Project name: 5KCV

Chain sequence(s)	A: IVKEGWLHKRGEYITWRPRYFLLKNDGTFIGYKERPAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8387
• Maximal score value: 1.8193
• Average score: -0.9675
• Total score value: -341.5247

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
6	I	A	1.3743
7	V	A	0.9414
8	K	A	-0.4899
9	E	A	-0.9533
10	G	A	-0.7521
11	W	A	-0.6284
12	L	A	0.0000
13	H	A	-1.4075
14	K	A	-1.8518
15	R	A	-2.0709
16	G	A	-1.6294
17	E	A	-1.6966
18	Y	A	0.1855
19	I	A	1.0369
21	T	A	-0.6795
22	W	A	-1.6434
23	R	A	-2.5092
24	P	A	-1.7700
25	R	A	-1.9298
26	Y	A	0.0000
27	F	A	0.0000
28	L	A	-0.0212
29	L	A	0.0000
30	K	A	-0.7258
31	N	A	-1.6681
32	D	A	-2.3448
33	G	A	-1.3550
34	T	A	0.0000
35	F	A	0.0000
36	I	A	0.0494
37	G	A	-1.0570
38	Y	A	-1.8708
39	K	A	-3.5863
40	E	A	-3.5342
41	R	A	-3.2119
42	P	A	-1.8989
50	A	A	-0.2118
51	P	A	-0.7913
52	L	A	0.0000
53	N	A	-1.4679
54	N	A	-0.5502
55	F	A	-0.1745
56	S	A	-0.9470
57	V	A	-0.9361
58	A	A	-1.0467
59	Q	A	-1.4826
60	C	A	0.0000
61	Q	A	-1.5552
62	L	A	-0.9560
63	M	A	-0.8962
64	K	A	-2.2901
65	T	A	-2.5101
66	E	A	-3.8387
67	R	A	-3.8247
68	P	A	-2.8302
69	R	A	-3.5544
70	P	A	-3.0160
71	N	A	-2.8197
72	T	A	0.0000
73	F	A	0.0000
74	I	A	-0.5746
75	I	A	0.0000
76	R	A	-0.9782
77	C	A	-0.3196
78	L	A	0.4456
79	Q	A	0.0944
80	W	A	0.3459
81	T	A	0.0000
82	T	A	0.5966
83	V	A	0.6524
84	I	A	0.2735
85	E	A	-1.0115
86	R	A	-1.1605
87	T	A	-0.9229
88	F	A	0.0000
89	H	A	-1.6274
90	V	A	0.0000
91	E	A	-2.4866
92	T	A	-1.9246
93	P	A	-2.4529
94	E	A	-3.3342
95	E	A	-2.8773
96	R	A	0.0000
97	E	A	-3.3698
98	E	A	-3.1835
99	W	A	0.0000
100	T	A	-1.8102
101	T	A	-1.3971
102	A	A	-1.1699
103	I	A	0.0000
104	Q	A	-1.4566
144	R	A	-1.7098
145	V	A	-1.1467
146	T	A	-1.0190
147	M	A	-0.8478
148	N	A	-1.9709
149	E	A	-2.0700
150	F	A	0.0000
151	E	A	-1.6579
152	Y	A	0.2782
153	L	A	0.2610
154	K	A	-0.4602
155	L	A	0.4158
156	L	A	0.3849
157	G	A	-0.6806
158	K	A	-1.7060
159	G	A	-1.0797
160	T	A	-0.5482
161	F	A	-0.8575
162	G	A	-1.6300
163	K	A	-1.3623
164	V	A	0.0000
165	I	A	0.0611
166	L	A	0.0000
167	V	A	0.0000
168	K	A	-1.2830
169	E	A	0.0000
170	K	A	-2.6611
171	A	A	-1.1847
172	T	A	-1.0592
173	G	A	-1.5359
174	R	A	-1.8628
175	Y	A	-1.1948
176	Y	A	0.0000
177	A	A	0.0000
178	M	A	0.0000
179	K	A	0.0000
180	I	A	0.0000
181	L	A	0.0000
182	K	A	-3.0561
183	K	A	-3.0892
201	V	A	1.8193
202	L	A	0.7303
203	Q	A	-1.1833
204	N	A	-2.0929
205	S	A	-1.9632
206	R	A	-2.4193
207	H	A	0.0000
208	P	A	-0.9283
209	F	A	0.0000
210	L	A	-0.3602
211	T	A	-0.4351
212	A	A	-1.1693
213	L	A	0.0000
214	K	A	-1.7816
215	Y	A	-0.7903
216	S	A	-0.4990
217	F	A	-0.7710
218	Q	A	-1.7861
219	T	A	-1.7462
220	H	A	-2.0651
221	D	A	-2.3703
222	R	A	-2.6678
223	L	A	0.0000
224	C	A	0.0000
225	F	A	0.0000
226	V	A	0.0000
227	M	A	0.0000
228	E	A	-0.9004
229	Y	A	-0.4628
230	A	A	0.0000
231	N	A	0.0000
232	G	A	0.0000
233	G	A	0.0000
234	E	A	-0.1090
235	L	A	0.0000
236	F	A	0.3891
237	F	A	0.7439
238	H	A	0.0000
239	L	A	0.0000
240	S	A	-1.2379
241	R	A	-2.5776
242	E	A	-2.9934
243	R	A	-2.8223
244	V	A	-1.0099
245	F	A	0.0000
246	S	A	-1.1056
247	E	A	-2.0883
248	D	A	-2.6149
249	R	A	-1.4521
250	A	A	0.0000
251	R	A	-1.4168
252	F	A	0.0000
253	Y	A	0.0000
254	G	A	0.0000
255	A	A	0.0000
256	E	A	0.0000
257	I	A	0.0000
258	V	A	0.0000
259	S	A	0.0000
260	A	A	0.0000
261	L	A	0.0000
262	D	A	-1.1266
263	Y	A	-1.0504
264	L	A	-0.8128
265	H	A	0.0000
266	S	A	-1.4946
267	E	A	-2.5359
268	K	A	-1.9238
269	N	A	-1.5693
270	V	A	-0.8957
271	V	A	0.0000
272	Y	A	-0.3478
273	R	A	-0.9077
274	D	A	-1.6413
275	L	A	0.0000
276	K	A	-1.2538
277	L	A	0.0000
278	E	A	-1.8546
279	N	A	-1.4007
280	L	A	0.0000
281	M	A	0.0000
282	L	A	0.0000
283	D	A	-1.7355
284	K	A	-2.5369
285	D	A	-2.6421
286	G	A	0.0000
287	H	A	0.0000
288	I	A	0.0000
289	K	A	-0.3729
290	I	A	0.0000
291	T	A	-0.5469
292	D	A	-0.2263
293	F	A	0.0194
294	G	A	-0.2740
295	L	A	0.0000
296	C	A	0.4198
313	P	A	-0.1709
314	E	A	-0.2716
315	Y	A	-0.3117
316	L	A	-0.1451
317	A	A	0.0000
318	P	A	0.0000
319	E	A	0.0000
320	V	A	0.0000
321	L	A	0.0000
322	E	A	-1.8901
323	D	A	-2.0331
324	N	A	-1.7796
325	D	A	-1.1875
326	Y	A	-0.4347
327	G	A	-0.5110
328	R	A	-0.4725
329	A	A	0.0000
330	V	A	0.0000
331	D	A	0.0000
332	W	A	0.0000
333	W	A	0.0000
334	G	A	0.0000
335	L	A	0.0000
336	G	A	0.0000
337	V	A	0.0000
338	V	A	0.0000
339	M	A	0.0000
340	Y	A	0.0000
341	E	A	0.0000
342	M	A	0.0000
343	M	A	0.0000
344	C	A	0.0000
345	G	A	-1.3622
346	R	A	-1.7228
347	L	A	-0.4636
348	P	A	-0.4465
349	F	A	0.0000
350	Y	A	0.1522
351	N	A	-1.6243
352	Q	A	-2.3731
353	D	A	-3.3002
354	H	A	-3.0141
355	E	A	-3.6457
356	K	A	-3.6249
357	L	A	0.0000
358	F	A	0.0000
359	E	A	-2.9336
360	L	A	-1.7259
361	I	A	0.0000
362	L	A	-0.9339
363	M	A	-0.5368
364	E	A	-2.4562
365	E	A	-2.7160
366	I	A	-1.7672
367	R	A	-2.3769
368	F	A	-1.1997
369	P	A	-1.2526
370	R	A	-2.1315
371	T	A	-0.9599
372	L	A	0.0000
373	G	A	-1.1631
374	P	A	-1.4804
375	E	A	-2.0903
376	A	A	0.0000
377	K	A	-1.2052
378	S	A	-1.1449
379	L	A	0.0000
380	L	A	0.0000
381	S	A	-0.7269
382	G	A	0.0000
383	L	A	0.0000
384	L	A	0.0000
385	K	A	-1.9075
386	K	A	-1.6605
387	D	A	-1.7735
388	P	A	-1.8331
389	K	A	-2.7301
390	Q	A	-2.4995
391	R	A	0.0000
392	L	A	-1.3865
393	G	A	0.0000
394	G	A	-2.0234
395	G	A	-2.3453
396	S	A	-1.9464
397	E	A	-2.9918
398	D	A	-2.2837
399	A	A	0.0000
400	K	A	-3.1542
401	E	A	-3.0196
402	I	A	0.0000
403	M	A	0.0000
404	Q	A	-2.4325
405	H	A	0.0000
406	R	A	-2.5327
407	F	A	0.0000
408	F	A	0.0000
409	A	A	-0.9623
410	G	A	-0.3959
411	I	A	0.1745
412	V	A	0.4360
413	W	A	-0.5868
414	Q	A	-1.8545
415	H	A	-2.1597
416	V	A	0.0000
417	Y	A	-1.7810
418	E	A	-3.1995
419	K	A	-2.9642
420	K	A	-2.9428
421	L	A	-1.2481
422	S	A	-1.0770
423	P	A	-1.1390
424	P	A	-0.9807
425	F	A	-1.0710
426	K	A	-2.4646
427	P	A	0.0000
428	Q	A	-2.0776
429	V	A	-1.9095
430	T	A	-1.2040
431	S	A	-1.5426
432	E	A	-2.4915
433	T	A	-1.5693
434	D	A	-1.5212
435	T	A	-0.8662
436	R	A	-1.7396
437	Y	A	-0.5076
438	F	A	0.2422