B | -2.6678 | |
| 44 | Q | B | -2.4812 | |
| 45 | G | B | -1.6034 | |
| 46 | L | B | 0.0000 | |
| 47 | E | B | -1.5079 | |
| 48 | W | B | 0.0000 | |
| 49 | I | B | 0.0000 | |
| 50 | G | B | 0.0000 | |
| 51 | R | B | 0.0000 | |
| 52 | I | B | 0.0000 | |
| 53 | D | B | -1.3749 | |
| 54 | P | B | 0.0000 | |
| 55 | A | B | -1.7200 | |
| 56 | N | B | -1.9299 | |
| 57 | G | B | -1.6790 | |
| 58 | D | B | -1.4993 | |
| 59 | T | B | -1.0119 | |
| 60 | K | B | -1.2113 | |
| 61 | Y | B | -0.7636 | |
| 62 | D | B | -1.3708 | |
| 63 | P | B | -1.7897 | |
| 64 | K | B | -2.3648 | |
| 65 | F | B | 0.0000 | |
| 66 | Q | B | -2.1439 | |
| 67 | G | B | -1.5059 | |
| 68 | K | B | -1.3465 | |
| 69 | A | B | 0.0000 | |
| 70 | T | B | -0.8471 | |
| 71 | I | B | 0.0000 | |
| 72 | T | B | -0.6316 | |
| 73 | A | B | -0.9676 | |
| 74 | D | B | -1.2084 | |
| 75 | T | B | -1.4082 | |
| 76 | S | B | -0.9180 | |
| 77 | S | B | -0.7612 | |
| 78 | N | B | -1.2135 | |
| 79 | T | B | 0.0000 | |
| 80 | A | B | 0.0000 | |
| 81 | Y | B | -0.5306 | |
| 82 | L | B | 0.0000 | |
| 83 | H | B | -1.3636 | |
| 84 | L | B | 0.0000 | |
| 85 | S | B | -0.9476 | |
| 86 | S | B | -0.9041 | |
| 87 | L | B | 0.0000 | |
| 88 | T | B | -0.7564 | |
| 89 | S | B | -0.6306 | |
| 90 | G | B | -0.5034 | |
| 91 | D | B | 0.0000 | |
| 92 | T | B | -0.1197 | |
| 93 | A | B | 0.0000 | |
| 94 | V | B | 0.1795 | |
| 95 | Y | B | 0.0000 | |
| 96 | Y | B | 0.0000 | |
| 97 | C | B | 0.0000 | |
| 98 | S | B | 0.0000 | |
| 99 | R | B | 0.0000 | |
| 100 | G | B | 0.0071 | |
| 101 | W | B | 0.0000 | |
| 102 | E | B | 0.0000 | |
| 103 | G | B | 0.0000 | |
| 104 | F | B | 0.0000 | |
| 105 | A | B | -0.1520 | |
| 106 | Y | B | 0.0793 | |
| 107 | W | B | -0.5469 | |
| 108 | G | B | 0.0000 | |
| 109 | Q | B | -1.6867 | |
| 110 | G | B | -0.8227 | |
| 111 | T | B | 0.0000 | |
| 112 | L | B | 0.9861 | |
| 113 | V | B | 0.0000 | |
| 114 | T | B | 0.3144 | |
| 115 | V | B | 0.0000 | |
| 116 | S | B | -0.4146 | |
| 117 | A | B | -0.5006 | |
| 132 | S | B | -0.9790 | |
| 133 | E | B | -1.6439 | |
| 134 | L | B | -0.4123 | |
| 135 | V | B | 0.7147 | |
| 136 | M | B | 0.0000 | |
| 137 | T | B | -0.5854 | |
| 138 | Q | B | -0.6076 | |
| 139 | T | B | -0.5214 | |
| 140 | P | B | -0.3211 | |
| 141 | A | B | -0.4011 | |
| 142 | S | B | -0.7046 | |
| 143 | L | B | -0.6392 | |
| 144 | A | B | -1.2994 | |
| 145 | V | B | 0.0000 | |
| 146 | S | B | -1.2267 | |
| 147 | L | B | -0.0872 | |
| 148 | G | B | -1.3188 | |
| 149 | Q | B | -1.9737 | |
| 150 | R | B | -2.7602 | |
| 151 | A | B | 0.0000 | |
| 152 | T | B | -0.6561 | |
| 153 | I | B | 0.0000 | |
| 154 | S | B | -0.8483 | |
| 155 | C | B | 0.0000 | |
| 156 | R | B | -2.6408 | |
| 157 | A | B | 0.0000 | |
| 158 | S | B | -1.3749 | |
| 159 | E | B | -2.3704 | |
| 160 | N | B | -3.1517 | |
| 161 | V | B | 0.0000 | |
| 162 | D | B | -2.3144 | |
| 163 | R | B | -1.6184 | |
| 164 | Y | B | -0.6682 | |
| 165 | G | B | -1.2741 | |
| 166 | N | B | -1.2147 | |
| 167 | S | B | -1.3266 | |
| 168 | F | B | 0.0000 | |
| 169 | M | B | 0.0000 | |
| 170 | H | B | 0.0000 | |
| 171 | W | B | 0.0000 | |
| 172 | Y | B | 0.0000 | |
| 173 | Q | B | 0.0000 | |
| 174 | Q | B | 0.0000 | |
| 175 | K | B | -1.3264 | |
| 176 | A | B | -0.8720 | |
| 177 | G | B | -1.1281 | |
| 178 | Q | B | -1.7186 | |
| 179 | P | B | -1.3092 | |
| 180 | P | B | 0.0000 | |
| 181 | K | B | -1.7520 | |
| 182 | L | B | 0.0000 | |
| 183 | L | B | 0.0000 | |
| 184 | I | B | 0.0000 | |
| 185 | Y | B | 0.0000 | |
| 186 | R | B | 0.0000 | |
| 187 | A | B | 0.0000 | |
| 188 | S | B | -0.3575 | |
| 189 | N | B | 0.0000 | |
| 190 | L | B | 0.1921 | |
| 191 | E | B | 0.0000 | |
| 192 | S | B | -0.4524 | |
| 193 | G | B | -0.3827 | |
| 194 | I | B | -0.2698 | |
| 195 | P | B | -0.1990 | |
| 196 | A | B | -0.3693 | |
| 197 | R | B | -1.2920 | |
| 198 | F | B | 0.0000 | |
| 199 | S | B | -0.4435 | |
| 200 | G | B | -0.3275 | |
| 201 | S | B | -0.7084 | |
| 202 | G | B | -1.5783 | |
| 203 | S | B | -1.9531 | |
| 204 | R | B | -3.3326 | |
| 205 | T | B | 0.0000 | |
| 206 | D | B | -2.6894 | |
| 207 | F | B | 0.0000 | |
| 208 | T | B | -0.8118 | |
| 209 | L | B | 0.0000 | |
| 210 | T | B | -0.9504 | |
| 211 | I | B | 0.0000 | |
| 212 | N | B | -2.7737 | |
| 213 | P | B | -2.2215 | |
| 214 | V | B | 0.0000 | |
| 215 | E | B | -1.8527 | |
| 216 | A | B | -1.0850 | |
| 217 | D | B | -1.9698 | |
| 218 | D | B | 0.0000 | |
| 219 | V | B | -0.3343 | |
| 220 | A | B | 0.0000 | |
| 221 | T | B | -0.7630 | |
| 222 | Y | B | 0.0000 | |
| 223 | F | B | 0.0000 | |
| 224 | C | B | 0.0000 | |
| 225 | Q | B | 0.0000 | |
| 226 | R | B | 0.0000 | |
| 227 | S | B | 0.0000 | |
| 228 | N | B | 0.0000 | |
| 229 | E | B | -2.1653 | |
| 230 | V | B | -0.7468 | |
| 231 | P | B | -0.7214 | |
| 232 | W | B | 0.0000 | |
| 233 | T | B | -0.1149 | |
| 234 | F | B | 0.0000 | |
| 235 | G | B | 0.0000 | |
| 236 | G | B | -0.7284 | |
| 237 | G | B | 0.0000 | |
| 238 | T | B | 0.0000 | |
| 239 | K | B | -1.2494 | |
| 240 | L | B | 0.0000 | |
| 241 | E | B | -1.6765 | |
| 242 | I | B | -1.3483 | |
| 243 | K | B | -2.5556 | |
| 244 | R | B | -2.7794 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine