| Chain sequence(s) |
A: ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP C: IKIKKIEDASNPLLLKRRKKARAL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | E | A | -2.6325 | |
| 5 | R | A | -2.7712 | |
| 6 | P | A | -1.7180 | |
| 7 | T | A | -1.0779 | |
| 8 | F | A | -0.9837 | |
| 9 | Y | A | -1.2055 | |
| 10 | R | A | -2.2923 | |
| 11 | Q | A | -2.0862 | |
| 12 | E | A | -2.6692 | |
| 13 | L | A | -1.8653 | |
| 14 | N | A | -2.3562 | |
| 15 | K | A | -2.5913 | |
| 16 | T | A | -1.4649 | |
| 17 | I | A | -0.9410 | |
| 18 | W | A | 0.0000 | |
| 19 | E | A | -1.3212 | |
| 20 | V | A | 0.0000 | |
| 21 | P | A | 0.0000 | |
| 22 | E | A | -2.3188 | |
| 23 | R | A | -1.5877 | |
| 24 | Y | A | 0.0000 | |
| 25 | Q | A | -1.3136 | |
| 26 | N | A | -1.2494 | |
| 27 | L | A | 0.0000 | |
| 28 | S | A | -0.0704 | |
| 29 | P | A | 0.2568 | |
| 30 | V | A | 1.5271 | |
| 31 | G | A | 0.3403 | |
| 32 | S | A | -0.1926 | |
| 33 | G | A | -0.5220 | |
| 34 | A | A | -0.3688 | |
| 35 | Y | A | -0.3432 | |
| 36 | G | A | -0.5707 | |
| 37 | S | A | -0.0171 | |
| 38 | V | A | 0.4521 | |
| 39 | C | A | 0.0000 | |
| 40 | A | A | 0.0908 | |
| 41 | A | A | 0.0000 | |
| 42 | F | A | -0.3353 | |
| 43 | D | A | 0.0000 | |
| 44 | T | A | -1.3189 | |
| 45 | K | A | -1.9460 | |
| 46 | T | A | -1.1012 | |
| 47 | G | A | -0.9358 | |
| 48 | L | A | -0.5285 | |
| 49 | R | A | -0.9744 | |
| 50 | V | A | 0.0000 | |
| 51 | A | A | 0.2117 | |
| 52 | V | A | 0.0000 | |
| 53 | K | A | -0.0682 | |
| 54 | K | A | 0.0000 | |
| 55 | L | A | 0.0000 | |
| 56 | S | A | -1.3675 | |
| 57 | R | A | -2.4637 | |
| 58 | P | A | 0.0000 | |
| 59 | F | A | -1.0518 | |
| 60 | Q | A | -1.0617 | |
| 61 | S | A | 0.4507 | |
| 62 | I | A | 1.7514 | |
| 63 | I | A | 1.9728 | |
| 64 | H | A | 0.3447 | |
| 65 | A | A | 0.0000 | |
| 66 | K | A | 0.1603 | |
| 67 | R | A | -0.2741 | |
| 68 | T | A | 0.0000 | |
| 69 | Y | A | 0.0000 | |
| 70 | R | A | 0.0000 | |
| 71 | E | A | 0.0000 | |
| 72 | L | A | 0.0000 | |
| 73 | R | A | -0.6965 | |
| 74 | L | A | 0.0000 | |
| 75 | L | A | -0.5571 | |
| 76 | K | A | -0.5043 | |
| 77 | H | A | -1.2424 | |
| 78 | M | A | 0.0000 | |
| 79 | K | A | -2.2788 | |
| 80 | H | A | -1.6848 | |
| 81 | E | A | -2.4178 | |
| 82 | N | A | 0.0000 | |
| 83 | V | A | 0.0000 | |
| 84 | I | A | 0.0000 | |
| 85 | G | A | -0.9411 | |
| 86 | L | A | 0.0000 | |
| 87 | L | A | 0.0922 | |
| 88 | D | A | 0.0680 | |
| 89 | V | A | 0.0000 | |
| 90 | F | A | 0.0000 | |
| 91 | T | A | 0.0000 | |
| 92 | P | A | -1.3851 | |
| 93 | A | A | 0.0000 | |
