Project name: 3N75 [mutate: DA457L, DA460L, DA470L, DB457L, DB460L, DB470L, DC457L, DC460L, DC470L, DD457L, DD460L, DD470L, DE457L, DE460L, DE470L]

Status: done

submitted: 2017-09-13 12:33:17, status changed: 2017-09-13 15:37:16
Settings
Chain sequence(s) A: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
C: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
B: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
E: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
D: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues DA457L, DA460L, DA470L, DB457L, DB460L, DB470L, DC457L, DC460L, DC470L, DD457L, DD460L, DD470L, DE457L, DE460L, DE470L
Energy difference between WT (input) and mutated protein (by FoldX) 2.58193 kcal/mol
Show buried residues

Minimal score value
-4.078
Maximal score value
2.8345
Average score
-0.701
Total score value
-2488.563

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3261
2 N A -1.1387
3 V A 0.0000
4 I A 0.0000
5 A A 0.0000
6 I A 0.0000
7 L A 0.0000
8 N A -1.3066
9 H A -1.4140
10 M A -0.6006
11 G A -0.6337
12 V A -0.6897
13 Y A -0.5273
14 F A 0.0000
15 K A 0.0000
16 E A -0.6554
17 E A -0.5920
18 P A 0.0000
19 I A -0.6954
20 R A -1.4210
21 E A -1.6176
22 L A 0.0000
23 H A -1.9910
24 R A -3.1509
25 A A 0.0000
26 L A 0.0000
27 E A -3.7431
28 R A -3.6233
29 L A -2.6756
30 N A -2.8404
31 F A 0.0000
32 Q A -1.4388
33 I A -0.7193
34 V A 0.0000
35 Y A 0.0835
36 P A 0.0000
37 N A -2.1346
38 D A -2.4019
39 R A -2.4279
40 D A -2.5580
41 D A 0.0000
42 L A 0.0000
43 L A -1.5473
44 K A -1.7347
45 L A 0.0000
46 I A 0.0000
47 E A -1.7815
48 N A -1.5453
49 N A 0.0000
50 A A -0.6800
51 R A -0.8878
52 L A 0.0000
53 C A 0.0000
54 G A 0.0000
55 V A 0.0000
56 I A 0.0000
57 F A 0.0000
58 D A 0.0000
59 W A 0.0000
60 D A -1.0630
61 K A -1.5101
62 Y A 0.0000
63 N A 0.0000
64 L A -0.4410
65 E A -1.9570
66 L A 0.0000
67 C A 0.0000
68 E A -2.1975
69 E A -2.0819
70 I A 0.0000
71 S A -2.1635
72 K A -2.7764
73 M A 0.0000
74 N A -1.7206
75 E A -1.7062
76 N A -0.8200
77 L A 0.0000
78 P A 0.0000
79 L A 0.0000
80 Y A 0.0000
81 A A 0.0000
82 F A 0.0000
83 A A 0.0000
84 N A -0.1929
85 T A 0.2079
86 Y A 0.9687
87 S A 0.0000
88 T A -0.0298
89 L A 0.0000
90 D A -0.5359
91 V A -0.7485
92 S A -0.6267
93 L A 0.0000
94 N A -1.6612
95 D A -2.4351
96 L A -2.3180
97 R A -2.8615
98 L A 0.0000
99 Q A -0.7593
100 I A -0.1440
101 S A -0.3496
102 F A 0.0000
103 F A 0.0000
104 E A -0.8198
105 Y A 0.0000
106 A A -0.7375
107 L A 0.0000
108 G A -1.2992
109 A A -1.4058
110 A A 0.0000
111 E A -3.7226
112 D A -3.6989
113 I A 0.0000
114 A A 0.0000
115 N A -3.8110
116 K A -3.8921
117 I A 0.0000
118 K A -3.7292
119 Q A -3.6566
120 T A -2.7570
121 T A 0.0000
122 D A -3.2685
123 E A -2.8823
124 Y A 0.0000
125 I A -0.5745
126 N A -0.8528
127 T A -0.3041
128 I A 0.6836
129 L A 0.7404
130 P A 0.0000
131 P A -0.7115
132 L A 0.0000
133 T A 0.0000
134 K A -0.0813
135 A A -0.5337
136 L A 0.0000
137 F A -0.4662
138 K A -1.3175
139 Y A -1.6564
140 V A 0.0000
141 R A -3.1497
142 E A -3.1334
143 G A -2.0627
144 K A -1.9195
145 Y A 0.5541
146 T A 0.9812
147 F A 2.1301
148 C A 1.3721
149 T A 0.4736
150 P A -0.2352
151 G A -0.1089
152 H A -0.3678
153 M A 0.3995
154 G A -0.7604
155 G A 0.0000
156 T A -0.6512
157 A A -0.6477
158 F A -0.0511
159 Q A -1.2456
160 K A -1.9004
161 S A -0.2891
162 P A 0.5360
163 V A 1.9647
164 G A 0.0000
165 S A 0.7672
166 L A 2.6177
167 F A 2.6713
168 Y A 1.3449
169 D A 0.5236
170 F A 2.4346
171 F A 1.8087
172 G A 0.2705
173 P A -0.9238
174 N A -1.6993
175 T A -0.5686
176 M A 0.0000
177 K A -1.5223
178 S A -1.1523
179 D A -1.0549
180 I A 0.0000
181 S A 0.5894
182 I A 1.6041
183 S A 0.8983
184 V A 0.0000
185 S A -0.5355
186 E A -1.5268
187 L A 0.0000
188 G A -1.1529
189 S A -0.7277
190 L A 0.0000
191 L A -0.7762
192 D A -2.0300
193 H A -1.9317
194 S A -2.0389
195 G A -2.0040
196 P A -1.9511
197 H A 0.0000
198 K A -3.2812
199 E A -3.0647
200 A A 0.0000
201 E A 0.0000
202 Q A -3.0464
203 Y A -2.0082
204 I A 0.0000
205 A A 0.0000
206 R A -2.6883
207 V A 0.0000
208 F A 0.0000
209 N A -1.6116
210 A A -1.9686
211 D A -2.4320
212 R A -2.9869
213 S A 0.0000
214 Y A 0.0000
215 M A 0.0000
216 V A 0.0000
217 T A 0.0000
218 N A -1.7047
219 G A -1.1951
220 T A 0.0000
221 S A -0.8404
222 T A 0.0000
223 A A 0.0000
224 N A 0.0000
225 K A 0.0184
226 I A 0.0000
227 V A 0.0000
228 G A 0.0000
229 M A 0.2523
230 Y A -0.1209
231 S A 0.0109
232 A A 0.0000
233 P A -0.4167
234 A A -0.6812
235 G A -0.9969
236 S A 0.0000
237 T A 0.0000
238 I A 0.0000
239 L A 0.0000
240 I A 0.0000
241 D A 0.0000
242 R A 0.0000
243 N A -0.6864
244 C A 0.0000
245 H A -1.4207
246 K A -1.2780
247 S A 0.0000
248 L A 0.0000
249 T A 0.0000
250 H A -0.4201
251 L A 0.0000
252 M A 0.0000
253 M A 0.2781
254 M A 0.4499
255 S A -0.2377
256 D A -0.9601
257 V A 0.0000
258 T A 0.0000
259 P A 0.0000
260 I A 0.0000
261 Y A 0.0000
262 F A 0.0000
263 R A -1.5842
264 P A 0.0000
265 T A -0.6402
266 R A 0.0000
267 N A 0.0000
268 A A -0.8975
269 Y A -0.0623
270 G A -0.1277
271 I A 0.0000
272 L A 0.0000
273 G A 0.0000
274 G A 0.0000
275 I A 0.0000
276 P A -0.9936
277 Q A -0.7207
278 S A -0.9629
279 E A -1.0018
280 F A 0.0000
281 Q A -1.6131
282 H A -1.7276
283 A A -1.0858
284 T A -1.1537
285 I A 0.0000
286 A A -1.7829
287 K A -2.9383
288 R A -2.1913
289 V A -2.0217
290 K A -3.3465
291 E A -3.3217
292 T A -2.0650
293 P A -1.4618
294 N A -1.8892
295 A A -1.3256
296 T A -0.5052
297 W A 0.0594
298 P A 0.0000
299 V A -0.2932
300 H A 0.0000
301 A A 0.0000
302 V A 0.0000
303 I A 0.0000
304 T A -0.1102
305 N A 0.0000
306 S A 0.0000
307 T A 0.0000
308 Y A 0.2736
309 D A 0.0000
310 G A 0.0000
311 L A 0.0000
312 L A 0.0000
313 Y A 0.0000
314 N A -1.5071
315 T A 0.0000
316 D A -2.4714
317 F A -1.4822
318 I A 0.0000
319 K A 0.0000
320 K A -2.4795
321 T A 0.0000
322 L A 0.0000
323 D A -2.1086
324 V A 0.0000
325 K A -2.2667
326 S A 0.0000
327 I A 0.0000
328 H A 0.0000
329 F A 0.0000
330 D A 0.0000
331 S A 0.0000
332 A A -0.0039
333 W A 0.3626
334 V A 0.0000
335 P A 0.0000
336 Y A 0.0000
337 T A 0.0000
338 N A -1.0708
339 F A 0.0000
340 S A 0.0000
341 P A -1.2051
342 I A -0.8999
343 Y A 0.0000
344 E A -2.3492
345 G A -1.7355
346 K A -1.3008
347 C A 0.0000
348 G A 0.0000
349 M A 0.0000
350 S A -1.6547
351 G A -1.7329
352 G A -1.7706
353 R A -2.6914
354 V A -2.4592
355 E A -3.0382
356 G A -2.3995
357 K A -2.2830
358 V A -1.4294
359 I A 0.0000
360 Y A 0.0000
361 E A 0.0000
362 T A 0.0000
363 Q A 0.0000
364 S A -0.2974
365 T A 0.0000
366 H A -0.3092
368 L A 0.0508
369 L A 0.0000
370 A A 0.2498
371 A A 0.5434
372 F A 1.4622
373 S A -0.0392
374 Q A -1.0638
375 A A 0.0000
376 S A 0.0000
377 M A 0.0000
378 I A 0.0000
379 H A 0.0000
380 V A 0.0000
381 K A 0.0000
382 G A 0.0000
383 D A -2.9724
384 V A -2.3343
385 N A -3.0400
386 E A -4.0780
387 E A -3.6374
388 T A -2.4609
389 F A 0.0000
390 N A -2.2662
391 E A -2.1001
392 A A 0.0000
393 Y A 0.0000
394 M A 0.1037
395 M A 0.6763
396 H A 0.0360
397 T A -0.0679
398 T A -0.1545
399 T A 0.1942
400 S A -0.0600
401 P A 0.0000
402 H A -0.9183
403 Y A 0.0000
404 G A 0.0936
405 I A 0.1188
406 V A 0.0000
407 A A 0.0000
408 S A 0.0000
409 T A 0.0000
410 E A 0.0000
411 T A 0.1007
412 A A 0.0000
413 A A 0.0000
414 A A 0.0969
415 M A 0.0581
416 M A 0.0000
417 K A -1.5490
418 G A -1.4992
419 N A -2.1355
420 A A -1.6145
421 G A 0.0000
422 K A -2.6465
423 R A -2.5771
424 L A -1.1189
425 I A 0.0000
426 N A -2.0223
427 G A -1.5763
428 S A 0.0000
429 I A 0.0000
430 E A -2.2082
431 R A -1.4603
432 A A 0.0000
433 I A -0.8329
434 K A -1.0537
435 F A 0.0000
436 R A 0.0000
437 K A -1.5504
438 E A 0.0000
439 I A 0.0000
440 K A -1.4840
441 R A -1.7381
442 L A 0.0000
443 R A -2.1000
444 T A -1.6921
445 E A -2.3097
446 S A -2.1374
447 D A -2.4317
448 G A -1.7230
449 W A -0.7544
450 F A 0.0000
451 F A 0.0000
452 D A -0.6201
453 V A 0.0000
454 W A 0.0000
455 Q A 0.0000
456 P A 0.0000
457 L A 1.2203 mutated: DA457L
458 H A 0.0866
459 I A 0.0000
460 L A 1.1660 mutated: DA460L
461 T A 0.2970
462 T A -0.4557
463 E A -0.6576
464 C A 0.0000
465 W A 0.0000
466 P A -1.1309
467 L A 0.0000
468 R A -1.4455
469 S A -1.1902
470 L A 0.8653 mutated: DA470L
471 S A 0.3699
472 T A -0.5466
473 W A 0.0568
474 H A 0.0000
475 G A -1.5391
476 F A 0.0000
477 K A -2.4914
478 N A -2.3217
479 I A -1.9165
480 D A -2.3425
481 N A -2.7520
482 E A -2.7507
483 H A 0.0000
484 M A 0.0000
485 Y A 0.0000
486 L A 0.0000
487 D A 0.0000
488 P A 0.0000
489 I A 0.0000
490 K A 0.0000
491 V A 0.0000
492 T A 0.0000
493 L A 0.0000
494 L A 0.0511
495 T A 0.0000
496 P A -0.2456
497 G A 0.0000
498 M A -1.4594
499 E A -3.3318
500 K A -3.4858
501 D A -3.3349
502 G A -2.4095
503 T A -1.9306
504 M A -1.1564
505 S A -1.2082
506 D A -1.6935
507 F A -0.2924
508 G A 0.0000
509 I A 0.0000
510 P A 0.0000
511 A A 0.0000
512 S A -0.1059
513 I A 0.0000
514 V A 0.0000
515 A A -0.5689
516 K A -1.0389
517 Y A 0.0000
518 L A 0.0000
519 D A -2.0023
520 E A -1.8391
521 H A -1.7855
522 G A -1.1784
523 I A -0.3696
524 V A 0.8526
525 V A 0.2041
526 E A -0.5099
527 K A -0.3858
528 T A -0.2997
529 G A -0.0086
530 P A 0.0000
531 Y A 0.0000
532 N A 0.0000
533 L A 0.0000
534 L A 0.0000
535 F A 0.0000
536 L A 0.1550
537 F A 0.0000
538 S A 0.1944
539 I A 0.2178
540 G A -0.2384
541 I A -0.2726
542 D A -1.1009
543 K A -0.9600
544 T A -1.0400
545 K A -1.3782
546 A A 0.0000
547 L A 0.0000
548 S A -0.5968
549 L A 0.0000
550 L A 0.0000
551 R A 0.0000
552 A A 0.0000
553 L A 0.0000
554 T A 0.0000
555 D A -0.9701
556 F A 0.0000
557 K A 0.0000
558 R A -1.2657
559 A A 0.0000
560 F A 0.0000
561 D A -0.9464
562 L A 0.3978
563 N A -0.5425
564 L A -0.6793
565 R A -2.0791
566 V A 0.0000
567 K A -2.4139
568 N A -2.0049
569 M A 0.0000
570 L A 0.0000
571 P A -1.7332
572 S A -1.9808
573 L A 0.0000
574 Y A -2.6032
575 R A -3.3528
576 E A -3.1958
577 D A -2.5510
578 P A -2.6124
579 E A -2.5073
580 F A -1.0719
581 Y A 0.0000
582 E A -2.4669
583 N A -2.1761
584 M A -1.7965
585 R A -2.1383
586 I A 0.0000
587 Q A -1.8041
588 E A -2.2734
589 L A 0.0000
590 A A 0.0000
591 Q A -2.1608
592 N A -1.6475
593 I A -0.8285
594 H A 0.0000
595 K A -1.2588
596 L A -0.8687
597 I A 0.0000
598 V A -0.7775
599 H A -1.0853
600 H A -1.2926
601 N A -1.5063
602 L A 0.0000
603 P A 0.0000
604 D A -2.2330
605 L A -1.5751
606 M A 0.0000
607 Y A -1.0107
608 R A -2.2340
609 A A 0.0000
610 F A -0.4044
611 E A -0.8186
612 V A -0.3786
613 L A 0.3022
614 P A 0.0000
615 T A 0.3590
616 M A 0.7980
617 V A 1.1535
618 M A 0.8168
619 T A 0.2795
620 P A 0.0000
621 Y A 0.0355
622 A A 0.0697
623 A A 0.0000
624 F A 0.1954
625 Q A -0.3517
626 K A -1.1322
627 E A -0.9517
628 L A 0.3774
629 H A -0.8893
630 G A -0.9906
631 M A -1.2377
632 T A -1.7675
633 E A -2.3845
634 E A -2.2919
635 V A -1.5647
636 Y A -1.6332
637 L A 0.0000
638 D A -2.7574
639 E A -2.4695
640 M A 0.0000
641 V A -1.0261
642 G A -0.6721
643 R A -0.7571
644 I A -0.0818
645 N A 0.0000
646 A A 0.0000
647 N A -0.4989
648 M A 0.0000
649 I A 0.0000
650 L A -0.4273
651 P A 0.0000
652 Y A -0.0484
653 P A 0.0521
654 P A 0.0000
655 G A -0.1171
656 V A 0.0000
657 P A 0.0000
658 L A 0.0000
659 V A 0.0000
660 M A 0.0000
661 P A 0.0000
662 G A 0.0000
663 E A 0.0000
664 M A 0.5757
665 I A 0.0000
666 T A -1.5598
667 E A -2.9013
668 E A -2.7149
669 S A 0.0000
670 R A -2.0578
671 P A -1.6143
672 V A 0.0000
673 L A 0.0000
674 E A -1.7454
675 F A 0.0000
676 L A 0.0000
677 Q A -1.5777
678 M A 0.0000
679 L A 0.0000
680 C A -1.9388
681 E A -2.2178
682 I A -1.0607
683 G A -1.4510
684 A A -1.2667
685 H A -0.9933
686 Y A -0.3978
687 P A -1.0536
688 G A -1.2489
689 F A -0.9004
690 E A -2.2524
691 T A -2.0527
692 D A -2.2445
693 I A 0.0000
694 H A -1.1926
695 G A -0.7017
696 A A -1.1017
697 Y A -1.1761
698 R A -2.7025
699 Q A -2.4073
700 A A -1.8333
701 D A -2.8548
702 G A -2.7461
703 R A -3.0534
704 Y A 0.0000
705 T A 0.0000
706 V A 0.0000
707 K A -1.5256
708 V A 0.0000
709 L A 0.0000
710 K A -3.0343
711 E A -2.6051
1 M B -0.1500
2 N B -1.0481
3 V B 0.0000
4 I B 0.0000
5 A B 0.0000
6 I B 0.0000
7 L B 0.0000
8 N B -1.2728
9 H B -1.3813
10 M B -0.5433
11 G B -0.5834
12 V B -0.6447
13 Y B -0.4692
14 F B 0.0000
15 K B 0.0000
16 E B -0.6116
17 E B -0.5735
18 P B 0.0000
19 I B -0.7207
20 R B -1.4732
21 E B -1.6706
22 L B 0.0000
23 H B -2.1114
24 R B -3.3915
25 A B 0.0000
26 L B 0.0000
27 E B -3.8027
28 R B -3.6243
29 L B -2.5860
30 N B -2.8058
31 F B 0.0000
32 Q B -1.4236
33 I B 0.0000
34 V B 0.0000
35 Y B -0.0165
36 P B 0.0000
37 N B -2.2353
38 D B -2.5896
39 R B -2.5257
40 D B -2.7114
41 D B 0.0000
42 L B 0.0000
43 L B -1.7584
44 K B -2.0185
45 L B 0.0000
46 I B 0.0000
47 E B -2.3642
48 N B -1.7975
49 N B 0.0000
50 A B -0.8258
51 R B -0.8453
52 L B 0.0000
53 C B 0.0000
54 G B 0.0000
55 V B 0.0000
56 I B 0.0000
57 F B 0.0000
58 D B 0.0000
59 W B 0.0000
60 D B -1.1625
61 K B -1.4082
62 Y B 0.0000
63 N B 0.0000
64 L B 0.0281
65 E B -1.6184
66 L B 0.0000
67 C B 0.0000
68 E B -2.6224
69 E B -2.1882
70 I B 0.0000
71 S B 0.0000
72 K B -2.7260
73 M B 0.0000
74 N B -1.6615
75 E B -1.7767
76 N B -1.0175
77 L B 0.0000
78 P B 0.0000
79 L B 0.0000
80 Y B 0.0000
81 A B 0.0000
82 F B 0.0000
83 A B 0.0000
84 N B -0.1298
85 T B 0.2244
86 Y B 0.9358
87 S B 0.0000
88 T B -0.0706
89 L B 0.0000
90 D B -0.4952
91 V B -0.8197
92 S B -0.6492
93 L B 0.0000
94 N B -1.7887
95 D B -2.4739
96 L B -2.3818
97 R B -2.6950
98 L B 0.0000
99 Q B -0.9390
100 I B -0.2210
101 S B -0.3392
102 F B 0.0000
103 F B 0.0000
104 E B -0.7687
105 Y B 0.0000
106 A B -0.6384
107 L B 0.0000
108 G B -1.2141
109 A B -1.3704
110 A B 0.0000
111 E B -3.7062
112 D B -3.6246
113 I B 0.0000
114 A B 0.0000
115 N B -3.6492
116 K B -3.6531
117 I B 0.0000
118 K B -3.5254
119 Q B -3.5519
120 T B -2.7267
121 T B 0.0000
122 D B -3.2673
123 E B -3.0289
124 Y B 0.0000
125 I B -0.6657
126 N B -1.0089
127 T B -0.4462
128 I B 0.5105
129 L B 0.6651
130 P B 0.0000
131 P B -0.6923
132 L B 0.0000
133 T B 0.0000
134 K B -0.1032
135 A B -0.5571
136 L B 0.0000
137 F B -0.4871
138 K B -1.3831
139 Y B -1.7168
140 V B -2.0169
141 R B -3.1418
142 E B -3.1498
143 G B -2.2128
144 K B -2.0764
145 Y B 0.2588
146 T B 0.8521
147 F B 2.0882
148 C B 1.3072
149 T B 0.4327
150 P B -0.2799
151 G B -0.0986
152 H B -0.3741
153 M B 0.3512
154 G B -0.8023
155 G B 0.0000
156 T B -0.6642
157 A B -0.6596
158 F B -0.0810
159 Q B -1.2925
160 K B -1.9308
161 S B -0.3038
162 P B 0.5502
163 V B 1.9698
164 G B 1.1713
165 S B 0.7667
166 L B 2.6643
167 F B 2.7696
168 Y B 1.3652
169 D B 0.5163
170 F B 2.4437
171 F B 1.7826
172 G B 0.2187
173 P B -0.9825
174 N B -1.7155
175 T B -0.5777
176 M B 0.0000
177 K B -1.6074
178 S B -1.1504
179 D B -1.0049
180 I B 0.0000
181 S B 0.0000
182 I B 1.2423
183 S B 0.6639
184 V B 0.0000
185 S B -0.7429
186 E B -1.7545
187 L B 0.0000
188 G B -1.2824
189 S B -0.8305
190 L B 0.0000
191 L B -0.6608
192 D B -2.0346
193 H B -1.9091
194 S B -2.0302
195 G B -2.0123
196 P B -1.9165
197 H B 0.0000
198 K B -3.2688
199 E B -2.9956
200 A B 0.0000
201 E B 0.0000
202 Q B -3.0343
203 Y B -1.9791
204 I B 0.0000
205 A B 0.0000
206 R B -2.7577
207 V B 0.0000
208 F B 0.0000
209 N B -1.8982
210 A B -2.1171
211 D B -2.5048
212 R B -3.0251
213 S B 0.0000
214 Y B 0.0000
215 M B 0.0000
216 V B 0.0000
217 T B 0.0000
218 N B -1.6967
219 G B 0.0000
220 T B 0.0000
221 S B -0.7834
222 T B 0.0000
223 A B 0.0000
224 N B 0.0000
225 K B 0.0270
226 I B 0.0000
227 V B 0.0000
228 G B 0.0000
229 M B 0.2538
230 Y B -0.1324
231 S B 0.0032
232 A B 0.0000
233 P B -0.4432
234 A B -0.7844
235 G B -1.0897
236 S B 0.0000
237 T B 0.0000
238 I B 0.0000
239 L B 0.0000
240 I B 0.0000
241 D B 0.0000
242 R B 0.0000
243 N B -0.4813
244 C B 0.0000
245 H B -1.0804
246 K B -1.1642
247 S B 0.0000
248 L B 0.0000
249 T B 0.0000
250 H B -0.3641
251 L B 0.0000
252 M B 0.0000
253 M B 0.3037
254 M B 0.5005
255 S B 0.0000
256 D B -1.2057
257 V B 0.0000
258 T B 0.0000
259 P B 0.0000
260 I B 0.0000
261 Y B 0.0000
262 F B 0.0000
263 R B -0.9895
264 P B -0.6913
265 T B -0.6712
266 R B 0.0000
267 N B 0.0000
268 A B -0.7799
269 Y B 0.0170
270 G B -0.0968
271 I B 0.0000
272 L B 0.0000
273 G B 0.0000
274 G B 0.0000
275 I B 0.0000
276 P B -0.8834
277 Q B -0.9248
278 S B -0.8840
279 E B -0.8650
280 F B 0.0000
281 Q B -1.4469
282 H B -1.7499
283 A B -1.1003
284 T B -1.1763
285 I B 0.0000
286 A B -1.8499
287 K B -2.9966
288 R B -2.2907
289 V B 0.0000
290 K B -3.4414
291 E B -3.3849
292 T B -2.1374
293 P B -1.4973
294 N B -1.9189
295 A B -1.3807
296 T B -0.5467
297 W B 0.0093
298 P B 0.0000
299 V B -0.1959
300 H B 0.0000
301 A B 0.0000
302 V B 0.0000
303 I B 0.0000
304 T B 0.0000
305 N B 0.0000
306 S B 0.0000
307 T B 0.0000
308 Y B 0.2552
309 D B 0.0000
310 G B 0.0000
311 L B 0.0000
312 L B 0.0000
313 Y B 0.0000
314 N B -1.4680
315 T B 0.0000
316 D B -2.4658
317 F B -1.5186
318 I B 0.0000
319 K B 0.0000
320 K B -2.4463
321 T B -1.7288
322 L B 0.0000
323 D B -2.2168
324 V B 0.0000
325 K B -2.3076
326 S B 0.0000
327 I B 0.0000
328 H B 0.0000
329 F B 0.0000
330 D B 0.0000
331 S B 0.0000
332 A B 0.0118
333 W B 0.2812
334 V B 0.0000
335 P B 0.0000
336 Y B 0.0000
337 T B 0.0000
338 N B -1.1810
339 F B 0.0000
340 S B 0.0000
341 P B -1.3718
342 I B 0.0000
343 Y B 0.0000
344 E B -2.3696
345 G B -1.6938
346 K B 0.0000
347 C B 0.0000
348 G B 0.0000
349 M B 0.0000
350 S B -1.6949
351 G B -1.7822
352 G B -1.8775
353 R B -2.8691
354 V B -2.5609
355 E B -3.1027
356 G B -2.4652
357 K B -2.4075
358 V B 0.0000
359 I B 0.0000
360 Y B 0.0000
361 E B 0.0000
362 T B 0.0000
363 Q B 0.0000
364 S B -0.3083
365 T B 0.0000
366 H B -0.1212
368 L B 0.1276
369 L B 0.0000
370 A B 0.3223
371 A B 0.6169
372 F B 1.5148
373 S B 0.0052
374 Q B -1.0461
375 A B 0.0000
376 S B 0.0000
377 M B 0.0000
378 I B 0.0000
379 H B 0.0000
380 V B 0.0000
381 K B 0.0000
382 G B 0.0000
383 D B -3.0561
384 V B -2.3928
385 N B -3.0570
386 E B -4.0664
387 E B -3.6217
388 T B -2.4807
389 F B 0.0000
390 N B -2.3229
391 E B -2.1422
392 A B 0.0000
393 Y B 0.0000
394 M B 0.0106
395 M B 0.6351
396 H B 0.0093
397 T B -0.1206
398 T B -0.1564
399 T B 0.1464
400 S B -0.1147
401 P B 0.0000
402 H B -0.9196
403 Y B 0.0000
404 G B 0.1052
405 I B 0.1387
406 V B 0.0000
407 A B 0.0000
408 S B 0.0000
409 T B 0.0000
410 E B 0.0000
411 T B 0.1268
412 A B 0.0000
413 A B 0.0000
414 A B 0.1588
415 M B 0.2031
416 M B 0.0000
417 K B -1.2111
418 G B -1.1915
419 N B -1.5602
420 A B -1.3198
421 G B 0.0000
422 K B -2.1471
423 R B -2.0455
424 L B -0.7778
425 I B 0.0000
426 N B -1.8906
427 G B -1.4349
428 S B 0.0000
429 I B 0.0000
430 E B -2.2320
431 R B -1.5590
432 A B 0.0000
433 I B -0.9868
434 K B -1.2419
435 F B 0.0000
436 R B 0.0000
437 K B -2.2302
438 E B 0.0000
439 I B 0.0000
440 K B -2.2898
441 R B -2.1273
442 L B 0.0000
443 R B -2.4120
444 T B -1.8172
445 E B -2.3239
446 S B -2.1069
447 D B -2.3968
448 G B -1.7324
449 W B -0.7809
450 F B 0.0000
451 F B 0.0000
452 D B -0.8559
453 V B 0.0000
454 W B 0.0000
455 Q B 0.0000
456 P B 0.4498
457 L B 1.1446 mutated: DB457L
458 H B -0.0728
459 I B 0.0000
460 L B 1.0607 mutated: DB460L
461 T B 0.1732
462 T B -0.7668
463 E B -1.2971
464 C B 0.0000
465 W B 0.0000
466 P B -1.3082
467 L B 0.0000
468 R B -1.7078
469 S B -1.3131
470 L B 0.7790 mutated: DB470L
471 S B 0.0000
472 T B -0.4834
473 W B 0.1218
474 H B 0.0000
475 G B -1.2244
476 F B 0.0000
477 K B -2.4068
478 N B -2.3218
479 I B -1.9636
480 D B -2.4124
481 N B -2.8475
482 E B -2.8318
483 H B 0.0000
484 M B 0.0000
485 Y B 0.0000
486 L B 0.0000
487 D B 0.0000
488 P B 0.0000
489 I B 0.0000
490 K B 0.0000
491 V B 0.0000
492 T B 0.0000
493 L B 0.0000
494 L B 0.0147
495 T B 0.0000
496 P B -0.2374
497 G B 0.0000
498 M B -1.4370
499 E B -3.2361
500 K B -3.3765
501 D B -3.2519
502 G B -2.1968
503 T B -1.7802
504 M B -1.3679
505 S B -1.4945
506 D B -1.8646
507 F B -0.3968
508 G B 0.0000
509 I B 0.0000
510 P B 0.0000
511 A B 0.0000
512 S B -0.1902
513 I B 0.0000
514 V B 0.0000
515 A B -0.5069
516 K B -1.0843
517 Y B 0.0000
518 L B 0.0000
519 D B -2.0307
520 E B -1.8326
521 H B -1.7780
522 G B -1.1721
523 I B -0.3354
524 V B 0.8218
525 V B 0.1354
526 E B -0.5806
527 K B -0.4002
528 T B -0.2855
529 G B 0.0159
530 P B 0.0702
531 Y B 0.0000
532 N B 0.0000
533 L B 0.0000
534 L B 0.0000
535 F B 0.0000
536 L B 0.1948
537 F B 0.0000
538 S B 0.2345
539 I B 0.2519
540 G B -0.1950
541 I B -0.2137
542 D B -1.0703
543 K B -0.9133
544 T B -0.9624
545 K B -1.2396
546 A B 0.0000
547 L B 0.0000
548 S B -0.5395
549 L B 0.0000
550 L B 0.0000
551 R B 0.0000
552 A B 0.0000
553 L B 0.0000
554 T B 0.0000
555 D B -1.3159
556 F B 0.0000
557 K B 0.0000
558 R B -1.5545
559 A B 0.0000
560 F B 0.0000
561 D B -1.3646
562 L B -0.2168
563 N B -0.7629
564 L B -0.7380
565 R B -1.8291
566 V B 0.0000
567 K B -2.2137
568 N B -1.8693
569 M B 0.0000
570 L B 0.0000
571 P B -1.6384
572 S B -1.9513
573 L B 0.0000
574 Y B -2.3441
575 R B -3.2636
576 E B -3.1571
577 D B -2.4463
578 P B -2.4972
579 E B -2.4310
580 F B -0.9959
581 Y B 0.0000
582 E B -2.2631
583 N B -2.0418
584 M B -1.6018
585 R B -1.9537
586 I B 0.0000
587 Q B -1.7356
588 E B -2.0576
589 L B 0.0000
590 A B 0.0000
591 Q B -2.3785
592 N B -1.9005
593 I B 0.0000
594 H B 0.0000
595 K B -2.5477
596 L B -1.6070
597 I B 0.0000
598 V B -1.5581
599 H B -1.7059
600 H B -1.6591
601 N B -2.0097
602 L B 0.0000
603 P B 0.0000
604 D B -1.8206
605 L B -1.2943
606 M B 0.0000
607 Y B -0.9478
608 R B -1.9950
609 A B 0.0000
610 F B 0.0000
611 E B -1.5279
612 V B -0.6212
613 L B 0.1085
614 P B 0.0000
615 T B 0.3535
616 M B 0.8078
617 V B 1.1079
618 M B 0.8320
619 T B 0.2411
620 P B 0.0000
621 Y B 0.0539
622 A B 0.0992
623 A B 0.0000
624 F B 0.3332
625 Q B -0.1742
626 K B -0.9659
627 E B -0.6864
628 L B 0.5167
629 H B -0.7585
630 G B -0.7851
631 M B -1.0004
632 T B -1.5528
633 E B -2.2545
634 E B -2.2368
635 V B -1.5503
636 Y B -1.2201
637 L B 0.0000
638 D B -2.0109
639 E B -2.1314
640 M B 0.0000
641 V B -0.9547
642 G B -0.6296
643 R B -0.7358
644 I B -0.0512
645 N B 0.0000
646 A B 0.0000
647 N B -0.5220
648 M B 0.0000
649 I B 0.0000
650 L B -0.4243
651 P B 0.0000
652 Y B 0.0575
653 P B 0.1178
654 P B 0.0000
655 G B -0.0731
656 V B 0.0000
657 P B 0.0000
658 L B 0.0000
659 V B 0.0000
660 M B 0.0000
661 P B 0.0000
662 G B 0.0000
663 E B 0.0000
664 M B 0.5437
665 I B 0.0000
666 T B -1.6257
667 E B -2.9738
668 E B -2.7588
669 S B 0.0000
670 R B -2.1495
671 P B -1.6737
672 V B 0.0000
673 L B 0.0000
674 E B -1.5985
675 F B 0.0000
676 L B 0.0000
677 Q B -1.3787
678 M B 0.0000
679 L B 0.0000
680 C B -1.9378
681 E B -2.1342
682 I B -1.0367
683 G B -1.3387
684 A B -1.1504
685 H B -0.9327
686 Y B -0.3357
687 P B -0.7757
688 G B -1.1460
689 F B -0.7812
690 E B -1.9194
691 T B -1.8971
692 D B -2.1778
693 I B 0.0000
694 H B -1.1934
695 G B -0.9060
696 A B -1.0563
697 Y B -1.0860
698 R B -2.5550
699 Q B -2.1829
700 A B -1.7245
701 D B -2.7314
702 G B -2.5362
703 R B -2.4881
704 Y B 0.0000
705 T B 0.0000
706 V B 0.0000
707 K B -1.5139
708 V B 0.0000
709 L B 0.0000
710 K B -2.6339
711 E B -2.4301
1 M C -0.5062
2 N C -1.2172
3 V C 0.0000
4 I C 0.0000
5 A C 0.0000
6 I C 0.0000
7 L C 0.0000
8 N C -1.2607
9 H C -1.3880
10 M C -0.5757
11 G C -0.5705
12 V C -0.6384
13 Y C -0.4900
14 F C 0.0000
15 K C 0.0000
16 E C -0.6432
17 E C -0.6422
18 P C 0.0000
19 I C -0.7893
20 R C -1.5875
21 E C -1.7354
22 L C 0.0000
23 H C -2.2944
24 R C -3.3322
25 A C 0.0000
26 L C 0.0000
27 E C -3.6435
28 R C -3.5149
29 L C -2.3391
30 N C -2.6863
31 F C 0.0000
32 Q C -1.4358
33 I C 0.0000
34 V C 0.0000
35 Y C 0.0238
36 P C 0.0000
37 N C -2.1640
38 D C -2.4826
39 R C -2.4386
40 D C -2.5989
41 D C 0.0000
42 L C 0.0000
43 L C -1.5767
44 K C -1.8684
45 L C 0.0000
46 I C 0.0000
47 E C -1.8977
48 N C -1.6752
49 N C 0.0000
50 A C -1.0549
51 R C -1.5380
52 L C 0.0000
53 C C 0.0000
54 G C 0.0000
55 V C 0.0000
56 I C 0.0000
57 F C 0.0000
58 D C 0.0000
59 W C 0.0000
60 D C -1.8083
61 K C -1.9102
62 Y C -1.2409
63 N C 0.0000
64 L C -0.3078
65 E C -2.0551
66 L C 0.0000
67 C C 0.0000
68 E C -2.9732
69 E C -2.2960
70 I C 0.0000
71 S C -2.2713
72 K C -2.8263
73 M C -1.9964
74 N C -1.5309
75 E C -1.6003
76 N C -0.6800
77 L C 0.0000
78 P C 0.0000
79 L C 0.0000
80 Y C 0.0000
81 A C 0.0000
82 F C 0.0000
83 A C 0.0000
84 N C -0.5115
85 T C 0.1771
86 Y C 0.8663
87 S C 0.0000
88 T C -0.1790
89 L C 0.0000
90 D C -0.6060
91 V C -0.9875
92 S C -0.7692
93 L C 0.0000
94 N C -1.5325
95 D C -2.3823
96 L C -2.3713
97 R C -2.6808
98 L C -1.5293
99 Q C -0.6049
100 I C -0.0703
101 S C -0.3294
102 F C 0.0000
103 F C 0.0000
104 E C -0.9030
105 Y C 0.0000
106 A C -0.6166
107 L C 0.0000
108 G C -1.2677
109 A C -1.4007
110 A C 0.0000
111 E C -3.6711
112 D C -3.5480
113 I C 0.0000
114 A C 0.0000
115 N C -3.3034
116 K C -3.6304
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