| Chain sequence(s) |
A: ILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRN P: TLPWDLW |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | I | A | 2.2161 | |
| 5 | L | A | 1.5153 | |
| 6 | P | A | 0.0000 | |
| 7 | I | A | 0.0000 | |
| 8 | R | A | -1.5362 | |
| 9 | F | A | -0.7565 | |
| 10 | Q | A | -1.7930 | |
| 11 | E | A | -1.7896 | |
| 12 | H | A | -1.2083 | |
| 13 | L | A | -0.9272 | |
| 14 | Q | A | -1.2529 | |
| 15 | L | A | 0.0000 | |
| 16 | Q | A | -1.9857 | |
| 17 | N | A | -1.8148 | |
| 18 | L | A | -1.2404 | |
| 19 | G | A | -1.3712 | |
| 20 | I | A | 0.0000 | |
| 21 | N | A | -1.8125 | |
| 22 | P | A | -1.4175 | |
| 23 | A | A | -0.9082 | |
| 24 | N | A | -0.9587 | |
| 25 | I | A | 0.0000 | |
| 26 | G | A | 0.0000 | |
| 27 | F | A | 0.4436 | |
| 28 | S | A | -0.2755 | |
| 29 | T | A | -0.5669 | |
| 30 | L | A | 0.0000 | |
| 31 | T | A | -0.0789 | |
| 32 | M | A | 0.0000 | |
| 33 | E | A | -0.5117 | |
| 34 | S | A | -0.8637 | |
| 35 | D | A | -1.3502 | |
| 36 | K | A | -1.5971 | |
| 37 | F | A | 0.0000 | |
| 38 | I | A | 0.0000 | |
| 39 | C | A | 0.0000 | |
| 40 | I | A | 0.0000 | |
| 41 | R | A | -1.2871 | |
| 42 | E | A | 0.0000 | |
| 43 | K | A | -1.7521 | |
| 44 | V | A | -0.0978 | |
| 45 | G | A | -1.1524 | |
| 46 | E | A | -2.3174 | |
| 47 | Q | A | -1.7655 | |
| 48 | A | A | -1.5990 | |
| 49 | Q | A | -1.2779 | |
| 50 | V | A | 0.0000 | |
| 51 | V | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | D | A | -1.7058 | |
| 55 | M | A | -1.6246 | |
| 56 | N | A | -2.3648 | |
| 57 | D | A | -2.6216 | |
| 58 | P | A | -1.5884 | |
| 59 | S | A | -1.5656 | |
| 60 | N | A | -1.9705 | |
| 61 | P | A | -1.0999 | |
| 62 | I | A | -0.3906 | |
| 63 | R | A | -1.0731 | |
| 64 | R | A | -0.7586 | |
| 65 | P | A | -0.7843 | |
| 66 | I | A | -0.7090 | |
| 67 | S | A | -0.6731 | |
| 68 | A | A | 0.0000 | |
| 69 | D | A | -1.6680 | |
| 70 | S | A | -0.9068 | |
| 71 | A | A | -0.4224 | |
| 72 | I | A | 0.0000 | |
| 73 | M | A | 0.0000 | |
| 74 | N | A | 0.0000 | |
| 75 | P | A | -0.1425 | |
| 76 | A | A | -0.1519 | |
| 77 | S | A | -0.4948 | |
| 78 | K | A | -1.0583 | |
| 79 | V | A | 0.0000 | |
| 80 | I | A | 0.0000 | |
| 81 | A | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | K | A | 0.0000 | |
| 84 | A | A | -1.1577 | |
| 85 | G | A | -1.8812 | |
| 86 | K | A | -2.5445 | |
| 87 | T | A | -1.2921 | |
| 88 | L | A | 0.0000 | |
| 89 | Q | A | -0.5102 | |
| 90 | I | A | 0.0000 | |
| 91 | F | A | -0.9996 | |
| 92 | N | A | -1.3063 | |
| 93 | I | A | 0.0000 | |
| 94 | E | A | -2.0574 | |
| 95 | M | A | -0.9655 | |
| 96 | K | A | -2.1203 | |
| 97 | S | A | -1.5853 | |
| 98 | K | A | -1.7442 | |
| 99 | M | A | -0.9383 | |
| 100 | K | A | -1.2267 | |
| 101 | A | A | -0.7388 | |
| 102 | H | A | -0.7548 | |
| 103 | T | A | -1.1388 | |
| 104 | M | A | 0.0000 | |
| 105 | T | A | -1.1224 | |
| 106 | D | A | -2.4400 | |
| 107 | D | A | -3.1620 | |
| 108 | V | A | 0.0000 | |
| 109 | T | A | -0.9556 | |
| 110 | F | A | -0.4185 | |
| 111 | W | A | 0.0000 | |
| 112 | K | A | -0.3354 | |
| 113 | W | A | 0.0000 | |
| 114 | I | A | 0.2573 | |
| 115 | S | A | 0.4656 | |
| 116 | L | A | 1.1453 | |
| 117 | N | A | -0.1227 | |
| 118 | T | A | 0.0000 | |
| 119 | V | A | 0.0000 | |
| 120 | A | A | 0.0000 | |
| 121 | L | A | 0.0000 | |
| 122 | V | A | 0.0000 | |
| 123 | T | A | 0.0000 | |
| 124 | D | A | -3.1667 | |
| 125 | N | A | -3.0927 | |
| 126 | A | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | Y | A | -0.2193 | |
| 129 | H | A | 0.0000 | |
| 130 | W | A | 0.0000 | |
| 131 | S | A | -0.9395 | |
| 132 | M | A | -1.2568 | |
| 133 | E | A | -2.4923 | |
| 134 | G | A | -2.4124 | |
| 135 | E | A | -2.7932 | |
| 136 | S | A | -1.8778 | |
| 137 | Q | A | -1.5731 | |
| 138 | P | A | -0.3770 | |
| 139 | V | A | 0.6213 | |
| 140 | K | A | -1.0596 | |
| 141 | M | A | -0.6207 | |
| 142 | F | A | 0.0000 | |
| 143 | D | A | -2.8317 | |
| 144 | R | A | -2.1369 | |
| 145 | H | A | -1.5161 | |
| 146 | S | A | -0.9706 | |
| 147 | S | A | -0.7193 | |
| 148 | L | A | 0.0000 | |
| 149 | A | A | -0.9183 | |
| 150 | G | A | -0.7823 | |
| 151 | C | A | -0.4148 | |
| 152 | Q | A | -0.2974 | |
| 153 | I | A | 0.0000 | |
| 154 | I | A | 0.0000 | |
| 155 | N | A | -0.3644 | |
| 156 | Y | A | 0.0000 | |
| 157 | R | A | -0.2922 | |
| 158 | T | A | -0.5320 | |
| 159 | D | A | 0.0000 | |
| 160 | A | A | -0.8982 | |
| 161 | K | A | -1.7398 | |
| 162 | Q | A | -1.4659 | |
| 163 | K | A | -2.4253 | |
| 164 | W | A | -1.2096 | |
| 165 | L | A | 0.0000 | |
| 166 | L | A | 0.0000 | |
| 167 | L | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | I | A | 0.0000 | |
| 171 | S | A | -0.2177 | |
| 172 | A | A | -0.7373 | |
| 173 | Q | A | -2.1390 | |
| 174 | Q | A | -2.5413 | |
| 175 | N | A | -2.6920 | |
| 176 | R | A | -2.1370 | |
| 177 | V | A | -0.7137 | |
| 178 | V | A | -0.1053 | |
| 179 | G | A | -0.3538 | |
| 180 | A | A | 0.0000 | |
| 181 | M | A | 0.0000 | |
| 182 | Q | A | 0.0000 | |
| 183 | L | A | 0.0000 | |
| 184 | Y | A | 0.0000 | |
| 185 | S | A | 0.0000 | |
| 186 | V | A | -1.7919 | |
| 187 | D | A | -3.1154 | |
| 188 | R | A | -3.0722 | |
| 189 | K | A | -2.3349 | |
| 190 | V | A | -0.1761 | |
| 191 | S | A | -0.7133 | |
| 192 | Q | A | -0.9270 | |
| 193 | P | A | -1.1561 | |
| 194 | I | A | -1.0092 | |
| 195 | E | A | -1.6708 | |
| 196 | G | A | 0.0000 | |
| 197 | H | A | 0.0000 | |
| 198 | A | A | 0.0000 | |
| 199 | A | A | 0.0000 | |
| 200 | S | A | 0.0000 | |
| 201 | F | A | 0.1260 | |
| 202 | A | A | -0.8240 | |
| 203 | Q | A | -2.0790 | |
| 204 | F | A | 0.0000 | |
| 205 | K | A | -2.9983 | |
| 206 | M | A | 0.0000 | |
| 207 | E | A | -2.8619 | |
| 208 | G | A | -1.9533 | |
| 209 | N | A | 0.0000 | |
| 210 | A | A | -1.9499 | |
| 211 | E | A | -3.2533 | |
| 212 | E | A | -3.3892 | |
| 213 | S | A | 0.0000 | |
| 214 | T | A | -1.1861 | |
| 215 | L | A | 0.0000 | |
| 216 | F | A | 0.0000 | |
| 217 | C | A | 0.0000 | |
| 218 | F | A | -0.0058 | |
| 219 | A | A | 0.0000 | |
| 220 | V | A | 0.0000 | |
| 221 | R | A | -0.9711 | |
| 222 | G | A | -1.2493 | |
| 223 | Q | A | -1.4029 | |
| 224 | A | A | -1.0088 | |
| 225 | G | A | -0.8136 | |
| 226 | G | A | -0.6350 | |
| 227 | K | A | -1.0358 | |
| 228 | L | A | 0.0000 | |
| 229 | H | A | -0.6257 | |
| 230 | I | A | 0.0000 | |
| 231 | I | A | -0.6045 | |
| 232 | E | A | -0.7553 | |
| 233 | V | A | 0.0000 | |
| 234 | G | A | -1.0930 | |
| 235 | T | A | -0.5547 | |
| 236 | P | A | -1.2053 | |
| 237 | P | A | -1.1592 | |
| 238 | T | A | -0.7931 | |
| 239 | G | A | -1.2488 | |
| 240 | N | A | -2.1293 | |
| 241 | Q | A | -2.0001 | |
| 242 | P | A | -1.3034 | |
| 243 | F | A | 0.0000 | |
| 244 | P | A | -1.3663 | |
| 245 | K | A | -1.9542 | |
| 246 | K | A | -1.0961 | |
| 247 | A | A | -0.7783 | |
| 248 | V | A | -0.4868 | |
| 249 | D | A | -1.2864 | |
| 250 | V | A | 0.0000 | |
| 251 | F | A | 1.4768 | |
| 252 | F | A | 0.1340 | |
| 253 | P | A | 0.0000 | |
| 254 | P | A | -1.3686 | |
| 255 | E | A | -2.4509 | |
| 256 | A | A | 0.0000 | |
| 257 | Q | A | -2.5721 | |
| 258 | N | A | -2.3025 | |
| 259 | D | A | 0.0000 | |
| 260 | F | A | 0.0000 | |
| 261 | P | A | 0.0000 | |
| 262 | V | A | 0.0000 | |
| 263 | A | A | 0.0344 | |
| 264 | M | A | 0.0000 | |
| 265 | Q | A | 0.0000 | |
| 266 | I | A | -0.5306 | |
| 267 | S | A | 0.0000 | |
| 268 | E | A | -2.9514 | |
| 269 | K | A | -2.8378 | |
| 270 | H | A | -2.0934 | |
| 271 | D | A | -1.6522 | |
| 272 | V | A | 0.0000 | |