| 94 | R | A | -2.6734 | |
| 95 | S | A | -1.9591 | |
| 96 | L | A | -1.9227 | |
| 97 | E | A | -2.9342 | |
| 98 | E | A | -3.3382 | |
| 99 | F | A | 0.0000 | |
| 100 | N | A | -2.4284 | |
| 101 | D | A | -1.5805 | |
| 102 | V | A | 0.0000 | |
| 103 | Y | A | 0.0000 | |
| 104 | L | A | 0.0000 | |
| 105 | V | A | 0.0000 | |
| 106 | T | A | -0.1624 | |
| 107 | H | A | -0.2176 | |
| 108 | L | A | -0.0620 | |
| 109 | M | A | 0.0000 | |
| 110 | G | A | -0.9027 | |
| 111 | A | A | -0.7485 | |
| 112 | D | A | -0.8814 | |
| 113 | L | A | 0.0000 | |
| 114 | N | A | -1.4319 | |
| 115 | N | A | -1.8956 | |
| 116 | I | A | 0.0000 | |
| 117 | V | A | -1.2894 | |
| 118 | K | A | -1.9858 | |
| 119 | C | A | -1.2181 | |
| 120 | Q | A | -1.5493 | |
| 121 | K | A | -2.1471 | |
| 122 | L | A | 0.0000 | |
| 123 | T | A | -1.2899 | |
| 124 | D | A | -1.4383 | |
| 125 | D | A | -1.8782 | |
| 126 | H | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | Q | A | -0.8475 | |
| 129 | F | A | 0.0000 | |
| 130 | L | A | 0.0000 | |
| 131 | I | A | 0.0000 | |
| 132 | Y | A | 0.0000 | |
| 133 | Q | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | R | A | 0.0000 | |
| 137 | G | A | 0.0000 | |
| 138 | L | A | 0.0000 | |
| 139 | K | A | -0.3404 | |
| 140 | Y | A | 0.0000 | |
| 141 | I | A | 0.0000 | |
| 142 | H | A | -0.6813 | |
| 143 | S | A | -0.6194 | |
| 144 | A | A | 0.0000 | |
| 145 | D | A | -2.1607 | |
| 146 | I | A | 0.0000 | |
| 147 | I | A | -0.3278 | |
| 148 | H | A | 0.0000 | |
| 149 | R | A | -0.7021 | |
| 150 | D | A | -0.8930 | |
| 151 | L | A | 0.0000 | |
| 152 | K | A | -0.8795 | |
| 153 | P | A | 0.0000 | |
| 154 | S | A | -0.9264 | |
| 155 | N | A | 0.0000 | |
| 156 | L | A | 0.0000 | |
| 157 | A | A | 0.0000 | |
| 158 | V | A | 0.0000 | |
| 159 | N | A | -1.4815 | |
| 160 | E | A | -2.6762 | |
| 161 | D | A | -2.6592 | |
| 162 | C | A | 0.0000 | |
| 163 | E | A | -1.3353 | |
| 164 | L | A | 0.0000 | |
| 165 | K | A | -0.8456 | |
| 166 | I | A | 0.0000 | |
| 167 | L | A | -0.8460 | |
| 168 | D | A | -1.7443 | |
| 169 | F | A | 0.0000 | |
| 170 | G | A | 0.0000 | |
| 171 | L | A | -0.6997 | |
| 172 | A | A | -0.7089 | |
| 173 | R | A | -1.7073 | |
| 184 | A | A | -0.3725 | |
| 185 | T | A | -0.7120 | |
| 186 | R | A | -1.5482 | |
| 187 | W | A | -0.6389 | |
| 188 | Y | A | 0.0000 | |
| 189 | R | A | -0.7096 | |
| 190 | A | A | 0.0000 | |
| 191 | P | A | 0.0000 | |
| 192 | E | A | 0.0000 | |
| 193 | I | A | 0.0000 | |
| 194 | M | A | 0.0000 | |
| 195 | L | A | 0.0287 | |
| 196 | N | A | -1.1261 | |
| 197 | W | A | 0.0000 | |
| 198 | M | A | -0.9841 | |
| 199 | H | A | -1.2155 | |
| 200 | Y | A | -0.5537 | |
| 201 | N | A | -0.9737 | |
| 202 | Q | A | -0.9331 | |
| 203 | T | A | 0.0000 | |
| 204 | V | A | 0.0000 | |
| 205 | D | A | 0.0000 | |
| 206 | I | A | 0.0000 | |
| 207 | W | A | 0.0000 | |
| 208 | S | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | G | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | I | A | 0.0000 | |
| 213 | M | A | 0.0000 | |
| 214 | A | A | 0.0000 | |
| 215 | E | A | -0.8084 | |
| 216 | L | A | 0.0000 | |
| 217 | L | A | -0.7113 | |
| 218 | T | A | -0.5220 | |
| 219 | G | A | -1.6831 | |
| 220 | R | A | -2.0841 | |
| 221 | T | A | -0.9647 | |
| 222 | L | A | -0.3311 | |
| 223 | F | A | 0.0000 | |
| 224 | P | A | -0.7016 | |
| 225 | G | A | -0.7905 | |
| 226 | T | A | -0.9968 | |
| 227 | D | A | -1.6490 | |
| 228 | H | A | -0.6756 | |
| 229 | I | A | 0.3793 | |
| 230 | D | A | -0.9240 | |
| 231 | Q | A | 0.0000 | |
| 232 | L | A | 0.0000 | |
| 233 | K | A | -1.0523 | |
| 234 | L | A | -0.6190 | |
| 235 | I | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | R | A | -2.3181 | |
| 238 | L | A | 0.0000 | |
| 239 | V | A | 0.0000 | |
| 240 | G | A | 0.0000 | |
| 241 | T | A | -1.2965 | |
| 242 | P | A | 0.0000 | |
| 243 | G | A | -1.3414 | |
| 244 | A | A | -1.7169 | |
| 245 | E | A | -2.7572 | |
| 246 | L | A | 0.0000 | |
| 247 | L | A | 0.0000 | |
| 248 | K | A | -3.1238 | |
| 249 | K | A | -3.0414 | |
| 250 | I | A | 0.0000 | |
| 251 | S | A | -1.8131 | |
| 252 | S | A | -1.8025 | |
| 253 | E | A | -2.5745 | |
| 254 | S | A | -1.8871 | |
| 255 | A | A | -1.6510 | |
| 256 | R | A | -2.8048 | |
| 257 | N | A | -2.4849 | |
| 258 | Y | A | -1.2405 | |
| 259 | I | A | 0.0000 | |
| 260 | Q | A | -2.0044 | |
| 261 | S | A | -1.1944 | |
| 262 | L | A | -0.8178 | |
| 263 | T | A | -0.7934 | |
| 264 | Q | A | -1.7975 | |
| 265 | M | A | -1.4241 | |
| 266 | P | A | -1.6542 | |
| 267 | K | A | -2.2754 | |
| 268 | M | A | -1.5054 | |
| 269 | N | A | -1.7346 | |
| 270 | F | A | 0.0000 | |
| 271 | A | A | -0.4866 | |
| 272 | N | A | -0.6433 | |
| 273 | V | A | 0.3713 | |
| 274 | F | A | 0.0000 | |
| 275 | I | A | 1.5155 | |
| 276 | G | A | 0.3515 | |
| 277 | A | A | 0.2965 | |
| 278 | N | A | -0.3411 | |
| 279 | P | A | -0.1946 | |
| 280 | L | A | -0.0394 | |
| 281 | A | A | 0.0000 | |
| 282 | V | A | 0.0000 | |
| 283 | D | A | -1.5243 | |
| 284 | L | A | 0.0000 | |
| 285 | L | A | 0.0000 | |
| 286 | E | A | -1.4183 | |
| 287 | K | A | -1.6132 | |
| 288 | M | A | 0.0000 | |
| 289 | L | A | 0.0000 | |
| 290 | V | A | -0.7486 | |
| 291 | L | A | -0.5892 | |
| 292 | D | A | -1.5768 | |
| 293 | S | A | 0.0000 | |
| 294 | D | A | -2.5303 | |
| 295 | K | A | -2.5261 | |
| 296 | R | A | 0.0000 | |
| 297 | I | A | 0.0000 | |
| 298 | T | A | -1.0711 | |
| 299 | A | A | 0.0000 | |
| 300 | A | A | -0.5174 | |
| 301 | Q | A | -1.2325 | |
| 302 | A | A | 0.0000 | |
| 303 | L | A | 0.0000 | |
| 304 | A | A | -0.4942 | |
| 305 | H | A | -0.4977 | |
| 306 | A | A | -0.1511 | |
| 307 | Y | A | 0.0000 | |
| 308 | F | A | 0.0000 | |
| 309 | A | A | -0.6503 | |
| 310 | Q | A | -1.4432 | |
| 311 | Y | A | 0.0000 | |
| 312 | H | A | -0.9989 | |
| 313 | D | A | 0.0000 | |
| 314 | P | A | -1.3162 | |
| 315 | D | A | -2.1318 | |
| 316 | D | A | -1.2580 | |
| 317 | E | A | 0.0000 | |
| 318 | P | A | -0.2110 | |
| 319 | V | A | 0.9442 | |
| 320 | A | A | -0.7121 | |
| 321 | D | A | -1.9386 | |
| 322 | P | A | -1.7006 | |
| 323 | Y | A | -1.9473 | |
| 324 | D | A | -2.7162 | |
| 325 | Q | A | -2.3268 | |
| 326 | S | A | -1.6966 | |
| 327 | F | A | 0.0000 | |
| 328 | E | A | -2.2545 | |
| 329 | S | A | -1.9403 | |
| 330 | R | A | -2.8987 | |
| 331 | D | A | -2.3433 | |
| 332 | L | A | -0.7605 | |
| 333 | L | A | 0.5847 | |
| 334 | I | A | 0.2716 | |
| 335 | D | A | -1.3845 | |
| 336 | E | A | -1.3222 | |
| 337 | W | A | 0.0000 | |
| 338 | K | A | -1.0691 | |
| 339 | S | A | -1.2157 | |
| 340 | L | A | -0.7896 | |
| 341 | T | A | 0.0000 | |
| 342 | Y | A | -0.3937 | |
| 343 | D | A | -0.9686 | |
| 344 | E | A | -0.2141 | |
| 345 | V | A | 0.6917 | |
| 346 | I | A | 1.6787 | |
| 347 | S | A | 0.7697 | |
| 348 | F | A | 1.1791 | |
| 349 | V | A | 1.8722 | |
| 350 | P | A | 0.4713 | |
| 351 | P | A | -0.1953 | |
| 352 | P | A | -0.1659 | |
| 1370 | I | C | -0.6471 | |
| 1371 | K | C | -2.3285 | |
| 1372 | I | C | 0.0000 | |
| 1373 | K | C | -3.6338 | |
| 1374 | K | C | -3.6475 | |
| 1375 | I | C | 0.0000 | |
| 1376 | E | C | -3.5207 | |
| 1377 | D | C | -3.7110 | |
| 1378 | A | C | 0.0000 | |
| 1379 | S | C | -1.3113 | |
| 1380 | N | C | 0.0000 | |
| 1381 | P | C | -0.3898 | |
| 1382 | L | C | 0.0000 | |
| 1383 | L | C | 0.0000 | |
| 1384 | L | C | 0.2155 | |
| 1385 | K | C | -1.1618 | |
| 1386 | R | C | 0.0000 | |
| 1387 | R | C | -1.9367 | |
| 1388 | K | C | -2.5202 | |
| 1389 | K | C | -1.8115 | |
| 1390 | A | C | -1.5465 | |
| 1391 | R | C | -2.0636 | |
| 1392 | A | C | -0.7735 | |
| 1393 | L | C | 0.5728 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine