Project name: 3N75 [mutate: DA457L, DA460L, DA470L, DB457L, DB460L, DB470L, DC457L, DC460L, DC470L, DD457L, DD460L, DD470L, DE457L, DE460L, DE470L]

Status: done

submitted: 2017-09-13 12:33:17, status changed: 2017-09-13 15:37:16
Settings
Chain sequence(s) A: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
C: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
B: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
E: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
D: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues DA457L, DA460L, DA470L, DB457L, DB460L, DB470L, DC457L, DC460L, DC470L, DD457L, DD460L, DD470L, DE457L, DE460L, DE470L
Energy difference between WD and mutated (by FoldX) 2.58193 kcal/mol
Show buried residues

Minimal score value
-4.078
Maximal score value
2.8345
Average score
-0.701
Total score value
-2488.563

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3261
2 N A -1.1387
3 V A 0.0000
4 I A 0.0000
5 A A 0.0000
6 I A 0.0000
7 L A 0.0000
8 N A -1.3066
9 H A -1.4140
10 M A -0.6006
11 G A -0.6337
12 V A -0.6897
13 Y A -0.5273
14 F A 0.0000
15 K A 0.0000
16 E A -0.6554
17 E A -0.5920
18 P A 0.0000
19 I A -0.6954
20 R A -1.4210
21 E A -1.6176
22 L A 0.0000
23 H A -1.9910
24 R A -3.1509
25 A A 0.0000
26 L A 0.0000
27 E A -3.7431
28 R A -3.6233
29 L A -2.6756
30 N A -2.8404
31 F A 0.0000
32 Q A -1.4388
33 I A -0.7193
34 V A 0.0000
35 Y A 0.0835
36 P A 0.0000
37 N A -2.1346
38 D A -2.4019
39 R A -2.4279
40 D A -2.5580
41 D A 0.0000
42 L A 0.0000
43 L A -1.5473
44 K A -1.7347
45 L A 0.0000
46 I A 0.0000
47 E A -1.7815
48 N A -1.5453
49 N A 0.0000
50 A A -0.6800
51 R A -0.8878
52 L A 0.0000
53 C A 0.0000
54 G A 0.0000
55 V A 0.0000
56 I A 0.0000
57 F A 0.0000
58 D A 0.0000
59 W A 0.0000
60 D A -1.0630
61 K A -1.5101
62 Y A 0.0000
63 N A 0.0000
64 L A -0.4410
65 E A -1.9570
66 L A 0.0000
67 C A 0.0000
68 E A -2.1975
69 E A -2.0819
70 I A 0.0000
71 S A -2.1635
72 K A -2.7764
73 M A 0.0000
74 N A -1.7206
75 E A -1.7062
76 N A -0.8200
77 L A 0.0000
78 P A 0.0000
79 L A 0.0000
80 Y A 0.0000
81 A A 0.0000
82 F A 0.0000
83 A A 0.0000
84 N A -0.1929
85 T A 0.2079
86 Y A 0.9687
87 S A 0.0000
88 T A -0.0298
89 L A 0.0000
90 D A -0.5359
91 V A -0.7485
92 S A -0.6267
93 L A 0.0000
94 N A -1.6612
95 D A -2.4351
96 L A -2.3180
97 R A -2.8615
98 L A 0.0000
99 Q A -0.7593
100 I A -0.1440
101 S A -0.3496
102 F A 0.0000
103 F A 0.0000
104 E A -0.8198
105 Y A 0.0000
106 A A -0.7375
107 L A 0.0000
108 G A -1.2992
109 A A -1.4058
110 A A 0.0000
111 E A -3.7226
112 D A -3.6989
113 I A 0.0000
114 A A 0.0000
115 N A -3.8110
116 K A -3.8921
117 I A 0.0000
118 K A -3.7292
119 Q A -3.6566
120 T A -2.7570
121 T A 0.0000
122 D A -3.2685
123 E A -2.8823
124 Y A 0.0000
125 I A -0.5745
126 N A -0.8528
127 T A -0.3041
128 I A 0.6836
129 L A 0.7404
130 P A 0.0000
131 P A -0.7115
132 L A 0.0000
133 T A 0.0000
134 K A -0.0813
135 A A -0.5337
136 L A 0.0000
137 F A -0.4662
138 K A -1.3175
139 Y A -1.6564
140 V A 0.0000
141 R A -3.1497
142 E A -3.1334
143 G A -2.0627
144 K A -1.9195
145 Y A 0.5541
146 T A 0.9812
147 F A 2.1301
148 C A 1.3721
149 T A 0.4736
150 P A -0.2352
151 G A -0.1089
152 H A -0.3678
153 M A 0.3995
154 G A -0.7604
155 G A 0.0000
156 T A -0.6512
157 A A -0.6477
158 F A -0.0511
159 Q A -1.2456
160 K A -1.9004
161 S A -0.2891
162 P A 0.5360
163 V A 1.9647
164 G A 0.0000
165 S A 0.7672
166 L A 2.6177
167 F A 2.6713
168 Y A 1.3449
169 D A 0.5236
170 F A 2.4346
171 F A 1.8087
172 G A 0.2705
173 P A -0.9238
174 N A -1.6993
175 T A -0.5686
176 M A 0.0000
177 K A -1.5223
178 S A -1.1523
179 D A -1.0549
180 I A 0.0000
181 S A 0.5894
182 I A 1.6041
183 S A 0.8983
184 V A 0.0000
185 S A -0.5355
186 E A -1.5268
187 L A 0.0000
188 G A -1.1529
189 S A -0.7277
190 L A 0.0000
191 L A -0.7762
192 D A -2.0300
193 H A -1.9317
194 S A -2.0389
195 G A -2.0040
196 P A -1.9511
197 H A 0.0000
198 K A -3.2812
199 E A -3.0647
200 A A 0.0000
201 E A 0.0000
202 Q A -3.0464
203 Y A -2.0082
204 I A 0.0000
205 A A 0.0000
206 R A -2.6883
207 V A 0.0000
208 F A 0.0000
209 N A -1.6116
210 A A -1.9686
211 D A -2.4320
212 R A -2.9869
213 S A 0.0000
214 Y A 0.0000
215 M A 0.0000
216 V A 0.0000
217 T A 0.0000
218 N A -1.7047
219 G A -1.1951
220 T A 0.0000
221 S A -0.8404
222 T A 0.0000
223 A A 0.0000
224 N A 0.0000
225 K A 0.0184
226 I A 0.0000
227 V A 0.0000
228 G A 0.0000
229 M A 0.2523
230 Y A -0.1209
231 S A 0.0109
232 A A 0.0000
233 P A -0.4167
234 A A -0.6812
235 G A -0.9969
236 S A 0.0000
237 T A 0.0000
238 I A 0.0000
239 L A 0.0000
240 I A 0.0000
241 D A 0.0000
242 R A 0.0000
243 N A -0.6864
244 C A 0.0000
245 H A -1.4207
246 K A -1.2780
247 S A 0.0000
248 L A 0.0000
249 T A 0.0000
250 H A -0.4201
251 L A 0.0000
252 M A 0.0000
253 M A 0.2781
254 M A 0.4499
255 S A -0.2377
256 D A -0.9601
257 V A 0.0000
258 T A 0.0000
259 P A 0.0000
260 I A 0.0000
261 Y A 0.0000
262 F A 0.0000
263 R A -1.5842
264 P A 0.0000
265 T A -0.6402
266 R A 0.0000
267 N A 0.0000
268 A A -0.8975
269 Y A -0.0623
270 G A -0.1277
271 I A 0.0000
272 L A 0.0000
273 G A 0.0000
274 G A 0.0000
275 I A 0.0000
276 P A -0.9936
277 Q A -0.7207
278 S A -0.9629
279 E A -1.0018
280 F A 0.0000
281 Q A -1.6131
282 H A -1.7276
283 A A -1.0858
284 T A -1.1537
285 I A 0.0000
286 A A -1.7829
287 K A -2.9383
288 R A -2.1913
289 V A -2.0217
290 K A -3.3465
291 E A -3.3217
292 T A -2.0650
293 P A -1.4618
294 N A -1.8892
295 A A -1.3256
296 T A -0.5052
297 W A 0.0594
298 P A 0.0000
299 V A -0.2932
300 H A 0.0000
301 A A 0.0000
302 V A 0.0000
303 I A 0.0000
304 T A -0.1102
305 N A 0.0000
306 S A 0.0000
307 T A 0.0000
308 Y A 0.2736
309 D A 0.0000
310 G A 0.0000
311 L A 0.0000
312 L A 0.0000
313 Y A 0.0000
314 N A -1.5071
315 T A 0.0000
316 D A -2.4714
317 F A -1.4822
318 I A 0.0000
319 K A 0.0000
320 K A -2.4795
321 T A 0.0000
322 L A 0.0000
323 D A -2.1086
324 V A 0.0000
325 K A -2.2667
326 S A 0.0000
327 I A 0.0000
328 H A 0.0000
329 F A 0.0000
330 D A 0.0000
331 S A 0.0000
332 A A -0.0039
333 W A 0.3626
334 V A 0.0000
335 P A 0.0000
336 Y A 0.0000
337 T A 0.0000
338 N A -1.0708
339 F A 0.0000
340 S A 0.0000
341 P A -1.2051
342 I A -0.8999
343 Y A 0.0000
344 E A -2.3492
345 G A -1.7355
346 K A -1.3008
347 C A 0.0000
348 G A 0.0000
349 M A 0.0000
350 S A -1.6547
351 G A -1.7329
352 G A -1.7706
353 R A -2.6914
354 V A -2.4592
355 E A -3.0382
356 G A -2.3995
357 K A -2.2830
358 V A -1.4294
359 I A 0.0000
360 Y A 0.0000
361 E A 0.0000
362 T A 0.0000
363 Q A 0.0000
364 S A -0.2974
365 T A 0.0000
366 H A -0.3092
368 L A 0.0508
369 L A 0.0000
370 A A 0.2498
371 A A 0.5434
372 F A 1.4622
373 S A -0.0392
374 Q A -1.0638
375 A A 0.0000
376 S A 0.0000
377 M A 0.0000
378 I A 0.0000
379 H A 0.0000
380 V A 0.0000
381 K A 0.0000
382 G A 0.0000
383 D A -2.9724
384 V A -2.3343
385 N A -3.0400
386 E A -4.0780
387 E A -3.6374
388 T A -2.4609
389 F A 0.0000
390 N A -2.2662
391 E A -2.1001
392 A A 0.0000
393 Y A 0.0000
394 M A 0.1037
395 M A 0.6763
396 H A 0.0360
397 T A -0.0679
398 T A -0.1545
399 T A 0.1942
400 S A -0.0600
401 P A 0.0000
402 H A -0.9183
403 Y A 0.0000
404 G A 0.0936
405 I A 0.1188
406 V A 0.0000
407 A A 0.0000
408 S A 0.0000
409 T A 0.0000
410 E A 0.0000
411 T A 0.1007
412 A A 0.0000
413 A A 0.0000
414 A A 0.0969
415 M A 0.0581
416 M A 0.0000
417 K A -1.5490
418 G A -1.4992
419 N A -2.1355
420 A A -1.6145
421 G A 0.0000
422 K A -2.6465
423 R A -2.5771
424 L A -1.1189
425 I A 0.0000
426 N A -2.0223
427 G A -1.5763
428 S A 0.0000
429 I A 0.0000
430 E A -2.2082
431 R A -1.4603
432 A A 0.0000
433 I A -0.8329
434 K A -1.0537
435 F A 0.0000
436 R A 0.0000
437 K A -1.5504
438 E A 0.0000
439 I A 0.0000
440 K A -1.4840
441 R A -1.7381
442 L A 0.0000
443 R A -2.1000
444 T A -1.6921
445 E A -2.3097
446 S A -2.1374
447 D A -2.4317
448 G A -1.7230
449 W A -0.7544
450 F A 0.0000
451 F A 0.0000
452 D A -0.6201
453 V A 0.0000
454 W A 0.0000
455 Q A 0.0000
456 P A 0.0000
457 L A 1.2203 mutated: DA457L
458 H A 0.0866
459 I A 0.0000
460 L A 1.1660 mutated: DA460L
461 T A 0.2970
462 T A -0.4557
463 E A -0.6576
464 C A 0.0000
465 W A 0.0000
466 P A -1.1309
467 L A 0.0000
468 R A -1.4455
469 S A -1.1902
470 L A 0.8653 mutated: DA470L
471 S A 0.3699
472 T A -0.5466
473 W A 0.0568
474 H A 0.0000
475 G A -1.5391
476 F A 0.0000
477 K A -2.4914
478 N A -2.3217
479 I A -1.9165
480 D A -2.3425
481 N A -2.7520
482 E A -2.7507
483 H A 0.0000
484 M A 0.0000
485 Y A 0.0000
486 L A 0.0000
487 D A 0.0000
488 P A 0.0000
489 I A 0.0000
490 K A 0.0000
491 V A 0.0000
492 T A 0.0000
493 L A 0.0000
494 L A 0.0511
495 T A 0.0000
496 P A -0.2456
497 G A 0.0000
498 M A -1.4594
499 E A -3.3318
500 K A -3.4858
501 D A -3.3349
502 G A -2.4095
503 T A -1.9306
504 M A -1.1564
505 S A -1.2082
506 D A -1.6935
507 F A -0.2924
508 G A 0.0000
509 I A 0.0000
510 P A 0.0000
511 A A 0.0000
512 S A -0.1059
513 I A 0.0000
514 V A 0.0000
515 A A -0.5689
516 K A -1.0389
517 Y A 0.0000
518 L A 0.0000
519 D A -2.0023
520 E A -1.8391
521 H A -1.7855
522 G A -1.1784
523 I A -0.3696
524 V A 0.8526
525 V A 0.2041
526 E A -0.5099
527 K A -0.3858
528 T A -0.2997
529 G A -0.0086
530 P A 0.0000
531 Y A 0.0000
532 N A 0.0000
533 L A 0.0000
534 L A 0.0000
535 F A 0.0000
536 L A 0.1550
537 F A 0.0000
538 S A 0.1944
539 I A 0.2178
540 G A -0.2384
541 I A -0.2726
542 D A -1.1009
543 K A -0.9600
544 T A -1.0400
545 K A -1.3782
546 A A 0.0000
547 L A 0.0000
548 S A -0.5968
549 L A 0.0000
550 L A 0.0000
551 R A 0.0000
552 A A 0.0000
553 L A 0.0000
554 T A 0.0000
555 D A -0.9701
556 F A 0.0000
557 K A 0.0000
558 R A -1.2657
559 A A 0.0000
560 F A 0.0000
561 D A -0.9464
562 L A 0.3978
563 N A -0.5425
564 L A -0.6793
565 R A -2.0791
566 V A 0.0000
567 K A -2.4139
568 N A -2.0049
569 M A 0.0000
570 L A 0.0000
571 P A -1.7332
572 S A -1.9808
573 L A 0.0000
574 Y A -2.6032
575 R A -3.3528
576 E A -3.1958
577 D A -2.5510
578 P A -2.6124
579 E A -2.5073
580 F A -1.0719
581 Y A 0.0000
582 E A -2.4669
583 N A -2.1761
584 M A -1.7965
585 R A -2.1383
586 I A 0.0000
587 Q A -1.8041
588 E A -2.2734
589 L A 0.0000
590 A A 0.0000
591 Q A -2.1608
592 N A -1.6475
593 I A -0.8285
594 H A 0.0000
595 K A -1.2588
596 L A -0.8687
597 I A 0.0000
598 V A -0.7775
599 H A -1.0853
600 H A -1.2926
601 N A -1.5063
602 L A 0.0000
603 P A 0.0000
604 D A -2.2330
605 L A -1.5751
606 M A 0.0000
607 Y A -1.0107
608 R A -2.2340
609 A A 0.0000
610 F A -0.4044
611 E A -0.8186
612 V A -0.3786
613 L A 0.3022
614 P A 0.0000
615 T A 0.3590
616 M A 0.7980
617 V A 1.1535
618 M A 0.8168
619 T A 0.2795
620 P A 0.0000
621 Y A 0.0355
622 A A 0.0697
623 A A 0.0000
624 F A 0.1954
625 Q A -0.3517
626 K A -1.1322
627 E A -0.9517
628 L A 0.3774
629 H A -0.8893
630 G A -0.9906
631 M A -1.2377
632 T A -1.7675
633 E A -2.3845
634 E A -2.2919
635 V A -1.5647
636 Y A -1.6332
637 L A 0.0000
638 D A -2.7574
639 E A -2.4695
640 M A 0.0000
641 V A -1.0261
642 G A -0.6721
643 R A -0.7571
644 I A -0.0818
645 N A 0.0000
646 A A 0.0000
647 N A -0.4989
648 M A 0.0000
649 I A 0.0000
650 L A -0.4273
651 P A 0.0000
652 Y A -0.0484
653 P A 0.0521
654 P A 0.0000
655 G A -0.1171
656 V A 0.0000
657 P A 0.0000
658 L A 0.0000
659 V A 0.0000
660 M A 0.0000
661 P A 0.0000
662 G A 0.0000
663 E A 0.0000
664 M A 0.5757
665 I A 0.0000
666 T A -1.5598
667 E A -2.9013
668 E A -2.7149
669 S A 0.0000
670 R A -2.0578
671 P A -1.6143
672 V A 0.0000
673 L A 0.0000
674 E A -1.7454
675 F A 0.0000
676 L A 0.0000
677 Q A -1.5777
678 M A 0.0000
679 L A 0.0000
680 C A -1.9388
681 E A -2.2178
682 I A -1.0607
683 G A -1.4510
684 A A -1.2667
685 H A -0.9933
686 Y A -0.3978
687 P A -1.0536
688 G A -1.2489
689 F A -0.9004
690 E A -2.2524
691 T A -2.0527
692 D A -2.2445
693 I A 0.0000
694 H A -1.1926
695 G A -0.7017
696 A A -1.1017
697 Y A -1.1761
698 R A -2.7025
699 Q A -2.4073
700 A A -1.8333
701 D A -2.8548
702 G A -2.7461
703 R A -3.0534
704 Y A 0.0000
705 T A 0.0000
706 V A 0.0000
707 K A -1.5256
708 V A 0.0000
709 L A 0.0000
710 K A -3.0343
711 E A -2.6051
1 M B -0.1500
2 N B -1.0481
3 V B 0.0000
4 I B 0.0000
5 A B 0.0000
6 I B 0.0000
7 L B 0.0000
8 N B -1.2728
9 H B -1.3813
10 M B -0.5433
11 G B -0.5834
12 V B -0.6447
13 Y B -0.4692
14 F B 0.0000
15 K B 0.0000
16 E B -0.6116
17 E B -0.5735
18 P B 0.0000
19 I B -0.7207
20 R B -1.4732
21 E B -1.6706
22 L B 0.0000
23 H B -2.1114
24 R B -3.3915
25 A B 0.0000
26 L B 0.0000
27 E B -3.8027
28 R B -3.6243
29 L B -2.5860
30 N B -2.8058
31 F B 0.0000
32 Q B -1.4236
33 I B 0.0000
34 V B 0.0000
35 Y B -0.0165
36 P B 0.0000
37 N B -2.2353
38 D B -2.5896
39 R B -2.5257
40 D B -2.7114
41 D B 0.0000
42 L B 0.0000
43 L B -1.7584
44 K B -2.0185
45 L B 0.0000
46 I B 0.0000
47 E B -2.3642
48 N B -1.7975
49 N B 0.0000
50 A B -0.8258
51 R B -0.8453
52 L B 0.0000
53 C B 0.0000
54 G B 0.0000
55 V B 0.0000
56 I B 0.0000
57 F B 0.0000
58 D B 0.0000
59 W B 0.0000
60 D B -1.1625
61 K B -1.4082
62 Y B 0.0000
63 N B 0.0000
64 L B 0.0281
65 E B -1.6184
66 L B 0.0000
67 C B 0.0000
68 E B -2.6224
69 E B -2.1882
70 I B 0.0000
71 S B 0.0000
72 K B -2.7260
73 M B 0.0000
74 N B -1.6615
75 E B -1.7767
76 N B -1.0175
77 L B 0.0000
78 P B 0.0000
79 L B 0.0000
80 Y B 0.0000
81 A B 0.0000
82 F B 0.0000
83 A B 0.0000
84 N B -0.1298
85 T B 0.2244
86 Y B 0.9358
87 S B 0.0000
88 T B -0.0706
89 L B 0.0000
90 D B -0.4952
91 V B -0.8197
92 S B -0.6492
93 L B 0.0000
94 N B -1.7887
95 D B -2.4739
96 L B -2.3818
97 R B -2.6950
98 L B 0.0000
99 Q B -0.9390
100 I B -0.2210
101 S B -0.3392
102 F B 0.0000
103 F B 0.0000
104 E B -0.7687
105 Y B 0.0000
106 A B -0.6384
107 L B 0.0000
108 G B -1.2141
109 A B -1.3704
110 A B 0.0000
111 E B -3.7062
112 D B -3.6246
113 I B 0.0000
114 A B 0.0000
115 N B -3.6492
116 K B -3.6531
117 I B 0.0000
118 K B -3.5254
119 Q B -3.5519
120 T B -2.7267
121 T B 0.0000
122 D B -3.2673
123 E B -3.0289
124 Y B 0.0000
125 I B -0.6657
126 N B -1.0089
127 T B -0.4462
128 I B 0.5105
129 L B 0.6651
130 P B 0.0000
131 P B -0.6923
132 L B 0.0000
133 T B 0.0000
134 K B -0.1032
135 A B -0.5571
136 L B 0.0000
137 F B -0.4871
138 K B -1.3831
139 Y B -1.7168
140 V B -2.0169
141 R B -3.1418
142 E B -3.1498
143 G B -2.2128
144 K B -2.0764
145 Y B 0.2588
146 T B 0.8521
147 F B 2.0882
148 C B 1.3072
149 T B 0.4327
150 P B -0.2799
151 G B -0.0986
152 H B -0.3741
153 M B 0.3512
154 G B -0.8023
155 G B 0.0000
156 T B -0.6642
157 A B -0.6596
158 F B -0.0810
159 Q B -1.2925
160 K B -1.9308
161 S B -0.3038
162 P B 0.5502
163 V B 1.9698
164 G B 1.1713
165 S B 0.7667
166 L B 2.6643
167 F B 2.7696
168 Y B 1.3652
169 D B 0.5163
170 F B 2.4437
171 F B 1.7826
172 G B 0.2187
173 P B -0.9825
174 N B -1.7155
175 T B -0.5777
176 M B 0.0000
177 K B -1.6074
178 S B -1.1504
179 D B -1.0049
180 I B 0.0000
181 S B 0.0000
182 I B 1.2423
183 S B 0.6639
184 V B 0.0000
185 S B -0.7429
186 E B -1.7545
187 L B 0.0000
188 G B -1.2824
189 S B -0.8305
190 L B 0.0000
191 L B -0.6608
192 D B -2.0346
193 H B -1.9091
194 S B -2.0302
195 G B -2.0123
196 P B -1.9165
197 H B 0.0000
198 K B -3.2688
199 E B -2.9956
200 A B 0.0000
201 E B 0.0000
202 Q B -3.0343
203 Y B -1.9791
204 I B 0.0000
205 A B 0.0000
206 R B -2.7577
207 V B 0.0000
208 F B 0.0000
209 N B -1.8982
210 A B -2.1171
211 D B -2.5048
212 R B -3.0251
213 S B 0.0000
214 Y B 0.0000
215 M B 0.0000
216 V B 0.0000
217 T B 0.0000
218 N B -1.6967
219 G B 0.0000
220 T B 0.0000
221 S B -0.7834
222 T B 0.0000
223 A B 0.0000
224 N B 0.0000
225 K B 0.0270
226 I B 0.0000
227 V B 0.0000
228 G B 0.0000
229 M B 0.2538
230 Y B -0.1324
231 S B 0.0032
232 A B 0.0000
233 P B -0.4432
234 A B -0.7844
235 G B -1.0897
236 S B 0.0000
237 T B 0.0000
238 I B 0.0000
239 L B 0.0000
240 I B 0.0000
241 D B 0.0000
242 R B 0.0000
243 N B -0.4813
244 C B 0.0000
245 H B -1.0804
246 K B -1.1642
247 S B 0.0000
248 L B 0.0000
249 T B 0.0000
250 H B -0.3641
251 L B 0.0000
252 M B 0.0000
253 M B 0.3037
254 M B 0.5005
255 S B 0.0000
256 D B -1.2057
257 V B 0.0000
258 T B 0.0000
259 P B 0.0000
260 I B 0.0000
261 Y B 0.0000
262 F B 0.0000
263 R B -0.9895
264 P B -0.6913
265 T B -0.6712
266 R B 0.0000
267 N B 0.0000
268 A B -0.7799
269 Y B 0.0170
270 G B -0.0968
271 I B 0.0000
272 L B 0.0000
273 G B 0.0000
274 G B 0.0000
275 I B 0.0000
276 P B -0.8834
277 Q B -0.9248
278 S B -0.8840
279 E B -0.8650
280 F B 0.0000
281 Q B -1.4469
282 H B -1.7499
283 A B -1.1003
284 T B -1.1763
285 I B 0.0000
286 A B -1.8499
287 K B -2.9966
288 R B -2.2907
289 V B 0.0000
290 K B -3.4414
291 E B -3.3849
292 T B -2.1374
293 P B -1.4973
294 N B -1.9189
295 A B -1.3807
296 T B -0.5467
297 W B 0.0093
298 P B 0.0000
299 V B -0.1959
300 H B 0.0000
301 A B 0.0000
302 V B 0.0000
303 I B 0.0000
304 T B 0.0000
305 N B 0.0000
306 S B 0.0000
307 T B 0.0000
308 Y B 0.2552
309 D B 0.0000
310 G B 0.0000
311 L B 0.0000
312 L B 0.0000
313 Y B 0.0000
314 N B -1.4680
315 T B 0.0000
316 D B -2.4658
317 F B -1.5186
318 I B 0.0000
319 K B 0.0000
320 K B -2.4463
321 T B -1.7288
322 L B 0.0000
323 D B -2.2168
324 V B 0.0000
325 K B -2.3076
326 S B 0.0000
327 I B 0.0000
328 H B 0.0000
329 F B 0.0000
330 D B 0.0000
331 S B 0.0000
332 A B 0.0118
333 W B 0.2812
334 V B 0.0000
335 P B 0.0000
336 Y B 0.0000
337 T B 0.0000
338 N B -1.1810
339 F B 0.0000
340 S B 0.0000
341 P B -1.3718
342 I B 0.0000
343 Y B 0.0000
344 E B -2.3696
345 G B -1.6938
346 K B 0.0000
347 C B 0.0000
348 G B 0.0000
349 M B 0.0000
350 S B -1.6949
351 G B -1.7822
352 G B -1.8775
353 R B -2.8691
354 V B -2.5609
355 E B -3.1027
356 G B -2.4652
357 K B -2.4075
358 V B 0.0000
359 I B 0.0000
360 Y B 0.0000
361 E B 0.0000
362 T B 0.0000
363 Q B 0.0000
364 S B -0.3083
365 T B 0.0000
366 H B -0.1212
368 L B 0.1276
369 L B 0.0000
370 A B 0.3223
371 A B 0.6169
372 F B 1.5148
373 S B 0.0052
374 Q B -1.0461
375 A B 0.0000
376 S B 0.0000
377 M B 0.0000
378 I B 0.0000
379 H B 0.0000
380 V B 0.0000
381 K B 0.0000
382 G B 0.0000
383 D B -3.0561
384 V B -2.3928
385 N B -3.0570
386 E B -4.0664
387 E B -3.6217
388 T B -2.4807
389 F B 0.0000
390 N B -2.3229
391 E B -2.1422
392 A B 0.0000
393 Y B 0.0000
394 M B 0.0106
395 M B 0.6351
396 H B 0.0093
397 T B -0.1206
398 T B -0.1564
399 T B 0.1464
400 S B -0.1147
401 P B 0.0000
402 H B -0.9196
403 Y B 0.0000
404 G B 0.1052
405 I B 0.1387
406 V B 0.0000
407 A B 0.0000
408 S B 0.0000
409 T B 0.0000
410 E B 0.0000
411 T B 0.1268
412 A B 0.0000
413 A B 0.0000
414 A B 0.1588
415 M B 0.2031
416 M B 0.0000
417 K B -1.2111
418 G B -1.1915
419 N B -1.5602
420 A B -1.3198
421 G B 0.0000
422 K B -2.1471
423 R B -2.0455
424 L B -0.7778
425 I B 0.0000
426 N B -1.8906
427 G B -1.4349
428 S B 0.0000
429 I B 0.0000
430 E B -2.2320
431 R B -1.5590
432 A B 0.0000
433 I B -0.9868
434 K B -1.2419
435 F B 0.0000
436 R B 0.0000
437 K B -2.2302
438 E B 0.0000
439 I B 0.0000
440 K B -2.2898
441 R B -2.1273
442 L B 0.0000
443 R B -2.4120
444 T B -1.8172
445 E B -2.3239
446 S B -2.1069
447 D B -2.3968
448 G B -1.7324
449 W B -0.7809
450 F B 0.0000
451 F B 0.0000
452 D B -0.8559
453 V B 0.0000
454 W B 0.0000
455 Q B 0.0000
456 P B 0.4498
457 L B 1.1446 mutated: DB457L
458 H B -0.0728
459 I B 0.0000
460 L B 1.0607 mutated: DB460L
461 T B 0.1732
462 T B -0.7668
463 E B -1.2971
464 C B 0.0000
465 W B 0.0000
466 P B -1.3082
467 L B 0.0000
468 R B -1.7078
469 S B -1.3131
470 L B 0.7790 mutated: DB470L
471 S B 0.0000
472 T B -0.4834
473 W B 0.1218
474 H B 0.0000
475 G B -1.2244
476 F B 0.0000
477 K B -2.4068
478 N B -2.3218
479 I B -1.9636
480 D B -2.4124
481 N B -2.8475
482 E B -2.8318
483 H B 0.0000
484 M B 0.0000
485 Y B 0.0000
486 L B 0.0000
487 D B 0.0000
488 P B 0.0000
489 I B 0.0000
490 K B 0.0000
491 V B 0.0000
492 T B 0.0000
493 L B 0.0000
494 L B 0.0147
495 T B 0.0000
496 P B -0.2374
497 G B 0.0000
498 M B -1.4370
499 E B -3.2361
500 K B -3.3765
501 D B -3.2519
502 G B -2.1968
503 T B -1.7802
504 M B -1.3679
505 S B -1.4945
506 D B -1.8646
507 F B -0.3968
508 G B 0.0000
509 I B 0.0000
510 P B 0.0000
511 A B 0.0000
512 S B -0.1902
513 I B 0.0000
514 V B 0.0000
515 A B -0.5069
516 K B -1.0843
517 Y B 0.0000
518 L B 0.0000
519 D B -2.0307
520 E B -1.8326
521 H B -1.7780
522 G B -1.1721
523 I B -0.3354
524 V B 0.8218
525 V B 0.1354
526 E B -0.5806
527 K B -0.4002
528 T B -0.2855
529 G B 0.0159
530 P B 0.0702
531 Y B 0.0000
532 N B 0.0000
533 L B 0.0000
534 L B 0.0000
535 F B 0.0000
536 L B 0.1948
537 F B 0.0000
538 S B 0.2345
539 I B 0.2519
540 G B -0.1950
541 I B -0.2137
542 D B -1.0703
543 K B -0.9133
544 T B -0.9624
545 K B -1.2396
546 A B 0.0000
547 L B 0.0000
548 S B -0.5395
549 L B 0.0000
550 L B 0.0000
551 R B 0.0000
552 A B 0.0000
553 L B 0.0000
554 T B 0.0000
555 D B -1.3159
556 F B 0.0000
557 K B 0.0000
558 R B -1.5545
559 A B 0.0000
560 F B 0.0000
561 D B -1.3646
562 L B -0.2168
563 N B -0.7629
564 L B -0.7380
565 R B -1.8291
566 V B 0.0000
567 K B -2.2137
568 N B -1.8693
569 M B 0.0000
570 L B 0.0000
571 P B -1.6384
572 S B -1.9513
573 L B 0.0000
574 Y B -2.3441
575 R B -3.2636
576 E B -3.1571
577 D B -2.4463
578 P B -2.4972
579 E B -2.4310
580 F B -0.9959
581 Y B 0.0000
582 E B -2.2631
583 N B -2.0418
584 M B -1.6018
585 R B -1.9537
586 I B 0.0000
587 Q B -1.7356
588 E B -2.0576
589 L B 0.0000
590 A B 0.0000
591 Q B -2.3785
592 N B -1.9005
593 I B 0.0000
594 H B 0.0000
595 K B -2.5477
596 L B -1.6070
597 I B 0.0000
598 V B -1.5581
599 H B -1.7059
600 H B -1.6591
601 N B -2.0097
602 L B 0.0000
603 P B 0.0000
604 D B -1.8206
605 L B -1.2943
606 M B 0.0000
607 Y B -0.9478
608 R B -1.9950
609 A B 0.0000
610 F B 0.0000
611 E B -1.5279
612 V B -0.6212
613 L B 0.1085
614 P B 0.0000
615 T B 0.3535
616 M B 0.8078
617 V B 1.1079
618 M B 0.8320
619 T B 0.2411
620 P B 0.0000
621 Y B 0.0539
622 A B 0.0992
623 A B 0.0000
624 F B 0.3332
625 Q B -0.1742
626 K B -0.9659
627 E B -0.6864
628 L B 0.5167
629 H B -0.7585
630 G B -0.7851
631 M B -1.0004
632 T B -1.5528
633 E B -2.2545
634 E B -2.2368
635 V B -1.5503
636 Y B -1.2201
637 L B 0.0000
638 D B -2.0109
639 E B -2.1314
640 M B 0.0000
641 V B -0.9547
642 G B -0.6296
643 R B -0.7358
644 I B -0.0512
645 N B 0.0000
646 A B 0.0000
647 N B -0.5220
648 M B 0.0000
649 I B 0.0000
650 L B -0.4243
651 P B 0.0000
652 Y B 0.0575
653 P B 0.1178
654 P B 0.0000
655 G B -0.0731
656 V B 0.0000
657 P B 0.0000
658 L B 0.0000
659 V B 0.0000
660 M B 0.0000
661 P B 0.0000
662 G B 0.0000
663 E B 0.0000
664 M B 0.5437
665 I B 0.0000
666 T B -1.6257
667 E B -2.9738
668 E B -2.7588
669 S B 0.0000
670 R B -2.1495
671 P B -1.6737
672 V B 0.0000
673 L B 0.0000
674 E B -1.5985
675 F B 0.0000
676 L B 0.0000
677 Q B -1.3787
678 M B 0.0000
679 L B 0.0000
680 C B -1.9378
681 E B -2.1342
682 I B -1.0367
683 G B -1.3387
684 A B -1.1504
685 H B -0.9327
686 Y B -0.3357
687 P B -0.7757
688 G B -1.1460
689 F B -0.7812
690 E B -1.9194
691 T B -1.8971
692 D B -2.1778
693 I B 0.0000
694 H B -1.1934
695 G B -0.9060
696 A B -1.0563
697 Y B -1.0860
698 R B -2.5550
699 Q B -2.1829
700 A B -1.7245
701 D B -2.7314
702 G B -2.5362
703 R B -2.4881
704 Y B 0.0000
705 T B 0.0000
706 V B 0.0000
707 K B -1.5139
708 V B 0.0000
709 L B 0.0000
710 K B -2.6339
711 E B -2.4301
1 M C -0.5062
2 N C -1.2172
3 V C 0.0000
4 I C 0.0000
5 A C 0.0000
6 I C 0.0000
7 L C 0.0000
8 N C -1.2607
9 H C -1.3880
10 M C -0.5757
11 G C -0.5705
12 V C -0.6384
13 Y C -0.4900
14 F C 0.0000
15 K C 0.0000
16 E C -0.6432
17 E C -0.6422
18 P C 0.0000
19 I C -0.7893
20 R C -1.5875
21 E C -1.7354
22 L C 0.0000
23 H C -2.2944
24 R C -3.3322
25 A C 0.0000
26 L C 0.0000
27 E C -3.6435
28 R C -3.5149
29 L C -2.3391
30 N C -2.6863
31 F C 0.0000
32 Q C -1.4358
33 I C 0.0000
34 V C 0.0000
35 Y C 0.0238
36 P C 0.0000
37 N C -2.1640
38 D C -2.4826
39 R C -2.4386
40 D C -2.5989
41 D C 0.0000
42 L C 0.0000
43 L C -1.5767
44 K C -1.8684
45 L C 0.0000
46 I C 0.0000
47 E C -1.8977
48 N C -1.6752
49 N C 0.0000
50 A C -1.0549
51 R C -1.5380
52 L C 0.0000
53 C C 0.0000
54 G C 0.0000
55 V C 0.0000
56 I C 0.0000
57 F C 0.0000
58 D C 0.0000
59 W C 0.0000
60 D C -1.8083
61 K C -1.9102
62 Y C -1.2409
63 N C 0.0000
64 L C -0.3078
65 E C -2.0551
66 L C 0.0000
67 C C 0.0000
68 E C -2.9732
69 E C -2.2960
70 I C 0.0000
71 S C -2.2713
72 K C -2.8263
73 M C -1.9964
74 N C -1.5309
75 E C -1.6003
76 N C -0.6800
77 L C 0.0000
78 P C 0.0000
79 L C 0.0000
80 Y C 0.0000
81 A C 0.0000
82 F C 0.0000
83 A C 0.0000
84 N C -0.5115
85 T C 0.1771
86 Y C 0.8663
87 S C 0.0000
88 T C -0.1790
89 L C 0.0000
90 D C -0.6060
91 V C -0.9875
92 S C -0.7692
93 L C 0.0000
94 N C -1.5325
95 D C -2.3823
96 L C -2.3713
97 R C -2.6808
98 L C -1.5293
99 Q C -0.6049
100 I C -0.0703
101 S C -0.3294
102 F C 0.0000
103 F C 0.0000
104 E C -0.9030
105 Y C 0.0000
106 A C -0.6166
107 L C 0.0000
108 G C -1.2677
109 A C -1.4007
110 A C 0.0000
111 E C -3.6711
112 D C -3.5480
113 I C 0.0000
114 A C 0.0000
115 N C -3.3034
116 K C -3.6304
117 I C 0.0000
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