Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCEGNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDLSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAP B: RKQLATKAARSAPAT |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | EA1148A |
Energy difference between WT (input) and mutated protein (by FoldX) | 0.828058 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.8735 | |
887 | V | A | 2.1700 | |
888 | S | A | 1.6138 | |
889 | I | A | 2.3224 | |
890 | Y | A | 1.0497 | |
891 | P | A | 0.0553 | |
892 | S | A | -0.9627 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.3316 | |
895 | E | A | -1.8226 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.4618 | |
898 | K | A | -2.0889 | |
899 | A | A | -1.3562 | |
900 | C | A | -1.5152 | |
901 | R | A | -2.8005 | |
902 | N | A | -2.0402 | |
903 | L | A | -0.3580 | |
904 | G | A | -1.3711 | |
905 | K | A | -2.5400 | |
906 | N | A | -2.3014 | |
907 | G | A | -1.2104 | |
908 | L | A | -0.2337 | |
909 | S | A | -1.2597 | |
910 | N | A | -1.6654 | |
911 | S | A | -0.4122 | |
912 | S | A | 0.0683 | |
913 | I | A | 0.7578 | |
914 | L | A | 0.6169 | |
915 | L | A | 0.5083 | |
916 | D | A | -1.8277 | |
917 | K | A | -1.8986 | |
918 | C | A | -0.7322 | |
919 | P | A | -0.7681 | |
920 | P | A | -1.0510 | |
921 | P | A | -1.5454 | |
922 | R | A | -2.1862 | |
923 | P | A | -1.3164 | |
924 | P | A | -0.8515 | |
925 | S | A | -0.6023 | |
926 | S | A | -0.1515 | |
927 | P | A | 0.2772 | |
928 | Y | A | 1.0007 | |
929 | P | A | 0.4516 | |
930 | P | A | -0.2056 | |
931 | L | A | -0.8559 | |
932 | P | A | -1.9234 | |
933 | K | A | -3.4397 | |
934 | D | A | -3.6320 | |
935 | K | A | -3.4703 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.5514 | |
938 | P | A | -1.6124 | |
939 | P | A | -0.9177 | |
940 | T | A | -0.3954 | |
941 | P | A | -0.1597 | |
942 | S | A | 0.3583 | |
943 | I | A | 0.6651 | |
944 | Y | A | 0.8024 | |
945 | L | A | -1.0092 | |
946 | E | A | -2.5102 | |
947 | N | A | -2.7600 | |
948 | K | A | -2.5593 | |
949 | R | A | -2.1576 | |
950 | D | A | -1.2444 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.2061 | |
953 | F | A | 1.4828 | |
954 | P | A | 0.6533 | |
955 | P | A | 0.0911 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.5557 | |
958 | Q | A | -1.2537 | |
959 | F | A | -0.6331 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.8211 | |
962 | N | A | -1.3273 | |
963 | P | A | -1.2893 | |
964 | N | A | -1.6483 | |
965 | N | A | -0.9402 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.2579 | |
972 | G | A | -0.8760 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -1.9089 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.6566 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.2139 | |
981 | L | A | -1.0497 | |
982 | G | A | -0.9761 | |
983 | L | A | -0.3800 | |
984 | F | A | 0.0000 | |
985 | S | A | -0.8287 | |
986 | T | A | -1.2178 | |
987 | K | A | -2.3513 | |
988 | T | A | -1.5409 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.3016 | |
991 | E | A | -2.6441 | |
992 | A | A | -1.6824 | |
993 | N | A | -1.6666 | |
994 | N | A | -2.6749 | |
995 | E | A | -2.6254 | |
996 | H | A | -1.2524 | |
997 | M | A | -0.2734 | |
998 | V | A | 0.0000 | |
999 | E | A | 0.0000 | |
1000 | V | A | 0.0000 | |
1001 | R | A | 0.0000 | |
1002 | T | A | -1.1175 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.4825 | |
1005 | L | A | -0.1392 | |
1006 | Q | A | -0.2850 | |
1007 | P | A | -0.3598 | |
1008 | A | A | -0.1411 | |
1009 | D | A | -0.6281 | |
1010 | E | A | -0.9085 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.7761 | |
1013 | D | A | -0.9753 | |
1014 | P | A | -0.8022 | |
1015 | T | A | -0.5130 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -1.0064 | |
1018 | K | A | -1.8158 | |
1019 | K | A | -1.3319 | |
1020 | I | A | -0.5868 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -1.0568 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.3521 | |
1025 | G | A | 0.0000 | |
1026 | N | A | -1.8484 | |
1027 | R | A | -2.5087 | |
1028 | S | A | -1.7806 | |
1029 | H | A | -1.3501 | |
1030 | T | A | -1.0577 | |
1031 | T | A | -1.3889 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.2531 | |
1034 | K | A | -2.4186 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | 0.0000 | |
1037 | Q | A | -1.6780 | |
1038 | Y | A | -0.6900 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.6855 | |
1041 | S | A | -0.7210 | |
1042 | S | A | -0.3930 | |
1043 | F | A | 0.2173 | |
1044 | Q | A | -1.4338 | |
1045 | E | A | -2.6338 | |
1046 | S | A | -1.8506 | |
1047 | L | A | -2.1850 | |
1048 | R | A | -4.3869 | |
1049 | E | A | -4.7215 | |
1050 | E | A | -4.4184 | |
1051 | N | A | -4.7213 | |
1052 | E | A | -4.9675 | |
1053 | K | A | -5.2490 | |
1054 | R | A | -4.4192 | |
1055 | S | A | -3.0915 | |
1056 | H | A | -2.9464 | |
1057 | H | A | -2.8933 | |
1058 | K | A | -3.1876 | |
1059 | D | A | -2.2278 | |
1060 | L | A | -0.0700 | |
1061 | S | A | -0.7404 | |
1062 | D | A | -1.7256 | |
1063 | S | A | -1.6369 | |
1064 | E | A | -2.4757 | |
1065 | S | A | -2.4561 | |
1066 | T | A | -2.4818 | |
1067 | S | A | -2.4974 | |
1068 | S | A | -3.9076 | |
1069 | D | A | -4.5837 | |
1070 | N | A | -4.1391 | |
1071 | S | A | -2.7568 | |
1072 | G | A | -2.2195 | |
1073 | R | A | -3.9773 | |
1074 | R | A | -4.4511 | |
1075 | R | A | -4.0873 | |
1076 | K | A | -3.2026 | |
1077 | G | A | 0.0000 | |
1078 | P | A | -1.2820 | |
1079 | F | A | -1.0620 | |
1080 | K | A | -1.5194 | |
1081 | T | A | -0.8084 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -0.9861 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | 0.0000 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.3067 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.4823 | |
1092 | D | A | -2.7821 | |
1093 | D | A | -3.7050 | |
1094 | K | A | -3.4396 | |
1095 | K | A | -2.4698 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -2.6905 | |
1098 | L | A | -0.2734 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.1132 | |
1101 | H | A | -1.1642 | |
1102 | E | A | 0.0000 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.6275 | |
1105 | K | A | -1.4900 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.2124 | |
1109 | F | A | 0.1512 | |
1110 | V | A | 0.0000 | |
1111 | R | A | -0.0399 | |
1112 | V | A | 0.7778 | |
1113 | V | A | 1.5707 | |
1114 | S | A | 0.6295 | |
1115 | A | A | 0.0938 | |
1116 | G | A | -0.0141 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.1629 | |
1121 | H | A | -0.4820 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -1.4543 | |
1124 | H | A | -1.2950 | |
1125 | T | A | -0.5658 | |
1126 | I | A | 0.0000 | |
1127 | L | A | -0.1290 | |
1128 | G | A | -0.1896 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.1022 | |
1131 | T | A | -0.1241 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | 0.0000 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | 0.1527 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4319 | |
1140 | G | A | 0.2233 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.0542 | |
1144 | P | A | 0.0000 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.1757 | |
1147 | Q | A | -0.4306 | |
1148 | A | A | -0.4239 | mutated: EA1148A |
1149 | N | A | -0.8791 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | -0.1184 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5952 | |
1162 | G | A | -0.4811 | |
1163 | D | A | -0.6114 | |
1164 | C | A | 0.0000 | |
1165 | E | A | 0.0000 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.6055 | |
1171 | E | A | -0.9022 | |
1172 | G | A | -0.4091 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | 0.0000 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.5363 | |
1177 | L | A | 0.0000 | |
1178 | N | A | -1.6114 | |
1179 | D | A | -2.9100 | |
1180 | F | A | -2.1672 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -3.9363 | |
1183 | K | A | -3.6335 | |
1184 | N | A | -2.7420 | |
1185 | N | A | -2.9869 | |
1186 | L | A | -2.0097 | |
1187 | N | A | -1.5683 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.3707 | |
1190 | M | A | 0.8714 | |
1191 | G | A | -0.0616 | |
1192 | S | A | 0.0000 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | -1.0600 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -2.6146 | |
1199 | D | A | -1.9950 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -1.9552 | |
1202 | E | A | -2.6290 | |
1203 | A | A | -1.4362 | |
1204 | N | A | -1.8302 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.7692 | |
1209 | R | A | -0.9847 | |
1210 | F | A | 0.0000 | |
1211 | I | A | 0.4223 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.3111 | |
1214 | P | A | -0.9359 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0137 | |
1232 | G | A | 0.3658 | |
1233 | W | A | 0.4736 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.4176 | |
1245 | T | A | -0.2387 | |
1246 | A | A | -0.7858 | |
1247 | C | A | -0.3720 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.5341 | |
1251 | L | A | 0.0000 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -1.1235 | |
1254 | E | A | -2.4695 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -1.6588 | |
1258 | W | A | -1.2759 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -1.2078 | |
1261 | L | A | -0.0470 | |
1262 | Q | A | -0.4538 | |
1263 | S | A | -0.5513 | |
1264 | V | A | -0.3712 | |
1265 | K | A | -1.0746 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.0000 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.2273 | |
1272 | H | A | -0.0754 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -0.8585 | |
1277 | M | A | 0.0000 | |
1278 | A | A | 0.0000 | |
1279 | R | A | -1.9731 | |
1280 | N | A | -1.8401 | |
1281 | I | A | -1.4458 | |
1282 | K | A | -2.0292 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.2368 | |
1285 | D | A | -1.9292 | |
1286 | P | A | -1.6589 | |
1287 | K | A | -2.3682 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -1.1467 | |
1290 | E | A | -0.9767 | |
1291 | M | A | -0.6861 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.3382 | |
1295 | C | A | 0.0036 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.1828 | |
1299 | T | A | -0.7279 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.1905 | |
1302 | Q | A | -1.8371 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -1.1691 | |
1306 | L | A | -0.4765 | |
1307 | R | A | -0.7750 | |
1308 | E | A | -0.9211 | |
1309 | A | A | -0.1959 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 0.8219 | |
1312 | A | A | 0.2948 | |
1313 | A | A | -0.1867 | |
1314 | G | A | -0.3941 | |
1315 | K | A | -0.9257 | |
1316 | E | A | -1.0668 | |
1317 | I | A | 0.4146 | |
1318 | I | A | 1.4147 | |
1319 | W | A | 0.7270 | |
1320 | H | A | 0.0000 | |
1321 | G | A | -0.6021 | |
1322 | R | A | -1.6528 | |
1323 | T | A | -1.9479 | |
1324 | K | A | -3.0049 | |
1325 | E | A | -3.1326 | |
1326 | E | A | -2.1007 | |
1327 | P | A | -1.3662 | |
1328 | A | A | 0.0000 | |
1329 | H | A | 0.0000 | |
1330 | Y | A | -0.0727 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.1828 | |
1333 | I | A | 1.1146 | |
1334 | C | A | -0.0444 | |
1335 | E | A | -0.5928 | |
1336 | V | A | -0.1937 | |
1337 | E | A | 0.0000 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.1808 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -0.8956 | |
1346 | N | A | -2.0041 | |
1347 | E | A | -1.9427 | |
1348 | S | A | -1.5662 | |
1349 | N | A | -2.2662 | |
1350 | S | A | -2.5114 | |
1351 | R | A | -3.2681 | |
1352 | K | A | -3.4715 | |
1353 | T | A | -2.1807 | |
1354 | Y | A | -1.1957 | |
1355 | I | A | -0.0174 | |
1356 | V | A | 0.0000 | |
1357 | H | A | 0.0000 | |
1358 | C | A | 0.0000 | |
1359 | Q | A | -1.7668 | |
1360 | D | A | -2.9620 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -4.0611 | |
1364 | K | A | -3.3940 | |
1365 | T | A | -2.3772 | |
1366 | S | A | -2.6350 | |
1367 | G | A | -2.8111 | |
1368 | N | A | -2.9384 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.1258 | |
1371 | N | A | -2.3043 | |
1372 | F | A | 0.0000 | |
1373 | V | A | -0.2284 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.0000 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | 0.0000 | |
1379 | K | A | -2.0920 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.8002 | |
1382 | D | A | -2.4313 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.8698 | |
1385 | Q | A | -2.7204 | |
1386 | V | A | -1.9484 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -2.1512 | |
1389 | Q | A | -2.1078 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.7588 | |
1392 | L | A | -0.2812 | |
1393 | A | A | -0.5709 | |
1394 | P | A | -0.5995 | |
17 | R | B | -2.4713 | |
18 | K | B | -2.4891 | |
19 | Q | B | -2.1708 | |
20 | L | B | -0.9790 | |
21 | A | B | -0.8240 | |
22 | T | B | -0.9226 | |
23 | K | B | -1.7689 | |
24 | A | B | -0.8874 | |
25 | A | B | -0.7025 | |
26 | R | B | -0.7370 | |
28 | S | B | -0.3855 | |
29 | A | B | -0.2379 | |
30 | P | B | -0.2906 | |
31 | A | B | -0.8454 | |
32 | T | B | -0.9614 |