Project name: dd02804f771d319
Status: done
submitted: 2018-10-12 17:00:13, status changed: 2018-10-12 17:17:13
Settings
Chain sequence(s)
|
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKEPPSSGEPPKSGDRSGYSSPGEPGTPGSRSRTPSLPTPPERTPKKVAVVREPPKSPESAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.5087
-
Maximal score value
-
2.391
-
Average score
-
-0.9545
-
Total score value
-
-420.916
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
-0.7575 |
|
2 |
A |
A |
0.0000 |
|
3 |
E |
A |
0.0000 |
|
4 |
P |
A |
0.0000 |
|
5 |
R |
A |
-2.6093 |
|
6 |
Q |
A |
-2.3746 |
|
7 |
E |
A |
-2.3010 |
|
8 |
F |
A |
-0.6703 |
|
9 |
E |
A |
-1.1720 |
|
10 |
V |
A |
0.6785 |
|
11 |
M |
A |
-0.6395 |
|
12 |
E |
A |
-1.3182 |
|
13 |
D |
A |
-0.9966 |
|
14 |
H |
A |
-0.4031 |
|
15 |
A |
A |
0.0000 |
|
16 |
G |
A |
-0.7719 |
|
17 |
T |
A |
-0.6661 |
|
18 |
Y |
A |
-0.2011 |
|
19 |
G |
A |
-0.4956 |
|
20 |
L |
A |
-0.5080 |
|
21 |
G |
A |
-1.2338 |
|
22 |
D |
A |
-2.4253 |
|
23 |
R |
A |
-2.9957 |
|
24 |
K |
A |
-3.5087 |
|
25 |
D |
A |
-3.1884 |
|
26 |
Q |
A |
-2.7039 |
|
27 |
G |
A |
-1.9945 |
|
28 |
G |
A |
-1.2885 |
|
29 |
Y |
A |
-0.8791 |
|
30 |
T |
A |
-0.1130 |
|
31 |
M |
A |
0.0000 |
|
32 |
H |
A |
-1.5010 |
|
33 |
Q |
A |
-2.2340 |
|
34 |
D |
A |
-3.1501 |
|
35 |
Q |
A |
-2.7189 |
|
36 |
E |
A |
-2.5633 |
|
37 |
G |
A |
-2.5487 |
|
38 |
D |
A |
-2.9311 |
|
39 |
T |
A |
0.0000 |
|
40 |
D |
A |
-0.9328 |
|
41 |
A |
A |
-0.2144 |
|
42 |
G |
A |
0.0000 |
|
43 |
L |
A |
-0.2420 |
|
44 |
K |
A |
-0.1653 |
|
45 |
E |
A |
-0.2182 |
|
46 |
S |
A |
-0.1888 |
|
47 |
P |
A |
-0.5779 |
|
48 |
L |
A |
0.0000 |
|
49 |
Q |
A |
-0.8065 |
|
50 |
T |
A |
-1.0350 |
|
51 |
P |
A |
-1.3871 |
|
52 |
T |
A |
-1.5308 |
|
53 |
E |
A |
-1.7957 |
|
54 |
D |
A |
-2.4079 |
|
55 |
G |
A |
-2.6345 |
|
56 |
S |
A |
-2.0310 |
|
57 |
E |
A |
-2.0329 |
|
58 |
E |
A |
-2.8798 |
|
59 |
P |
A |
-2.3085 |
|
60 |
G |
A |
0.0000 |
|
61 |
S |
A |
-2.0863 |
|
62 |
E |
A |
-2.5351 |
|
63 |
T |
A |
-1.8053 |
|
64 |
S |
A |
-2.2631 |
|
65 |
D |
A |
-2.7610 |
|
66 |
A |
A |
-2.4236 |
|
67 |
K |
A |
-2.4321 |
|
68 |
S |
A |
-1.5457 |
|
69 |
T |
A |
-1.0831 |
|
70 |
P |
A |
0.0000 |
|
71 |
T |
A |
-1.1537 |
|
72 |
A |
A |
0.0000 |
|
73 |
E |
A |
-1.9483 |
|
74 |
D |
A |
-0.8246 |
|
75 |
V |
A |
1.0069 |
|
76 |
T |
A |
0.2274 |
|
77 |
A |
A |
0.0000 |
|
78 |
P |
A |
0.1739 |
|
79 |
L |
A |
0.2162 |
|
80 |
V |
A |
-0.5092 |
|
81 |
D |
A |
-1.9319 |
|
82 |
E |
A |
-2.6267 |
|
83 |
G |
A |
-1.4117 |
|
84 |
A |
A |
-0.7795 |
|
85 |
P |
A |
-0.8104 |
|
86 |
G |
A |
-0.6062 |
|
87 |
K |
A |
-0.7042 |
|
88 |
Q |
A |
-0.9039 |
|
89 |
A |
A |
0.0000 |
|
90 |
A |
A |
-0.6321 |
|
91 |
A |
A |
-1.0573 |
|
92 |
Q |
A |
-2.0659 |
|
93 |
P |
A |
-1.4337 |
|
94 |
H |
A |
-1.7139 |
|
95 |
T |
A |
-1.3839 |
|
96 |
E |
A |
-1.2667 |
|
97 |
I |
A |
0.2649 |
|
98 |
P |
A |
-0.7041 |
|
99 |
E |
A |
-1.9556 |
|
100 |
G |
A |
-1.1980 |
|
101 |
T |
A |
-1.1480 |
|
102 |
T |
A |
-1.5741 |
|
103 |
A |
A |
-1.8351 |
|
104 |
E |
A |
-2.6230 |
|
105 |
E |
A |
-2.1550 |
|
106 |
A |
A |
-1.3798 |
|
107 |
G |
A |
-1.3802 |
|
108 |
I |
A |
0.0000 |
|
109 |
G |
A |
-1.1970 |
|
110 |
D |
A |
-1.7381 |
|
111 |
T |
A |
-1.2033 |
|
112 |
P |
A |
-0.8977 |
|
113 |
S |
A |
-0.2901 |
|
114 |
L |
A |
-0.1270 |
|
115 |
E |
A |
-1.4340 |
|
116 |
D |
A |
-1.9263 |
|
117 |
E |
A |
-2.3794 |
|
118 |
A |
A |
-1.4723 |
|
119 |
A |
A |
-1.0476 |
|
120 |
G |
A |
-1.1185 |
|
121 |
H |
A |
-1.4878 |
|
122 |
V |
A |
-0.5761 |
|
123 |
T |
A |
-1.2942 |
|
124 |
Q |
A |
-1.2202 |
|
125 |
A |
A |
-1.2967 |
|
126 |
R |
A |
-2.0129 |
|
127 |
M |
A |
-1.4917 |
|
128 |
V |
A |
-0.5434 |
|
129 |
S |
A |
-1.6892 |
|
130 |
K |
A |
-2.1406 |
|
131 |
S |
A |
0.0000 |
|
132 |
K |
A |
-1.2191 |
|
133 |
D |
A |
-0.8377 |
|
134 |
G |
A |
0.1336 |
|
135 |
T |
A |
-0.2602 |
|
136 |
G |
A |
0.0000 |
|
137 |
S |
A |
-1.0309 |
|
138 |
D |
A |
-1.4062 |
|
139 |
D |
A |
-1.7956 |
|
140 |
K |
A |
-1.6198 |
|
141 |
K |
A |
-2.2098 |
|
142 |
A |
A |
0.0000 |
|
143 |
K |
A |
-2.4887 |
|
144 |
G |
A |
-1.5189 |
|
145 |
A |
A |
0.0000 |
|
146 |
D |
A |
-2.4903 |
|
147 |
G |
A |
-2.1428 |
|
148 |
K |
A |
-2.7035 |
|
149 |
T |
A |
-2.0190 |
|
150 |
K |
A |
-1.5972 |
|
151 |
I |
A |
0.7152 |
|
152 |
A |
A |
-0.4469 |
|
153 |
T |
A |
0.0000 |
|
154 |
P |
A |
-0.4673 |
|
155 |
R |
A |
-1.0400 |
|
156 |
G |
A |
-0.8874 |
|
157 |
A |
A |
-0.4857 |
|
158 |
A |
A |
-0.5039 |
|
159 |
P |
A |
-0.4832 |
|
160 |
P |
A |
-0.7857 |
|
161 |
G |
A |
-1.2675 |
|
162 |
Q |
A |
-1.4168 |
|
163 |
K |
A |
-1.3589 |
|
164 |
G |
A |
-0.7537 |
|
165 |
Q |
A |
-1.2577 |
|
166 |
A |
A |
-1.2359 |
|
167 |
N |
A |
-1.7206 |
|
168 |
A |
A |
-1.3378 |
|
169 |
T |
A |
0.0000 |
|
170 |
R |
A |
-1.0358 |
|
171 |
I |
A |
0.0000 |
|
172 |
P |
A |
-0.8608 |
|
173 |
A |
A |
-1.3113 |
|
174 |
K |
A |
-2.2608 |
|
175 |
T |
A |
-1.2464 |
|
176 |
P |
A |
-1.0479 |
|
177 |
P |
A |
-0.7813 |
|
178 |
A |
A |
-1.3455 |
|
179 |
P |
A |
-2.1897 |
|
180 |
K |
A |
-3.3445 |
|
181 |
E |
A |
-3.1761 |
|
182 |
P |
A |
-1.8509 |
|
183 |
P |
A |
-1.0201 |
|
184 |
S |
A |
-0.3545 |
|
185 |
S |
A |
-0.1145 |
|
186 |
G |
A |
-1.0843 |
|
187 |
E |
A |
-1.9885 |
|
188 |
P |
A |
0.0000 |
|
189 |
P |
A |
0.0000 |
|
190 |
K |
A |
-1.6481 |
|
191 |
S |
A |
0.0000 |
|
192 |
G |
A |
-1.6160 |
|
193 |
D |
A |
-2.2206 |
|
194 |
R |
A |
-2.4685 |
|
195 |
S |
A |
-1.6466 |
|
196 |
G |
A |
-1.4596 |
|
197 |
Y |
A |
-0.9583 |
|
198 |
S |
A |
-1.1118 |
|
199 |
S |
A |
-1.1451 |
|
200 |
P |
A |
-1.0683 |
|
201 |
G |
A |
-1.1780 |
|
202 |
E |
A |
-1.1027 |
|
203 |
P |
A |
-0.9267 |
|
204 |
G |
A |
-0.8543 |
|
205 |
T |
A |
-0.7437 |
|
206 |
P |
A |
-0.9458 |
|
207 |
G |
A |
-1.1744 |
|
208 |
S |
A |
0.0000 |
|
209 |
R |
A |
-2.0752 |
|
210 |
S |
A |
-1.1606 |
|
211 |
R |
A |
-1.4788 |
|
212 |
T |
A |
0.0000 |
|
213 |
P |
A |
-0.9623 |
|
214 |
S |
A |
-0.1071 |
|
215 |
L |
A |
1.0895 |
|
216 |
P |
A |
0.0000 |
|
217 |
T |
A |
-0.8291 |
|
218 |
P |
A |
-1.1616 |
|
219 |
P |
A |
-1.7441 |
|
220 |
E |
A |
-2.3785 |
|
221 |
R |
A |
-2.0859 |
|
222 |
T |
A |
0.0000 |
|
223 |
P |
A |
0.0000 |
|
224 |
K |
A |
-2.5100 |
|
225 |
K |
A |
-1.7997 |
|
226 |
V |
A |
-0.2647 |
|
227 |
A |
A |
0.1175 |
|
228 |
V |
A |
1.0240 |
|
229 |
V |
A |
-0.3402 |
|
230 |
R |
A |
-2.0909 |
|
231 |
E |
A |
-2.4489 |
|
232 |
P |
A |
-1.8926 |
|
233 |
P |
A |
-1.7706 |
|
234 |
K |
A |
-2.2773 |
|
235 |
S |
A |
-1.8463 |
|
236 |
P |
A |
-1.4754 |
|
237 |
E |
A |
-1.4805 |
|
238 |
S |
A |
-1.1424 |
|
239 |
A |
A |
-1.1066 |
|
240 |
K |
A |
-1.5547 |
|
241 |
S |
A |
-2.1647 |
|
242 |
R |
A |
-1.7062 |
|
243 |
L |
A |
-1.0722 |
|
244 |
Q |
A |
-0.5470 |
|
245 |
T |
A |
-1.2044 |
|
246 |
A |
A |
-0.8567 |
|
247 |
P |
A |
-0.3484 |
|
248 |
V |
A |
0.8816 |
|
249 |
P |
A |
-0.5569 |
|
250 |
M |
A |
-0.4790 |
|
251 |
P |
A |
-0.6715 |
|
252 |
D |
A |
-0.8428 |
|
253 |
L |
A |
0.0000 |
|
254 |
K |
A |
-0.9771 |
|
255 |
N |
A |
0.0000 |
|
256 |
V |
A |
-1.4927 |
|
257 |
K |
A |
-2.2687 |
|
258 |
S |
A |
-1.7427 |
|
259 |
K |
A |
-2.3341 |
|
260 |
I |
A |
-2.1284 |
|
261 |
G |
A |
0.0000 |
|
262 |
S |
A |
-1.8124 |
|
263 |
T |
A |
-1.4599 |
|
264 |
E |
A |
-2.3684 |
|
265 |
N |
A |
-2.3734 |
|
266 |
L |
A |
-1.4258 |
|
267 |
K |
A |
-1.2976 |
|
268 |
H |
A |
-1.0850 |
|
269 |
Q |
A |
-1.4368 |
|
270 |
P |
A |
-1.0548 |
|
271 |
G |
A |
-1.2182 |
|
272 |
G |
A |
-1.1131 |
|
273 |
G |
A |
-1.1903 |
|
274 |
K |
A |
-0.8168 |
|
275 |
V |
A |
0.8526 |
|
276 |
Q |
A |
0.7533 |
|
277 |
I |
A |
2.3910 |
|
278 |
I |
A |
1.6805 |
|
279 |
N |
A |
-0.7226 |
|
280 |
K |
A |
-1.7854 |
|
281 |
K |
A |
-1.2680 |
|
282 |
L |
A |
-0.0673 |
|
283 |
D |
A |
-0.4352 |
|
284 |
L |
A |
0.9047 |
|
285 |
S |
A |
0.1380 |
|
286 |
N |
A |
-0.6060 |
|
287 |
V |
A |
0.9593 |
|
288 |
Q |
A |
-0.1151 |
|
289 |
S |
A |
-0.4595 |
|
290 |
K |
A |
-1.6767 |
|
291 |
C |
A |
0.0000 |
|
292 |
G |
A |
-0.8114 |
|
293 |
S |
A |
-1.3366 |
|
294 |
K |
A |
-2.6006 |
|
295 |
D |
A |
-2.2840 |
|
296 |
N |
A |
0.0000 |
|
297 |
I |
A |
-1.5690 |
|
298 |
K |
A |
-1.9767 |
|
299 |
H |
A |
-1.1916 |
|
300 |
V |
A |
0.0000 |
|
301 |
P |
A |
0.0000 |
|
302 |
G |
A |
-0.1485 |
|
303 |
G |
A |
0.0000 |
|
304 |
G |
A |
0.0000 |
|
305 |
S |
A |
-0.6413 |
|
306 |
V |
A |
0.1369 |
|
307 |
Q |
A |
-0.1061 |
|
308 |
I |
A |
0.0000 |
|
309 |
V |
A |
1.8611 |
|
310 |
Y |
A |
1.5461 |
|
311 |
K |
A |
-0.2442 |
|
312 |
P |
A |
0.0000 |
|
313 |
V |
A |
0.0000 |
|
314 |
D |
A |
-1.0509 |
|
315 |
L |
A |
0.0000 |
|
316 |
S |
A |
-0.1247 |
|
317 |
K |
A |
0.3518 |
|
318 |
V |
A |
0.4418 |
|
319 |
T |
A |
-0.4543 |
|
320 |
S |
A |
-0.5213 |
|
321 |
K |
A |
-0.3221 |
|
322 |
C |
A |
0.0000 |
|
323 |
G |
A |
0.0000 |
|
324 |
S |
A |
-0.7910 |
|
325 |
L |
A |
0.4474 |
|
326 |
G |
A |
0.0000 |
|
327 |
N |
A |
0.0000 |
|
328 |
I |
A |
0.4624 |
|
329 |
H |
A |
-1.1745 |
|
330 |
H |
A |
-1.7993 |
|
331 |
K |
A |
-1.7704 |
|
332 |
P |
A |
-0.8811 |
|
333 |
G |
A |
-1.0511 |
|
334 |
G |
A |
-0.9916 |
|
335 |
G |
A |
-1.6515 |
|
336 |
Q |
A |
-1.8082 |
|
337 |
V |
A |
0.0000 |
|
338 |
E |
A |
-1.8503 |
|
339 |
V |
A |
-0.2603 |
|
340 |
K |
A |
-1.6082 |
|
341 |
S |
A |
-1.2310 |
|
342 |
E |
A |
-1.3200 |
|
343 |
K |
A |
-1.6718 |
|
344 |
L |
A |
-0.9797 |
|
345 |
D |
A |
-1.0392 |
|
346 |
F |
A |
-1.2043 |
|
347 |
K |
A |
-2.1797 |
|
348 |
D |
A |
-1.7310 |
|
349 |
R |
A |
-2.4677 |
|
350 |
V |
A |
-1.4802 |
|
351 |
Q |
A |
-0.9081 |
|
352 |
S |
A |
-0.9629 |
|
353 |
K |
A |
-0.9835 |
|
354 |
I |
A |
-0.3142 |
|
355 |
G |
A |
-0.6741 |
|
356 |
S |
A |
-0.4988 |
|
357 |
L |
A |
0.4391 |
|
358 |
D |
A |
-0.7359 |
|
359 |
N |
A |
-1.6842 |
|
360 |
I |
A |
0.0000 |
|
361 |
T |
A |
-1.1039 |
|
362 |
H |
A |
-0.6837 |
|
363 |
V |
A |
-0.2587 |
|
364 |
P |
A |
-0.8086 |
|
365 |
G |
A |
-0.9975 |
|
366 |
G |
A |
-1.1253 |
|
367 |
G |
A |
-1.5061 |
|
368 |
N |
A |
0.0000 |
|
369 |
K |
A |
-1.5713 |
|
370 |
K |
A |
0.0000 |
|
371 |
I |
A |
0.0000 |
|
372 |
E |
A |
-2.1307 |
|
373 |
T |
A |
0.0000 |
|
374 |
H |
A |
-1.2165 |
|
375 |
K |
A |
-0.5932 |
|
376 |
L |
A |
1.4686 |
|
377 |
T |
A |
0.5764 |
|
378 |
F |
A |
1.6174 |
|
379 |
R |
A |
-0.3416 |
|
380 |
E |
A |
-2.0396 |
|
381 |
N |
A |
-1.9150 |
|
382 |
A |
A |
-1.8734 |
|
383 |
K |
A |
-2.3229 |
|
384 |
A |
A |
0.0000 |
|
385 |
K |
A |
-1.4098 |
|
386 |
T |
A |
0.0000 |
|
387 |
D |
A |
-0.9421 |
|
388 |
H |
A |
-0.4055 |
|
389 |
G |
A |
-0.5028 |
|
390 |
A |
A |
-1.0192 |
|
391 |
E |
A |
-1.5714 |
|
392 |
I |
A |
0.0592 |
|
393 |
V |
A |
0.9758 |
|
394 |
Y |
A |
-0.0673 |
|
395 |
K |
A |
-1.1172 |
|
396 |
S |
A |
-0.6019 |
|
397 |
P |
A |
-0.6986 |
|
398 |
V |
A |
0.0000 |
|
399 |
V |
A |
-0.6331 |
|
400 |
S |
A |
0.0000 |
|
401 |
G |
A |
-1.9818 |
|
402 |
D |
A |
-1.7675 |
|
403 |
T |
A |
-1.6025 |
|
404 |
E |
A |
-2.3760 |
|
405 |
P |
A |
0.0000 |
|
406 |
R |
A |
-1.3969 |
|
407 |
H |
A |
-1.5117 |
|
408 |
L |
A |
-1.0721 |
|
409 |
S |
A |
0.0000 |
|
410 |
N |
A |
-0.5105 |
|
411 |
V |
A |
-0.3472 |
|
412 |
S |
A |
-0.6211 |
|
413 |
S |
A |
0.0000 |
|
414 |
T |
A |
-1.2453 |
|
415 |
G |
A |
-0.9721 |
|
416 |
S |
A |
0.0000 |
|
417 |
I |
A |
0.0000 |
|
418 |
D |
A |
-1.1852 |
|
419 |
M |
A |
0.0000 |
|
420 |
V |
A |
0.0000 |
|
421 |
D |
A |
-0.7881 |
|
422 |
S |
A |
0.0000 |
|
423 |
P |
A |
-0.7572 |
|
424 |
Q |
A |
-0.4064 |
|
425 |
L |
A |
0.9134 |
|
426 |
A |
A |
0.5103 |
|
427 |
T |
A |
0.2015 |
|
428 |
L |
A |
0.3651 |
|
429 |
A |
A |
-0.3300 |
|
430 |
D |
A |
-1.4365 |
|
431 |
E |
A |
-1.7214 |
|
432 |
V |
A |
-0.2774 |
|
433 |
S |
A |
-0.0776 |
|
434 |
A |
A |
0.1798 |
|
435 |
S |
A |
0.2335 |
|
436 |
L |
A |
0.7809 |
|
437 |
A |
A |
-0.4925 |
|
438 |
K |
A |
-1.8549 |
|
439 |
Q |
A |
-2.0989 |
|
440 |
G |
A |
-1.2572 |
|
441 |
L |
A |
-0.3372 |
|