| Chain sequence(s) |
A: MRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY C: MRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY B: MRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY D: MRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 0 | M | A | -1.2460 | |
| 1 | R | A | -1.6946 | |
| 2 | S | A | -0.7694 | |
| 3 | F | A | 0.0000 | |
| 4 | F | A | 0.0000 | |
| 5 | S | A | -0.6652 | |
| 6 | F | A | -0.2125 | |
| 7 | L | A | 0.0000 | |
| 8 | G | A | 0.0000 | |
| 9 | E | A | -0.8442 | |
| 10 | A | A | 0.0000 | |
| 11 | F | A | 0.0000 | |
| 12 | D | A | -1.3448 | |
| 13 | G | A | 0.0000 | |
| 14 | A | A | 0.0000 | |
| 15 | R | A | -1.6702 | |
| 16 | D | A | -1.4815 | |
| 17 | M | A | 0.0000 | |
| 18 | W | A | -0.8886 | |
| 19 | R | A | -1.4800 | |
| 20 | A | A | 0.0000 | |
| 21 | Y | A | -0.7006 | |
| 22 | S | A | -1.1708 | |
| 23 | D | A | 0.0000 | |
| 24 | M | A | -1.0886 | |
| 25 | R | A | -1.9236 | |
| 26 | E | A | -2.4447 | |
| 27 | A | A | -1.5174 | |
| 28 | N | A | -1.4429 | |
| 29 | Y | A | 0.1305 | |
| 30 | I | A | 1.5775 | |
| 31 | G | A | 0.2087 | |
| 32 | S | A | 0.0000 | |
| 33 | D | A | -0.7523 | |
| 34 | K | A | -1.1851 | |
| 35 | Y | A | 0.0000 | |
| 36 | F | A | 0.0000 | |
| 37 | H | A | 0.0000 | |
| 38 | A | A | 0.0000 | |
| 39 | R | A | -1.1078 | |
| 40 | G | A | 0.0000 | |
| 41 | N | A | 0.0000 | |
| 42 | Y | A | -1.5156 | |
| 43 | D | A | -1.4763 | |
| 44 | A | A | 0.0000 | |
| 45 | A | A | -1.4093 | |
| 46 | K | A | -2.3988 | |
| 47 | R | A | -1.9046 | |
| 48 | G | A | -1.0800 | |
| 49 | P | A | -0.4105 | |
| 50 | G | A | 0.0000 | |
| 51 | G | A | 0.0000 | |
| 52 | V | A | -0.2882 | |
| 53 | W | A | 0.0434 | |
| 54 | A | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | E | A | -2.0276 | |
| 57 | A | A | -1.2647 | |
| 58 | I | A | -0.9334 | |
| 59 | S | A | 0.0000 | |
| 60 | D | A | -2.4928 | |
| 61 | A | A | 0.0000 | |
| 62 | R | A | -1.2678 | |
| 63 | E | A | -1.4945 | |
| 64 | N | A | -1.3101 | |
| 65 | I | A | -0.5207 | |
| 66 | Q | A | 0.0000 | |
| 67 | R | A | -1.1729 | |
| 68 | F | A | 0.0863 | |
| 69 | F | A | 0.7818 | |
| 70 | G | A | -0.2489 | |
| 71 | H | A | -1.3110 | |
| 72 | G | A | -1.4069 | |
| 73 | A | A | -1.3586 | |
| 74 | E | A | -2.1622 | |
| 75 | D | A | -2.1468 | |
| 76 | S | A | 0.0000 | |
| 77 | L | A | 0.1624 | |
| 78 | A | A | -0.5254 | |
| 79 | D | A | 0.0000 | |
| 80 | Q | A | -1.3732 | |
| 81 | A | A | -0.5584 | |
| 82 | A | A | 0.0000 | |
| 83 | N | A | 0.0000 | |
| 84 | E | A | -2.2528 | |
| 85 | W | A | -1.5991 | |
| 86 | G | A | 0.0000 | |
| 87 | R | A | -1.7202 | |
| 88 | S | A | -1.5483 | |
| 89 | G | A | -2.1453 | |
| 90 | K | A | -2.8134 | |
| 91 | D | A | -3.0860 | |
| 92 | P | A | 0.0000 | |
| 93 | N | A | -2.3893 | |
| 94 | H | A | -2.1044 | |
| 95 | F | A | -1.0967 | |
| 96 | R | A | -1.3602 | |
| 97 | P | A | -0.4020 | |