| 273 | V | A | 0.0000 | |
| 274 | F | A | 0.0000 | |
| 275 | L | A | 0.0000 | |
| 276 | I | A | 0.0000 | |
| 277 | T | A | 0.0000 | |
| 278 | K | A | 0.0000 | |
| 279 | Y | A | -0.5379 | |
| 280 | G | A | 0.0000 | |
| 281 | Y | A | -0.7352 | |
| 282 | I | A | 0.0000 | |
| 283 | H | A | 0.0000 | |
| 284 | L | A | 0.0000 | |
| 285 | Y | A | 0.0000 | |
| 286 | D | A | 0.0000 | |
| 287 | L | A | 0.0000 | |
| 288 | E | A | -0.6791 | |
| 289 | T | A | -0.3458 | |
| 290 | G | A | 0.0000 | |
| 291 | T | A | -0.0828 | |
| 292 | C | A | 0.4224 | |
| 293 | I | A | 0.0000 | |
| 294 | Y | A | 0.3053 | |
| 295 | M | A | -0.1306 | |
| 296 | N | A | -1.5293 | |
| 297 | R | A | -1.5609 | |
| 298 | I | A | -0.7283 | |
| 299 | S | A | 0.0000 | |
| 300 | G | A | -1.2870 | |
| 301 | E | A | -1.5187 | |
| 302 | T | A | 0.0000 | |
| 303 | I | A | 0.0000 | |
| 304 | F | A | 0.0000 | |
| 305 | V | A | 0.2232 | |
| 306 | T | A | -0.0400 | |
| 307 | A | A | 0.0000 | |
| 308 | P | A | -0.8438 | |
| 309 | H | A | -1.2599 | |
| 310 | E | A | -2.0686 | |
| 311 | A | A | -0.9301 | |
| 312 | T | A | -1.0948 | |
| 313 | A | A | -1.5285 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | I | A | 0.0000 | |
| 317 | G | A | 0.0000 | |
| 318 | V | A | 0.0000 | |
| 319 | N | A | 0.0000 | |
| 320 | R | A | -1.2377 | |
| 321 | K | A | -2.0032 | |
| 322 | G | A | 0.0000 | |
| 323 | Q | A | -1.3459 | |
| 324 | V | A | 0.0000 | |
| 325 | L | A | 0.0000 | |
| 326 | S | A | 0.0000 | |
| 327 | V | A | 0.0000 | |
| 328 | C | A | -0.7758 | |
| 329 | V | A | 0.0000 | |
| 330 | E | A | -1.6852 | |
| 331 | E | A | -3.0524 | |
| 332 | E | A | -2.4964 | |
| 333 | N | A | -1.0796 | |
| 334 | I | A | 0.0000 | |
| 335 | I | A | -0.0187 | |
| 336 | P | A | -0.1403 | |
| 337 | Y | A | 0.7305 | |
| 338 | I | A | 0.0000 | |
| 339 | T | A | -0.6028 | |
| 340 | N | A | -0.6784 | |
| 341 | V | A | 1.4903 | |
| 342 | L | A | 0.4807 | |
| 343 | Q | A | -1.2698 | |
| 344 | N | A | -1.1650 | |
| 345 | P | A | -1.3199 | |
| 346 | D | A | -1.7852 | |
| 347 | L | A | 0.0000 | |
| 348 | A | A | 0.0000 | |
| 349 | L | A | 0.9221 | |
| 350 | R | A | 0.0530 | |
| 351 | M | A | 0.0838 | |
| 352 | A | A | 0.4633 | |
| 353 | V | A | 1.0158 | |
| 354 | R | A | -0.7274 | |
| 355 | N | A | -1.1293 | |
| 1 | T | P | 0.4207 | |
| 2 | L | P | 1.3591 | |
| 3 | P | P | 0.8568 | |
| 4 | W | P | 0.0000 | |
| 5 | D | P | 0.0000 | |
| 6 | L | P | 1.4030 | |
| 7 | W | P | 1.0759 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine