Project name: 4RAG

Chain sequence(s)	A: GAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEKAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.733
• Maximal score value: 1.3744
• Average score: -0.9998
• Total score value: -361.9368

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	G	A	0.1169
3	A	A	0.3897
4	F	A	0.7730
5	L	A	-0.6214
6	D	A	-2.0145
7	K	A	-2.2770
8	P	A	-1.6569
9	K	A	-1.7880
10	M	A	-1.4719
11	E	A	-2.4468
12	K	A	-2.1018
13	H	A	-1.9549
14	N	A	-2.0059
15	A	A	-1.1878
16	Q	A	-1.8222
17	G	A	-1.3081
18	Q	A	-1.8960
19	G	A	-1.3174
20	N	A	-1.7418
21	G	A	-1.6133
22	L	A	0.0000
23	R	A	-1.8138
24	Y	A	-0.9379
25	G	A	0.0000
26	L	A	0.0000
27	S	A	0.0000
28	S	A	-0.9167
29	M	A	0.0000
30	Q	A	0.0000
31	G	A	0.0000
32	W	A	-1.0623
33	R	A	-1.1265
34	V	A	-0.3563
35	E	A	-1.3813
36	M	A	-0.9524
37	E	A	-1.2302
38	K	A	0.0000
39	A	A	-0.9754
40	H	A	-0.8665
41	T	A	-0.5835
42	A	A	0.0784
43	V	A	0.4819
44	I	A	-0.3974
45	G	A	-1.0503
46	L	A	0.0000
47	P	A	-1.1992
48	S	A	-1.0796
49	G	A	-1.2987
50	L	A	0.0000
51	E	A	-2.2822
52	S	A	-1.5120
53	W	A	0.0000
54	S	A	0.0000
55	F	A	0.0000
56	F	A	0.0000
57	A	A	0.0000
58	V	A	0.0000
59	Y	A	0.0000
60	D	A	-0.6349
61	G	A	0.0000
62	H	A	-0.6574
63	A	A	-1.0679
64	G	A	-1.4825
65	S	A	-1.6585
66	Q	A	-2.0375
67	V	A	0.0000
68	A	A	0.0000
69	K	A	-2.3317
70	Y	A	-1.4260
71	C	A	0.0000
72	C	A	-1.3751
73	E	A	-2.3284
74	H	A	-1.4926
75	L	A	0.0000
76	L	A	-0.8264
77	D	A	-1.5271
78	H	A	-1.6504
79	I	A	0.0000
80	T	A	-1.6778
81	N	A	-2.3967
82	N	A	-2.5771
83	Q	A	-2.7909
84	D	A	-3.1822
85	F	A	0.0000
86	K	A	-3.0349
87	G	A	-2.1481
88	S	A	-1.1363
89	A	A	-0.5251
90	G	A	-0.8100
91	A	A	-0.5333
92	P	A	-1.1497
93	S	A	-1.0494
94	V	A	-1.0120
95	E	A	-2.3934
96	N	A	-2.4681
97	V	A	0.0000
98	K	A	-2.2969
99	N	A	-2.5697
100	G	A	0.0000
101	I	A	0.0000
102	R	A	-2.1012
103	T	A	-1.8920
104	G	A	0.0000
105	F	A	0.0000
106	L	A	-1.6050
107	E	A	-2.6812
108	I	A	0.0000
109	D	A	0.0000
110	E	A	-2.5792
111	H	A	-1.8966
112	M	A	0.0000
113	R	A	-1.8417
114	V	A	-1.7263
115	M	A	-1.8921
116	S	A	-2.8145
117	E	A	-3.4697
118	K	A	-3.6079
119	K	A	-3.4972
120	H	A	-3.0249
121	G	A	-2.3776
122	A	A	-1.4592
123	D	A	-1.9109
124	R	A	-2.6289
125	S	A	0.0000
126	G	A	0.0000
127	S	A	0.0000
128	T	A	0.0000
129	A	A	0.0000
130	V	A	0.0000
131	G	A	0.0000
132	V	A	0.0000
133	L	A	0.0000
134	I	A	0.0000
135	S	A	0.0000
136	P	A	-1.4882
137	Q	A	-2.2709
138	H	A	-1.7890
139	T	A	0.0000
140	Y	A	0.0000
141	F	A	0.0000
142	I	A	0.0000
143	N	A	0.0000
144	C	A	0.0000
145	G	A	0.0000
146	D	A	-0.8369
147	S	A	0.0000
148	R	A	-0.5895
149	G	A	0.0000
150	L	A	0.0000
151	L	A	0.0000
152	C	A	0.0000
153	R	A	-2.7006
154	N	A	-3.0642
155	R	A	-3.6729
156	K	A	-3.3720
157	V	A	-1.6471
158	H	A	-1.1716
159	F	A	-0.0388
160	F	A	0.3171
161	T	A	0.0000
162	Q	A	-1.3361
163	D	A	-1.3398
164	H	A	0.0000
165	K	A	-1.1797
166	P	A	0.0000
167	S	A	-0.8638
168	N	A	-1.1331
169	P	A	-0.6721
170	L	A	0.1140
171	E	A	0.0000
172	K	A	-2.1643
173	E	A	-2.7301
174	R	A	-2.1664
175	I	A	0.0000
176	Q	A	-2.6542
177	N	A	-2.9425
178	A	A	0.0000
179	G	A	-1.3230
180	G	A	0.0000
181	S	A	-1.0976
182	V	A	-0.6022
183	M	A	0.5977
184	I	A	1.3744
185	Q	A	-0.6893
186	R	A	-1.3255
187	V	A	0.0000
188	N	A	-1.0216
189	G	A	-0.7187
190	S	A	-0.6713
191	L	A	-0.6257
192	A	A	-0.6093
193	V	A	0.0000
194	S	A	0.0000
195	R	A	0.0000
196	A	A	0.0000
197	L	A	0.0000
198	G	A	0.0000
199	D	A	0.0000
200	F	A	-1.0342
201	D	A	-1.6571
202	Y	A	-0.3364
203	K	A	0.0000
204	C	A	0.0677
205	V	A	-0.6349
206	H	A	-1.1186
207	G	A	-1.3674
208	K	A	-1.7886
209	G	A	-1.2603
210	P	A	-1.1015
211	T	A	-1.0960
212	E	A	-2.2415
213	Q	A	0.0000
214	L	A	-1.0520
215	V	A	0.0000
216	S	A	0.0000
217	P	A	0.0000
218	E	A	-1.0668
219	P	A	0.0000
220	E	A	-1.2972
221	V	A	-0.9803
222	H	A	-0.9418
223	D	A	-1.5491
224	I	A	0.0000
225	E	A	-2.7708
226	R	A	-2.6203
227	S	A	-2.7987
228	E	A	-3.6935
229	E	A	-3.5451
230	D	A	-3.1413
231	D	A	0.0000
232	Q	A	-2.0410
233	F	A	0.0000
234	I	A	0.0000
235	I	A	0.0000
236	L	A	0.0000
237	A	A	0.0000
238	C	A	0.0000
239	D	A	-1.2684
240	G	A	0.0000
241	I	A	0.0000
242	W	A	0.0000
243	D	A	-2.0898
244	V	A	-0.8603
245	M	A	0.0000
246	G	A	-1.4895
247	N	A	-1.5626
248	E	A	-3.1156
249	E	A	-2.5954
250	L	A	0.0000
251	C	A	0.0000
252	D	A	-2.4344
253	F	A	0.0000
254	V	A	0.0000
255	R	A	-1.3446
256	S	A	-0.5258
257	R	A	0.0000
258	L	A	0.0000
259	E	A	-1.2253
260	V	A	-0.9368
261	T	A	-1.3162
262	D	A	-2.6253
263	D	A	-2.2733
264	L	A	0.0000
265	E	A	-2.3174
266	K	A	-2.6383
267	V	A	0.0000
268	C	A	0.0000
269	N	A	-1.7320
270	E	A	-1.3141
271	V	A	0.0000
272	V	A	0.0000
273	D	A	-0.6431
274	T	A	0.0000
275	C	A	0.0000
276	L	A	0.0000
277	Y	A	-0.4492
278	K	A	-0.9838
279	G	A	-0.9563
280	S	A	0.0000
281	R	A	-1.8093
282	D	A	-1.4960
283	N	A	0.0000
284	M	A	0.0000
285	S	A	0.0000
286	V	A	0.0000
287	I	A	0.0000
288	L	A	0.0000
289	I	A	0.0000
290	C	A	0.0000
291	F	A	0.0000
292	P	A	-1.8993
293	N	A	-2.4444
294	A	A	0.0000
295	P	A	-1.7485
296	K	A	-2.0387
297	V	A	-0.7507
298	S	A	-1.0800
299	P	A	-1.5465
300	E	A	-2.5913
301	A	A	-1.8534
302	V	A	-1.4000
303	K	A	-3.3726
304	K	A	-3.7330
305	E	A	-2.5045
306	A	A	-2.5514
307	E	A	-3.4945
308	L	A	0.0000
309	D	A	-2.3218
310	K	A	-2.7141
311	Y	A	-1.3030
312	L	A	0.0000
313	E	A	-2.2868
314	C	A	-1.5269
315	R	A	-1.8751
316	V	A	0.0000
317	E	A	-2.9589
318	E	A	-3.2714
319	I	A	0.0000
320	I	A	-1.3004
321	K	A	-2.4572
327	V	A	1.1087
328	P	A	-0.0093
329	D	A	-0.9035
330	L	A	-0.5282
331	V	A	-0.0385
332	H	A	-1.1760
333	V	A	0.0000
334	M	A	0.0000
335	R	A	-2.1068
336	T	A	-1.3947
337	L	A	0.0000
338	A	A	-1.5794
339	S	A	-1.4035
340	E	A	-1.7145
341	N	A	-1.7015
342	I	A	0.0000
343	P	A	-0.8751
344	S	A	-0.8762
345	L	A	-0.8712
346	P	A	0.0000
347	P	A	-1.3455
348	G	A	-1.6732
349	G	A	0.0000
350	E	A	-1.9620
351	L	A	-1.0602
352	A	A	-0.7940
353	S	A	0.0000
354	K	A	0.0000
355	R	A	-0.9740
356	N	A	-1.0969
357	V	A	-0.9523
358	I	A	0.0000
359	E	A	-1.3776
360	A	A	-1.3781
361	V	A	0.0000
362	Y	A	0.0000
363	N	A	-1.8578
364	R	A	-2.2949
365	L	A	-0.9126
366	N	A	-0.5661
367	P	A	-0.5500
368	Y	A	0.7889