| 98 | A | A | -0.5743 | |
| 99 | G | A | -0.7689 | |
| 100 | L | A | 0.0000 | |
| 101 | P | A | -1.6038 | |
| 102 | E | A | -2.7237 | |
| 103 | K | A | -2.5557 | |
| 104 | Y | A | -1.5836 | |
| 0 | M | B | -1.2917 | |
| 1 | R | B | -1.7021 | |
| 2 | S | B | -0.7898 | |
| 3 | F | B | 0.0000 | |
| 4 | F | B | 0.0000 | |
| 5 | S | B | -0.7035 | |
| 6 | F | B | -0.2104 | |
| 7 | L | B | 0.0000 | |
| 8 | G | B | 0.0000 | |
| 9 | E | B | -0.8010 | |
| 10 | A | B | 0.0000 | |
| 11 | F | B | 0.0000 | |
| 12 | D | B | -1.2734 | |
| 13 | G | B | 0.0000 | |
| 14 | A | B | 0.0000 | |
| 15 | R | B | -1.5627 | |
| 16 | D | B | 0.0000 | |
| 17 | M | B | 0.0000 | |
| 18 | W | B | -0.7978 | |
| 19 | R | B | -1.3777 | |
| 20 | A | B | 0.0000 | |
| 21 | Y | B | -0.7089 | |
| 22 | S | B | -1.2380 | |
| 23 | D | B | 0.0000 | |
| 24 | M | B | -1.1575 | |
| 25 | R | B | -1.8494 | |
| 26 | E | B | -2.3987 | |
| 27 | A | B | -1.4103 | |
| 28 | N | B | -1.5352 | |
| 29 | Y | B | 0.0469 | |
| 30 | I | B | 1.4063 | |
| 31 | G | B | -0.2385 | |
| 32 | S | B | 0.0000 | |
| 33 | D | B | -1.9604 | |
| 34 | K | B | -2.1439 | |
| 35 | Y | B | 0.0000 | |
| 36 | F | B | 0.0000 | |
| 37 | H | B | 0.0000 | |
| 38 | A | B | 0.0000 | |
| 39 | R | B | -1.1773 | |
| 40 | G | B | 0.0000 | |
| 41 | N | B | 0.0000 | |
| 42 | Y | B | -1.4564 | |
| 43 | D | B | -1.5931 | |
| 44 | A | B | 0.0000 | |
| 45 | A | B | -1.3618 | |
| 46 | K | B | -2.4188 | |
| 47 | R | B | -1.9319 | |
| 48 | G | B | -1.1094 | |
| 49 | P | B | -0.4084 | |
| 50 | G | B | 0.0000 | |
| 51 | G | B | 0.0000 | |
| 52 | V | B | -0.1943 | |
| 53 | W | B | 0.1326 | |
| 54 | A | B | 0.0000 | |
| 55 | A | B | 0.0000 | |
| 56 | E | B | -1.7721 | |
| 57 | A | B | -1.1791 | |
| 58 | I | B | -0.8126 | |
| 59 | S | B | 0.0000 | |
| 60 | D | B | -2.3598 | |
| 61 | A | B | 0.0000 | |
| 62 | R | B | -1.1011 | |
| 63 | E | B | -1.3429 | |
| 64 | N | B | -1.0752 | |
| 65 | I | B | -0.4235 | |
| 66 | Q | B | -0.3072 | |
| 67 | R | B | -1.0562 | |
| 68 | F | B | 0.2052 | |
| 69 | F | B | 0.6200 | |
| 70 | G | B | -0.2800 | |
| 71 | H | B | -1.3560 | |
| 72 | G | B | -1.5640 | |
| 73 | A | B | -1.4361 | |
| 74 | E | B | -2.2325 | |
| 75 | D | B | -2.5102 | |
| 76 | S | B | 0.0000 | |
| 77 | L | B | 0.1180 | |
| 78 | A | B | -0.6272 | |
| 79 | D | B | 0.0000 | |
| 80 | Q | B | -1.2078 | |
| 81 | A | B | -0.3953 | |
| 82 | A | B | 0.0000 | |
| 83 | N | B | 0.0000 | |
| 84 | E | B | -1.8485 | |
| 85 | W | B | -1.4768 | |
| 86 | G | B | 0.0000 | |
| 87 | R | B | 0.0000 | |
| 88 | S | B | -1.3288 | |
| 89 | G | B | -2.0370 | |
| 90 | K | B | -2.6694 | |
| 91 | D | B | -3.0808 | |
| 92 | P | B | 0.0000 | |
| 93 | N | B | -2.5977 | |
| 94 | H | B | -2.3124 | |
| 95 | F | B | -1.5784 | |
| 96 | R | B | -1.7642 | |
| 97 | P | B | -0.6711 | |
| 98 | A | B | -0.6242 | |
| 99 | G | B | -0.8126 | |
| 100 | L | B | 0.0000 | |
| 101 | P | B | -1.6016 | |
| 102 | E | B | -2.7698 | |
| 103 | K | B | -2.6156 | |
| 104 | Y | B | 0.0000 | |
| 0 | M | C | -1.5122 | |
| 1 | R | C | -2.2214 | |
| 2 | S | C | -1.0934 | |
| 3 | F | C | 0.0000 | |
| 4 | F | C | 0.0000 | |
| 5 | S | C | -0.9262 | |
| 6 | F | C | -0.2942 | |
| 7 | L | C | 0.0000 | |
| 8 | G | C | -0.5807 | |
| 9 | E | C | -0.8715 | |
| 10 | A | C | 0.0000 | |
| 11 | F | C | 0.0000 | |
| 12 | D | C | -1.1931 | |
| 13 | G | C | 0.0000 | |
| 14 | A | C | 0.0000 | |
| 15 | R | C | -1.3828 | |
| 16 | D | C | -1.4663 | |
| 17 | M | C | 0.0000 | |
| 18 | W | C | -0.9895 | |
| 19 | R | C | -1.9228 | |
| 20 | A | C | 0.0000 | |
| 21 | Y | C | -1.0013 | |
| 22 | S | C | -1.4163 | |
| 23 | D | C | 0.0000 | |
| 24 | M | C | -1.4145 | |
| 25 | R | C | -2.1254 | |
| 26 | E | C | -2.5008 | |
| 27 | A | C | -1.4663 | |
| 28 | N | C | -1.6244 | |
| 29 | Y | C | -0.0297 | |
| 30 | I | C | 1.4460 | |
| 31 | G | C | -0.1050 | |
| 32 | S | C | 0.0000 | |
| 33 | D | C | -1.8063 | |
| 34 | K | C | -2.0257 | |
| 35 | Y | C | 0.0000 | |
| 36 | F | C | 0.0000 | |
| 37 | H | C | 0.0000 | |
| 38 | A | C | 0.0000 | |
| 39 | R | C | -1.1984 | |
| 40 | G | C | 0.0000 | |
| 41 | N | C | 0.0000 | |
| 42 | Y | C | -1.3258 | |
| 43 | D | C | -1.3571 | |
| 44 | A | C | 0.0000 | |
| 45 | A | C | -1.3048 | |
| 46 | K | C | -2.3223 | |
| 47 | R | C | -1.8707 | |
| 48 | G | C | -1.1050 | |
| 49 | P | C | -0.4322 | |
| 50 | G | C | 0.0000 | |
| 51 | G | C | 0.0000 | |
| 52 | V | C | -0.1976 | |
| 53 | W | C | 0.0856 | |
| 54 | A | C | 0.0000 | |
| 55 | A | C | 0.0000 | |
| 56 | E | C | -1.9170 | |
| 57 | A | C | -1.2827 | |
| 58 | I | C | -0.7894 | |
| 59 | S | C | 0.0000 | |
| 60 | D | C | -2.4800 | |
| 61 | A | C | 0.0000 | |
| 62 | R | C | -1.2756 | |
| 63 | E | C | -1.4955 | |
| 64 | N | C | -1.3297 | |
| 65 | I | C | -0.4841 | |
| 66 | Q | C | -0.6686 | |
| 67 | R | C | -1.1399 | |
| 68 | F | C | 0.1917 | |
| 69 | F | C | 0.7236 | |
| 70 | G | C | -0.4362 | |
| 71 | H | C | -1.4169 | |
| 72 | G | C | -1.6688 | |
| 73 | A | C | -1.4598 | |
| 74 | E | C | -2.3028 | |
| 75 | D | C | -2.5759 | |
| 76 | S | C | 0.0000 | |
| 77 | L | C | 0.0317 | |
| 78 | A | C | -0.7335 | |
| 79 | D | C | 0.0000 | |
| 80 | Q | C | -1.5302 | |
| 81 | A | C | -0.6765 | |
| 82 | A | C | 0.0000 | |
| 83 | N | C | 0.0000 | |
| 84 | E | C | -2.1854 | |
| 85 | W | C | -1.4958 | |
| 86 | G | C | 0.0000 | |
| 87 | R | C | 0.0000 | |
| 88 | S | C | -1.4013 | |
| 89 | G | C | -1.9971 | |
| 90 | K | C | -2.6652 | |
| 91 | D | C | -3.0768 | |
| 92 | P | C | 0.0000 | |
| 93 | N | C | -2.6233 | |
| 94 | H | C | -2.3353 | |
| 95 | F | C | -1.5471 | |
| 96 | R | C | -1.6552 | |
| 97 | P | C | -0.5771 | |
| 98 | A | C | -0.3216 | |
| 99 | G | C | -0.7636 | |
| 100 | L | C | 0.0000 | |
| 101 | P | C | -1.5563 | |
| 102 | E | C | -2.7185 | |
| 103 | K | C | -2.5496 | |
| 104 | Y | C | -1.5777 | |
| 0 | M | D | -1.5004 | |
| 1 | R | D | -2.1828 | |
| 2 | S | D | -1.0912 | |
| 3 | F | D | 0.0000 | |
| 4 | F | D | 0.0000 | |
| 5 | S | D | -0.8097 | |
| 6 | F | D | -0.3108 | |
| 7 | L | D | 0.0000 | |
| 8 | G | D | -0.5632 | |
| 9 | E | D | -0.8865 | |
| 10 | A | D | 0.0000 | |
| 11 | F | D | 0.0000 | |
| 12 | D | D | -1.2378 | |
| 13 | G | D | 0.0000 | |
| 14 | A | D | 0.0000 | |
| 15 | R | D | -1.4917 | |
| 16 | D | D | -1.4669 | |
| 17 | M | D | 0.0000 | |
| 18 | W | D | -0.9541 | |
| 19 | R | D | -1.7468 | |
| 20 | A | D | 0.0000 | |
| 21 | Y | D | -0.7903 | |
| 22 | S | D | -1.2037 | |
| 23 | D | D | 0.0000 | |
| 24 | M | D | -1.0990 | |
| 25 | R | D | -1.7527 | |
| 26 | E | D | -2.3199 | |
| 27 | A | D | -1.3537 | |
| 28 | N | D | -1.4550 | |
| 29 | Y | D | 0.0980 | |
| 30 | I | D | 1.5339 | |
| 31 | G | D | 0.0036 | |
| 32 | S | D | 0.0000 | |
| 33 | D | D | -1.2074 | |
| 34 | K | D | -1.6719 | |
| 35 | Y | D | 0.0000 | |
| 36 | F | D | 0.0000 | |
| 37 | H | D | 0.0000 | |
| 38 | A | D | 0.0000 | |
| 39 | R | D | -1.2337 | |
| 40 | G | D | 0.0000 | |
| 41 | N | D | 0.0000 | |
| 42 | Y | D | -1.4409 | |
| 43 | D | D | -1.3395 | |
| 44 | A | D | 0.0000 | |
| 45 | A | D | -1.3928 | |
| 46 | K | D | -2.3404 | |
| 47 | R | D | -1.8643 | |
| 48 | G | D | -1.0869 | |
| 49 | P | D | -0.4271 | |
| 50 | G | D | 0.0000 | |
| 51 | G | D | 0.0000 | |
| 52 | V | D | -0.5413 | |
| 53 | W | D | -0.0170 | |
| 54 | A | D | 0.0000 | |
| 55 | A | D | 0.0000 | |
| 56 | E | D | -2.0617 | |
| 57 | A | D | -1.3596 | |
| 58 | I | D | -0.9026 | |
| 59 | S | D | 0.0000 | |
| 60 | D | D | -2.4851 | |
| 61 | A | D | 0.0000 | |
| 62 | R | D | -1.2069 | |
| 63 | E | D | -1.7138 | |
| 64 | N | D | -1.3863 | |
| 65 | I | D | -0.7122 | |
| 66 | Q | D | -1.1007 | |
| 67 | R | D | -1.9024 | |
| 68 | F | D | -0.4219 | |
| 69 | F | D | 0.4176 | |
| 70 | G | D | -0.7112 | |
| 71 | H | D | -1.6829 | |
| 72 | G | D | -1.4534 | |
| 73 | A | D | -1.4266 | |
| 74 | E | D | -1.9295 | |
| 75 | D | D | -2.0301 | |
| 76 | S | D | 0.0000 | |
| 77 | L | D | 0.2836 | |
| 78 | A | D | -0.3737 | |
| 79 | D | D | 0.0000 | |
| 80 | Q | D | -1.2369 | |
| 81 | A | D | -0.4765 | |
| 82 | A | D | 0.0000 | |
| 83 | N | D | 0.0000 | |
| 84 | E | D | -2.3143 | |
| 85 | W | D | -1.6994 | |
| 86 | G | D | 0.0000 | |
| 87 | R | D | -1.8210 | |
| 88 | S | D | -1.6360 | |
| 89 | G | D | -2.2214 | |
| 90 | K | D | -2.9737 | |
| 91 | D | D | -3.2054 | |
| 92 | P | D | 0.0000 | |
| 93 | N | D | -2.6457 | |
| 94 | H | D | -2.3706 | |
| 95 | F | D | -1.5119 | |
| 96 | R | D | -1.6463 | |
| 97 | P | D | -0.5431 | |
| 98 | A | D | -0.1360 | |
| 99 | G | D | -0.7716 | |
| 100 | L | D | 0.0000 | |
| 101 | P | D | -1.5495 | |
| 102 | E | D | -2.7155 | |
| 103 | K | D | -2.5385 | |
| 104 | Y | D | -1.5603 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine