Project name: e26f61eef8f5791

Chain sequence(s)	A: MEFGLSWLFLVAILKGVQCEVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAIIGLMVGGVVIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVICFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; C: MDMRVPAQLLGLLMLWVSGSSGDVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC; B: MEFGLSWLFLVAILKGVQCEVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAIIGLMVGGVVIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVICFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; D: MDMRVPAQLLGLLMLWVSGSSGDVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2282
• Maximal score value: 4.1943
• Average score: -0.6173
• Total score value: -876.5449

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.5333
2	E	A	-0.1416
3	F	A	1.4100
4	G	A	1.0094
5	L	A	1.8428
6	S	A	1.5420
7	W	A	2.3554
8	L	A	2.9541
9	F	A	3.7945
10	L	A	4.1943
11	V	A	3.9717
12	A	A	3.1457
13	I	A	3.4239
14	L	A	2.3990
15	K	A	0.4635
16	G	A	0.0000
17	V	A	2.7020
18	Q	A	2.5230
19	C	A	2.0111
20	E	A	0.0000
21	V	A	1.3361
22	Q	A	0.0000
23	L	A	0.0000
24	L	A	1.2128
25	E	A	-0.0866
26	S	A	-0.5147
27	G	A	-0.6004
28	G	A	-0.2199
29	G	A	-0.0853
30	L	A	0.4586
31	V	A	-0.3138
32	Q	A	-1.2102
33	P	A	-1.7688
34	G	A	-1.4566
35	G	A	-0.9786
36	S	A	-1.2443
37	L	A	-0.9459
38	R	A	-1.9614
39	L	A	0.0000
40	S	A	-0.4214
41	C	A	0.0000
42	A	A	-0.2284
43	A	A	0.0000
44	S	A	0.4196
45	G	A	0.4410
46	F	A	0.3419
47	T	A	-0.3957
48	F	A	0.0000
49	S	A	-1.5695
50	N	A	-1.1326
51	Y	A	0.0118
52	G	A	-1.0853
53	M	A	0.0000
54	S	A	-0.0723
55	W	A	0.0000
56	V	A	0.0000
57	R	A	-0.6942
58	Q	A	-1.0209
59	A	A	0.0000
60	P	A	-1.3152
61	G	A	-1.6075
62	K	A	-2.5143
63	G	A	-1.8227
64	L	A	0.0000
65	E	A	-1.6185
66	W	A	0.0000
67	V	A	0.0000
68	A	A	0.0000
69	S	A	-0.4542
70	I	A	0.0000
71	R	A	-2.8886
72	S	A	-2.4999
73	G	A	-2.1277
74	G	A	-2.1008
75	G	A	-2.5350
76	R	A	-2.7353
77	T	A	-1.2964
78	Y	A	-0.0585
79	Y	A	-0.5844
80	S	A	0.0000
81	D	A	-2.6758
82	N	A	-2.7035
83	V	A	0.0000
84	K	A	-2.6576
85	G	A	-2.0684
86	R	A	-1.8718
87	F	A	0.0000
88	T	A	-0.9359
89	I	A	0.0000
90	S	A	-1.2389
91	R	A	-2.1061
92	D	A	-2.3658
93	N	A	-2.8225
94	S	A	-2.1546
95	K	A	-2.8185
96	N	A	-2.3508
97	T	A	0.0000
98	L	A	0.0000
99	Y	A	-0.6289
100	L	A	0.0000
101	Q	A	-1.3075
102	M	A	0.0000
103	N	A	-1.4359
104	S	A	-1.2819
105	L	A	0.0000
106	R	A	-2.8424
107	A	A	-2.0000
108	E	A	-2.4300
109	D	A	0.0000
110	T	A	-0.6404
111	A	A	0.0000
112	V	A	0.4511
113	Y	A	0.0000
114	Y	A	0.0000
115	C	A	0.0000
116	A	A	0.2814
117	I	A	0.5389
118	I	A	0.9567
119	G	A	0.7806
120	L	A	2.2984
121	M	A	2.7108
122	V	A	2.7545
123	G	A	0.0000
124	G	A	0.0000
125	V	A	1.0871
126	V	A	0.0000
127	I	A	0.2454
128	W	A	0.0000
129	G	A	0.0000
130	Q	A	-1.0730
131	G	A	0.0000
132	T	A	0.0000
133	L	A	0.9060
134	V	A	0.0000
135	T	A	-0.1499
136	V	A	0.0000
137	S	A	-0.9603
138	S	A	-0.7469
139	A	A	-0.5241
140	S	A	-0.5641
141	T	A	-0.7827
142	K	A	-1.4275
143	G	A	-1.4517
144	P	A	-0.6896
145	S	A	-0.1889
146	V	A	0.0000
147	F	A	-0.3114
148	P	A	-0.8786
149	L	A	0.0000
150	A	A	0.0000
151	P	A	0.0000
152	S	A	-0.9018
153	S	A	-0.6670
154	K	A	-1.1160
155	S	A	-0.9475
156	T	A	-0.9139
157	S	A	-0.8054
158	G	A	-0.8673
159	G	A	-0.9163
160	T	A	-0.7005
161	A	A	0.0000
162	A	A	0.0000
163	L	A	0.0000
164	G	A	0.0000
165	C	A	0.0000
166	L	A	0.0000
167	V	A	0.0000
168	K	A	0.0000
169	D	A	-0.5395
170	Y	A	0.0000
171	F	A	0.0000
172	P	A	-0.6639
173	E	A	-0.8898
174	P	A	-0.8809
175	V	A	-0.7538
176	T	A	-0.6268
177	V	A	-0.2775
178	S	A	-0.5041
179	W	A	0.0000
180	N	A	-0.8213
181	S	A	-0.7736
182	G	A	-0.6332
183	A	A	-0.3016
184	L	A	-0.0461
185	T	A	-0.2073
186	S	A	-0.1836
187	G	A	-0.2131
188	V	A	0.1772
189	H	A	-0.1020
190	T	A	0.0133
191	F	A	0.0000
192	P	A	-0.3809
193	A	A	0.0440
194	V	A	0.2620
195	L	A	0.6648
196	Q	A	0.0723
197	S	A	-0.1514
198	S	A	-0.2662
199	G	A	-0.0836
200	L	A	-0.0615
201	Y	A	0.3117
202	S	A	0.1142
203	L	A	0.0000
204	S	A	0.0000
205	S	A	0.0000
206	V	A	0.0000
207	V	A	0.0000
208	T	A	-0.1544
209	V	A	0.0000
210	P	A	-0.5544
211	S	A	-0.5857
212	S	A	-0.5684
213	S	A	-0.7081
214	L	A	-0.8800
215	G	A	-1.0661
216	T	A	-0.8906
217	Q	A	-1.5401
218	T	A	-1.1787
219	Y	A	0.0000
220	I	A	-1.1889
221	C	A	0.0000
222	N	A	-1.6145
223	V	A	0.0000
224	N	A	-1.9100
225	H	A	0.0000
226	K	A	-2.6753
227	P	A	-1.6458
228	S	A	-1.9350
229	N	A	-2.4579
230	T	A	-2.0858
231	K	A	-2.6485
232	V	A	-1.4754
233	D	A	-2.4538
234	K	A	-1.7752
235	K	A	-2.0099
236	V	A	0.0000
237	E	A	-2.6306
238	P	A	-1.6479
239	K	A	-1.7999
240	S	A	-1.4574
241	C	A	-1.2081
242	D	A	-2.8609
243	K	A	-3.2153
244	T	A	-2.2541
245	H	A	-2.5513
246	T	A	-1.7983
247	C	A	-0.6412
248	P	A	-0.6700
249	P	A	-0.0444
250	C	A	0.4217
251	P	A	-0.2520
252	A	A	-1.1160
253	P	A	-1.6008
254	E	A	-2.1217
255	A	A	-0.5495
256	L	A	0.5108
257	G	A	-0.0174
258	A	A	-0.5029
259	P	A	0.0000
260	S	A	0.1372
261	V	A	0.0000
262	F	A	1.4781
263	L	A	1.2466
264	F	A	1.4984
265	P	A	-0.0051
266	P	A	0.0000
267	K	A	-2.1552
268	P	A	-1.3885
269	K	A	-1.1339
270	D	A	0.0000
271	T	A	0.0000
272	L	A	-0.3634
273	M	A	0.2742
274	I	A	1.2926
275	S	A	-0.1511
276	R	A	-1.6605
277	T	A	-0.8036
278	P	A	0.0000
279	E	A	-1.0063
280	V	A	0.0000
281	T	A	0.6304
282	C	A	0.0000
283	V	A	0.0000
284	V	A	0.0000
285	V	A	-0.9456
286	D	A	-1.7207
287	V	A	0.0000
288	S	A	-2.2948
289	H	A	-2.6528
290	E	A	-3.1548
291	D	A	-2.5923
292	P	A	-2.3441
293	E	A	-2.1254
294	V	A	-0.1504
295	I	A	1.7302
296	C	A	1.2778
297	F	A	0.6640
298	N	A	-0.3725
299	W	A	0.0000
300	Y	A	-0.9673
301	V	A	-0.8815
302	D	A	-1.6729
303	G	A	-0.6516
304	V	A	0.5601
305	E	A	-1.3164
306	V	A	-0.8915
307	H	A	-2.0456
308	N	A	-2.2033
309	A	A	-1.7410
310	K	A	-2.4807
311	T	A	-1.5838
312	K	A	-2.8191
313	P	A	-2.5197
314	R	A	-3.7965
315	E	A	-4.2282
316	E	A	-3.7057
317	Q	A	-2.4276
318	Y	A	-0.1190
319	N	A	-1.3089
320	S	A	-1.4125
321	T	A	-2.1021
322	Y	A	-3.0724
323	R	A	-3.3346
324	V	A	0.0000
325	V	A	-0.9703
326	S	A	0.0000
327	V	A	-0.7209
328	L	A	0.0000
329	T	A	-0.6020
330	V	A	0.0000
331	L	A	0.1304
332	H	A	-0.5192
333	Q	A	-1.5735
334	D	A	-1.6881
335	W	A	0.0000
336	L	A	-1.1882
337	N	A	-2.2692
338	G	A	-2.2517
339	K	A	-2.3692
340	E	A	-2.6517
341	Y	A	0.0000
342	K	A	-1.3721
343	C	A	0.0000
344	K	A	-0.5135
345	V	A	0.0000
346	S	A	-0.0009
347	N	A	0.0000
348	K	A	-2.1099
349	A	A	-1.7011
350	L	A	0.0000
351	P	A	-0.6177
352	A	A	-0.3914
353	P	A	-0.3356
354	I	A	-0.0599
355	E	A	-0.9617
356	K	A	-0.6880
357	T	A	-0.8108
358	I	A	-0.4067
359	S	A	-1.3258
360	K	A	-1.4110
361	A	A	-1.0061
362	K	A	-2.2187
363	G	A	-1.8341
364	Q	A	-2.0174
365	P	A	-2.2197
366	R	A	-2.8773
367	E	A	-2.9333
368	P	A	0.0000
369	Q	A	-1.4960
370	V	A	0.0000
371	Y	A	0.0000
372	T	A	0.0000
373	L	A	0.0000
374	P	A	-0.4536
375	P	A	-1.0014
376	S	A	-1.5890
377	R	A	-2.8750
378	E	A	-2.9561
379	E	A	0.0000
380	M	A	-2.1072
381	T	A	-1.9448
382	K	A	-2.9548
383	N	A	-2.9780
384	Q	A	-2.9333
385	V	A	0.0000
386	S	A	0.0000
387	L	A	0.0000
388	T	A	0.0000
389	C	A	0.0000
390	L	A	0.0000
391	V	A	0.0000
392	K	A	-0.5535
393	G	A	-1.1930
394	F	A	0.0000
395	Y	A	-1.2983
396	P	A	0.0000
397	S	A	-0.4197
398	D	A	-0.9802
399	I	A	0.0000
400	A	A	0.0000
401	V	A	-0.3010
402	E	A	-0.8880
403	W	A	0.0000
404	E	A	-1.6388
405	S	A	0.0000
406	N	A	-1.8344
407	G	A	-1.8749
408	Q	A	-2.3155
409	P	A	-1.9644
410	E	A	-1.9356
411	N	A	-2.3315
412	N	A	-2.0825
413	Y	A	-1.2797
414	K	A	-1.2133
415	T	A	-0.4009
416	T	A	0.0000
417	P	A	-0.1913
418	P	A	0.1286
419	V	A	0.4816
420	L	A	0.6669
421	D	A	0.0000
422	S	A	-1.0158
423	D	A	-1.8226
424	G	A	-0.9533
425	S	A	0.0000
426	F	A	0.1009
427	F	A	0.0000
428	L	A	0.0000
429	Y	A	0.0000
430	S	A	0.0000
431	K	A	0.0000
432	L	A	0.0000
433	T	A	-1.2602
434	V	A	0.0000
435	D	A	-2.9547
436	K	A	-2.8498
437	S	A	-2.1467
438	R	A	-1.9114
439	W	A	0.0000
440	Q	A	-1.9724
441	Q	A	-2.1124
442	G	A	-1.3096
443	N	A	-0.6297
444	V	A	0.5815
445	F	A	0.0000
446	S	A	-0.7216
447	C	A	0.0000
448	S	A	0.0000
449	V	A	0.0000
450	M	A	0.0000
451	H	A	0.0000
452	E	A	-1.5862
453	A	A	-1.9919
454	L	A	-1.7368
455	H	A	-1.8992
456	N	A	-1.7921
457	H	A	-1.3672
458	Y	A	-0.6616
459	T	A	-0.9154
460	Q	A	-1.4518
461	K	A	-1.2997
462	S	A	-0.4441
463	L	A	0.0000
464	S	A	0.0167
465	L	A	-0.5274
466	S	A	-0.6998
467	P	A	-0.9865
468	G	A	-1.6273
469	K	A	-2.3925
470	M	B	0.8516
471	E	B	-0.2518
472	F	B	1.3759
473	G	B	0.9972
474	L	B	1.9311
475	S	B	1.7488
476	W	B	2.6616
477	L	B	3.6843
478	F	B	4.0079
479	L	B	4.1182
480	V	B	3.8434
481	A	B	2.6185
482	I	B	2.6177
483	L	B	1.4699
484	K	B	-0.6118
485	G	B	-0.0843
486	V	B	0.7358
487	Q	B	-0.5934
488	C	B	-0.3852
489	E	B	-1.6124
490	V	B	-0.6326
491	Q	B	-0.6799
492	L	B	0.0000
493	L	B	1.1179
494	E	B	0.1613
495	S	B	-0.5091
496	G	B	-0.5752
497	G	B	-0.5492
498	G	B	-0.1316
499	L	B	0.8519
500	V	B	0.0108
501	Q	B	-1.0866
502	P	B	-1.6574
503	G	B	-1.3808
504	G	B	-0.9196
505	S	B	-1.0733
506	L	B	-0.9501
507	R	B	-2.0208
508	L	B	0.0000
509	S	B	-0.4396
510	C	B	0.0000
511	A	B	-0.2769
512	A	B	0.0000
513	S	B	-0.5460
514	G	B	-0.9421
515	F	B	-0.4230
516	T	B	-0.5759
517	F	B	0.0000
518	S	B	-1.4586
519	N	B	-1.3469
520	Y	B	-0.5151
521	G	B	0.0000
522	M	B	0.0000
523	S	B	0.0000
524	W	B	0.0000
525	V	B	0.0000
526	R	B	0.0000
527	Q	B	-1.1563
528	A	B	0.0000
529	P	B	-1.3183
530	G	B	-1.6348
531	K	B	-2.5669
532	G	B	-1.9025
533	L	B	0.0000
534	E	B	-1.7442
535	W	B	0.0000
536	V	B	0.0000
537	A	B	0.0000
538	S	B	0.0000
539	I	B	0.0000
540	R	B	-1.6000
541	S	B	0.0000
542	G	B	-1.7826
543	G	B	-1.8506
544	G	B	-2.1398
545	R	B	-2.2313
546	T	B	-0.7944
547	Y	B	0.0132
548	Y	B	-0.2888
549	S	B	-1.3190
550	D	B	-2.0845
551	N	B	-2.2338
552	V	B	0.0000
553	K	B	-1.4636
554	G	B	0.3983
555	R	B	-0.1299
556	F	B	0.0000
557	T	B	-0.4672
558	I	B	0.0000
559	S	B	-0.8629
560	R	B	-1.4174
561	D	B	-2.0252
562	N	B	-2.4649
563	S	B	-1.9832
564	K	B	-2.7173
565	N	B	-2.2048
566	T	B	0.0000
567	L	B	0.0000
568	Y	B	-0.6354
569	L	B	0.0000
570	Q	B	-1.3666
571	M	B	0.0000
572	N	B	-0.8939
573	S	B	-1.0034
574	L	B	0.0000
575	R	B	-2.7071
576	A	B	-1.9895
577	E	B	-2.4134
578	D	B	0.0000
579	T	B	-0.8518
580	A	B	0.0000
581	V	B	0.0059
582	Y	B	0.0000
583	Y	B	0.0000
584	C	B	0.0000
585	A	B	0.0000
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1358	N	D	-1.5162
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1371	E	D	-2.2688
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1373	D	D	-2.0951
1374	S	D	-1.7498
1375	K	D	-2.3681
1376	D	D	-1.7254
1377	S	D	0.0000
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1392	Y	D	0.0000
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1394	K	D	-3.4126
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1398	Y	D	0.0000
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1400	C	D	0.0000
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1402	V	D	0.0000
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1404	H	D	0.0000
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1407	L	D	-0.2431
1408	S	D	-0.4724
1409	S	D	-0.6460
1410	P	D	-0.5397
1411	V	D	-0.2047
1412	T	D	-0.6638
1413	K	D	-1.0411
1414	S	D	-0.8846
1415	F	D	-1.0512
1416	N	D	-2.1489
1417	R	D	-2.4283
1418	G	D	-2.2135
1419	E	D	-2.1097
1420	C	D	-0.7910