Chain sequence(s) |
A: EVHVLCLGLDNSGKTTIIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLEENIKDKPWHICASDAIIKGEGLQEGVDWLQDQI C: EVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIIKGEGLQEGVDWLQDQIQ B: KEVHVVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVVAKEELDTLLNHPDIKHRRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQIQ |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
17 | E | A | -2.0434 | |
18 | V | A | 0.0000 | |
19 | H | A | -1.6733 | |
20 | V | A | 0.0000 | |
21 | L | A | 0.0000 | |
22 | C | A | 0.0000 | |
23 | L | A | 0.0000 | |
24 | G | A | 0.0000 | |
25 | L | A | 0.0000 | |
26 | D | A | 0.0000 | |
27 | N | A | -0.8744 | |
28 | S | A | 0.0000 | |
29 | G | A | -0.0735 | |
30 | K | A | 0.0000 | |
31 | T | A | -0.0884 | |
32 | T | A | -0.0889 | |
33 | I | A | 0.0000 | |
34 | I | A | 0.0000 | |
35 | N | A | -0.9487 | |
36 | K | A | -0.8175 | |
37 | L | A | -1.1400 | |
38 | K | A | -1.7604 | |
39 | P | A | -1.5487 | |
40 | S | A | -1.2842 | |
41 | N | A | -1.6558 | |
42 | A | A | -1.4827 | |
43 | Q | A | -1.7119 | |
44 | S | A | -1.6135 | |
45 | Q | A | -1.9016 | |
46 | N | A | -1.6532 | |
47 | I | A | -0.4413 | |
48 | L | A | 0.5910 | |
49 | P | A | 0.8185 | |
50 | T | A | 1.2093 | |
51 | I | A | 2.1260 | |
52 | G | A | 0.0000 | |
53 | F | A | 1.4542 | |
54 | S | A | 1.2056 | |
55 | I | A | 1.1289 | |
56 | E | A | -0.5386 | |
57 | K | A | -2.0651 | |
58 | F | A | 0.0000 | |
59 | K | A | -2.2711 | |
60 | S | A | -1.4404 | |
61 | S | A | -0.9442 | |
62 | S | A | -0.7353 | |
63 | L | A | 0.0000 | |
64 | S | A | -1.7965 | |
65 | F | A | 0.0000 | |
66 | T | A | 0.0000 | |
67 | V | A | 0.0000 | |
68 | F | A | 0.0000 | |
69 | D | A | 0.0000 | |
70 | M | A | 0.0000 | |
71 | S | A | 0.0000 | |
72 | G | A | 0.0000 | |
73 | Q | A | 0.0000 | |
74 | G | A | -0.9639 | |
75 | R | A | -1.1117 | |
76 | Y | A | -0.4493 | |
77 | R | A | -1.1415 | |
78 | N | A | -1.8495 | |
79 | L | A | -1.0128 | |
80 | W | A | 0.0000 | |
81 | E | A | -2.6522 | |
82 | H | A | -2.2186 | |
83 | Y | A | -1.5612 | |
84 | Y | A | 0.0000 | |
85 | K | A | -2.9366 | |
86 | E | A | -2.3064 | |
87 | G | A | 0.0000 | |
88 | Q | A | -1.9054 | |
89 | A | A | 0.0000 | |
90 | I | A | 0.0000 | |
91 | I | A | 0.0000 | |
92 | F | A | 0.0000 | |
93 | V | A | 0.0000 | |
94 | I | A | 0.0000 | |
95 | D | A | -0.7539 | |
96 | S | A | 0.0000 | |
97 | S | A | -1.8017 | |
98 | D | A | -1.4524 | |
99 | R | A | -1.7547 | |
100 | L | A | -0.2382 | |
101 | R | A | 0.0000 | |
102 | M | A | 0.0000 | |
103 | V | A | 0.5156 | |
104 | V | A | 0.0000 | |
105 | A | A | 0.0000 | |
106 | K | A | -1.6122 | |
107 | E | A | -2.3797 | |
108 | E | A | -1.8725 | |
109 | L | A | 0.0000 | |
110 | D | A | -2.8274 | |
111 | T | A | -2.0835 | |
112 | L | A | 0.0000 | |
113 | L | A | -1.7789 | |
114 | N | A | -2.4270 | |
115 | H | A | -2.0931 | |
116 | P | A | -2.0191 | |
117 | D | A | -2.6567 | |
118 | I | A | 0.0000 | |
119 | K | A | -3.4609 | |
120 | H | A | -3.0620 | |
121 | R | A | -3.0090 | |
122 | R | A | -3.3054 | |
123 | I | A | 0.0000 | |
124 | P | A | 0.0000 | |
125 | I | A | 0.0000 | |
126 | L | A | 0.0000 | |
127 | F | A | 0.0000 | |
128 | F | A | 0.0000 | |
129 | A | A | 0.0000 | |
130 | N | A | 0.0000 | |
131 | K | A | -1.0130 | |
132 | M | A | -1.3523 | |
133 | D | A | -2.3135 | |
134 | L | A | -1.8225 | |
135 | R | A | -3.1060 | |
136 | D | A | -3.0196 | |
137 | A | A | -2.0644 | |
138 | V | A | -1.1577 | |
139 | T | A | 0.0000 | |
140 | S | A | 0.0000 | |
141 | V | A | -0.3877 | |
142 | K | A | -0.6306 | |
143 | V | A | 0.0000 | |
144 | S | A | -0.8431 | |
145 | Q | A | -1.4255 | |
146 | L | A | -0.3228 | |
147 | L | A | 0.0000 | |
148 | C | A | -1.1719 | |
149 | L | A | 0.0000 | |
150 | E | A | -2.6147 | |
151 | N | A | -2.7138 | |
152 | I | A | -2.2866 | |
153 | K | A | -3.3376 | |
154 | D | A | -3.6241 | |
155 | K | A | 0.0000 | |
156 | P | A | -1.1322 | |
157 | W | A | -0.6292 | |
158 | H | A | -0.0559 | |
159 | I | A | 0.1521 | |
160 | C | A | 0.0000 | |
161 | A | A | -0.2980 | |
162 | S | A | 0.0000 | |
163 | D | A | -0.7026 | |
164 | A | A | 0.0000 | |
165 | I | A | 0.6596 | |
166 | K | A | -1.2307 | |
167 | G | A | -0.8315 | |
168 | E | A | -0.9245 | |
169 | G | A | -0.7839 | |
170 | L | A | 0.0000 | |
171 | Q | A | -1.4623 | |
172 | E | A | -1.6261 | |
173 | G | A | 0.0000 | |
174 | V | A | 0.0000 | |
175 | D | A | -2.3648 | |
176 | W | A | -1.3906 | |
177 | L | A | 0.0000 | |
178 | Q | A | -1.2264 | |
179 | D | A | -1.8747 | |
180 | Q | A | -0.8048 | |
181 | I | A | 0.8090 | |
16 | K | B | -2.9654 | |
17 | E | B | -3.1056 | |
18 | V | B | 0.0000 | |
19 | H | B | -1.1585 | |
20 | V | B | 0.0000 | |
21 | L | B | 0.0000 | |
22 | C | B | 0.0000 | |
23 | L | B | 0.0000 | |
24 | G | B | 0.0000 | |
25 | L | B | 0.0000 | |
26 | D | B | -1.2313 | |
27 | N | B | -1.4284 | |
28 | S | B | 0.0000 | |
29 | G | B | -0.3450 | |
30 | K | B | 0.0000 | |
31 | T | B | 0.0198 | |
32 | T | B | 0.1156 | |
33 | I | B | 0.0000 | |
34 | I | B | 0.0000 | |
35 | N | B | 0.0000 | |
36 | K | B | -0.6796 | |
37 | L | B | -0.9867 | |
38 | K | B | -1.4491 | |
39 | P | B | -1.2051 | |
40 | S | B | -1.2748 | |
41 | N | B | -1.5740 | |
42 | A | B | -1.2868 | |
43 | Q | B | -1.3517 | |
44 | S | B | -1.1830 | |
45 | Q | B | -1.6320 | |
46 | N | B | -1.2408 | |
47 | I | B | 0.3211 | |
48 | L | B | 1.3962 | |
49 | P | B | 0.8161 | |
50 | T | B | 1.2538 | |
51 | I | B | 2.1001 | |
52 | G | B | 0.8165 | |
53 | F | B | 1.4151 | |
54 | S | B | 1.0032 | |
55 | I | B | 1.0030 | |
56 | E | B | -0.4315 | |
57 | K | B | -2.1365 | |
58 | F | B | 0.0000 | |
59 | K | B | -2.6509 | |
60 | S | B | -1.3522 | |
61 | S | B | -0.9126 | |
62 | S | B | -1.5932 | |
63 | L | B | 0.0000 | |
64 | S | B | -2.4290 | |
65 | F | B | 0.0000 | |
66 | T | B | 0.0000 | |
67 | V | B | 0.0000 | |
68 | F | B | 0.0000 | |
69 | D | B | 0.0000 | |
70 | M | B | 0.0000 | |
71 | S | B | 0.0000 | |
72 | G | B | 0.0000 | |
73 | Q | B | -1.3101 | |
74 | G | B | -1.7704 | |
75 | R | B | -2.1039 | |
76 | Y | B | -0.8826 | |
77 | R | B | -1.7241 | |
78 | N | B | -2.1196 | |
79 | L | B | -1.1123 | |
80 | W | B | 0.0000 | |
81 | E | B | -2.4335 | |
82 | H | B | -2.1508 | |
83 | Y | B | -1.5884 | |
84 | Y | B | 0.0000 | |
85 | K | B | -2.8560 | |
86 | E | B | -2.4004 | |
87 | G | B | 0.0000 | |
88 | Q | B | -1.6489 | |
89 | A | B | 0.0000 | |
90 | I | B | 0.0000 | |
91 | I | B | 0.0000 | |
92 | F | B | 0.0000 | |
93 | V | B | 0.0000 | |
94 | I | B | 0.0000 | |
95 | D | B | -1.0758 | |
96 | S | B | 0.0000 | |
97 | S | B | -1.8154 | |
98 | D | B | -1.4056 | |
99 | R | B | -1.1784 | |
100 | L | B | 0.8907 | |
101 | R | B | 0.2422 | |
102 | M | B | 0.0000 | |
103 | V | B | 1.5946 | |
104 | V | B | 0.6390 | |
105 | A | B | 0.0000 | |
106 | K | B | -0.5060 | |
107 | E | B | -1.7310 | |
108 | E | B | -1.2998 | |
109 | L | B | 0.0000 | |
110 | D | B | -1.7850 | |
111 | T | B | -1.6512 | |
112 | L | B | 0.0000 | |
113 | L | B | -1.6573 | |
114 | N | B | -2.3153 | |
115 | H | B | -1.8468 | |
116 | P | B | -1.8456 | |
117 | D | B | -2.2669 | |
118 | I | B | 0.0000 | |
119 | K | B | -3.3836 | |
120 | H | B | -2.9616 | |
121 | R | B | -2.9059 | |
122 | R | B | -3.2508 | |
123 | I | B | 0.0000 | |
124 | P | B | 0.0000 | |
125 | I | B | 0.0000 | |
126 | L | B | 0.0000 | |
127 | F | B | 0.0000 | |
128 | F | B | 0.0000 | |
129 | A | B | 0.0000 | |
130 | N | B | 0.0000 | |
131 | K | B | -1.0214 | |
132 | M | B | -1.4155 | |
133 | D | B | -2.2683 | |
134 | L | B | -1.8538 | |
135 | R | B | -2.8834 | |
136 | D | B | -3.1321 | |
137 | A | B | -2.1103 | |
138 | V | B | 0.0000 | |
139 | T | B | -0.4911 | |
140 | S | B | 0.0000 | |
141 | V | B | 0.5506 | |
142 | K | B | -0.6415 | |
143 | V | B | 0.0000 | |
144 | S | B | 0.0000 | |
145 | Q | B | -1.1971 | |
146 | L | B | 0.2982 | |
147 | L | B | 0.0000 | |
148 | C | B | -1.0956 | |
149 | L | B | 0.0000 | |
150 | E | B | -2.8286 | |
151 | N | B | -2.8051 | |
152 | I | B | -2.2758 | |
153 | K | B | -3.3808 | |
154 | D | B | -3.5861 | |
155 | K | B | 0.0000 | |
156 | P | B | -1.1317 | |
157 | W | B | -0.6464 | |
158 | H | B | 0.1379 | |
159 | I | B | 0.4966 | |
160 | C | B | 0.0000 | |
161 | A | B | -0.1612 | |
162 | S | B | 0.0000 | |
163 | D | B | 0.0000 | |
164 | A | B | 0.0000 | |
165 | I | B | 0.6459 | |
166 | K | B | -1.5158 | |
167 | G | B | -1.3651 | |
168 | E | B | -1.9668 | |
169 | G | B | -1.1864 | |
170 | L | B | 0.0000 | |
171 | Q | B | -1.1071 | |
172 | E | B | 0.0000 | |
173 | G | B | 0.0000 | |
174 | V | B | 0.0000 | |
175 | D | B | 0.0000 | |
176 | W | B | -0.6477 | |
177 | L | B | 0.0000 | |
178 | Q | B | 0.0000 | |
179 | D | B | -2.2918 | |
180 | Q | B | -1.6313 | |
181 | I | B | -1.1683 | |
182 | Q | B | -1.9987 | |
17 | E | C | -2.0774 | |
18 | V | C | 0.0000 | |
19 | H | C | -1.6626 | |
20 | V | C | 0.0000 | |
21 | L | C | 0.0000 | |
22 | C | C | 0.0000 | |
23 | L | C | 0.0000 | |
24 | G | C | 0.0000 | |
25 | L | C | 0.0000 | |
26 | D | C | 0.0000 | |
27 | N | C | -0.8232 | |
28 | S | C | 0.0000 | |
29 | G | C | -0.0067 | |
30 | K | C | 0.0000 | |
31 | T | C | -0.0594 | |
32 | T | C | 0.0142 | |
33 | I | C | 0.0000 | |
34 | I | C | 0.0000 | |
35 | N | C | 0.0000 | |
36 | K | C | -0.6408 | |
37 | L | C | -1.0125 | |
38 | K | C | -1.4858 | |
39 | P | C | -1.2037 | |
40 | S | C | -1.2016 | |
41 | N | C | -1.6013 | |
42 | A | C | -1.3583 | |
43 | Q | C | -1.5102 | |
44 | S | C | -1.4622 | |
45 | Q | C | -1.7999 | |
46 | N | C | -1.5672 | |
47 | I | C | -0.2954 | |
48 | L | C | 0.6899 | |
49 | P | C | 0.6669 | |
50 | T | C | 0.9390 | |
51 | I | C | 1.4776 | |
52 | G | C | 0.6545 | |
53 | F | C | 1.2200 | |
54 | S | C | 0.9876 | |
55 | I | C | 0.8935 | |
56 | E | C | -0.5024 | |
57 | K | C | -1.9808 | |
58 | F | C | 0.0000 | |
59 | K | C | -2.4128 | |
60 | S | C | -1.5359 | |
61 | S | C | -1.0283 | |
62 | S | C | -1.1936 | |
63 | L | C | 0.0000 | |
64 | S | C | -1.8003 | |
65 | F | C | 0.0000 | |
66 | T | C | -1.1450 | |
67 | V | C | 0.0000 | |
68 | F | C | 0.0000 | |
69 | D | C | 0.0000 | |
70 | M | C | 0.0000 | |
71 | S | C | 0.0000 | |
72 | G | C | 0.0000 | |
73 | Q | C | 0.0000 | |
74 | G | C | -0.9076 | |
75 | R | C | -1.1057 | |
76 | Y | C | -0.4512 | |
77 | R | C | -1.2170 | |
78 | N | C | -1.8569 | |
79 | L | C | -1.0336 | |
80 | W | C | 0.0000 | |
81 | E | C | -2.7418 | |
82 | H | C | -2.3498 | |
83 | Y | C | -1.9010 | |
84 | Y | C | 0.0000 | |
85 | K | C | -3.2300 | |
86 | E | C | -3.0320 | |
87 | G | C | 0.0000 | |
88 | Q | C | -1.8058 | |
89 | A | C | 0.0000 | |
90 | I | C | 0.0000 | |
91 | I | C | 0.0000 | |
92 | F | C | 0.0000 | |
93 | V | C | 0.0000 | |
94 | I | C | 0.0000 | |
95 | D | C | -0.6785 | |
96 | S | C | 0.0000 | |
97 | S | C | -1.9039 | |
98 | D | C | -1.4777 | |
99 | R | C | -1.8636 | |
100 | L | C | -0.3206 | |
101 | R | C | 0.0000 | |
102 | M | C | 0.0000 | |
103 | V | C | 0.6587 | |
104 | V | C | 0.0000 | |
105 | A | C | 0.0000 | |
106 | K | C | -1.2460 | |
107 | E | C | -2.1038 | |
108 | E | C | -1.5978 | |
109 | L | C | 0.0000 | |
110 | D | C | -2.7736 | |
111 | T | C | -2.0019 | |
112 | L | C | 0.0000 | |
113 | L | C | -1.7529 | |
114 | N | C | -2.4310 | |
115 | H | C | -1.9510 | |
116 | P | C | -1.7908 | |
117 | D | C | -2.2791 | |
118 | I | C | 0.0000 | |
119 | K | C | -3.0616 | |
120 | H | C | -2.8408 | |
121 | R | C | -2.9503 | |
122 | R | C | -3.3342 | |
123 | I | C | 0.0000 | |
124 | P | C | 0.0000 | |
125 | I | C | 0.0000 | |
126 | L | C | 0.0000 | |
127 | F | C | 0.0000 | |
128 | F | C | 0.0000 | |
129 | A | C | 0.0000 | |
130 | N | C | 0.0000 | |
131 | K | C | -0.9846 | |
132 | M | C | -1.2826 | |
133 | D | C | -2.2450 | |
134 | L | C | -1.7505 | |
135 | R | C | -2.8017 | |
136 | D | C | -3.0818 | |
137 | A | C | -1.9865 | |
138 | V | C | -0.9339 | |
139 | T | C | 0.0403 | |
140 | S | C | 0.5080 | |
141 | V | C | 1.1178 | |
142 | K | C | -0.3089 | |
143 | V | C | 0.0000 | |
144 | S | C | 0.0000 | |
145 | Q | C | -1.0608 | |
146 | L | C | -0.1819 | |
147 | L | C | 0.0000 | |
148 | C | C | -1.2714 | |
149 | L | C | 0.0000 | |
150 | E | C | -2.7886 | |
151 | N | C | -2.7240 | |
152 | I | C | -2.4238 | |
153 | K | C | -3.4566 | |
154 | D | C | -3.6442 | |
155 | K | C | -2.5821 | |
156 | P | C | -1.1624 | |
157 | W | C | -0.5077 | |
158 | H | C | -0.1525 | |
159 | I | C | 0.2862 | |
160 | C | C | 0.0000 | |
161 | A | C | -0.3786 | |
162 | S | C | 0.0000 | |
163 | D | C | 0.0000 | |
164 | A | C | 0.0000 | |
165 | I | C | 0.5136 | |
166 | K | C | -1.5939 | |
167 | G | C | 0.0000 | |
168 | E | C | -2.6632 | |
169 | G | C | -1.9742 | |
170 | L | C | 0.0000 | |
171 | Q | C | -2.8696 | |
172 | E | C | -3.2074 | |
173 | G | C | 0.0000 | |
174 | V | C | 0.0000 | |
175 | D | C | -3.3118 | |
176 | W | C | -2.0499 | |
177 | L | C | 0.0000 | |
178 | Q | C | -2.1334 | |
179 | D | C | -2.7525 | |
180 | Q | C | -1.7295 | |
181 | I | C | -1.0159 | |
182 | Q | C | -1.7381 |