Project name: dde5a5e69a79389

Chain sequence(s)	A: MASLPYLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLNDRARSLVVPAYAYRKLHPKQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.082
• Maximal score value: 0.9245
• Average score: -0.7222
• Total score value: -267.2138

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.9245
2	A	A	0.3078
3	S	A	-0.0761
4	L	A	0.2051
5	P	A	-0.2146
6	Y	A	-0.1495
7	L	A	-0.1601
8	Q	A	0.0000
9	K	A	-2.1911
10	E	A	-2.0261
11	S	A	-1.4134
12	V	A	0.0000
13	F	A	0.0000
14	Q	A	-2.0171
15	S	A	-1.6485
16	G	A	-1.1344
17	A	A	-0.4849
18	H	A	-1.0233
19	A	A	0.0000
20	Y	A	0.0000
21	R	A	0.0000
22	I	A	0.0000
23	P	A	0.0000
24	A	A	0.0000
25	L	A	0.0000
26	L	A	0.0000
27	Y	A	-0.5145
28	L	A	0.0000
29	P	A	-1.0867
30	G	A	-1.1602
31	Q	A	-1.5313
32	Q	A	-1.9489
33	S	A	0.0000
34	L	A	0.0000
35	L	A	0.0000
36	A	A	0.0000
37	F	A	0.0000
38	A	A	0.0000
39	E	A	0.0000
40	Q	A	-0.3412
41	R	A	0.0000
42	A	A	-0.9508
43	S	A	-1.4433
44	K	A	-2.3454
45	K	A	-2.8497
46	D	A	-2.9075
47	E	A	-2.4409
48	H	A	-2.0267
49	A	A	0.0000
50	E	A	-1.2847
51	L	A	-0.4128
52	I	A	0.0000
53	V	A	0.0000
54	L	A	0.0000
55	R	A	-1.5138
56	R	A	-1.7479
57	G	A	0.0000
58	D	A	-2.1705
59	Y	A	-1.6071
60	D	A	-1.6346
61	A	A	-0.9040
62	P	A	-0.6322
63	T	A	-0.6666
64	H	A	-0.9125
65	Q	A	-1.3700
66	V	A	0.0000
67	Q	A	-2.1190
68	W	A	-1.6050
69	Q	A	-2.0666
70	A	A	-1.4057
71	Q	A	-1.6358
72	E	A	-2.0238
73	V	A	-0.5365
74	V	A	0.0000
75	A	A	-0.6002
76	Q	A	-0.9952
77	A	A	0.0000
78	R	A	-2.3005
79	L	A	-2.0647
80	D	A	-2.3859
81	G	A	-1.8451
82	H	A	-1.7422
83	R	A	0.0000
84	S	A	0.0000
85	M	A	-0.4459
86	N	A	0.0000
87	P	A	0.0000
88	C	A	0.0000
89	P	A	0.0000
90	L	A	0.0000
91	Y	A	0.0291
92	D	A	0.0000
93	A	A	-0.7119
94	Q	A	-1.3413
95	T	A	-0.7271
96	G	A	-0.6273
97	T	A	-0.3876
98	L	A	0.0000
99	F	A	0.0000
100	L	A	0.0000
101	F	A	0.0000
102	F	A	0.0000
103	I	A	0.0000
104	A	A	0.0000
105	I	A	0.0000
106	P	A	-0.8327
107	G	A	-1.3594
108	Q	A	-1.7443
109	V	A	-0.9501
110	T	A	-1.8885
111	E	A	-2.4301
112	Q	A	-2.5069
113	Q	A	-2.1498
114	Q	A	0.0000
115	L	A	-1.9984
116	Q	A	-2.2879
117	T	A	-1.4397
118	R	A	-1.8552
119	A	A	-0.9451
120	N	A	-0.8358
121	V	A	-0.1097
122	T	A	0.0000
123	R	A	-1.2100
124	L	A	0.0000
125	C	A	0.0000
126	Q	A	0.0000
127	V	A	0.0000
128	T	A	-0.2967
129	S	A	0.0000
130	T	A	-0.6026
131	D	A	-1.0507
132	H	A	-1.0818
133	G	A	-1.2684
134	R	A	-2.0916
135	T	A	-1.1297
136	W	A	-0.6237
137	S	A	-0.4210
138	S	A	-0.8651
139	P	A	-1.4093
140	R	A	-1.5090
141	D	A	-1.7306
142	L	A	0.0000
143	T	A	0.0000
144	D	A	-2.0285
145	A	A	-1.0162
146	A	A	0.0000
147	I	A	0.0000
148	G	A	-1.2855
149	P	A	-1.0555
150	A	A	0.0000
151	Y	A	-1.5193
152	R	A	-2.4367
153	E	A	-1.9630
154	W	A	0.0000
155	S	A	0.0000
156	T	A	0.0000
157	F	A	0.0000
158	A	A	0.0000
159	V	A	0.0000
160	G	A	0.0000
161	P	A	0.0000
162	G	A	0.0000
163	H	A	0.0000
164	C	A	0.0000
165	L	A	0.0078
166	Q	A	0.0000
167	L	A	0.0000
168	N	A	-2.0796
169	D	A	-2.0995
170	R	A	-2.4647
171	A	A	-1.8833
172	R	A	-1.9752
173	S	A	0.0000
174	L	A	0.0000
175	V	A	0.0000
176	V	A	0.0000
177	P	A	0.0000
178	A	A	0.0000
179	Y	A	0.0000
180	A	A	0.0000
181	Y	A	0.0000
182	R	A	-1.3783
183	K	A	-1.3663
184	L	A	0.1676
185	H	A	-1.0944
186	P	A	-1.4548
187	K	A	-2.5005
188	Q	A	-2.1813
189	R	A	-2.3496
190	P	A	0.0000
191	I	A	-0.5845
192	P	A	0.0000
193	S	A	0.0000
194	A	A	0.0000
195	F	A	0.0000
196	C	A	0.0000
197	F	A	0.0000
198	L	A	0.0000
199	S	A	0.0000
200	H	A	-1.6322
201	D	A	-1.5287
202	H	A	-1.4896
203	G	A	0.0000
204	R	A	-2.1860
205	T	A	-1.2048
206	W	A	0.0000
207	A	A	-0.4456
208	R	A	-0.7507
209	G	A	0.0000
210	H	A	-1.0212
211	F	A	-0.4123
212	V	A	-0.7593
213	A	A	-0.9348
214	Q	A	-1.2688
215	D	A	-1.0011
216	T	A	0.0000
217	L	A	0.0000
218	E	A	0.0000
219	C	A	0.0000
220	Q	A	0.0000
221	V	A	0.0000
222	A	A	0.0000
223	E	A	-0.9394
224	V	A	0.0000
225	E	A	-2.4052
229	Q	A	-1.9994
230	R	A	-2.1314
231	V	A	0.0000
232	V	A	0.0000
233	T	A	0.0000
234	L	A	0.0000
235	N	A	0.0000
236	A	A	0.0000
237	R	A	-0.7332
238	S	A	0.0000
239	H	A	-1.8388
240	L	A	-1.2562
241	R	A	-2.0963
242	A	A	0.0000
243	R	A	0.0000
244	V	A	0.0000
245	Q	A	0.0000
246	A	A	0.0000
247	Q	A	-1.5422
248	S	A	0.0000
249	T	A	-1.4010
250	N	A	-1.2314
251	D	A	-1.0095
252	G	A	0.0000
253	L	A	-0.7675
254	D	A	-1.5509
255	F	A	-1.5798
256	Q	A	-2.3287
257	E	A	-2.8285
258	S	A	-1.6927
259	Q	A	-1.5725
260	L	A	-0.7310
261	V	A	0.0000
262	K	A	-2.7207
263	K	A	-2.6426
264	L	A	0.0000
265	V	A	-0.9296
266	E	A	0.0000
267	P	A	0.0000
268	P	A	-1.0439
269	P	A	-1.1762
270	Q	A	-1.7734
271	G	A	0.0000
272	C	A	0.0000
273	Q	A	0.0000
274	G	A	0.0000
275	S	A	0.0000
276	V	A	0.0000
277	I	A	0.0000
278	S	A	-0.2517
279	F	A	0.0000
280	P	A	-0.7488
281	S	A	-1.1513
282	P	A	-1.1282
283	R	A	-1.9370
288	S	A	-1.1180
289	P	A	-1.3916
290	A	A	-1.2249
291	Q	A	-1.4039
292	W	A	0.0000
293	L	A	0.0000
294	L	A	0.0000
295	Y	A	0.0000
296	T	A	0.0000
297	H	A	0.0000
298	P	A	0.0000
299	T	A	-0.6643
300	H	A	-0.8186
301	S	A	-0.5728
302	W	A	0.0471
303	Q	A	-1.1693
304	R	A	-1.4317
305	A	A	-1.6269
306	D	A	-1.4133
307	L	A	0.0000
308	G	A	0.0000
309	A	A	0.0000
310	Y	A	0.0000
311	L	A	0.0000
312	N	A	0.0000
313	P	A	-1.3299
314	R	A	-2.1870
315	P	A	0.0000
316	P	A	-1.0857
317	A	A	-1.2122
318	P	A	-1.7210
319	E	A	-2.5397
320	A	A	-1.7675
321	W	A	0.0000
322	S	A	-1.4316
323	E	A	-2.0846
324	P	A	-0.9225
325	V	A	0.0506
326	L	A	0.2858
327	L	A	0.0000
328	A	A	0.0000
329	K	A	-1.8652
330	G	A	-1.9877
331	S	A	-2.1355
332	C	A	0.0000
333	A	A	0.0000
334	Y	A	0.0000
335	S	A	0.0000
336	D	A	0.0000
337	L	A	0.0000
338	Q	A	-0.1798
339	S	A	-0.3200
340	M	A	0.0000
341	G	A	-0.8014
342	T	A	-0.6748
343	G	A	0.0000
344	P	A	-0.8288
345	D	A	-1.5344
346	G	A	-1.2327
347	S	A	0.0000
348	P	A	-0.7485
349	L	A	0.0000
350	F	A	0.0000
351	G	A	0.0000
352	C	A	0.0000
353	L	A	0.0000
354	Y	A	0.0000
355	E	A	0.0000
356	A	A	0.0000
357	N	A	-2.9451
358	D	A	-3.0084
359	Y	A	-2.2207
360	E	A	-3.0820
361	E	A	-2.3144
362	I	A	0.0000
363	V	A	0.0000
364	F	A	0.0000
365	L	A	0.0000
366	M	A	0.0000
367	F	A	0.0000
368	T	A	0.0000
369	L	A	0.0000
370	K	A	-1.2980
371	Q	A	-0.8423
372	A	A	0.0000
373	F	A	-0.2418
374	P	A	-0.3597
375	A	A	-0.0470
376	E	A	-0.3787
377	Y	A	0.5495